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Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage

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Current Medical Science 2022年第2期42卷 249-266页

作者： Kuldeep Singh JADAUN Sidharth MEHAN Aarti SHARMA ehraz mehmood siddiqui Sumit KUMAR NaifALSUHAYMI Neuropharmacology Division Department of PharmacologyISF College of PharmacyMogaPunjab142001India Department of Emergency Medical Services Faculty of Health Sciences-AlQunfudahUmm Al-Qura UniversityMekkahSaudi Arabia

Objective Intracerebral hemorrhage(ICH)refers to predominant,sporadic,and non-traumatic bleeding in the brain *** PI3K/AKT/mTOR signaling pathway is an important signal transduction pathway regulated by enzyme-linked receptors and has many biological functions in *** plays a key role in neuronal metabolism,gene expression regulation,and tissue homeostasis in the healthy and diseased *** In the present study,the role of the PI3K/AKT/mTOR pathway inhibitor chrysophanol(CPH)(10 mg/kg and 20 mg/kg,orally)in the improvement of ICH-associated neurological defects in rats was *** blood(20µL/5 min/unilateral/intracerebroventricular)mimics ICH-like defects involving cellular and molecular dysfunction and neurotransmitter *** current study also included various behavioral assessments to examine cognition,memory,and motor and neuromuscular *** protein expression levels of PI3K,AKT,and mTOR as well as myelin basic protein and apoptotic markers,such as Bax,Bcl-2,and caspase-3,were examined using ELISA ***,the levels of various neuroinflammatory cytokines and oxidative stress markers were ***,the neurological severity score,brain water content,gross brain pathology,and hematoma size were used to indicate neurological function and brain *** CPH was found to be neuroprotective by restoring neurobehavioral alterations and significantly reducing the elevated PI3K,AKT,and mTOR protein levels,and modulating the apoptotic markers such as Bax,Bcl-2,and caspase-3 in rat brain *** substantially reduced the inflammatory cytokines like interleukin(IL)-1β,IL-6,and tumor necrosis factor-α.CPH administration restored the neurotransmitters GABA,glutamate,acetylcholine,dopamine,and various oxidative stress *** Our results show that CPH may be a promising therapeutic approach for overcoming neuronal damage caused by the overexpression of the PI3K/AKT/mTOR signal

关键词： intracerebral hemorrhage autologous blood PI3K/AKT/mTOR hematoma chrysophanol apoptosis neurotransmitter neuroinflammation

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Antiacanthamoebic properties of natural and marketed honey in Pakistan

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 967-972页

作者： Farzana Abubakar Yousuf Malik Hassan mehmood Abdul Malik Ruqaiyyah siddiqui Naveed Ahmed Khan Department of Biological and Biomedical Sciences Aga Khan University Department of Biological Sciences Faculty of Science and Technology Sunway University

Objective: To determine antiacanthamoebic activity of natural and marketed honey ***: Natural honey samples were collected directly from the bee hive and marketed honey samples were purchased from the local market in Karachi, Pakistan. Both honey samples were tested for their flavonoid content(quercetin equivalent per gram of the extract) and phenolic content(gallic acid equivalent per gram). Furthermore, their antioxidant activity was determined by measuring 2,2-diphenyl-1-picrylhydrazyl. Using amoebistatic and amoebicidal assays, the effects of honey samples were tested against growth and viability of Acanthamoeba ***: Natural honey exhibited potent amoebistatic and amoebicidal effects, in a concentration-dependent manner. Honey-treated Acanthamoeba castellanii showed loss of acanthopodia, following which amoebae detached, rounded up, reduced in size,decreased in cytoplasmic mass and they were observed floating in the culture ***, honey-treated amoebae did not revive when inoculated in fresh growth medium, however, glycerol-treated amoebae exhibited viable trophozoite and active growth. In contrast, marketed honey samples varied in their efficacy against Acanthamoeba castellanii. The proportion of flavonoid, as determined by quercetin measurements and the proportion of phenolic, as determined by gallic acid measurements was higher in natural honey compared with marketed honey. Similarly, the antioxidant activity, as determined by 2,2-diphenyl-1-picrylhydrazyl scavenging activity was higher in natural honey vs. marketed ***: This study shows that natural honey has antiacanthamoebic properties and possesses higher flavonoid, phenolic and antioxidant properties compared with the marketed honey. These findings are of concern to the public, health officials, and to the manufacturers regarding production of honey for medical applications.

