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Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction

World Journal of Gastroenterology 2012年第21期18卷 2735-2738页

作者： Toshihiro Nishizawa Hidekazu Suzuki Takama Maekawa Naohiko Harada Tatsuya Toyokawa Toshio Kuwai Masanori Ohara Takahiro Suzuki Masahiro Kawanishi Kenji Noguchi Toshiyuki Yoshio Shinji Katsushima Hideo Tsuruta eiji masuda Munehiro Tanaka Shunsuke Katayama Norio Kawamura Yuko Nishizawa Toshifumi Hibi Masahiko Takahashi Division of Gastroenterology National Hospital Organization Tokyo Medical CenterTokyo 1528902 Japan Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of MedicineTokyo 1608582 Japan Division of Gastroenterology National Hospital Organization Kyoto Medical CenterKyoto 6128555 Japan Division of Gastroenterology National Kyushu Medical CenterFukuoka 8108563 Japan Division of Gastroenterology National Hospital Organization Fukuyama Medical CenterFukuyama 7208520 Japan Division of Gastroenterology National Hospital Organization Kure Medical CenterKure 7370023 Japan Division of Gastroenterology National Hospital Organization Hakodate Medical CenterHakodate 0418512 Japan Division of Gastroenterology National Hospital Organization Maizuru Medical CenterMaizuru 6258502 Japan Division of Gastroenterology National Hospital Organization Higashihiroshima Medical CenterHigashihiroshima 7390041 Japan Division of Gastroenterology National Hospital Organization Sendai Medical CenterSendai 9838520 Japan Division of Gastroenterology National Hospital Organization Osaka Medical CenterOsaka 5400006 Japan Division of Gastroenterology National Hospital Organization Ureshino Medical CenterUreshino 8430393 Japan Division of Gastroenterology National Hospital Organization Osaka Minami Medical CenterKawachinagano 5868521 Japan Division of Gastroenterology National Hospital Organization Fukuoka Higashi Medical CenterKoga 8113195 Japan Division of Gastroenterology National Hospital Organization Yonago Medical CenterYonago 6838518 Japan Division of Gastroenterology National Hospital Organization Disaster Medical CenterTachikawa 1900014 Japan Pharmaceutical Department National Center for Global Health and MedicineTokyo 1658655 Japan

We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT.

关键词： Helicobacter pylori Amoxicillin Dual therapy Eradication Urea breath test

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The role of water in Earth's mantle

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National Science Review 2020年第1期7卷 224-232页

作者： eiji Ohtani Graduate School of Science Tohoku University

Geophysical observations suggest that the transition zone is wet locally. Continental and oceanic sediment components together with the basaltic and peridotitic components might be transported and accumulated in the transition zone. Low-velocity anomalies at the upper mantle–transition zone boundary might be caused by the existence of dense hydrous magmas. Water can be carried farther into the lower mantle by the slabs. The anomalous Q and shear wave regions locating at the uppermost part of the lower mantle could be caused by the existence of fluid or wet magmas in this region because of the water-solubility contrast between the minerals in the transition zone and those in the lower mantle. δ-H solid solution AlO2H–MgSiO4H2carries water into the lower mantle. Hydrogen-bond symmetrization exists in high-pressure hydrous phases and thus they are stable at the high pressures of the lower mantle. Thus, theδ-H solid solution in subducting slabs carries water farther into the bottom of the lower mantle. Pyrite FeO2Hxis formed due to a reaction between the core and hydrated slabs. This phase could be a candidate for the anomalous regions at the core–mantle boundary.

关键词： water hydrous phase subducting slab transition zone lower mantle hydrogen-bond symmetrization core–mantle boundary

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Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer

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World Journal of Gastroenterology 2009年第20期15卷 2520-2525页

作者： eiji Oki Yan Zhao Rintaro Yoshida Takanobu masuda Koji Ando Masahiiko Sugiyama Eriko Tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara Department of Surgery and Science Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan Department of Gastroenterology National Kyushu Cancer Center 3-1-1 Notame Minarni-ku Fukuoka 811-1395 Japan

AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric ***:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c *** microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct ***:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological *** found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation ***:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of ***, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis.

关键词： Checkpoint with forkhead-associated and ring finger Methylation Microsatellite instability Gastric cancer p53

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Postoperative functional evaluation of gastrectomy for gastric cancer

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Chinese Journal of Cancer Research 2022年第6期34卷 567-574页

作者： eiji Nomura Department of Gastroenterological and General Surgery Tokai University Hachioji HospitalTokyo 192-0032Japan

To improve the quality of surgical procedures for gastric cancer,it is essential to consider many components comprehensively,including gastric motility,small intestinal absorption,hormones that affect gastric motility and appetite,presence or absence of vagus nerve preservation,esophageal regurgitation on endoscopic findings,in addition to whether or not there is a physiological route for food passage through the ***,proper functional evaluation cannot be performed without considering the form and amount of energy in the nutritional supplement to be loaded,and the posture at the time of *** results of functional evaluation vary according to the method selected from many available options,but we believe that use of the most physiologically accurate,appropriate and selectable option will enable us to arrive at the best resection/reconstruction *** have reported that it is important to consider the preservation of three elements when performing gastrectomy:1)reduction of the extent of gastrectomy,2)preservation of the pylorus,and 3)preservation of the vagus nerve;among which preservation of the remnant stomach is the most ***,the selection of a reconstruction method that maintains secretion of hormones beneficial to gastric motility preserves the energy balance inherent in the human body,and also provides better quality of life.

