检索结果-南通市图书馆

Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第20期15卷 2520-2525页

作者： eiji oki Yan Zhao Rintaro Yoshida Takanobu Masuda Koji Ando Masahiiko Sugiyama Eriko Tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara Department of Surgery and Science Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan Department of Gastroenterology National Kyushu Cancer Center 3-1-1 Notame Minarni-ku Fukuoka 811-1395 Japan

AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric ***:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c *** microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct ***:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological *** found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation ***:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of ***, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis.

关键词： Checkpoint with forkhead-associated and ring finger Methylation Microsatellite instability Gastric cancer p53

Mathematical Model for Dynamic Pump-Wavelength Selection Switch

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Optimization 2015年第1期4卷 1-9页

作者： Nattapong Kitsuwan Dwina Fitriyandini Siswanto eiji oki Department of Communication Engineering and Informatics The University of Electro-Communications Tokyo Japan

This paper presents a mathematical model based on dynamic pump-wavelength selection for an optical packet switch (OPS). In the OPS, multiple packets that carry the same wavelength from different input ports could be addressed to the same output port at the same time slot. This condition is called wavelength contention. Of those contended packets, only one is forwarded to the output fiber while the others are dropped. Parametric wavelength conversion is used to convert the contended wavelengths into available non-contending wavelengths. The OPS based on the dynamic pump-wavelength selection scheme, where the pump-wavelengths are adjusted based on the requests in every time slot, uses a heuristic matching algorithm to minimize the number of packet losses. However, there is no guarantee that the heuristic algorithm outputs the optimum result. The mathematical model presented in this paper is used to confirm the performance of the heuristic matching algorithm for the DPS-based OPS. A simulation shows that the heuristic matching algorithm achieves the same performance as the optimum solution provided by the mathematical model.

关键词： Optical Packet Switching Wavelength Converter Optimization

BPaL/BpaLM regimen:A bright future for drug-resistant tuberculosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 335-337页

作者： oki Nugraha Putra Telly Purnamasari Department of Clinical and Community Pharmacy Faculty of PharmacyHang Tuah UniversitySurabayaIndonesia Pre-Clinical and Clinical Studies National Research and Innovation AgencyBogorWest JavaIndonesia

Indonesia is one of the countries with the highest burden of tuberculosis and drug-resistant tuberculosis(DR-TB)across the *** on data from the World Health Organization(WHO)Global TB Report 2023,it is estimated that there are 10000 cases of DR-TB in ***,a novel antitubercular drug,has been implemented to treat DR-TB *** was administered either a shorter(9 months)or individualized treatment regimen(18 months).However,long treatment duration with various adverse events affects patient ***,a short treatment with less medication is urgently *** 2022,the WHO announced an alternative regimen-bedaquiline,pretomanid,linezolid,and moxifloxacin(BPaLM)to treat DR-TB patients for six months without resistance to fluoroquinolones[1].This recommendation is based on previous clinical trials of TB,Zenix TB,and *** introduction of BPaL and BPaLM provided a bright future for treating DR-TB patients.

关键词： tuberculosis drug treatment

Expulsion of geopressured hydrothermal system along active faults and its relation to the occurrence of earthquakes in the Shinanogawa seismic belt, Japan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2005年第2期48卷 273-281页

作者： Yasue oki Osamu Sato Research Institute for Hazards in Snowy Areas Niigata University Niigata 950-2181JapanResearch Institute for Hazards in Snowy Areas Niigata UniversityNiigata 950-2181Japan

