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The CRAFITY score can identify patients with hepatocellular carcinoma showing poor response to treatment with atezolizumab and bevacizumab

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 148-150页

作者： Sabine Lieb Sebastian Ebel Daniel Seehofer Thomas Berg Florian van bommel Division of Hepatology Department of Medicine IILeipzig University Medical CenterLeipzigGermany Department of Diagnostic and Interventional Radiology Leipzig University Medical CenterLeipzigGermany Department of Visceral VascularThoracic and Transplant SurgeryLeipzig University Medical CenterLeipzigGermany

With great interest we have read the comment of *** on the recently published CRAFITY score for the prediction of response to anti-programmed death(ligand)1[PD-(L)1]-based immunotherapy in patients with unresectable h... 详细信息

关键词： patients hepatocellular carcinoma

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照明的明天:什么是热点

照明工程学报 2011年第3期22卷 1-4,8页

作者： Wout van bommel 徐红妹复旦大学上海200433 复旦大学电光源研究所上海200433

从社会、产品和应用的角度,举例说明未来数年照明的"热点"。从社会的角度,说明可持续发展以及相关节能产品和应用设计的持续重要性。要更加关注完全无废料的设计,即"从摇篮到摇篮"(from cradle to cradle)的设计。从产品的角度,说明固... 详细信息

从社会、产品和应用的角度,举例说明未来数年照明的"热点"。从社会的角度,说明可持续发展以及相关节能产品和应用设计的持续重要性。要更加关注完全无废料的设计,即"从摇篮到摇篮"(from cradle to cradle)的设计。从产品的角度,说明固态将成为许多产品应用的标准。在固态照明方面,由于所提供的数据常常有误而令新用户不满,因此向固态照明转变的脚步会放缓。若有效控制固态照明中的眩光,须有新型的光学设计。目前的评价体系,是通过经验方法获得,完全不适用于固态照明环境,因此需要全新的眩光评价体系。普通室内照明的显色性和色表规格,过去以白炽灯为基准,现在须设定严格的新标准。在应用方面,若要达到非视觉生物效应,智能动态照明也要成为一种标准。我们将看到,为减少因生物钟失调而出现的问题,会广泛应用光学治疗。在固定路灯方面,随着汽车系统本身的发展,不会再优先考虑物体的能见度。我们需要的不再是路灯亮度概念,而是更加三维的概念。若综合考虑中间视觉的所有效果,路灯光源的最有效光谱应该偏暖白光。老年人会丧失短波长视觉能力,是其中的主要原因。

关键词：可持续性固态照明眩光非视觉生物效应

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光源的光谱与低照明水平——中间视觉的基础

照明工程学报 2009年第4期20卷 1-4页

作者： Wout van bommel 周太明（译）林燕丹（译） Nuehen The Netherlands 复旦大学光源研究所上海200493

在诸如道路等需要低亮度水平照明的场合,采用什么样的灯的光谱(色温,显色性)对视觉有利?这一问题不仅在我国而且在世界范围内都是非常热门的议题。现在,LED正受到照明界的重视,而采用LED可以产生各种光色以及各种不同色调的白光,所以这... 详细信息

在诸如道路等需要低亮度水平照明的场合,采用什么样的灯的光谱(色温,显色性)对视觉有利?这一问题不仅在我国而且在世界范围内都是非常热门的议题。现在,LED正受到照明界的重视,而采用LED可以产生各种光色以及各种不同色调的白光,所以这一讨论显得尤为重要。CIE前任主席van bommel教授为了引导讨论沿着正确的方向进行,专门撰写了这篇论文。文章深入浅出地介绍了中间视觉的基本概念,纠正了某些不太科学的认识。这篇论文将在世界主要照明杂志上发表。我们将它介绍给读者,希望对大家有所帮助。

关键词：中间视觉明水光谱基础光源世界范围 LED 照明

Workplace harassment faced by female Nepalese migrants working aboard

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Global Health Journal 2024年第3期8卷 128-132页

