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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi shima Tavoosi Amir Hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi Mohammad-Mahdi Salarabedi Syed Azizur Rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi Mohammad Ahmadvand Wael M Abdel-Rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

Gastrointestinal viral shedding in children with SARS‑CoV‑2:a systematic review and meta‑analysis

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World Journal of Pediatrics 2022年第9期18卷 582-588页

作者： Sepideh Benvari shima Mahmoudi Mohsen Mohammadi Department of Microbiology Faculty of MedicineQazvin University of Medical SciencesQazvinIran Pediatric Infectious Disease Research Center Tehran University of Medical SciencesTehranIran Non-Communicable Pediatric Diseases Research Center Health Research InstituteBabol University of Medical SciencesBabolIran

Background Coronavirus disease 2019(COVID-19)has diferent manifestations in pediatric *** is assumed that they might present more gastrointestinal symptoms with a diferent viral shedding pattern in gastrointestinal *** this systematic review and meta-analysis,we aimed to evaluate the viral shedding pattern in gastrointestinal specimens of children with *** We searched all published studies in English language in PubMed,Web of Science,and Scopus,up to date as of October *** search included the term"severe acute respiratory syndrome coronavirus 2,COVID-19,SARS-CoV-2,novel coronavirus,or coronavirus;and shed,excrete,secret,or carriage;and stool or rectal;and children or pediatrics".We included studies evaluating SARS-CoV-2 shedding in gastrointestinal specimens,including rectal swabs and stool samples of children with COVID-19 *** excluded duplicated data,case reports,and studies without original *** Twelve studies met the eligibility criteria for the qualitative synthesis,10 of which were included in the *** pooled prevalence of gastrointestinal severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA in children with COVID-19 was 86%(95%confdence interval 73%–96%,I 2=62.28%).After respiratory specimen had become negative,72%(43/60)had persistent shedding in gastrointestinal *** gastrointestinal RNA had a positive test result for more than 70 days after symptoms *** Gastrointestinal shedding of SARS-CoV-2 might occur in a substantial portion of children and might persist long after negative respiratory *** research is recommended to fnd the role of SARS-CoV-2 gastrointestinal shedding in transmission in children.

关键词： Coronavirus disease 2019(COVID-19) Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Viral shedding

葛根素衍生物的设计合成及其对酪氨酸酶的激活作用研究

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林产化学与工业 2024年第4期44卷 61-69页

作者：朱号天宋科于华忠贺健刘诗马郭婕吉首大学林产化工工程湖南省重点实验室湖南张家界427000 吉首大学化学化工学院湖南吉首416000

以葛根素为原料,设计合成8个葛根素衍生物(PD_(1)~PD_(8)),通过质谱和核磁共振氢谱确定其化学结构,利用酪氨酸酶多巴速率氧化法测定各衍生物对酪氨酸酶的激活活性,并利用分子对接模拟探讨各衍生物与酪氨酸酶的结合情况,酶动力学分析确... 详细信息

以葛根素为原料,设计合成8个葛根素衍生物(PD_(1)~PD_(8)),通过质谱和核磁共振氢谱确定其化学结构,利用酪氨酸酶多巴速率氧化法测定各衍生物对酪氨酸酶的激活活性,并利用分子对接模拟探讨各衍生物与酪氨酸酶的结合情况,酶动力学分析确定激活类型。8个葛根素衍生物结构鉴定为:4'-甲氧基-葛根素(PD_(1))、4'-乙氧基-葛根素(PD2)、4'-丙氧基-葛根素(PD3)、7-O-乙酰基-葛根素(PD4)、7-O-三甲基乙酰基-葛根素(PD5)、7-甲氧基-葛根素(PD6)、7-O-乙氧羰基亚甲基-葛根素(PD7)、7,4'-O-二乙氧羰基亚甲基-葛根素(PD_(8))。激活活性测定结果表明:PD6为混合型激活,PD6的半激活浓度EC50=0.416 mmol/L,高于葛根素(EC50=0.434 mmol/L)。

关键词：葛根素衍生物合成酪氨酸酶激活剂动力学分析

A Stable Numerical Scheme Based on the Hybridized Discontinuous Galerkin Method for the Ito-Type Coupled KdV System

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Communications on Applied Mathematics and Computation 2022年第4期4卷 1351-1373页

作者： shima Baharlouei Reza Mokhtari Nabi Chegini Department of Mathematical Sciences Isfahan University of Technology84156-83111 IsfahanIran Department of Mathematics Tafresh University39518-79611 TafreshIran

The purpose of this paper is to develop a hybridized discontinuous Galerkin(HDG)method for solving the Ito-type coupled KdV *** fact,we use the HDG method for discre-tizing the space variable and the backward Euler explicit method for the time *** linearize the system,the time-lagging approach is also *** numerical stability of the method in the sense of the L2 norm is proved using the energy method under certain assumptions on the stabilization parameters for periodic or homogeneous Dirichlet bound-ary *** experiments confirm that the HDG method is capable of solving the system *** is observed that the best possible rate of convergence is achieved by the HDG ***,it is being illustrated numerically that the corresponding con-servation laws are satisfied for the approximate solutions of the Ito-type coupled KdV *** to the numerical experiments,it is verified that the HDG method could be more efficient than the LDG method for solving some Ito-type coupled KdV systems by comparing the corresponding computational costs and orders of convergence.