The 1995 Northern Niigata Earthquake (M 6.0) occurred at a shallow depth in the Niigata seismic gap. The anomaly areas in temperature, electrical conductivity and Cl- concentration of groundwater trend northeast as linear distribution in the epicentral area and are approximately coincident with the area of the seismic intensity 6 (JMA scale). The distributions of seismic intensity 6 and groundwater anomalies convincingly imaged the presence of a buried active fault beneath the epicentral area. The occurrence of this earthquake and the anomalies of groundwater were related to the expulsion of geopressured hydrothermal system (GHS). All epicenters of the destructive earthquakes along the Shinanogawa seismic belt are actually located in the buried active fault zones characterized by the areas of temperature and geochemical anomalies of groundwater. These earthquakes might have been triggered by the activity of GHS. The expulsion of GHS along an active fault in combination with the thermal softening of fault zone attributed to high rock temperature may reduce fracture strength of the rock, and trigger earthquake occurrence. The dimension of the anomaly area of groundwater temperature at the epicentral area reflected the scale of the earthquake fault. The linear anomaly areas of groundwater resulting from the expulsion of GHS and having no historical destructive earthquake are of the predicated areas of future destructive earthquakes. Monitoring of groundwater conditions in these areas may provide useful information regarding the future occurrence of earthquakes.

关键词： Shinanogawa seismic belt, 1995 Northern Niigata Earthquake, geopressured hydrothermal system (GHS),buried active fault, expulsion of GHS.

大肠高、中分化腺癌临床特点、遗传不稳定性、TP53与KRAS基因突变的差异比较

在线全文

学校读者我要写书评

暂无评论

现代生物医学进展 2010年第6期10卷 1061-1064页

作者：赵岩郑志超挂地吉弘冲英次张涛张剑军赵宜良前原喜彦辽宁省肿瘤医院第三外科辽宁沈阳110042 九州大学大学院医学研究院消化器综合外科

目的:近年来大肠中分化腺癌检出比例有所增高。本研究旨在探讨大肠中分化腺癌临床病理学及分子遗传学特征。方法:回顾过去30年1073例大肠癌的病理分型,比较其中328例高、中分化腺癌临床病理学特点。激光细胞学扫描技术,双荧光高分辨率... 详细信息

目的:近年来大肠中分化腺癌检出比例有所增高。本研究旨在探讨大肠中分化腺癌临床病理学及分子遗传学特征。方法:回顾过去30年1073例大肠癌的病理分型,比较其中328例高、中分化腺癌临床病理学特点。激光细胞学扫描技术,双荧光高分辨率微卫星不稳定性技术评价129例大肠癌遗传不稳定性特点,TP53、KRAS基因突变采用直接测序法检测。结果:由1979年始每10年为1组,至2008年计3组。中分化腺癌所占比例分别为37%、38%及55%。其中的328例大肠癌高、中分化腺癌病理学研究表明,中分化者较高分化者病期晚、浸润深、淋巴结转移率高、静脉侵袭阳性率高。对74例高分化腺癌与55例中分化腺癌的分子遗传学研究表明,高、中分化腺癌的DNA倍体与微卫星不稳定性情况无显著性差异,TP53与KRAS基因突变频率也无显著差异。但TP53的移码突变仅在高分化腺癌中检出(4例,P<0.05)。KRAS的颠换突变在高分化癌中检出5例(23%),在中分化癌中检出12例(57%),差异有显著性意义(P<0.05)。结论:高、中分化腺癌在临床病理学特征方面存在明显差异。大肠中分化腺癌较高分化腺癌生物学行为差,发现时病期较晚,治疗随访中需要引起足够重视。两种病理学类型的肿瘤遗传不稳定性急基因突变频率等背景相似,但基因突变谱的差别提示两种腺癌的发生背景的不同。

关键词：大肠癌高分化腺癌中分化腺癌遗传不稳定性突变

A transverse local feedback linearization approach to human head movement control

在线全文

学校读者我要写书评

暂无评论

Control Theory and Technology 2017年第4期15卷 288-300页

作者： oki, Takafumi Ghosh, Bijoy K. Department of Mathematics and Statistics Texas Tech University Lubbock U.S.A.

