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World Journal of Gastroenterology 2007年第42期13卷 5635-5641页

作者： edwina s baskin-bey Akira Anan Hajime Isomoto steven F Bronk Gregory J Gores Department of Medicine Division of Gastroenterology and Hepatology Miles and Shirely Fitterman Center for Digestive Diseases Mayo Clinic College of Medicine Rochester MN 55905 United States

AIM： To ascertain whether constitutive androstane receptor （CAR） activation by 1,4-bis-[2-（3,5,- dichloropyridyloxy）] benzene （TCPOBOP） modulates steatohepatitis in the methionine choline-deficient （MCD） diet-fed ***： C57/BL6 wild-type mice were fed the MCD or standard diet for 2 wk and were treated with either the CAR agonist, TCPOBOP, or the CAR inverse agonist, ***： Expression of CYP2B10 and CYP3A11, known CAR target genes, increased 30-fold and 45-fold, respectively, in TCPOBOP-treated mice fed the MCD diet. TCPOBOP treatment reduced hepatic steatosis （44.6 ＋ 5.4% vs 30.4 ＋ 4.5%, P 〈 0.05） and serum triglyceride levels （48 ＋ 8 vs 20 ＋ 1 mg/dL, P 〈 0.05） in MCD diet- fed mice as compared with the standard diet-fed mice. This reduction in hepatic steatosis was accompanied by an increase in enzymes involved in fatty acid microsomal co-oxidation and peroxisomal p-oxidation, namely CYP4A10, LPBE, and 3-ketoacyI-CoA thiolase. The reduction in steatosis was also accompanied by a reduction in liver cell apoptosis and inflammation. In contrast, androstanol was without effect on any of the above ***： CAR activation stimulates induction of genes involved in fatty acid oxidation, and ameliorates hepatic steatosis, apoptosis and inflammation.

关键词： Apoptosis CYP4A Fatty acid oxidation,Inflammation

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腔内放射治疗直肠腺癌

中华放射肿瘤学杂志 1991年第4期 35-36页

作者： P bey M Pernot D Peisest s Hosstetfer 法国 CentreAlexisVautrin.Brabois

局限的直肠癌如果全身状况欠佳,不宜作根治术时,可以对经选择的,小的直肠癌用电凝固行局部放射治疗。材料与方法从1979年1月至1989年9月,对83例85个直肠腺癌病灶采用腔内放射治疗。全组病例中18例有手术禁忌症,其余大多数病人不愿意... 详细信息

局限的直肠癌如果全身状况欠佳,不宜作根治术时,可以对经选择的,小的直肠癌用电凝固行局部放射治疗。材料与方法从1979年1月至1989年9月,对83例85个直肠腺癌病灶采用腔内放射治疗。全组病例中18例有手术禁忌症,其余大多数病人不愿意接受根治手术。

关键词：内放射治疗直肠腺癌电凝固局部放射治疗全身状况高分化腺癌手术禁忌症根治术根治手术局部控制率

Convalescent plasma: A potential therapeutic option for COVID-19 patients

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Asian Pacific Journal of Tropical Medicine 2020年第11期13卷 477-486页

作者： swee Li Ng Tsuey Ning soon Wei Hsum Yap Kai Bin Liew Ya Chee Lim Long Chiau Ming Yin-Quan Tang bey Hing Goh Biofunctional Molecule Exploratory Research Group(BMEX) School of PharmacyMonash University MalaysiaBandar SunwayMalaysia school of Biosciences Faculty of Medical and Health SciencesTaylor’s UniversitySubang JayaSelangorMalaysia Faculty of Pharmacy University of CyberjayaCyberjayaSelangorMalaysia PAP Rashidah sa'adatul Bolkiah Institute of Health sciences Universiti Brunei DarussalamGadongBrunei Darussalam College of Pharmaceutical sciences Zhejiang UniversityHangzhouP.R.China

The new coronavirus disease(COVID-19)outbreak has challenged us to take unprecedented steps to bring this pandemic under *** view of the urgency of this situation,convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current *** is mainly due to the fact that convalescent plasma has been studied in a few case series with promising *** addition,on-going large clinical trials aimed to further evaluate the effectiveness,safety,and optimal dosage,duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising ***,this article aims to provide an overview of possible mechanisms of actions of convalescent plasma,its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.

