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New insights on premature ejaculation： a review of ：lefinition, classification, prevalence and treatmeni

Asian Journal of Andrology 2012年第6期14卷 822-829页

作者： ege c serefoglu theodore r saitz Tulane University School of Medicine Department of Urology New Orleans LA 70112 USA

There are ongoing debates about the definition, classification and prevalence of premature ejaculation （PE）. The first evidence-based definition of PE was limited to heterosexual men with lifelong PE who engage in vaginal intercourse. Unfortunately, many patients with the complaint of PE do not meet these criteria. However, these men can be diagnosed as one of the PE subtypes, namely acquired PE, natural variable PE or premature-like ejaculatory dysfunction. Nevertheless, the validity of these subtypes has not yet been supported by evidence. The absence of a universally accepted PE definition and lack of standards for data acquisition have resulted in prevalence studies that have reported conflicting rates. The very high prevalence of 20%-30% is probably due to the vague terminology used in the definitions at the time when such surveys were conducted. Although many men may complain of PE when questioned for a population-based prevalence study, only a few of them will actively seek treatment for their complaint, even though most of these patients would define symptoms congruent with PE. The complaints of acquired PE patients may be more severe, whereas complaints of patients experiencing premature-like ejaculatory dysfunction seem to be least severe among men with various forms of PE. Although numerous treatment modalities have been proposed for management of PE, only antidepressants and topical anaesthetic creams have currently been proven to be effective. However, as none of the treatment modalities have been approved by the regulatory agencies, further studies must be carried to develop a beneficial treatment strategy for PE.

关键词： definition ejaculatory disorders epidemiology premature ejaculation sexual dysfunction treatment

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Gene mapping of serotoninergic system polymorphisms provides insight on pathology and treatment of men with lifelong premature ejaculation

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Asian Journal of Andrology 2014年第4期16卷 643-643页

作者： theodore r saitz ege can serefoglu Departments of Urology Oregon Health and Science University Portland Oregon USA Urology Bagcilar Training and Research Hospital IstanbuI Turkey.

In spite of its long history and high prevalence, the exact pathophysiology of premature ejaculation （PE） remains to be unknown？ Over a decade ago, Waldinger et al.2 initially suggested that hypersensitivity of 5-HT1A receptors and/or hypofunction of 5-HT2c receptors might be responsible for this phenomenon; thus, the daily use of a selective serotonin reuptake inhibitor has now emerged as an effective treatment for delaying ejaculation.

关键词： rEcEPTOr GENE

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