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Creutzfeldt-Jakob disease presenting with bilateral hearing loss:A case report

World Journal of Clinical Cases 2022年第18期10卷 6333-6337页

作者： Seunghee Na Se A lee Jong Dae lee eek-sung lee Tae-Kyeong lee Department of Neurology Incheon St.Mary’s HospitalThe Catholic University of KoreaIncheon 21431South Korea Department of Otorhinolaryngology-Head and Neck Surgery Soonchunhyang University Bucheon HospitalBucheon 14584South Korea Department of Neurology Soonchunhyang University Bucheon HospitalBucheon 14584South Korea

BACKGROUND Sporadic Creutzfeldt-Jakob disease(s CJD)is a prion disease characterized as a fatal transmissible neurodegenerative disorder.Dizziness is often the first presenting symptom of s CJD,but hearing loss as an early manifestation is very rare.CASE SUMMARY A 76-year-old man presented with bilateral sudden hearing impairment and dizziness for 10 d.He was taking medications for hypertension and diabetes.He denied any difficulty with activities of daily living or hearing impairment before the onset of symptoms.Pure tone audiometry showed bilateral severe hearing impairment.Brain magnetic resonance imaging(MRI)and laboratory tests were within normal limits.Given his diagnosis of sudden sensory hearing loss,the patient received corticosteroid treatment but it was ineffective.Two weeks later,he complained of aggravated gait impairment,disorientation,and cognitive impairment.Repeat brain MRI showed diffuse cortical high signal intensities on diffusion-weighted imaging.In cerebrospinal fluid analysis,the real-time quaking-induced conversion assay was positive,and 14-3-3 protein was detected in the by western blotting.Considering all the data,we diagnosed probable s CJD,and the patient’s symptoms rapidly progressed into akinetic mutism.CONCLUSION For patients with abrupt bilateral hearing impairment,especially in the elderly,various differential diagnoses,including s CJD,should be considered.

关键词： Case report Creutzfeldt-Jakob disease Bilateral hearing loss Diffusion-weighted imaging Real-time quaking-induced conversion assay

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Virtual Reality-Based Random Dot Kinematogram

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Computers, Materials & Continua 2021年第9期68卷 4205-4213页

作者： Jun Ma Hyo-Jung Kim Ji-Soo Kim eek-sung lee Min Hong Department of Software Convergence Soonchunhyang UniversityAsan31538Korea Research Administration Team Seoul National University Bundang HospitalSeongnam13620Korea Dizziness Center Clinical Neuroscience CenterDepartment of NeurologySeoul National University Bundang HospitalSeongnam13620Korea Department of Neurology Seoul National University College of MedicineSeoul03080Korea Department of Neurology College of MedicineSoonchunhyang UniversityBucheon14584Korea Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea

This research implements a random dot kinematogram(RDK)using virtual reality(VR)and analyzes the results based on normal subjects.Visual motion perception is one of visual functions localized to a specific cortical area,the human motion perception area(human analogue for the middle temporal/middle superior temporal area)located in the parieto–occipito–temporal junction of the human brain.The RDK measures visual motion perception capabilities.The stimuli in conventional RDK methods are presented using a monitor screen,so these devices require a spacious dark room for installation and use.Recently,VR technology has been implemented in different medical domains.The test method proposed in this study include a VR-based RDK that can independently measure human motion perception abilities without any spatial constraints via a VR head-mounted display.Subsequently,the VR-based RDK was implemented,and the visual perception abilities of the normal subjects were measured based on varying coherences.In both screen-and VR-based RDK tests,the easier the stimulus is,the higher the correct answer rate and the shorter the reaction time.No significant differences in coherence thresholds were observed between the two test methods.The VRbased RDK proposed in this study can be used as a diagnosis tool for visual motion perception and neurodegenerative disorders affecting the posterior region of the brain.