关键词： Hybridized discontinuous Galerkin(HDG)method Stability analysis Ito-type coupled KdV system Conservation laws

A computational fluid dynamics investigation of a novel flooded-bed dust scrubber with vibrating mesh

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International Journal of Mining Science and Technology 2022年第3期32卷 525-537页

作者： Zhaokuan Lu Aishwarya Rath Seyed Hassan Amini Aaron Noble shima Shahab Department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Department of Mining Engineering West Virginia UniversityMorgantownWV 26506USA Department of Mining and Minerals Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA

This work proposes a vibrating mesh screen as an alternative to the static mesh screen currently used in conventional flooded-bed dust scrubbers for removing airborne coal mine dust in the continuous mining *** assessments suggest that a vibrating screen may improve the dust collection efficiency of scrubber systems and mitigate the clogging issues associated with the conventional *** evaluate this hypothesis,computational fluid dynamics(CFD)simulations were carried out to assess the effects of vibration conditions(i.e.,frequency and amplitude)on the dust particle-mesh interaction and mesh wetting conditions,which are the two decisive factors in determining the dust collection *** results suggest that the vibrating mesh screen can enhance dust particle collision opportunities on the mesh and increase mesh wetted area as compared to the static mesh *** effects of mesh screen aperture,coal dust concentration,and spray nozzle flow rate on the performance of the vibrating mesh are also ***,a simplified three-phase flow simulation including airflow,dust particles,and water droplet spray is performed,and the results reflect a significant improvement of dust collection efficiency in the liquid-coated vibrating mesh screen.

关键词： Dust control Air filtration Flooded-bed scrubber Vibrating mesh filter Continuous miner Computational fluid dynamics Multiphase flow

Regenerating historical districts through tactical urbanism:A case study of Sarpol neighborhood in Isfahan Province,Iran

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Frontiers of Architectural Research 2023年第6期12卷 1234-1245页

作者： Mohammad Salehi shima Taheri Amirhosein Shabani Department of Urban Planning Najafabad BranchIslamic Azad UniversityNajafabadIran Department of Architecture Isfahan(Khorasgan)BranchIslamic Azad UniversityIsfahanIran Department of Architecture Faculty of EngineeringShahid Ashrafi Esfahani UniversityIsfahanIran Advancement in Architecture and Urban Planning Research Center Najafabad BranchIslamic Azad UniversityNajafabadIran

This paper examines historical urban fabrics’challenges regarding quality of life and visual disturbances despite their cultural and identity *** and socialoriented approaches considering social,economic,and cultural dimensions preserve and enhance these valuable *** urbanism,with its people-oriented approach,can address these *** study focused on Sarpol in Khomeinishahr County,Isfahan Province of *** city’s urban structure divides into two parts:despite its active social structure and valuable spaces,Sarpol is a historic neighborhood with significant *** followed Corbin and Strauss’s version of Grounded Theory in the qualitative research *** and snowball sampling methods were employed to select 21 participants from the Sarpol neighborhood for semi-structured *** analysis involved three stages of coding:open,axial,and *** themes included religious participation,identity,sustainable social bonds,indigenous dependence,and low environmental *** central issue identified was the crucial role of religious and cultural values as a driving force for tactical urbanism,which emerged as the most critical semantic domain related to the research problem.

关键词： Tactical urbanism Urban regeneration Historical fabrics Neighborhood Grounded theory Social-oriented approaches

Assessment of the relationship between the return to work and the severity of work-related upper limb injuries using the whole person impairment

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中华创伤杂志：英文版 2023年第2期26卷 77-82页

作者： Mahin Hosseininejad shima Javadifar Saber Mohammadi Elham Mirzamohammadi Occupational Medicine Department School of MedicineIran University of Medical SciencesTehranIran

