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Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease

World Journal of Diabetes 2024年第5期15卷 935-944页

作者： eiji kawasaki Hidekazu Tamai Takahiro Fukuyama Yoko Sagara Ryutaro Hidaka Aira Uchida Masayuki Tojikubo Narihito Tatsumoto Yuko Akehi Yuji Hiromatsu The Diabetes Thyroid and Endocrine CenterShin-Koga HospitalKurume 830-8577Japan

BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD *** commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical *** To investigate the frequency of anti-islet autoantibodies in AITD *** Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these *** The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two ***,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,***,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for ***,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual *** the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D com

关键词： Anti-islet autoantibodies Autoimmune thyroid disease Real-world practice Retrospective study Type 1 diabetes

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Efficacy of omarigliptin,once-weekly dipeptidyl peptidase-4 inhibitor,in patients with type 2 diabetes

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World Journal of Diabetes 2021年第12期12卷 2087-2095页

作者： eiji kawasaki Yuko Nakano Takahiro Fukuyama Aira Uchida Yoko Sagara Hidekazu Tamai Masayuki Tojikubo Yuji Hiromatsu Nobuhiko Koga Department of Diabetes and Endocrinology Shin-Koga HospitalKurume 830-8577Japan

BACKGROUND Omarigliptin is one of several once-weekly dipeptidyl peptidase-4 inhibitors(DPP-4is).Despite the high frequency of switching from various daily DPP-4is to omarigliptin in actual clinical practice,data regarding its efficacy in patients with type 2 diabetes(T2D)after switching are *** To analyze the efficacy of omarigliptin in Japanese patients with T2D who had previously received treatment with other glucose-lowering *** Forty-nine T2D patients treated for the first time with omarigliptin were recruited retrospectively and divided into four groups defined as either add-on or switched from daily DPP-4is:switched from linagliptin,switched from sitagliptin,and switched from *** a 3-mo follow-up,the clinical parameters among these groups were assessed and compared,with the impact of the switch on glycemic variability as measured by continuous glucose monitoring also being evaluated in the switched *** Hemoglobin A1c levels saw a significant decrease of-0.32%±0.41%in the add-on group(P=0.002).However,the other groups’variables depended on the preswitch daily DPP-4i:switched from linagliptin,-0.05%±0.22%;switched from sitagliptin,-0.17%±0.33%;and switched from vildagliptin,0.45%±0.42%,which saw significant worsening(P=0.0007).Multivariate logistic regression analysis revealed that switching from vildagliptin to omarigliptin was independently associated with worsening glycemic control(P=0.0013).The mean and standard deviation of sensor glucose value,the mean amplitude of glycemic excursions,and the mean of daily difference significantly improved when switching the patient from either linagliptin or sitagliptin to ***,in patients switched from vildagliptin,not only did the glucose variability indices see no improvements,the mean of daily difference even underwent significant *** Administering omarigliptin as add-on therapy or switching to it from sitagliptin and linagliptin,but not v

关键词： Omarigliptin Once-weekly dipeptidyl peptidase-4 inhibitor Real-world practice Retrospective study Type 2 diabetes

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Chemical Components of Snake Venom Acting on Tumor Cells and Blood Clot

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中国医科大学学报 1987年第S3期 1-26页

作者： Shigeyuki Terada,eiji Kimotc,Hiroshi kawasaki,Yoshiaki Tsuzuki Fukuoka University Japan Fukuoka University Japan Daiichi Pharmacological Fukuoka Japan Daiichi Pharmacological Fukuoka Japan

Agkistrodon halys venom contains various enzymes,most of which are hydrolyticenzymes except L-amino acid oxidase. Crude A. halys venom and the injectionpowder prepared from the venom were cytotoxic in vitro to various tumor cells as wellas normal proliferating *** purification of the-crude venom,the in vitro cyto-toxic substance was identified as L-amino acid *** in vivo antitumor effectof the venom infection powder was investigated, but no clear suppression of thegrowth of tumor cells was observed. Thrombin-like coagulant enzyme was also isolatedfrom the crude venom. Differences in the properties between this enzyme and bovinethrombin were examined. The venom coagulant enzyme showed a microheterogeneitydue to varying contents of sialic acid. Presence of several endopeptidases(proteinases)was also demonstrated in the venom which may participate in the degradation offibrin clot.