关键词： Random dot kinematogram virtual reality visual psychophysics diagnostic device

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Quantitative autonomic function test in differentiation of multiple system atrophy from idiopathic Parkinson disease

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Chinese Medical Journal 2019年第16期132卷 1919-1924页

作者： Ji-Yun Park Dongseok Yang Hei-Jun Yang Hyun Ah Kim Saeromi Kim Deokhyun Heo Jeong-Ho Park eek-sung lee Tae-Kyeong lee Department of Neurology Ulsan University HospitalUniversity of Ulsan College of MedicineUlsan 44033Korea Department of Physical Medicine and Rehabilitation Ulsan University HospitalUniversity of Ulsan College of MedicineUlsan 44033Korea Department of Neurology Keimyu叩 University School of MedicineDaegu 42601Korea Department of Neurology College of MedicineSoonchunhyang UniversitySoonchunhyang University Bucheon HospitalBucheon 14584Korea

Background:Differential diagnosis of idiopathic Parkinson disease (IPD) and multiple system atrophy-Parkinson type (MSA-P) is challenging since they share clinical features with parkinsonism and autonomic dysfunction.To distinguish MSA-P from IPD when the symptoms are relatively mild,we investigated the usefulness of the quantitative fractionalized autonomic indexes and evaluated the correlations of autonomic test indexes and functional status.Methods:Thirty-six patients with parkinsonism (22 with IPD and 14 with MSA-P) in Soonchunhyang University Bucheon Hospital from February 2014 to June 2015 were prospectively enrolled in the study.We compared fractionalized autonomic indexes and composite autonomic scoring scale between patients with IPD and MSA-P with Hoehn and Yahr (H&Y) score ≤3.Parasympathetic indexes included expiratory/inspiratory ratio during deep breathing,Valsalva ratio (VR),and regression slope of systolic blood pressure (BP) in early phase Ⅱ (vagal baroreflex sensitivity) during Valsalva maneuver.Sympathetic adrenergic indexes were pressure recovery time (PRT) and adrenergic baroreflex sensitivity (BRSa) (BP decrement associated with phase 3 divided by the PRT),sympathetic index 1,sympathetic index 3,early phase Ⅱ mean BP drop,and pulse pressure reduction rate.Additionally,we compared the unified multiple system atrophy rating scale (UMSARS) and H&Y scores and the autonomic indexes in all patients.Results:PRT was significantly different between the IPD and MSA-P groups (P =0.004) despite the similar BP drop during tilt.Cutoff value of PRT was 5.5 s (sensitivity,71.4%;specificity,72.7%).VR (r =-0.455,P =0.009) and BRSa (r =-0.356,P =0.036) demonstrated a significant correlation with UMSARS and H&Y scores.Conclusions:Among the cardiovascular autonomic indexes,PRT can be a useful parameter in differentiating the early stage of MSA-P from that of IPD.Moreover,VR,and BRSa may be the optimal indexes in determining functional symptom severity.

关键词： Parkinson disease Multiple system atrophy Autonomic dysfunction Cardiovascular autonomic indexes

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Process-Based Crop Modeling for High Applicability with Attention Mechanism and Multitask Decoders

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Plant Phenomics 2023年第2期5卷 378-390页

作者： Taewon Moon Dongpil Kim sungmin Kwon Jung eek Son Department of Agriculture Forestry and BioresourcesSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul 08826Republic of Korea Protected Horticulture Research Institute National Institute of Horticultural&Herbal ScienceRural Development AdministrationHaman 52054Republic of Korea