Purpose:Upper limb disorders are one of the most common and important types of occupational ***,identifying the factors influencing return to work following these injuries is essential to reduce the dimensions of the *** this study,we investigated the return to work and associated factors following occupational injuries leading to upper limb ***:In this retrospective cohort study,the rate of return to work and associated factors were assessed in 256 workers with work-related upper limb injury referred to a teaching hospital from March 2011 to December *** inclusion criterion was a history of occupational injury resulting in upper limb impairment,and exclusion criteria included the presence of simultaneous impairment in other organs,congenital or non-occupational limb defects as well as patients with incomplete information in their medical ***’’ records,including age at the time of injury,gender,date of injury,marital status,education,level of amputation and injury,whole person impairment (WPI) and physiotherapy (prescribed by the physician) were *** WPI was calculated to assess the extent of the *** analyzes were performed by SPSS version ***:The rate of return to work was 54.3%,in which 51.8% for the same job and 48.2% for a new *** main factors associated with non-return to work were more days off work (p = 0.001),higher injury severity (p = 0.001),and dominant hand injury (p = 0.034).Conclusion:The number of days off work,the WPI,and dominant hand injury are the most important determinant in returning to *** addition,increased job satisfaction and support from co-workers and employers are work-related factors that can lead to an increased return to work.

关键词： Occupational injury Upper limb impairment Return to work Whole person impairment

Parameterization and Explicit Modeling of Cloud Microphysics:Approaches, Challenges, and Future Directions

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Advances in Atmospheric Sciences 2023年第5期40卷 747-790页

作者： Yangang LIU Man-Kong YAU Shin-ichiro shima Chunsong LU Sisi CHEN Environmental and Climate Sciences Department Brookhaven National LaboratoryUptonNY11973USA Department of Atmospheric Sciences McGill UniversityMontrealH3A 0B8Canada Graduated School of Information Science University of HyogoKobe 650-0047Japan College of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjing 210044China National Center for Atmospheric Research BoulderCO80307USA

Cloud microphysical processes occur at the smallest end of scales among cloud-related processes and thus must be parameterized not only in large-scale global circulation models(GCMs)but also in various higher-resolution limited-area models such as cloud-resolving models(CRMs)and large-eddy simulation(LES)*** of giving a comprehensive review of existing microphysical parameterizations that have been developed over the years,this study concentrates purposely on several topics that we believe are understudied but hold great potential for further advancing bulk microphysics parameterizations:multi-moment bulk microphysics parameterizations and the role of the spectral shape of hydrometeor size distributions;discrete vs“continuous”representation of hydrometeor types;turbulence-microphysics interactions including turbulent entrainment-mixing processes and stochastic condensation;theoretical foundations for the mathematical expressions used to describe hydrometeor size distributions and hydrometeor morphology;and approaches for developing bulk microphysics *** presented are the spectral bin scheme and particle-based scheme(especially,super-droplet method)for representing explicit *** advantages and disadvantages are elucidated for constructing cloud models with detailed microphysics that are essential to developing processes understanding and bulk microphysics ***-resolved direct numerical simulation(DNS)models are described as an emerging technique to investigate turbulence-microphysics interactions at the most fundamental level by tracking individual particles and resolving the smallest turbulent eddies in turbulent *** challenges and future research directions are explored as well.

关键词： cloud microphysics parameterizations systems theory bin microphysics particle-based microphysics particleresolved direct numerical simulations

Chemical treatment for sand production control:A review of materials,methods,and field operations

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Petroleum Science 2023年第3期20卷 1640-1658页

作者： Ali Safaei Mohammad Asefi Mohsen Ahmadi Tayebe Pourshamsi shima Baloochestanzadeh Ali Khalilnezhad Masoud Riazi Enhanced Oil Recovery(EOR)Research Centre IOR/EOR Research InstituteShiraz UniversityShirazIran Iran Food and Drug Administration(IFDA) Gerash University of Medical SciencesGerashIran Faculty of Petroleum and Natural Gas Engineering Sahand University of TechnologyTabrizIran

Sand production from loosely consolidated reservoirs is one of the critical issues in the oil and gas in-dustry all around the world that can cause many problems,such as erosion of surface and well equip-ment,sand accumulation in wells and operation facilities,buckling of casing in cased-hole wells and well productivity *** production control methods include restrictive production rate,mechanical methods(slotted liner,wire-wrapped screen,pre-packed screen,frac-pack,gravel pack,high-rate water pack)and chemical consolidation that chemical method is considered for more effectiveness in sand production alleviation due to increasing formation strength in near wellbore *** review provides an overview on the laboratory and filed operation investigations of chemical remedy for sand *** used chemical agents and more common laboratory tests for evaluating the chemical performance in sand consolidation are introduced in this ***,the results of field operations and in-jections of chemicals into the desired formation are also *** results show that the chemical sand consolidation is more effective in newly perforated wells which have no sand production experi-ence and have a production history of less than two ***,it was concluded that the main challenges in applying this method are permeability and capillary force reduction around the wellbore and selective injection into the targeted formation layers.

关键词： Sand production Loosely consolidated reservoirs Formation strength Chemical remedy Permeabilityreduction