关键词： Gastric cancer gastrectomy functional evaluation

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Implications of excess ^(210)Pb and ^(137)Cs in sediment cores from Mikawa Bay, Japan

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Journal of Environmental Sciences 2009年第5期21卷 707-712页

作者： LU Xueqiang MATSUMOTO eiji Tianjin Academy of Environmental Sciences Tianjin 300191 China Graduate School of Environmental Studies Nagoya University Nagoya 464-8601 Japan

Four sediment cores were collected from Mikawa Bay, Japan, and excess ^210pb and ^137Cs were measured by gamma spectrometry. Sedimentation rates for the four cores were determined by ^210Pb method. The sedimentation rate range is 0.10-0.70 g/（cm^***）. The bio-mixing depth for each core is less than 7.0 cm, and was determined by the excess 210^pb profiles as well. Therefore, the bioturbation is slight. The 210^pb-derived dates coincided with the results from ^137Cs geochronology. Acceleration in sedimentation rate due to environmental alteration has been found in cores A2.5 and 05AS8, representing two depocenters due to their topography. Evidence of the Tokal Flood in 2000 was found in core 05AS8 according to the profiles of both radioisotopes and trace metals.

关键词： ^210pb ^137Cs sedimentation rate Mikawa Bay

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Nano-structural Modification of Amorphous Carbon Thin Films by Low-energy Electron Beam Irradiation

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材料热处理学报 2004年第05B期25卷 1247-1252页

作者： eiji Iwamura Masanori Yamaguchi PRESTO Japan Science and Technology Agency Tokyo JapanLamp Company Ushio INC. Himeji Japan

A new approach using a low-energy electron beam radiation system was investigated to synthesize carbon hybrid structures in amorphous carbon thin films. Two types of amorphous carbon films, which were 15at% iron containing film and with column/inter-column structures, were deposited onto Si substrates by a sputtering technique and subsequently exposed to an electron shower of which the energy and dose rate were much smaller compared to an intense electron beam used in a transmission electron microscopy. As a result of the low-energy and low-dose electron irradiation process, graphitic structures formed in amorphous matrix at a relatively low temperature up to 450 K. Hybrid carbon thin films containing onion-like structures in an amorphous carbon matrix were synthesized by dynamic structural modification of iron containing amorphous carbon thin films. It was found that the graphitization progressed more in the electron irradiation than in annealing at 773 K, and it was attributed to thermal and catalytic effects which are strongly related to grain growth of metal clusters. On the other hand, a reversal of TEM image contrast was observed in a-C films with column/inter-column structures. It is presumed that preferable graphitization occurred in the inter-column regions induced by electron irradiation.

关键词：无定形碳溅射石墨化低能电子注辐射毫微结构

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STUDY OF TEXTURE EFFECT ON STRAIN LOCALIZATION OF BCC STEEL SHEETS

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Acta Mechanica Solida Sinica 2000年第2期13卷 95-104页

作者： eiji Nakamachi Osaka Institute of Technology Osaka 535-8585Japan

Using elastic crystalline viscoplastic finite element (FE) annlysis, the formability of BCC steel sheets was assessed. An orientation probability assignment method in the FE modeling procedure, which can be categorized as an inhomogenized material modeling, was newly proposed. In the study, the crystal orientations of three materials, mild steel, dual phase steel and the high strength steel, were obtained by Xray diffraction and orientation distribution function (ODF) analyses. The measured ODF results have revealed clearly different textures in the sheets, featured by orientation fibers, skeleton lines and selected orientations in Euler angle space, which are closely related to the plastic anisotropy. Then, the crystal orientations were assigned to FE integration points by using this ODF data, individually. The FE analyses of the standard limiting dome height (LDH) test show how the fiber textures affect the extent of strain localization in the forming processes. It was confirmed by comparison with experimental results that this FE code could predict the extreme strain localization and assess the sheet formability.