Crop models have been developed for wide research purposes and scales,but they have low compatibility due to the diversity of current modeling studies.Improving model adaptability can lead to model integration.Since deep neural networks have no conventional modeling parameters,diverse input and output combinations are possible depending on model training.Despite these advantages,no process-based crop model has been tested in full deep neural network complexes.The objective of this study was to develop a process-based deep learning model for hydroponic sweet peppers.Attention mechanism and multitask learning were selected to process distinct growth factors from the environment sequence.The algorithms were modified to be suitable for the regression task of growth simulation.Cultivations were conducted twice a year for 2 years in greenhouses.The developed crop model,DeepCrop,recorded the highest modeling efficiency(=0.76)and the lowest normalized mean squared error(=0.18)compared to accessible crop models in the evaluation with unseen data.The t-distributed stochastic neighbor embedding distribution and the attention weights supported that DeepCrop could be analyzed in terms of cognitive ability.With the high adaptability of DeepCrop,the developed model can replace the existing crop models as a versatile tool that would reveal entangled agricultural systems with analysis of complicated information.

关键词： Deep replace versatile

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Study of industrially applied methods for verification, validation and uncertainty quantification of simulator models

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International Journal of Modeling, Simulation, and Scientific Computing 2015年第2期6卷 56-84页

作者： Magnus eek Sogol Kharrazi Hampus Gavel Johan Olvander Saab Aeronautics Linkoping SE-58188Sweden Swedish National Road and Transport Research Institute(VTI)Linkoping SE-58195Sweden Linkoping University Linkoping SE-58183Sweden

To better utilize the potential of system simulation models and simulators,industrially applicable methods for Verification,Validation and Uncertainty Quantification(VV&UQ)are crucial.This paper presents an exploratory case study of VV&UQ techniques applied on models integrated in aircraft system simulators at Saab Aeronautics and in driving simulators at the Swedish National Road and Transport Research Institute(VTI).Results show that a large number of Verification and Validation(V&V)techniques are applied,some of which are promising for further development and use in simulator credibility assessment.Regarding the application of UQ,a large gap between academia and this part of industry has been identified,and simplified methods are needed.The applicability of the NASA Credibility Assessment Scale(CAS)at the studied organizations is also evaluated and it can be concluded that the CAS is considered to be a usable tool for achieving a uniform level of V&V for all models included in a simulator,although its implementation at the studied organizations requires tailoring and coordination.

关键词： Simulator credibility simulation model verification validation uncertainty quantification V&V VV&UQ NASA Credibility Assessment Scale

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Hypo-Anxious Phenotype of Adolescent Offspring Prenatally Exposed to LPS Is Associated with Reduced mGluR5 Expression in Hippocampus

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Open Journal of Medical Psychology 2014年第3期3卷 202-211页

作者： Dany Arsenault Aijun Zhu Chunyu Gong Kun-eek Kil Sreekanth Kura Ji-Kyung Choi Anna-Liisa Brownell Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School Charlestown USA

Many studies have reported long-term modulation of metabotropic glutamate receptor 5 (mGluR5) by inflammatory processes and a pharmacological modulation of mGluR5 is known to regulate anxiety level. However, it is not known if non-pharmacological modulation of mGluR5 by inflammation impaired the unconditional level of anxiety. In this study, we investigated this relation in LPS prenatal immune challenge (120 μg/kg, 3x i.p. injection in late gestation), a developmental model of neuroinflammation in which some studies have reported hypo-anxious phenotype. Using positron emission tomographic imaging (PET) approaches, we have demonstrated a decrease in the binding potential of [18F]fluoro-5-(2-pyridinylethynyl)benzonitrile([18F]FPEB, a radioligand for mGluR5) in hippocampus of adolescent offspring prenatally exposed to LPS, without significant change in the binding of [11C]peripheral benzodiazepine receptor 28 ([11C]PBR28), an inflammatory marker. In addition, dark-light box emergence test revealed a lower level of anxiety in LPS-exposed offspring and this behavioural phenotype was associated with the binding potential of [18F]FPEB in hippocampus. These results confirm that neuroinflammation during developmental phase modulates the physiology of mGluR5 and this alteration can be associated with behavioural phenotype related to anxiety. In addition, this study supports a hypotheses that mGluR5 could be used as a diagnostic target in anxiety.