关键词： Agkistrodon halys venom Effect of cytotoxicity Thrombin-like enzyme Venom coagulant enzyme Endopeptidase

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Sequential elevation of autoantibodies to thyroglobulin and glutamic acid decarboxylase in type 1 diabetes

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World Journal of Diabetes 2013年第5期4卷 227-230页

作者： eiji kawasaki Jun-ichi Yasui Masako Tsurumaru Haruko Takashima Toshiyuki Ikeoka Fumi Mori Satoru Akazawa Ikuko Ueki Masakazu Kobayashi Hironaga Kuwahara Norio Abiru Hironori Yamasaki Atsushi Kawakami Department of Metabolism/Diabetes and Clinical Nutrition Nagasaki University Hospital First Department of Internal Medicine Nagasaki University Graduates School of Biomedical Sciences Clinical Research Center Nagasaki University Hospital Center for Health and Community Medicine Nagasaki University

We have previously reported the high levels of glutamic acid decarboxylase 65 autoantibodies(GAD65A)in patients with type 1 diabetes and autoimmune thyroid *** we describe a 32-year-old Japanese female with a thirteen-year history of type 1 diabetes whose levels of GAD65A were elevated just after the emergence of anti-thyroid *** 19 years of age,she developed diabetic ketoacidosis and was diagnosed with type 1 *** had GAD65A,insulinoma-associated antigen-2 autoantibodies(IA-2A),and zinc transporter-8 autoantibodies(ZnT8A),but was negative for antibodies to thyroid peroxidase(TPOAb)and thyroglobulin(TGAb)at disease ***8A and IA-2A turned negative 2-3 years after the onset,whereas GAD65A were persistently positive at lower level(approximately 40 U/mL).However,just after the emergence of TGAb at disease duration of 12.5 years,GAD65A levels were reelevated up to5717 U/mL in the absence of ZnT8A and *** thyroid function was normal and TPOAb were consistently *** has a HLA-DRB1*03:01/*04:01-DQB1*02:01/*03:02 *** positivity for GAD65A might be associated with increased risk to develop anti-thyroid autoimmunity.

关键词： Autoimmune thyroid disease Case report Glutamic acid decarboxylase autoantibodies Type 1diabetes

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Lightning Induced Surge on the Distribution Lines in the House near by the Lightning Point

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Journal of Energy and Power Engineering 2012年第5期6卷 840-844页

作者： Aiko Takahara Ryoji Oshiro eiji Kaneko Graduate School of Electrical and Electronic Engineering University of the Ryukyus Okinawa 903-0213 Japan Toshiba Corporation Hamakawasaki Works Kawasaki 210-0862 Japan

Recently, a lightning surge is recognized as one of the biggest risks to the society. If the surges induced by lightning invade into low voltage distribution lines, there might be a possibility of giving some severe damages to the systems. Therefore, it is necessary to examine these induced phenomena. FDTD （finite difference time domain） method which treats objects as three-dimensional solid circuits is applied to analyze these induced phenomena. VSTL （Virtual Surge Test Lab.） is the surge analysis simulation program using FDTD method. In this paper, the lightning induced phenomena on the low voltage distribution line in the house are analyzed by using VSTL. In this paper, investigation results about induced surge when a lightning struck the point nearby the house, and about a suppressing effect of surges by comparing the results of analysis with and without SPD （surge protective device） are shown. As a result, it is confirmed that SPD is effective for suppressing lightning surge.

关键词： Lightning surge induced phenomena FDTD method distribution line VSTL.

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Feasibility of large experimental animal models in testing novel therapeutic strategies for diabetes

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World Journal of Diabetes 2021年第4期12卷 306-330页

作者： Masaki Nagaya Koki Hasegawa Ayuko Uchikura Kazuaki Nakano Masahito Watanabe Kazuhiro Umeyama Hitomi Matsunari Kenji Osafune eiji Kobayashi Hiromitsu Nakauchi Hiroshi Nagashima Meiji University International Institute for Bio-Resource Research Meiji UniversityKawasaki 214-8571KanagawaJapan Department of Immunology St.Marianna University School of MedicineKawasaki 261-8511KanagawaJapan Laboratory of Medical Bioengineering Department of Life SciencesSchool of AgricultureMeiji UniversityKawasaki 214-8571KanagawaJapan Research and Development PorMedTec Co.LtdKawasaki 214-0034KanagawaJapan Center for iPS Cell Research and Application(CiRA) Kyoto UniversityKyoto 606-8507KyotoJapan Department of Organ Fabrication Keio University School of MedicineShinjuku 160-8582TokyoJapan Institute for Stem Cell Biology and Regenerative Medicine Department of GeneticsStanford University School of MedicineStanford UniversityStanfordCA 94305United States Division of Stem Cell Therapy Institute of Medical ScienceThe University of TokyoMinato 108-8639TokyoJapan

Diabetes is among the top 10 causes of death in adults and caused approximately four million deaths worldwide in *** incidence and prevalence of diabetes is predicted to *** alleviate this potentially severe situation,safer and more effective therapeutics are urgently *** have long been the mainstay as preclinical models for basic research on diabetes,although they are not ideally suited for translating basic knowledge into clinical *** validate and optimize novel therapeutics for safe application in humans,an appropriate large animal model is *** animals,especially pigs, are well suited for biomedical research and share many similarities with humans,including body size,anatomical features,physiology,and ***,pigs already play an important role in translational studies,including clinical trials for *** in genetic engineering over the past few decades has facilitated the development of transgenic animals,including porcine models of *** article discusses features that attest to the attractiveness of genetically modified porcine models of diabetes for testing novel treatment strategies using recent technical advances.