In the mid-nineteenth century, Donders had proposed that for every human head rotating away from the primary pointing direction, the rotational vectors in the direction of the corresponding axes of rotation, is restricted to lie on a surface. Donders＇ intuition was that under such a restriction, the head orientation would be a function of its pointing direction. In this paper, we revisit Donders＇ Law and show that indeed the proposed intuition is true for a restricted class of head-orientations satisfying a class of quadratic Donders＇ surfaces, if the head points to a suitable neighborhood of the frontal pointing direction. Moreover, on a suitably chosen subspace of the 3D rotation group SO（3）, we describe a head movement dynamical system with input control signals that are the three external torques on the head provided by muscles. Three output signals are also suitably chosen as follows. Two of the output signals are coordinates of the frontal pointing direction. The third signal measures deviation of the state vector from the Donders＇ surface. We claim that the square system is locally feedback linearizable on the subspace chosen, and the linear dynamics is decomposed into parts, transverse and tangential to the Donders＇ surface. We demonstrate our approach by synthesizing a tracking and path-following controller. Additionally, for different choices of the Donders＇ surface parameters, head gaits are visualized by simulating different movement patterns of the head-top vector, as the head-pointing vector rotates around a circle.

关键词： Head movement Donders' surface transverse feedback linearization Fick-Gimbal

Mobilization and Acquisition of Sparingly Soluble P-Sources by Brassica Cultivars under P-Starved Environment I. Differential Growth Response,P-Efficiency Characteristics and P-Remobilization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2009年第11期51卷 1008-1023页

作者： Muhammad Shahbaz Akhtar Yoko oki Tadashi Adachi Department of Environmental Management Engineering Faculty of Environmental Science and TechnologyThe Graduate School of Environmental ScienceOkayama University

Phosphorus （P） starvation is highly notorious for limiting plant growth around the globe. To combat P-starvation, plants constantly sense the changes in their environment, and elicit an elegant myriad of plastic responses and rescue strategies to enhance P-solublization and acquisition from bound soil P-forms. Relative growth responses, P-solublization and P- acquisition ability of 14 diverse Brassica cultivars grown with sparingly soluble P-sources （Rock-P （RP） and Ca3（PO4）2 （TCP）） were evaluated in a solution culture experiment. Cultivars showed considerable genetic diversity in terms of biomass accumulation, concentration and contents of P and Ca in shoots and roots, P-stress factor （PSF） and P use efficiency. Cultivars showed variable P-stress tolerance, and cultivars depicting low PSF and high P-efficiency values were better adaptable to P-starvation. In experiment 2, after initial feeding on optimum nutrition for 12 d after transplanting （DAT）, class-I （low P-tolerant （Oscar and Con-II）） and class-II （low P-sensitive （Gold Rush and RL-18）） cultivars were exposed to P-free environment for 25 d. All of the cultivars remobilized P from above ground parts to their roots during growth in P-free environment, the magnitude of which was variable in tested cultivars. P-concentrations （[P]s） at 37 DAT were higher in developing compared with developed leaves. Translocation of absorbed P from metabolically inactive to active sites in P- stressed plants may have helped class-I cultivars to establish a better rooting system, which provided a basis for enhanced P-utilization efficiency （PUE） and tolerance against P-stress. By supplying TCP and RP spatially separated from other nutrients in split root study, class-I cultivars were still able to mobilize RP and TCP more efficiently compared with class-II cultivars. To compare the growth behavior under P-stress, cultivars were grown in pots for 41 d after sowing, using a soil low in P （NaHCO3-extractable P = 3.97 mg/kg, Mehlich

关键词： Brassica Ca3(PO4)2 P-remobilization P-stress P-use efficiency P-stress factor rock phosphate.