关键词： Behavior Anxiety Immune Response Inflammation mGluR5

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绿色工艺设计

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设计 2013年第4期26卷 72-77页

作者： leeble Piet Hein eek

用废弃物设计产品的概念已经不新鲜，但形成一系列体系完整、风格明显的设计却并不容易。荷兰工业设计师皮特·海因埃克（PIETHEINeek）用废木料设计的家具，从1990年初开始至今已创造出了独特的美学风格，也为自己创造出了不同凡响的... 详细信息

用废弃物设计产品的概念已经不新鲜，但形成一系列体系完整、风格明显的设计却并不容易。荷兰工业设计师皮特·海因埃克（PIETHEINeek）用废木料设计的家具，从1990年初开始至今已创造出了独特的美学风格，也为自己创造出了不同凡响的设计声望。

关键词：绿色工艺设计美学风格工业设计师设计产品废弃物废木料新鲜家具

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现代冷链配送的进程

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中国食品工业 2000年第12期 38-39页

作者： Lars eek Frigoscandia Equipment AB(瑞典)公司

在发达及发展中国家,冷冻食品已经成为千家万户的生活必需品,消费估计高达4,000万吨/年,对于这类食品,配送系统和冷藏技术至关重要。冷冻食品的质量与新鲜食品很接近,有时候甚至比新鲜食品更好。从感官和营养价值的观点来看。

关键词：冷冻食品配送系统冷冻设备冷藏技术

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它真的是壁纸么?——真假难辨的“错视画”艺术

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现代装饰（家居） 2016年第1期 154-155页

作者： Piet Hein eek 李薇

Trompe l＇oeil一词原是法语,Trompe意为迷惑、欺骗,l＇oeil意为眼睛,因此Trompe loeil可以理解为＂欺骗眼睛＂,在汉语中这个词则被泽为＂错视画＂,也有＂乱真之作＂的译法。＂错视画＂是一种在二维平面上创造出极端逼真的三维幻觉的艺... 详细信息

Trompe l＇oeil一词原是法语,Trompe意为迷惑、欺骗,l＇oeil意为眼睛,因此Trompe loeil可以理解为＂欺骗眼睛＂,在汉语中这个词则被泽为＂错视画＂,也有＂乱真之作＂的译法。＂错视画＂是一种在二维平面上创造出极端逼真的三维幻觉的艺术形式.其通过意象的方法给人们制造出视错觉,表现的逼真程度能够欺骗人们的眼睛。＂错视画＂艺术经常被用于绘画、建筑壁画之中,前不久,来自荷兰的设计师Piet Hein eek则运用＂错视画＂艺术为壁纸品牌NLXL设计了一款极具立休感的壁纸。

关键词：错视大理石墙面真假难辨逼真程度词则词原视错觉

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仿真旧木壁纸

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现代装饰（家居） 2011年第6期 158-159页

作者： Piet Hein eek 肖俊

随着二氧化碳的大量排放、环境污染严重,人们对低碳环保生活理念的追求和倡导与日俱增;而木材这种质地坚硬、纹理色泽美观、触感温和的材料能给人以温暖质朴的感受,同时它还能随着时间的流逝和使用的过程印刻上岁月的痕迹,令空间环境散... 详细信息

随着二氧化碳的大量排放、环境污染严重,人们对低碳环保生活理念的追求和倡导与日俱增;而木材这种质地坚硬、纹理色泽美观、触感温和的材料能给人以温暖质朴的感受,同时它还能随着时间的流逝和使用的过程印刻上岁月的痕迹,令空间环境散发一种怀旧的气息,瞬间就能让人有家的感觉。令人慨叹的是现代人为追求这种怀旧魅力,不惜花费血本将木材做"旧",以达到预期的效果。然而木材做"旧"不仅费时费工,造价高昂,同时也违背了现如今提倡的环保理念。

关键词：费时费工造价高昂生活理念空间环境软布令人工业设计师透气性能创作过程产品规格

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