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Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage

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Current Medical Science 2022年第2期42卷 249-266页

作者： Kuldeep Singh JADAUN Sidharth MEHAN Aarti SHARMA ehraz mehmood siddiqui Sumit KUMAR NaifALSUHAYMI Neuropharmacology Division Department of PharmacologyISF College of PharmacyMogaPunjab142001India Department of Emergency Medical Services Faculty of Health Sciences-AlQunfudahUmm Al-Qura UniversityMekkahSaudi Arabia

Objective Intracerebral hemorrhage(ICH)refers to predominant,sporadic,and non-traumatic bleeding in the brain *** PI3K/AKT/mTOR signaling pathway is an important signal transduction pathway regulated by enzyme-linked receptors and has many biological functions in *** plays a key role in neuronal metabolism,gene expression regulation,and tissue homeostasis in the healthy and diseased *** In the present study,the role of the PI3K/AKT/mTOR pathway inhibitor chrysophanol(CPH)(10 mg/kg and 20 mg/kg,orally)in the improvement of ICH-associated neurological defects in rats was *** blood(20µL/5 min/unilateral/intracerebroventricular)mimics ICH-like defects involving cellular and molecular dysfunction and neurotransmitter *** current study also included various behavioral assessments to examine cognition,memory,and motor and neuromuscular *** protein expression levels of PI3K,AKT,and mTOR as well as myelin basic protein and apoptotic markers,such as Bax,Bcl-2,and caspase-3,were examined using ELISA ***,the levels of various neuroinflammatory cytokines and oxidative stress markers were ***,the neurological severity score,brain water content,gross brain pathology,and hematoma size were used to indicate neurological function and brain *** CPH was found to be neuroprotective by restoring neurobehavioral alterations and significantly reducing the elevated PI3K,AKT,and mTOR protein levels,and modulating the apoptotic markers such as Bax,Bcl-2,and caspase-3 in rat brain *** substantially reduced the inflammatory cytokines like interleukin(IL)-1β,IL-6,and tumor necrosis factor-α.CPH administration restored the neurotransmitters GABA,glutamate,acetylcholine,dopamine,and various oxidative stress *** Our results show that CPH may be a promising therapeutic approach for overcoming neuronal damage caused by the overexpression of the PI3K/AKT/mTOR signal

关键词： intracerebral hemorrhage autologous blood PI3K/AKT/mTOR hematoma chrysophanol apoptosis neurotransmitter neuroinflammation

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Film Flow of Nano-Micropolar Fluid with Dissipation Effect

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2487-2512页

作者： Abuzar Abid siddiqui Mustafa Turkyilmazoglu Department of Basic Sciences&Humanities Faculty of Engineering&TechnologyBahauddin Zakariya UniversityMultanPakistan Department of Mathematics Hacettepe UniversityAnkaraTürkiye Department of Medical Research China Medical University HospitalChina Medical UniversityTaichungTaiwanChina

The physical problem of the thin film flow of a micropolar fluid over a dynamic and inclined substrate under the influence of gravitational and thermal forces in the presence of nanoparticles is *** different types of nanoparticle samples are accounted for in this current study,namely gold Au,silver Ag,molybdenum disulfide MoS_(2),aluminum oxide Al_(2)O_(3),and silicon dioxide SiO_(2).Blood,a micropolar fluid,serves as the common base *** exact closed-form solution for this problem is derived for the first time in the *** results are particularly validated against those for the Newtonian fluid and show excellent *** was found that increasing values of the spin boundary condition and micropolarity lead to a reduction in both the thermal and momentum boundary layers.A quantitative decay in the Nusselt number for a micropolar fluid,as compared to a Newtonian one for all the tested nanoparticles,is *** and silver nanoparticles(i)intensify in the flow parameter as the concentration of nanoparticles increases(ii)yield a higher thermal transfer rate,whereas molybdenum disulfide,aluminum oxide,and silicon dioxide exhibit a converse attitude for both Newtonian and micropolar *** reduction in film thickness for fluid comprising gold particles,as compared to the rest of the nanoparticles,is remarkable.

