检索结果-南通市图书馆

A systematic review of progenitor survival and maturation in Parkinsonian models

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini eilís dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain repair for Parkinson's disease:is the answer in the matrix?

引用

Neural Regeneration Research 2018年第7期13卷 1187-1188页

作者： Niamh Moriarty eilís dowd Pharmacology & Therapeutics and Galway Neuroscience Centre National University of Ireland

Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name,there is still an irrefutable need for a therapy that targets the underlying pathophys... 详细信息

关键词： Brain repair for Parkinson’s disease:is the answer in the matrix

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The loaded matrix:neurotrophin-enriched hydrogels for stem cell brain repair in Parkinson's disease

引用

Neural Regeneration Research 2025年第8期20卷 2315-2316页

作者： Giulia Comini eilis dowd Pharmacology&Therapeutics University of GalwayGalwayIreland

More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet cl... 详细信息

关键词： clinical loaded eventually

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

引用

Neural Regeneration Research 2025年第1期20卷 205-206页

作者： sarah Fullam sean O’dowd Antoinette O’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbon sequestration potential of the Habanero reservoir when carbon dioxide is used as the heat exchange fluid

引用

Journal of Rock Mechanics and Geotechnical Engineering 2016年第1期8卷 50-59页

作者： Chaoshui Xu Peter dowd Qi Li school of Civil Environmental and Mining Engineering & South Australia Centre for Geothermal Energy Research University of Adelaide state Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil Mechanics Chinese Academy of Sciences

The use of sequestered carbon dioxide(CO) as the heat exchange fluid in enhanced geothermal system(EGs) has significant potential to increase their productivity, contribute further to reducing carbon emissions and increase the economic viability of geothermal power generation. Coupled COsequestration and geothermal energy production from hot dry rock(HDR) EGs were first proposed 15 years ago but have yet to be practically implemented. This paper reviews some of the issues in assessing these systems with particular focus on the power generation and COsequestration capacity. The Habanero geothermal field in the Cooper Basin of south Australia is assessed for its potential COstorage capacity if supercritical COis used as the working fluid for heat extraction. The analysis suggests that the major COsequestration mechanisms are the storage in the fracture-stimulation damaged zone followed by diffusion into the pores within the rock matrix. The assessment indicates that 5% of working fluid loss commonly suggested as the storage capacity might be an over-estimate of the long-term COsequestration capacity of EGs in which supercritical COis used as the circulation fluid.

关键词： Carbon sequestration Carbon dioxide(CO_2) geological storage capacity Enhanced geothermal system(EGs) CO_2-EGs Habanero project

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antibiotic use in early childhood and risk of obesity: longitudinal analysis of a national cohort

引用

World Journal of Pediatrics 2019年第4期15卷 390-397页

作者： Dervla Kelly Alan Kelly Tom O'dowd Catherine B.Hayes Department of Public Health and Primary Care Trinity College DublinRussell CenterTallaght CrossDublin 24Ireland

Background Taking oral antibiotics during childhood has been linked with an increased risk of childhood *** study assessed any potential association in number of courses of antibiotics taken between 2-3 and 4-5 years of age and body mass trajectory up to age *** The study was a secondary analysis of 8186 children and their parents from the infant cohort of the Irish National Longitudinal study of *** use was measured by parental recall between ages 2-3 and *** models described the relationship between antibiotic exposure and body mass index (BMI) standard deviation scores andbinary outcomes,and examined interactions between covariates,which included socioeconomic status,diet assessed by food frequency questionnaires and maternal *** Any antibiotic usage between 2 and 3 years did not predict risk of overweight or obesity at age *** or more courses of antibiotics between 2 and 3 years were independently associated with obesity at age 5 (odds ratio 1.6,95% confidence interval 1.11-2.31).Effect size was modest (coefficient + 0.09 body mass sD units,standard error 0.04,P =0.037).Maternal BMI modified the relationship:≥ 4 courses of antibiotics between 2 and 3 years were associated with a + 0.12 body mass sD units increase in weight at age 5 among children of normal-weight mothers (P=0.035),but not in children of overweight *** Number of antibiotic courses,rather than antibiotic use,may be an important factor in any link between early antibiotic exposure and subsequent childhood *** is needed to confirm differential effects on babies of normal versus overweight/obese mothers independent of socioeconomic factors.