关键词： Coronavirus Convalescent plasma COVID-19 sARs-COV-2 Neutralizing antibody Immunomodulation Convalescent plasma transfusion

Mass Tourism, Transportation Pollution and Environmental Damage: Is It Possible to Manage "The Environment"?

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Mass Tourism, Transportation Pollution and Environmental Dam...

Effect of the Concentration of spirulina platensis on the Growth of Bifidobacterium breve

2005全国博士生学术论坛（交通运输工程学科）

作者： Zhang Xiangyang, Ding Huiping (school of Economics and Management , bey ing Jiaotong University, bey ing 100044)

＜正＞ Tourism is one of the largest and fastest growing industries in the world. It can be considered one of the most remarkable socio-economic phenomena in the recent decades. From what was once an activity enjoyed by only a small group of relatively well-off people during the first half of the last century, it gradually became a mass phenomenon during the post-World War Ⅱperiod, particularly from the 1970s onwards. Tourism is an important source of income, employment and wealth in many countries. International tourism now accounts for a larger share of foreign exchange receipts and export earnings, than any other industry in the world. But, while tourism provides considerable economic benefits for many countries, regions and communities, its rapid expansion has also had detrimental environmental and socio-cultural impacts. Due to the dramatic development of tourism, the transport of passengers has been of major importance to socio-economic systems. It is essential for economic development and provides people with the freedom to realize their individual and collective purposes. Unfortunately, as currently employed, transport services are responsible for a variety of adverse impacts to environment and generate many concerns for sustainability. This paper focuses on the negative environmental impacts resulting from mass tourism and transportation pollution. It cites some documented cases where it is applicable. It also provides an analysis of these factors as well. Finally, this paper gives some recommendations at all levels of responsibility. It proposes that the promotion of sustainable tourism development;internalizing social costs of transport;environmental impact assessment （EIA）;properly planned and public education are all essential parts for maximizing its socio-economic benefits and minimizing its environmental impact.

关键词： mass tourism environment damage environment protection sustainable tourism sustainable transport

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Journal of Life sciences 2013年第12期7卷 1219-1227页

作者： sarra Bensehaila Lynda Benhadja Amel Doumandji Fayza bey Abderrahmen Benzaiche Laboratory of Natural and Local Bioresources Department of Biology Faculty of Sciences University of Hassiba BenboualiChief02000 Algeria Laboratory of Vegetable Biotechnology Department of Agricultural Sciences Faculty of Agro-Veterinary University of SafidDAHLAB Blida 09000 Algeria Laboratory of Applied Microbiology Faculty of Natural and Live Science University of Tlemcen Tlemcen 13000 Algeria

The aim of this study is to demonstrate the influence of spirulina platensis on the growth of Bifidobacteium breve in the infantile milk. The authors used a stump of Bifidobacterium breve isolated from the new saddles which was born after identification and characterization. The follow-up of the kinetics of growth of B. breve in the milk enriched by various concentrations of spirulina （0, 1, 5 and 10 mg/mL） was realized, and the authors estimated the antimicrobial effect of the cultures realised on three pathogenic bacteria： a bacteria isolated from saddles ＂salmonella ssp.＂, two reference stumps ＂staphylococcus aureus ATCC25923＂ and ＂Escherichia coli ATCC25922＂. The growth rate was 0.11 hl for the culture of B. breve associated with spirulina （10 mg/mL）, 0.09 hl for the culture of B. breve enriched with spirulina （5 mg/mL） and 0.08 hl for the culture of B. breve enriched with spirulina （1 mg/mL）. In the case of the pure culture of B. breve, the growth rate was 0.07 h1. The authors observed inhibitory effects of B. breve in the various cultures towards the considered pathogenic bacteria. The optimal antimicrobial activity was observed in the preculture bifid with the algae culture （10 mg/mL） towards salmonella ssp. （Zi = 25 mm）, s. aureus ATCC25923 （Zi = 26 mm） and E. coli ATCC25922 （Zi = 28 mm）.