关键词： Thin film flow micropolar fluid nanoparticles molybdenum disulfide inclined substrate

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Decoding the fruit microbiome:A climate smart strategy to manage postharvest decays

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Horticultural Plant Journal 2024年第5期10卷 1061-1072页

作者： Manori Kuruppu Kong Lih Ling Phebe Ding Khairulmazmi Ahmad Asgar Ali Yasmeen siddiqui Laboratory of Sustainable Agronomy and Crop Protection Institute of Plantation StudiesUniversiti Putra MalaysiaSerdang 43400Malaysia Department of Plant Protection Faculty of AgricultureUniversiti Putra MalaysiaSerdang 43400Malaysia Centre of Excellence for Post-harvest Biotechnology(CEFB) School of BiosciencesUniversity of Nottingham MalaysiaJalan Broga43500 SemenyihSelangorMalaysia Department of Biological Sciences College of ScienceKing Faisal UniversityAl Ahsa31982Saudi Arabia

There is an urgent necessity to shift our diets toward those rich in fruits and vegetables and at reduce postharvest losses of *** 20%-50%of fruits and vegetables are lost due to poor postharvest handling and pathogen infections in developing countries while it was estimated as 5%-35%in developed countries. Fresh fruits have evolved with a plethora of microorganisms having important roles in maintaining fruit health. However, little information is available on the dynamics, structure, and functional capacities of underpinning fruit microbiomes. The present review discussed environmental conditions favoring fruit-harbored antagonists and their different modes of action for suppressing postharvest pathogens in fruits. It also provides information on omics technologies such as next-generation sequencing (NGS),metaproteomics, metatranscriptomic, and metabolomics studies to characterize fruit microbiomes. With the advent of NGS and meta-omics technologies, microbiome research could bring remarkable development and understanding in succeeding biological treatments. In addition, they may provide us with a fundamental understanding of microclimate requirements for fruit microbiome establishment and microbiome shifts during post-harvest storage, which would be advantageous in developing composite biocontrol treatments for post-harvest decay management.

关键词： Biological control Food loss Fruit microbiome Meta-omics Microclimate Postharvest decay

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Impact of surgical management of upper tract urothelial cancer in octogenarians:A population-based study

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Current Urology 2024年第3期18卷 225-231页

作者： Shu Wang Michael Phelan Mohummad Minhaj siddiqui Division of Urology Department of SurgeryUniversity of Maryland School of MedicineBaltimoreMDUSA Veterans Affairs Maryland Healthcare System BaltimoreMDUSA

Background Upper tract urothelial carcinoma(UTUC)is an aggressive disease with a high progression *** standardmanagement for this disease is *** sparing nonradical surgery is an alternative therapeutic *** men with limited life expectancy,the potential harm of UTUC progression must be weighed against surgical morbidity and mortality,and thus,more conservative approaches may be *** study aims to investigate the comparative benefits of radical and conservative surgical management in patients older than 80 years with localized *** and methods A search was conducted in the Surveillance,Epidemiology,and End Results database for patients older than 80 years who were diagnosed with localized(T1–2N0M0)cancer in the renal pelvis or ureter as the only malignancy from 2004 to *** were divided into 3 therapeutic groups:no surgery,local intervention(ie,local tumor excision or segmented ureterectomy),and radical surgery(nephroureterectomy).Demographic and cancer-related parameter data were *** regression analysis was conducted to investigate predictors for surgical ***-Meier curves and Cox regression were used to analyze survival *** Data from 774 patients were analyzed,including 205 in the no-surgery group,181 in the local intervention group,and 388 in the radical surgery ***,African American patients with T1 stage disease were less likely to receive surgical *** surgically treated patients,renal pelvic tumors,and high-grade and T2 stage disease were associated with radical *** treated patients had a longer median overall survival(OS)than in those treated nonsurgically(13,35,and 47 months in no-surgery,local intervention,and radical surgery groups,respectively;p<0.001).Although surgically treated patients demonstrated higher 5-year OS(8.8%[no surgery],23.2%[local intervention],and 23.5%[radical surgery],p<0.001)and 5-year disease-specif

关键词： Older adults Surgery Surveillance,Epidemiology,and End Results Survival Upper tract urothelial carcinoma

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Predicting potential invasion risks of Leucaena leucocephala(Lam.)de Wit in the arid area of Saudi Arabia

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Journal of Arid Land 2024年第7期16卷 983-999页

作者： Haq S MARIFATUL Darwish MOHAMMED Waheed MUHAMMAD Kumar MANOJ siddiqui H MANZER Bussmann W RAINER Department of Ethnobotany Institute of BotanyIlia State UniversityTbilisi 0162Georgia The Centre of Excellence on Sustainable Land Management(CoE-SLM) Indian Council of Forestry Research and EducationDehradun 248006India Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Botany State Museum for Natural HistoryKarlsruhe 76133Germany