关键词： Antibiotics Body mass index Early childhood Infants Obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

sisters and rebels

Sisters and rebels

引用

作者： Jacquelyn dowd Hall.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Fungal dysbiosis predicts the diagnosis of pediatric Crohn's disease

引用

World Journal of Gastroenterology 2018年第39期24卷 4510-4516页

作者： Mohammad I El Mouzan Kirill s Korolev Mohammad A Al Mofarreh Rajita Menon Harland s Winter Ahmad A Al sarkhy scot E dowd Ahmad M Al Barrag Asaad A Assiri Department of Pediatrics King Saud UniversityRiyadh 11461Saudi Arabia Department of Pediatrics Supervisor of Prince Abdullah Bin Khalid Celiac Disease Research ChairKing Saud UniversityRiyadh 11461Saudi Arabia Bioinformatics Program Boston UniversityBostonMA 02215United States Al Mofarreh PolyClinic Riyadh 11423Saudi Arabia MassGeneral Hospital for Children BostonMA 02114United States MRDNA ShallowaterTX 79363United States Department of Microbiology King Saud UniversityRiyadh 11461Saudi Arabia

AIM To investigate the accuracy of fungal dysbiosis inmucosa and stool for predicting the diagnosis of Crohn's disease(CD). METHODs Children were prospectively enrolled in two medical centers: one university hospital and one private gastroenterology clinic in the city of Riyadh, Kingdom of saudi Arabia. The children with confirmed diagnosis of CD by standard guidelines were considered cases, and the others were considered non-inflammatory bowel disease controls. Mucosal and stool samples were sequenced utilizing Illumina Miseq chemistry following the manufacturer's protocols, and abundance and diversity of fungal taxa in mucosa and stool were analyzed. sparse logistic regression was used to predict the diagnosis of CD. The accuracy of the classifier was tested by computing the receiver operating characteristic curves with 5-fold stratified cross-validation under 100 permutations of the training data partition and the mean area under the curve(AUC) was calculated. REsULTs All the children were saudi nationals. There were 15 children with CD and 20 controls. The mean age was 13.9(range: 6.7-17.8) years for CD children and 13.9(3.25-18.6) years for controls, and 10/15(67%) of the CD and 13/20(65%) of the control subjects were boys. CD locations at diagnosis were ileal(L1) in 4 and colonic(L3) in 11 children, while CD behavior was non-stricturing and non-penetrating(B1) in 12 and stricturing(B2) in 3 children. The mean AUC for the fungal dysbiosis classifier was significantly higher in stools(AUC = 0.85 ± 0.057) than in mucosa(AUC = 0.71 ± 0.067)(P st fungal species were significantly more depleted in stools than mucosal samples, except for saccharomyces cerevisiae and s. bayanus, which were significantly more abundant. Diversity was significantly more reduced in stools than in mucosa. CONCLUsION We found high AUC of fungal dysbiosis in fecal samples of children with CD, suggesting high accuracy in predicting diagnosis of CD.

关键词： Fungiome Mycobiome Crohn’s disease Inflammation saudi children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?

引用

World Journal of Gastroenterology 2018年第9期24卷 971-981页

作者： Denise E Brennan Colin dowd Colm O'Morain Deirdre McNamara sinéad M smith Department of Clinical Medicine School of Medicine Trinity College Dublin

AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODs DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. REsULTs Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was s1/M2 at 44.8%(n = 74/165), followed by s2/M2 at 26.7%(n = 44/165), s1/M1 at 23.6%(n = 39/165) and s2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor *** Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A s2-containing) strains of H. pylori are associated with primary clarithromycin resistance.

关键词： Helicobacter pylori Antibiotic resistance Fluoroquinolone Clarithromycin Virulence factor VacA CagA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Face of Angel

引用

英语画刊（高三·社会综合版） 2011年第1期 26-27页

作者： Helen dowd

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：