关键词： Honey Acanthamoeba Amoebicidal Amoebistatic

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Root-Of-Trust for Continuous Integration and Continuous Deployment Pipeline in Cloud Computing

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Computers, Materials & Continua 2022年第11期73卷 2223-2239页

作者： Abdul Saboor Mohd Fadzil Hassan Rehan Akbar Erwin Susanto Syed Nasir mehmood Shah Muhammad Aadil siddiqui Saeed Ahmed Magsi High-Performance Cloud Computing Centre(HPC3) Department of Computer&Information SciencesUniversiti Teknologi PETRONASSeri IskandarPerakMalaysia Centre for Research in Data Science(CeRDaS) Department of Computer&Information SciencesUniversiti Teknologi PETRONASSeri IskandarPerakMalaysia School of Electrical Engineering Telkom UniversityBandungIndonesia KICSIT Institute of Space Technology(IST)IslamabadPakistan Department of Electrical and Electronics Engineering Universiti Teknologi PETRONASSeri IskandarPerakMalaysia

Cloud computing has gained significant use over the last decade due to its several benefits,including cost savings associated with setup,deployments,delivery,physical resource sharing across virtual machines,and availability of on-demand cloud ***,in addition to usual threats in almost every computing environment,cloud computing has also introduced a set of new threats as consumers share physical resources due to the physical co-location ***,since there are a growing number of attacks directed at cloud environments(including dictionary attacks,replay code attacks,denial of service attacks,rootkit attacks,code injection attacks,etc.),customers require additional assurances before adopting cloud ***,the continuous integration and continuous deployment of the code fragments have made cloud services more prone to security *** this study,the model based on the root of trust for continuous integration and continuous deployment is proposed,instead of only relying on a single signon authentication method that typically uses only id and *** underlying study opted hardware security module by utilizing the Trusted Platform Module(TPM),which is commonly available as a cryptoprocessor on the motherboards of the personal computers and data center *** preliminary proof of concept demonstrated that the TPM features can be utilized through RESTful services to establish the root of trust for continuous integration and continuous deployment pipeline and can additionally be integrated as a secure microservice feature in the cloud computing environment.

关键词： Root of Trust(RoT) Trusted Platform Module(TPM) cryptoprocessor microservices Hardware Security Modules(HSM) DevOps

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A review of recent advancements in finite element formulation for sandwich plates

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Chinese Journal of Aeronautics 2019年第4期32卷 785-798页

作者： Shehzaib IRFAN Faisal siddiqui Aerospace Engineering Department College of Aeronautical Engineering National University of Sciences and TechnologyRisalpur

Use of composite structures is exponentially growing in different fields due to their higher strength-to-weight ratio. This application trend requires that accurate theoretical explanations and their finite element models be developed for analyzing sandwich plates before finalizing the designs. This paper reviews the recent research trends of finite element formulations developed for analyzing sandwich plates. This paper reviews the finite element models developed after the year 2000. Initially, the finite element formulations based on first order shear deformation theory, higher order shear deformation theories, mixed solid-shell elements, zig-zag theories and global–local theories are presented. Then, some finite element formulations developed to analyze a very new class of structures called piezoelectric structures are presented. At the end, some formulations to analyze a very critical phenomenon called buckling are presented.

关键词： Buckling Finite element FSDT HSDT Laminated composites Piezoelectric Sandwich plates Zig-zag theory

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TiO_2-water nanofluid in a porous channel under the effects of an inclined magnetic field and variable thermal conductivity

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Applied Mathematics and Mechanics(English Edition) 2018年第8期39卷 1201-1216页

作者： A.A.siddiqui M.SHEIKHOLESLAMI Department of Basic Sciences Bahauddin Zakariya University Department of Mechanical Engineering Babol Noshirvani Uiniversity of Technology