The presence of invasive plant species poses a substantial ecological impact,thus comprehensive evaluation of their potential range and risk under the influence of climate change is *** study uses maximum entropy(MaxEnt)modeling to forecast the likelihood of Leucaena leucocephala(Lam.)de Wit invasion in Saudi Arabia under present and future climate change *** the MaxEnt modeling,we integrated climatic and soil data to predict habitat suitability for the invasive *** conducted a detailed analysis of the distribution patterns of the species,using climate variables and ecological *** focused on the important influence of temperature seasonality,temperature annual range,and precipitation *** distribution modeling used robust measures of area under the curve(AUC)and receiver-operator characteristic(ROC)curves,to map the invasion extent,which has a high level of accuracy in identifying appropriate *** complex interaction that influenced the invasion of *** was highlighted by the environmental parameters using Jackknife ***,the actual geographic area where *** was found in Saudi Arabia was considerably smaller than the theoretical maximum range,suggesting that it had the capacity to expand *** MaxEnt model exhibited excellent prediction accuracy and produced reliable results based on the data from the ROC *** and temperature were the primary factors influencing the potential distribution of ***,an estimated area of 216,342 km^(2)in Saudi Arabia was at a high probability of invasion by *** investigated the potential for increased invasion hazards in the future due to climate change scenarios(Shared Socioeconomic Pathways(SSPs)245 and 585).The analysis of key climatic variables,including temperature seasonality and annual range,along with soil properties such as clay composition and nitrogen content,unveiled their substanti

关键词： area under the curve invasive species invasion risks climate change MaxEnt model

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Insight into Metabolomic Profiling of Tinospora cordifolia: Recent Advances and Future Perspectives of Quality Control

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 137-148页

作者： Atiqul Islam C.Anurag Nazia siddiqui Xianting Ding Alok Sharma College of Pharmacy JSS Academy of Technical EducationNoidaUttar PradeshIndia Department of Pharmaceutical Technology MIETMeerutUttar PradeshIndia Institute for Personalized Medicine School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina

The objective of this study was to offer a review of previous works on Tinospora cordifolia(TC) metabolomics with a highlight on the use of metabolomics in comparative evaluations between varieties and selection of optimum cultivation, collection, and extraction procedures, providing insights into pharmaceutical and food product quality monitoring. Scholarly databases were searched to gather relevant information on TC's therapeutic usefulness, phytoconstituent studies, metabolomics, and applications. Pub Chem was used to learn the structures of several of the metabolites. The various medicinal properties of TC were extensively researched. The most essential portions of the plant in Ayurvedic medicines are the stems. Bioactive phytochemicals such as steroidal lactones, alkaloids, diterpenoids, and phenolic compounds are present in the roots and leaves. Metabolomic analysis revealed that, in addition to the season and geographical region of the sample collected, the metabolite profiles of TC also depend on the parts of the plant taken as a sample and also the plant's stage of growth. The amounts of secondary metabolites differed between morpho/chemotypes within the TC species. Despite the fact that research on TC began several decades ago, the diversity of phytoconstituents was not appreciated because of a lack of reliable techniques for phytochemical fingerprinting. The uncovering of several novel metabolites was aided by advances in chromatography combined with mass spectrometry. To produce a full metabolomic profile, researchers used mutually complementary techniques. Following that, data analysis and searches against spectrum databases allowed for signal annotation and interpretation of metabolites in large quantities without separating them separately. The current review includes a critical assessment of metabolomic data and an overview of the technique's various applications. It is vital to establish the metrics of quality control of herbal medicines in order to

关键词： Analytical tools metabolomics quality control secondary metabolites Tinospora cordifolia

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Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada siddiqui Aditi Srivastava Aparna Misra Snober S.Mir Department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India Department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

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Comparative Study of the Effects of Nano ZnO and CuO on the Biodegradation,Biocompatibility,and Antibacterial Properties of Micro-arc Oxidation Coating of Magnesium Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 242-254页

作者： Ying Shen Xianfeng Shan Iniobong P.Etim Muhammad Ali siddiqui Yang Yang Zewen Shi Xuping Su Junxiu Chen Key Laboratory of Materials Surface Science and Technology of Jiangsu Province Changzhou UniversityChangzhou213164China Department of Stomatology The Affiliated Xinhua Hospital of Dalian UniversityDalian116000China Department of Physics University of CalabarCalabar540242Nigeria Metallurgical Engineering Department NED University of Engineering and TechnologyUniversity RoadKarachi75270Pakistan Ningbo No.2 Hospital Ningbo315010China