关键词： Bifidobacterium breve spirulina plantensis association growth probiotics.

Crude Oil Degradation Potential of Indigenous Hydrocarbonoclastic Bacterial strain Acinetobacter johnsonii Firstly Isolated from Marine sediments of Oran Port,Algeria

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Journal of Environmental science and Engineering(A) 2019年第4期8卷 131-140页

作者： Faiza Bendadeche Mohamed bey Baba Hamed sidi-Mohammed El-Amine Abi Ayad Laboratory of Aquaculture and Bioremediation(AquaBior) Department of BiotechnologyFaculty of Nature and Life SciencesUniversity of Oran 1 Ahmed Ben BellaOran 31000Algeria Higher school of Biological sciences of Oran Oran 31000Algeria

Petroleum contaminants caused great damages to environment and human ***,the port of Oran is subject of pollution mainly by PAHs(Polycyclic Aromatic Hydrocarbons)as a result of the large flow of *** bioremediation by indigenous microorganisms is an important means for their reduction and *** the present work,a hydrocarbonoclastic bacterium strain sP49F2 was considered,firstly isolated from the contaminated marine sediments and seawater at the port of Oran(Algeria),using Bushnell-Hass mineral salt medium,and identified on the basis of morphological and biochemical characteristics and molecular tools by analysis of partial 16s rRNA gene sequence,using the Basic Local Alignment search Tool program on the data base of NCBI(National Centre for Biotechnology Information),and the EzBioCloud 16s rRNA *** of growth of this isolate on crude oil during 20 days of culture was studied at temperature 25℃,3%(w/v)of NaCl concentration and pH 7,at 140 rpm(Revolutions Per Minute).strain sP49F2 was identified molecularly as Acinetobacter johnsonii,and might support high concentrations of crude oil(up to 10%,v/v).Results of growth kinetic on crude oil as sole energy and carbon source by the isolate strain showed that the stationary phase was attained at day ***,train Acinetobacter johnsonii sP49F2 could efficiently utilize crude oil as its sole carbon and energy source,and could be used as a wonderful native biological alternative for the bioremediation of the port of Oran,and marine area polluted by petroleum hydrocarbons,as an eco-friendly efficacy degrader,and may be suitable for biotechnological applications.

关键词： Crude oil Acinetobacter johnsonii bioremediation marine sediments 16s rDNA.

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抗磷脂抗体与心血管疾病

心血管病学进展 1993年第5期14卷 306-307页

作者： bey.,HLC 余艳辉湖南医科大学临床药理国家培训中心

血管炎症是自身性免疫疾病包括系统性红斑狼疮(s LE)和原发性血管炎(如结节性动脉炎、Wegener’s肉芽肿、Takayasn’s动脉炎)的共同特性。这些炎症以管壁损伤、中性粒细胞、单核细胞和淋巴细胞外周血管浸润以及免疫球蛋白和补体蛋白的... 详细信息

血管炎症是自身性免疫疾病包括系统性红斑狼疮(s LE)和原发性血管炎(如结节性动脉炎、Wegener’s肉芽肿、Takayasn’s动脉炎)的共同特性。这些炎症以管壁损伤、中性粒细胞、单核细胞和淋巴细胞外周血管浸润以及免疫球蛋白和补体蛋白的沉着为特征。近年来发现一种与抗磷脂抗体有关的自身免疫性血管损伤,在组织炎症的其它证状缺乏时,表现为血管栓塞。临床上确定抗磷脂抗体按敏感高低分为AC A(anticardiolipid antibody),狼疮抗凝剂和VDRL测定三种。抗磷脂抗体可见于慢性感染如梅毒、疟疾、麻风,自身免疫性疾病。

关键词：抗磷脂抗体心脏血管疾病

Results of Combined Chemotherapy and External Beam Radiotherapy for Unilateral Intra-Orbital Retinoblastoma—A Multi-Institutional study from Mali

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Open Journal of Pediatrics 2019年第1期9卷 39-46页