The TiO2-water based nanofluid flow in a channel bounded by two porous plates under an oblique magnetic field and variable thermal conductivity is formulated as a boundary-value problem(BVP). The BVP is analytically solved with the homotopy analysis method(HAM). The result shows that the concentration of the nanoparticles is independent of the volume fraction of TiO2nanoparticles, the magnetic field intensity, and the angle. It is inversely proportional to the mass diffusivity. The fluid speed decreases whereas the temperature increases when the volume fraction of the TiO2nanoparticles increases. This confirms the fact that the occurrence of the TiO2nanoparticles results in the increase in the thermal transfer rate. The fluid speed decreases and the temperature increases for both the pure water and the nanofluid when the magnetic field intensity and angle increase. The maximum velocity does not exist at the middle of the symmetric channel, which is in contrast to the plane-Poiseuille flow, but it deviates a little bit towards the lower plate, which absorbs the fluid with a very low suction velocity. If this suction velocity is increased, the temperature in the vicinity of the lower plate will be *** explicit expression for the friction factor-Reynolds number is then developed. It is shown that the Hartmann number of the nanofluid is smaller than that of pure water,while the Nusselt number of the nanofluid is larger than that of pure water. However,both the parameters increase if the magnetic field intensity increases.

关键词： TiO2 Nusselt number oblique magnetic field nanofluid homotopy analysis method(HAM) thermal transfer

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An approach to Iocational marginal price based zonal congestion management in deregulated electricity market

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Frontiers in Energy 2016年第2期10卷 240-248页

作者： Md SARWAR Anwar Shahzad siddiqui Department of Electrical Engineering Jamia Millia Islamia (A Central University) New Delhi 110025 India

Congestion of transmission line is a vital issue and its management pose a technical challenge in power system deregulation. Congestion occurs in deregulated electricity market when transmission capacity is not sufficient to simultaneously accommodate all constraints of power transmission through a line. Therefore, to manage congestion, a locational marginal price （LMP） based zonal congestion management approach in a deregulated elec- tricity market has been proposed in this paper. As LMP is an economic indicator and its difference between two buses across a transmission line provides the measure of the degree of congestion, therefore, it is efficiently and reliably used in deregulated electricity market for conges- tion management. This paper utilizes the difference of LMP across a transmission line to categorize various congestion zones in the system. After the identification of congestion zones, distributed generation is optimally placed in most congestion sensitive zones using LMP difference in order to manage congestion. The performance of the proposed methodology has been tested on the IEEE 14-bus system and IEEE 57-bus system.

关键词： locational marginal price (LMP) distributed generation pool market deregulated electricity market,congestion management

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Optimal Location and Sizing of Conglomerate DG-FACTS using an Artificial Neural Network and Heuristic Probability Distribution Methodology for Modern Power System Operations

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Protection and Control of Modern Power Systems 2022年第1期7卷 124-148页

作者： Anwar Shahzad siddiqui Prashant Department of Electrical Engineering Faculty of Engineering&TechnologyJamia Millia IslamiaJamia NagarOkhlaNew Delhi 110025India

In existing power system networks,the positioning and sizing of multi-DG is critical at the optimum locations for effective energy *** optimal power flow is assessed using the NR method(without DG)in which performance parameters such as real power loss,accuracy,selectivity and MSE are obtained,but in an undesirable *** meet load demand;multi-DGs are placed and their optimal locations are assessed by the proposed heuristic probability distribution methodology and an ANN because existing techniques provides poor performance parameters for selecting the location and sizing of *** optimal positions of multi-DGs are estimated in terms of performance parameters including real power loss of transmission network,accuracy,selectivity and MSE,while the performance parameters obtained with the ANN are better than the heuristic ***,the sizing of multi-DGs is evaluated in relation to active and reactive *** is found that that sizes of multi-DGs are smaller with ANN than with heuristic *** is preferable to connect the buses having lowest real power losses with the smallest *** performance analysis is tested in the standard IEEE 9-bus and IEEE 57-bus systems on *** improve the distortion level in real and reactive power,multi-FACTS namely TCSC,TSC and STATCOM are *** switching of TCSC and TSC is done by SPWM while STATCOM switching is controlled with *** locations of multi-FACTS devices are chosen for buses having larger distortion and the sizing of multi-FACTS devices is also optimally *** application of multi-FACTS devices helps to improve power quality and fulfill load demand with minimal size in order to make the system economical.