作者： Padam P Simkhada edwin van Teijlingen Manju Gurung Samjhana Bhujel Kalpana Gyawali Sharada P Wasti School of Human and Health Sciences University of HuddersfieldHuddersfieldHD13DHUnited Kingdom Centre for Midwifery and Women's Health Faculty of Health&Social SciencesBournemouth UniversityBournemouth BH88GPUnited Kingdom Pourakhi Nepal Makhamali MargMaharajgunj Kathmandu 44600Nepal Green Tara Nepal BaluwatarKathmandu 44600Nepal Faculty of Education Tribhuvan UniversityKathmandu 44600Nepal School of Human Sciences Faculty of EducationHealth and Human SciencesGreenwich UniversityLondonSE109LSUnited Kingdom

Background:Nepal has a long history of labour migration over the *** can experience a range of problems in their destination countries,and women are more at risk than *** paper is the first to explore the problems faced by Nepalese women migrants while working ***:This study was conducted among 1,889 women who were registered as migrant returnees at an organisation called Pourakhi *** study extracted and analysed data from a non-governmental organisation that supports returning female migrant workers in ***:Around half(43.1%)of the women were 35 or older,30.9% were illiterate,and 63.6% were in their first overseas *** than one-third(38.5%)had self-reported workplace *** violence was the most prevalent(68%),followed by verbal abuse(37.5%),mental stress(29.7%),and sexual abuse(14.1%).Women who were illiterate(adjusted odds ratio[AOR]1.25,95% confidence interval[CI):1.01 to 1.55),unmarried(AOR 1.27,95%CI:1.05 to 1.56),worked abroad twice or more(AOR 1.35,95%CI:1.10 to 1.66),changed their place of work(AOR 2.38,95%CI:1.42 to 4.01),lived without documents(AOR 1.24,95%CI:1.03 to 1.50),worked as domestics(AOR 3.56,95%CI:2.03 to 6.23),worked in other than Gulf Cooperation Council countries(AOR 1.45,95%CI:1.06 to 1.99),women who did not have a fixed salary(AOR 1.64,95%CI:1.28 to 2.10)and did not receive salary(AOR 3.71,95%CI:2.88 to 4.77)were more likely to be harassed at ***:Our findings suggest that the host governments should introduce and enforce policies protecting women in the *** women should be provided with better information about health risks and hazards as well as how to improve preventive measures in destination countries to reduce workplace harassment.

关键词： Health problems Migration Exploitation Middle East South Asia

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城市美化照明和人的情感

城市美化照明和人的情感

Comparative analysis of Solanum stoloniferum responses to probing by the green peach aphid Myzus persicae and the potato aphid Macrosiphum euphorbiae

走近CIE 26th——中国照明学会（2005）学术年会

作者： van bommel 飞利浦照明

介绍在20世纪初,室外照明只关注于乘车人的视觉能见度,上世纪50年代,de Boer是第一个将视觉的舒适程度添加到道路照明的能见度方面的研究者。由于驾车者们已经利用舒适的高速公路来进行长途旅行,因此道路照明的视觉舒适度就显得十分重要... 详细信息

介绍在20世纪初,室外照明只关注于乘车人的视觉能见度,上世纪50年代,de Boer是第一个将视觉的舒适程度添加到道路照明的能见度方面的研究者。由于驾车者们已经利用舒适的高速公路来进行长途旅行,因此道路照明的视觉舒适度就显得十分重要了,而交通的安全又是一个潜在的因素,对视觉舒适的关心使新的道路照明更加令人愉快。所以,到20世纪70年代的后期,包括城市环境照明的道路照明被认为是机动化交通的一部分。Canminada和van bommel最早系统研究了侧重于个人和社会安全的居住区道路上居民和行人的需求,并于1980年出版其研究成果,他们

关键词：室外照明城市照明道路照明情感视觉能见度视觉舒适度

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Insect Science 2013年第2期20卷 207-227页