This research systematically examined the degradation,antibacterial effects,and biocompatibility of micro-arc oxidation(MAO)coatings with nano CuO and ZnO on extruded Mg *** copper(Cu)and Zinc(Zn)possess antibacterial *** findings demonstrated that adding ZnO will appreciably reduce the degradation rate of MAO-coating alloy due to the self-sealing micro ***+MAO coating exhibited excellent antibacterial performance,with an antibacterial rate of over 90%within 6 h co-cultured with Staphylococcus ***,the antibacterial rate of ZnO+MAO coating reached 90%after 12 h *** test using MG63 cell indicated that the incorporation of CuO and ZnO did not notably affect the cell viability rate of the ***,after 14 days of culture,the CuO+MAO and ZnO+MAO coated samples exhibited higher alkaline phosphatase(ALP)activity than the MAO-coated and uncoated samples,suggesting favorable osteogenic properties.

关键词： Copper oxide Zinc oxide Micro-arc oxidation(MAO)coating Corrosion behavior Antibacterial characteristics

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How Agent Orange impacts prostate cancer risk,pathology,and treatment outcomes

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Current Urology 2024年第2期18卷 79-86页

作者： Awais Paracha Zohair siddiqui Ali Abid Ekamjit Deol Fatima Waheed Zachary Hamilton Saint Louis University School of Medicine Saint LouisMOUSA Saint Louis University Saint LouisMOUSA New York Institute of Technology College of Osteopathic Medicine OldWestburyNYUSA Department of Surgery Division of UrologySaint Louis University School of MedicineSaint LouisMOUSA

Between 2.6 and 3.8 million veterans served in Vietnam while the US military dispersed Agent Orange(AO),although the exact number of exposed individuals is *** Orange,an herbicide,is a known risk factor for various cancers,including sarcoma and leukemia,but less is known about its link with prostate cancer(PC).Prostate cancer is the most commonly diagnosed malignancy in men and the fifth most common cause of cancer-related death in men *** 2023,approximately 288,300 patients will be given a diagnosis of PC,and an estimated 34,700 fatalities will occur in the United ***,whether the pathologic characteristics of PC among those exposed to AO differ from those in the general population remains *** review synthesizes the literature regarding the impact of AO exposure on PC incidence and disease course.A comprehensive PubMed literature search of articles published beginning in 1950 was performed using the primary search terms“Agent Orange,”“TCDD,”and“tetrachlorodibenzodioxin”and the secondary search terms“prostate cancer”or“prostate neoplasm.”The search was limited to studies that focused on human participants and were published in *** authors thoroughly reviewed the retrieved articles for relevancy to the study aims:discussion of PC diagnosis,prognosis,or management among patients exposed to *** 108 studies identified in our search,13 were included in this systematic *** within studies concerning AO exposure with relation to PC incidence,age at diagnosis or treatment initiation,and PC severity seemed to be mixed and generally ***,the literature seems to indicate that there are no significant differences in survivorship between exposed and unexposed veterans who are given a diagnosis of *** these heterogeneous outcomes,the evidence does not encourage a significantly different approach to the diagnosis and management of PC for veterans exposed to *** shouldmake case-by-case decision

关键词： Agent Orange 2,3,7,8-Tetrachlorodibenzo-p-dioxin Prostate cancer Veterans

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Aldosterone synthase inhibitor“Baxdrostat”for resistant hypertension:A clinical approach or futuristic idea?

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Chronic Diseases and Translational Medicine 2024年第2期10卷 146-148页

作者： Muhammad Osama siddiqui Ayaan Ahmed Qureshi Arooba siddiqui Noor ul ain Liaquat National Hospital and Medical College KarachiSindhPakistan Karachi Medical and Dental College KarachiSindhPakistan

The American College of Cardiology/American Heart Association defines resistant hypertension(RH)as a clinical blood pressure(BP)reading of>130/80 mmHg in patients taking three antihypertensive drugs,including a renin–angiotensin system inhibitor,a calcium channel blocker(CCB),and a diuretic at well-tolerated doses.1,2 It is reported from multiple population-based surveys that in the United States,there is an approximately 12%–15%prevalence of RH among adults diagnosed with hypertension.2 A prospective study demonstrates that 20%of people diagnosed with RH had primary hyperaldosteronism.3,4 In addition to the classic three antihypertensive drugs,spironolactone and mineralocorticoid are also administered for ***,with respect to the safety profile of spironolactone,it has been reported to have several side effects such as low testosterone production,menstrual irregularities,and excessively raised serum potassium levels,leaving the drug unfit for the longitudinal therapeutic purpose of treating RH.

关键词： hypertension drugs hypertensive

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