关键词： crystalline plasticity texture orientation distribution function strain localization finite element analysis

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Dilute long period stacking/order(LPSO)-variant phases along the composition gradient in a Mg-Ho-Cu alloy

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Journal of Magnesium and Alloys 2022年第6期10卷 1573-1580页

作者： Kai Guan Daisuke Egusa eiji Abe Department of Materials Science and Engineering The University of TokyoTokyo 113-8656Japan Research Center for Structural Materials National Institute for Materials ScienceTsukuba 305-0047Japan

We have systematically investigated the microstructures of as-cast Mg_(97.49)Ho_(1.99)Cu_(0.43)Zr_(0.09)alloy by atomic resolution high-angle annular dark field scanning transmission electron microscopy(HAADF-STEM), revealing the coexistence of 18R, 14H and 24R long period stacking/order(LPSO) phases with fully coherent interfaces along step-like composition gradient in a blocky intermetallic compound distributed at grain boundary. The short-range order(SRO) L1_(2)-type Cu_(6)Ho_(8)clusters embedded across AB’C’A-stacking fault layers are directly revealed at atomic scale. Importantly, the order degree of SRO clusters in the present dilute alloy is significant lower than previous 6M and 7M in-plane order reported in ternary Mg-TM(transition metal)-RE(rare earth) alloys, which can be well matched by 9M in-plane order. This directly demonstrates that SRO in-plane L1_(2)-type clusters can be expanded into more dilute composition regions bounded along the definite TM/RE ratio of 3/4. In addition, the estimated chemical compositions of solute enriched stacking fault(SESF) in all LPSO variants are almost identical with the ideal SESF composition of 9M in-plane order, regardless of the type of LPSO phases. The results further support the viewpoint that robust L1_(2)-type TM_(6)RE_(8)clusters play an important role in governing LPSO phase formation.

关键词： Magnesium alloys Long period stacking/order(LPSO)phases Short-range order(SRO)clusters High-angle annular dark field scanning transmission electron microscopy(HAADF-STEM)

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Three-dimensional stereotactic surface projection in the statistical analysis of single photon emission computed tomography data for distinguishing between Alzheimer's disease and depression

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World Journal of Psychiatry 2017年第2期7卷 121-127页

作者： eiji Kirino Department of Psychiatry Juntendo University School of Medicine Department of Psychiatry Juntendo University Shizuoka Hospital Juntendo Institute of Mental Health

AIM To evaluate usefulness of single photon emission computed tomography(SPECT) with three-dimensional stereotactic surface projection(3D-SSP) in distinguishing between Alzheimer's disease(AD) and *** We studied 43 patients who presented with both depressive symptoms and memory disturbance. Each subject was evaluated using the following:(1) the Minimal Mental State Examination;(2) the Hamilton Rating Scale for Depression;(3) Clinical Global Impression-Severity scale(CGI-S); and(4) SPECT imaging with *** The MMSE scores correlated significantly with the maximum Z-scores of AD-associated regions. CGI-S scores correlated significantly with the maximum Z-scores of depression-associated regions. Factor analysis identified three significant factors. Of these, Factor 1 could be interpreted as favouring a tendency for AD, Factor 2 as favouring a tendency for pseudo-dementia, and Factor 3 as favouring a depressive *** We investigated whether these patients could be categorized as types: Type A(true AD), Type B(pseudodementia), Type C(occult AD), and Type D(true depression). The factor scores in factor analysis supported the validity of this classification. Our results suggest that SPECT with 3D-SSP is highly useful for distinguishing between depression and depressed mood in the early stage of AD.

关键词： Alzheimer’s disease Three-dimensional stereotactic surface projection Single photon emission computed tomography Pseudo-dementia Depression

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Function-preserving gastrectomy for gastric cancer in Japan

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World Journal of Gastroenterology 2016年第26期22卷 5888-5895页

作者： eiji Nomura Kunio Okajima Department of Gastroenterology and General Surgery Tokai University Hachioji Hospital Hachioji Tokyo 192-0032 Japan Emeritus professor of Osaka Medical College Takatsuki Osaka 569-8686 Japan

Surgery used to be the only therapy for gastric cancer, and since its ability to cure gastric cancer was the focus of attention, less attention was paid to functionpreserving surgery in gastric cancer, though it was studied for gastroduodenal ulcer. Maki et al developed pylorus-preserving gastrectomy for gastric ulcer in 1967. At the same time, the definition of early gastric cancer(EGC) was being considered, histopathological investigations of EGC were carried out, and the validity of modified surgery was sustained. After the development of H2-blockers, the number of operations for gastroduodenal ulcers decreased, and the number of EGC patients increased simultaneously. As a result, the indications for pylorus-preserving gastrectomy for EGC in the middle third of the stomach extended, and various alterations were added. Since then, many kinds of function-preserving gastrectomies have been performed and studied in other fields of gastric cancer, and proximal gastrectomy, jejunal pouch interposition, segmental gastrectomy, and local resection have been performed. On the other hand, from the overall perspective, it can be said that endoscopic resection, which was launched at almost the same time, is the ultimate function-preserving surgery under the current circumstances. The current function-preserving gastrectomies that are often performed and studied are pylorus-preserving gastrectomy and proximal gastrectomy. The reasons for this are that these procedures that can be performed with systemic lymph node dissection, and they include three important elements:(1) reduction of the extent of gastrectomy;(2) preservation of the pylorus; and(3) preservation of the vagal nerve. In addition, these operations are more likely to be performed with a laparoscopic approach as minimally invasive surgery. Of the above-mentioned three elements, reduction of the extent of gastrectomy is the most important in our view. Therefore, we should try to reduce the extent of gastrectomy if cu

关键词： Early gastric cancer Function-preserving gastrectomy Quality of life Laparoscopic surgery

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