关键词： Pancreatic islet Diabetes mellitus Pig Transgenic Genetic engineering Transplantation Xenotransplantation

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Determination of Bed Void Fraction from Fixed Bed Breakthrough Curve

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Journal of Chemistry and Chemical Engineering 2011年第3期5卷 202-206页

作者： Junpei Fujiki Toshiaki Kusaba Shinji Miyamoto eiji Furuya Department of Applied Chemistry Meo＇i University 1-1-1 Higashimita Tama-ku Kawasaki 214-85 71 Japan Process Development Center Idemitsu Kosan Co. Ltd. 1-1 Anesakikaigan Ichihara Chiba Japan

Accurate physical and chemical properties of adsorbents are required for the efficient design of fixed bed adsorbers. The bed void and particle void are significant physical properties. One of the experimentally determination technique for the bed void is a breakthrough curve method. In the present paper, experimental conditions for determining the bed void from breakthrough curve were investigated because complex conditions are required. The values of bed void were determined from theoretical elution curve at the point of c/c0 = 0.5 under the condition of negligible amount adsorbed. The bed void value determined from elution curve was clearly affected by particle void and fluid velocity, and regarded as ＂apparent＂ bed void values. For large porosity particles, it was difficult to determine the true bed void value due to the effect of penetration into macro pores. Then, the bed void fraction can be determined safely from breakthrough curve when particles possessing small particle void are used.

关键词： Bed void particle void fixed bed breakthrough.

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Estimation of Physiologic Ability and Surgical Stress Scoring System Appraises Laparoscopy-Assisted and Open Distal Gastrectomy in Treatment of Early Gastric Cancer

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Journal of Cancer Therapy 2013年第9期4卷 1-5页

作者： Hideki Bou Hideyuki Suzuki Kentaro Maejima Hidetsugu Hanawa Masanori Watanabe eiji Uchida Department of Surgery Nippon Medical School Tokyo Japan Institute of Gastroenterology Nippon Medical School Musashi-kosugi Hospital Kawasaki Japan

Laparoscopy-assisted distal gastrectomy (LADG) has been widely used to treat early gastric cancer (EGC). The Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system predicts the risk of fatal postoperative complications by quantifying the patient’s reserve and degree of surgical stress, but there have been a few reports of use of the E-PASS scoring system to assess the risk of mortality following special types of surgical procedures such as LADG. In this study we assessed the feasibility of LADG versus open distal gastrectomy (ODG) by the E-PASS scoring system. The subjects of this study consisted of 69 stage IA gastric cancer patients who underwent LADG (LADG group) and 69 stage IA gastric cancer patients who underwent ODG (ODG group). The mean age of the patients in the LADG group was 68.6 years, which was significantly higher than the mean age of 63.4 years in the ODG group. There were no statistically significant differences between the groups in operation time or preoperative risk score, but there were statistically significant differences in blood loss, surgical stress score, comprehensive risk score, and duration of postoperative hospital stay. We conclude that using the E-PASS scoring system, LADG appreciates a more beneficial procedure for the treatment of EGC than ODG.

关键词： E-PASS LADG ODG

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Sleep conditions and quality of life among patients with ischemic heart disease after elective percutaneous coronary intervention

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Health 2013年第3期5卷 532-537页

作者： Yuko Yasuhara Haruo Kobayashi Tetsuya Tanioka eiji Fujikawa Hiroyuki Fujinaga Warapon Kongsuwan Rozzano C. Locsin Christine E. Lynn College of Nursing Florida Atlantic University Boca Raton USA Department of Cardiovascular Internal Medicine Tokushima Prefectural Central Hospital Tokushima Japan Department of Medical Nursing Faculty of Nursing Prince of Songkla University Songkhla Thailand Department of Nursing Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan Department of Nursing Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan Department of Nursing Tokushima Prefectural Central Hospital Tokushima Japan Faculty of Medical Welfare Kawasaki University of Medical Welfare Kurashiki Japan