Intraspecific Variations of Phosphorus Absorption and Remobilization, P Forms, and Their Internal Buffering in Brassica Cultivars Exposed to a P-Stressed Environment

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2008年第6期50卷 703-716页

作者： M. Shahbaz Akhtar Yoko oki Tadashi Adachi Department of Environmental Management Engineering Faculty of Environmental Science and Technology Graduate School of Environmental Science Okayama University CADGK and Institute of Soil and Environmental Sciences University of Agriculture Faisalabad Pakistan

Translocation of absorbed phosphorus （P） from metabolically inactive sites to active sites in plants growing under P deprivation may increase its P utilization efficiency （PUE）. Acclimation to phosphate （Pi） starvation may be caused by a differential storage pool of vacuolar P, its release, and the intensity of re-translocation of absorbed P as P starvation inducible environmental cues （PSlEC） from ambient environment. Biomass assay and three P forms, namely inorganic （Pi）, organic （Po）, and acid-soluble total （Ptas） were estimated in Brassica cultivars exposed to 10 d P deprivation in the culture media. Considering that -aPi/at denotes the rate of Pi release, Pi release velocity （RSPi） was determined as the tangent to the equations obtained for Pi f（t） at the mean point in the period of greatest Pi decrease, whereas the inverse of the RSPi was an estimate of the internal Pi buffering capacity （IBCPi）. Inter cultivar variations in size of the non-metabolic Pi pool, RSPi, re-translocation of Pi from less to more active metabolic sites, and preferential Pi source and sink compartments were evaluated under P starvation. The cultivar ＇Brown Raya＇ showed the highest Pi storage ability under adequate external P supply, and a more intensive release than ＇Rain Bow＇ and ＇Dunkled＇ under P stress. Cultivar ＇B.S.A＇ was inferior to ＇Con-l＇ in its ability to store and use Pi. Roots and upper leaves were the main sink of Pi stored in the lower and middle leaves of all cultivars and showed lower IBCPi and larger RSPi values than lower and middle leaves. In another trial, six cultivars were exposed to P-free nutrition for 29 d after initial feeding on optimum nutrition for 15 d. With variable magnitude, all of the cultivars re-translocatad P from the above ground parts to their roots under P starvation, and [P] at 44 d after transplanting was higher in developing leaves compared with developed leaves. Under P deprivation, translocation of absorbed P from metabolically inactive to ac

关键词： Brassica internal Pi buffering capacity P absorption and remobilization Pi homeostasis Pi release velocity vacuolar P

Early efficacy of individual regimens containing bedaquiline in patients with drug resistant tuberculosis

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2023年第4期16卷 169-175页

作者： oki Nugraha Putra Yulistiani Yulistiani Soedarsono Soedarsono Susi Subay Doctoral Program of Pharmacy Faculty of PharmacyAirlangga UniversitySurabayaIndonesia Program Study of Pharmacy Faculty of MedicineHang Tuah UniversitySurabayaIndonesia Faculty of Pharmacy Airlangga UniversitySurabayaIndonesia Faculty of Medicine Hang Tuah UniversitySurabayaIndonesia Department of Pulmonology and Respiratory Medicine Dr.Soetomo HospitalSurabayaIndonesia

Objective:To evaluate early efficacy of sputum conversion within 6 months of individual regimens containing bedaquiline in patients with drug resistant ***:We conducted a retrospective study among patients with drug resistant tuberculosis who were receiving individual regimens containing *** primary outcome was sputum conversion of both smear and culture within 6 months of *** used medical records of drug resistant tuberculosis patients from January 2020 to December *** study was conducted at *** Hospital,Indonesia from August to October ***:In this study,44 eligible drug resistant tuberculosis patients were initiated on regimens containing *** were 52.3%males and the median age was 45.5 *** rates of previous treatment(70.5%)and lung cavity(36.4%)were *** most common companion drugs included clofazimine,cycloserine,levofloxacin,and *** smear and culture conversion was seen in 79.4%and 82.1%at the 2nd month,*** than 97%patients had smear and culture conversion at the end of 6 ***:Among drug resistant tuberculosis patients,individual regimens containing bedaquiline were associated with high rates of smear and culture conversion at the end of 6 *** efficacy of regimens containing bedaquiline can be used to predict cure rate at the end of treatment.

关键词： Bedaquiline Individual regimen Drug resistant tuberculosis Efficacy