作者： Boubacar Togo Fousseyni Traore Konimba Diabate Fatou sylla Aichata Tall Affiatou simaga Bakarou Kamate Hawa Diall Pierre Togo Abdoul Karim Doumbia Pierre bey Francis Eshun Department of Pediatrics Gabriel Toure HospitalBamakoMali Radiation Therapy service National Hospital of MaliBamakoMali Institute of Tropical Ophthalmology of Africa(IOTA) BamakoMali Department of Histopathology Hospital of Point GBamakoMali Curie Institute et AMCC ParisFrance Phoenix Children’s Hospital PhoenixAZUSA

Retinoblastoma (RB) treatment aims at saving the life and preserving useful vision. In most low-income countries, because of delays in diagnosis, advanced disease presentation is quite common. This prospective study aimed at evaluating the treatment results of orbital RB with regards to overall survival rate of the patients treated with chemotherapy and radiotherapy. The study was performed from 01 November 2011 to 31 December 2015 in the paediatric oncology unit of Gabriel Touré Teaching Hospital, Bamako, Mali and The Institute of Tropical Ophthalmology of Africa (IOTA), Bamako, Mali. All intra-orbital non-metastatic RB cases not previously treated by chemotherapy or radiotherapy were included in this study. Fourteen patients were included into the study. Median age was 2 years, and sex ratio 2.5 (M = 10;F = 4). Right eye (n = 12, 85.7%) was more often affected than left eye (n = 2;14.3%). Chemotherapy toxicities were mainly haematological including grade 3 anemia (n = 2;7%) and grade 4 neutropenia (n = 3;11%). Twelve patients (86%) were enucleated after neoadjuvant chemotherapy. Two patients (14%) abandoned treatment before enucleation. The IRss pathology staging was: stage IIIa in 6 patients (50%), and stage II in six patients (50%). six children (43%) received orbital radiotherapy at total dose of 45 Gy;six children (43%) achieved complete remission;Overall survival rate was 48% at 4 years (95% CI: 22.5% - 74.4%). In conclusion, the therapeutic strategy based on neoadjuvant chemotherapy followed by enucleation, adjuvant chemotherapy and external beam radiotherapy, was beneficial in patients with stage III disease, achieving an event-free survival rate of 48%.

关键词： Orbital Retinoblastoma Children Mali

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现代内燃机增材制造技术

汽车与新动力 2021年第6期4卷 43-46页

作者： B.LINDEMANN[德] s.GHETTI[德] R.bey[德] C.KAYACAN[德] 李媛媛(译) 不详

基于轻型发动机LeiMot研究项目,FEV公司与其合作伙伴共同开发了全新的研究方法,采用了通过增材制造(AM)技术生产的大型发动机部件,同时扩大了塑料应用范围,减轻整机质量,并优化了其功能。

关键词：内燃机增材制造技术塑料曲轴箱冷却

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埃森蒂森克虏伯楼,埃森,德国

世界建筑 2019年第4期 22-27页

作者：天妮 JsWD建筑事务所查克斯&莫雷尔事务所

校园内的所有建筑的立面都是按照'外壳与内核'的原则进行设计的,表现为两种立面类型:'外壳'界定了建筑体量朝向外部和开放空间的立面,而'内核'则是内院与中庭空间。这些设计旨在强调建筑之间的聚合感及同质性,强调超越建筑体量,可共享... 详细信息

校园内的所有建筑的立面都是按照'外壳与内核'的原则进行设计的,表现为两种立面类型:'外壳'界定了建筑体量朝向外部和开放空间的立面,而'内核'则是内院与中庭空间。这些设计旨在强调建筑之间的聚合感及同质性,强调超越建筑体量,可共享且形式化的建筑语言。'外壳'由穿插在柱、梁或基本建筑结构中的通体合金玻璃幕墙组成,幕墙具有热效应。合金外壳以不同间距安置在立面之外作为遮阳系统,这些系统因不同建筑而各异。为呈现统一的建筑风格,所有建筑外部都包覆着'不锈钢',且以垂直结构为主。因此楼层水平方向的线条得以融入背景,且使每个建筑的整体高度看起来均匀一致。

关键词：遮阳系统遮阳设计蒂森克虏伯校园建筑