In Japan, percutaneous coronary intervention (PCI) is a major therapeutic intervention for ischemic heart disease (IHD). Previous studies suggested that an association of the risk of IHD caused by sleep duration was related to factors closely associated with daily activities. However, in Japan, there is no study about this relationship objectively measured using the actigraphy in patients with IHD. Moreover, there is little reported data about sleep condition and early outcomes of patient’s Health-Related Quality of Life (QOL) after PCI. This study determines the correlations between sleep conditions and QOL (measured by SF36 version 2) of 25 patients with IHD who underwent elective PCI. Data were collected seven days after PCI using night-sleep condition. Using Spearman’s rank test, the results revealed positive correlation between vitality score and longest sleep duration (ρ = 0.43, p = 0.031): social functioning (SF) score and duration of night-time sleep (ρ = 0.42, p = 0.037);total sleep duration (ρ = 0.45, p = 0.026), and longest sleep duration (ρ = 0.44, p = 0.024);mental health score and longest sleep duration (ρ = 0.54, p = 0.006). However, negative correlation was found between physical functioning score and arousal during sleep (ρ = -0.44, p = 0.027). Sleep condition was significantly correlated with QOL. In particular, SF score was positively related to night-time sleep. This seems to indicate that SF score might be related to night-time sleep condition. Moreover, the longest sleep durations were correlated with the mental component summary. The results of the study suggest that not only the length of whole sleep durations leads to better QOL, but also the increase the amount of uninterrupted sleep.

关键词： Ischemic Heart Disease Actigraphy Sleep Condition Health-Related Quality of Life

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Integrated genome-wide differentiation and association analyses identify causal genes underlying breeding-selected grain quality traits in japonica rice

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Molecular Plant 2023年第9期16卷 1460-1477页

作者： Hideki Yoshida Satoshi Okada Fanmiao Wang Shohei Shiota Masaki Mori Mayuko Kawamura Xue Zhao Yiqiao Wang Naho Nishigaki Asako Kobayashi Kotaro Miura Shinya Yoshida Masaru Ikegami Akitoshi Ito Lin-Tzu Huang Yue-le Caroline Hsing Yoshiyuki Yamagata Yoichi Morinaka Masanori Yamasaki Toshihisa Kotake eiji Yamamoto Jian Sun Ko Hirano Makoto Matsuoka Institute of Fermentation Sciences Fukushima UniversityFukushima 960-1248Japan Bioscience and Biotechnology Center Nagoya UniversityNagoyaAichi 464-8601Japan Food Resources Education and Research Center Graduate School of Agricultural ScienceKobe UniversityUzuranoKasaiHyogo 675-2103Japan Research Center of Genetic Resources NARO2-1-1 KannondaiTsukubaIbaraki 305-8602Japan Rice Research Institute Shenyang Agricultural UniversityShenyangChina Division of Life Science Graduate School of Science and EngineeringSaitama University255 Shimo-okuboSakura-kuSaitamaJapan Fukui Agricultural Experiment Station Fukui 918-8215Japan Department of Bioscience and Biotechnology Fukui Prefectural UniversityFukui 910-1195Japan Hyogo Prefectural Research Center for Agriculture Forestry and FisheriesKasaiHyogo 679-0198Japan Research Insttute for Food and Agriculture Ryukoku UniversityOotsuShiga 520-2194Japan Food Research Centre Aichi Centre for Industry and Science Technology2-1-1 Shimpukuji-choNagoyaAichi 451-0083Japan institute of Plant and Microbial Biology Academia SinicaTaipeiTaiwanChina Department of Agronomy National Taiwan UniversityTaipeiTaiwanChina lant Breeding Laboratory Facultyf gricultureKyushu University744MoookaNishikuFukukaJapan Graduate School of Agiculture Meji University1-1-1 Higashi-MitaTama-kuKawasakiKanagawa 214571Japa Crop Science Laboratory Faculty of AgricultureNigata UniversityIkarashiNishi-kuNigata 950-2181Japan

Improving grain quality is a primary objective in contemporary rice *** modern rice breeding has developed two different types of rice,eating and sake-brewing rice,with different grain characteristics,indicating the selection of variant gene alleles during the breeding *** the critical importance of promptly and efficiently identifying genes selected in past breeding for future molecular breeding,we conducted genome scans for divergence,genome-wide association studies,and map-based ***,we successfully identified two genes,OsMnS and OsWOX9D,both contributing to rice grain *** encodes a mannan synthase that increases the white core frequency in the endosperm,a desirable trait for sake brewing but decreases the grain appearance ***9D encodes a grass-specific homeobox-containing transcription factor,which enhances grain width for better sake ***,haplotype analysis revealed that their defective alleles were selected in East Asia,but not Europe,during modern *** addition,our analyses indicate that a reduction in grain mannan content during African rice domestication may also be caused a defective OsMnS allele due to breeding *** study not only reveals the delicate balance between grain appearance quality and nutrition in rice but also provides a new strategy for isolating causal genes underlying complex traits,based on the concept of“breeding-assisted genomics”in plants.

关键词： rice grain quality sake brewing mannan genomic analysis

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