关键词： DG Location Sizing FACTS ANN ANFIS

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Effect of Seed Bacterization on Plant Growth Response and Induction of Disease Resistance in Chilli

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Agricultural Sciences in China 2009年第8期8卷 963-971页

作者： Yasmeen siddiqui Sariah Meon Laboratory of Food Crops and Floriculture Institute of Tropical AgricultureUniversiti Putra Malaysia (UPM)

This study aimed to examine the induction of disease resistance, and growth response in chilli plants elicited by plant growth promoting endophytic bacteria [Pseudomonas aeruginosa （UPMP3）, Burkholderia cepacia （UPMB3）, and Serratia marcescens （UPMS3）]. Seed bacterization with UPMP3 and UPMB3 significantly increased peroxidase （PO）, polyphenol oxidase （PPO）, and phenylalanine ammonia-lyase （PAL） activities. This increase corresponded to greater reduction in pre-and post-emergence damping-off caused by Sclerotium rolfsii. UPMS3 alone or as mixture with UPMP3 and UPMB3 did not show any significant reduction in disease incidence. However, all the isolates tested did not inhibit the seed germination and seedling establishment in chilli.

关键词： endophytic bacteria induced resistance PO PPO PAL Sclerotium rolfsii

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Biosynthesis of Flower-Shaped CuO Nanostructures and Their Photocatalytic and Antibacterial Activities

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Nano-Micro Letters 2020年第2期12卷 224-234页

作者： Hafsa siddiqui MSQureshi Fozia Zia Haque Department of Physics Sha-Shib College of Science and ManagementBhopal 462030India Optical Nanomaterial Lab Department of PhysicsMaulana Azad National Institute of TechnologyBhopal 462003India

Copper oxide nanoflowers(CuO-NFs)have been synthesized through a novel green route using Tulsi leaves-extracted eugenol(4-allyl-2-methoxyphenol)as reducing *** results reveal the growth of crystalline singlephase CuO-NFs with monoclinic *** prepared CuO-NFs can effectively degrade methylene blue with 90%*** also show strong barrier against ***(27±2 mm)at the concentration of 100μg mL−1,while at the concentration of 25μg mL−1 weak barrier has been found against all examined bacterial *** results provide important evidence that CuO-NFs have sustainable performance in methylene blue degradation as well as bacterial organisms.

关键词： Copper oxide O.Sanctum Eugenol Biosynthesis Photocatalysis Antibacterial

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Investigation on the process parameters of TIG-welded aluminum alloy through mechanical and microstructural characterization

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Defence Technology（防务技术） 2021年第4期17卷 1234-1248页

作者： Muhammad Samiuddin Jing-long Li Muhammad Taimoor Mohammad Nouman siddiqui Sumair Uddin siddiqui Jiang-tao Xiong State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072PR China Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical UniversityXi’an710072PR China Metallurgical Engineering Department NED University of Engineering and TechnologyKarachi75850Pakistan Department of Aeronautics and Astronautics Institute of Space TechnologyIslamabad44000Pakistan

Multi-pass TIG welding was conducted on plates(15×300×180 mm^(3))of aluminum alloy Al-5083 that usually serves as the component material in structural applications such as cryogenics and chemical processing *** formation and solidification cracking are the most common defects when TIG welding Al-5083 alloy,which is sensitive to the welding heat *** the experiment,the heat input was varied from 0.89 kJ/mm to 5 kJ/mm designed by the combination of welding torch travel speed and welding ***,micro-Vicker hardness and Charpy impact tests were executed to witness the impetus response of heat input on the mechanical properties of the *** inspection was performed to assess the joint’s quality and welding *** results show that all the specimens displayed inferior mechanical properties as compared to the base *** was established that porosity was progressively abridged by the increase of heat *** results also clinched that the use of medium heat input(1-2 kJ/mm)offered the best mechanical properties by eradicating welding defects,in which only about 18.26% of strength was *** yield strength of all the welded specimens remained unaffected indica ted no influence of heat *** melted zone(PMZ)width also affected by heat input,which became widened with the increase of heat *** grain size of PMZ was found to be coarser than the respective grain size in the fusion *** impact testing revealed that the absorbed energy by low heat input specimen(welded at high speed)was greater than that of high heat input(welded at low speed)because of low porosity and the formation of equiaxed grains which induce better impact ***(-196℃)impact testing was also performed and the results corroborate that impact properties under the cryogenic environment revealed no appreciable change after welding at designated heat ***,Macro and micro fractured surfaces of tensile and impact spe

关键词： Tungsten inert gas welding(TIG) Heat input Welding defects Tensile strength Charpy impact strength Micro-vicker hardness SEM

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