作者： Adriana E. Alvarez Viviana G. Broglia Anahi M. Alberti D'Amato Doret Wouters edwin van der Vossen Elisa Garzo W. Fred Tjallingii Marcel Dicke Ben Vosman Laboratory of Entomology Wageningen University P.O. Box 8031 6700 EH 2Plant Breeding Wageningen UR P.O. Box 386 6700 AAWageningen The Netherlands Plant Breeding Wageningen UR P.O. Box 386 6700 AA Wageningen The Netherlands

Plants protect themselves against aphid attacks by species-specific de- fense mechanisms. Previously, we have shown that Solanum stoloniferum Schlechtd has resistance factors to Myzus persicae Sulzer （Homoptera： Aphididae） at the epidermal/mesophyll level that are not effective against Macrosiphum euphorbiae Thomas （Homoptera： Aphididae）. Here, we compare the nymphal mortality, the pre-reproductive development time, and the probing behavior of M. persicae and M. euphorbiae on S. stoloniferum and Solanum tuberosum L. Furthermore, we analyze the changes in gene expression in S. stoloniferum 96 hours post infestation by either aphid species. Although the M. euphorbiae probing behavior shows that aphids encounter more probing constrains on phloem activities-longer probing and salivation time- on S. stoloniferum than on S. tuberosum, the aphids succeeded in reaching a sustained ingestion of phloem sap on both plants. Probing by M. persicae on S. stoloniferum plants resulted in limited feeding only. Survival of M. euphorbiae and M. persicae was affected on young leaves, but not on senescent leaves of S. stoloniferum. Infestation by M. euphorbiae changed the expression of more genes than M. persicae did. At the systemic level both aphids elicited a weak response. Infestation orS. stoloniferum plants with a large number ofM. persicae induced morphological changes in the leaves, leading to the development of pustules that were caused by disrupted vascular parenchyma and surrounding tissue. In contrast, an infesta- tion by M. euphorbiae had no morphological effects. Both plant species can be regarded as good host for M. euphorbiae, whereas only S. tuberosum is a good host for M. persicae and S. stoloniferum is not. Infestation ofS. stoloniferum by M. persicae or M. euphorbiae changed the expression of a set of plant genes specific for each of the aphids as well as a set of common genes.

关键词： cDNA microarrays electrical penetration graph insect-plant interactions,Solanum tuberosum wild potato

Preparing for Pillars One and Two: How Tax Administrations Can Get Ahead of the Game

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Belt and Road Initiative Tax Journal 2022年第1期3卷 68-76页

作者： edwin Visser Fieke van der Vlist Pedro Schoueri Jurriaan Weerman PwC Netherlands

Implementing and complying with the requirements of the OECD/G20 Inclusive Framework’s Two-Pillar solution presents enormous practical challenges for taxpayers and tax *** least of these is a complex data challenge with over 120 data points needed for Pillar 2 *** tackle these effectively,tax administrations should work with each other,and with taxpayers,to develop a coordinated approach drawing on the concept of Cooperative *** an approach should aim to reduce the administrative burden,increase certainty,and provide a joint learning curve for tax administrations and *** the right data systems and training people to work with the data will take time and need to start now;if businesses and tax administrations wait until all the rules and regulations have been finalised,it will be too *** addition,the Pillar 2 Model Rules do not provide for a multilateral mechanism to determine and allocate the top-up *** Belt and Road Initiative jurisdictions could consider working together to develop a binding mechanism to allocate the top-up tax between themselves.

关键词： Pillar 2 Pillar 1 Tax administration Tax certainty Cooperative compliance

<i>In vitro</i>measurement of tibiofemoral kinematics after patient-specific unicompartmental knee replacement

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Journal of Biomedical Science and Engineering 2012年第12期5卷 729-736页

作者： Dawie van den Heever Cornie Scheffer Pieter Erasmus edwin Dillon Department of Mechanical and Mechatronic Engineering Stellenbosch University Stellenbosch South Africa Department of Orthopaedic Surgery Stellenbosch University Stellenbosch South Africa Stellenbosch Medi-Clinic Stellenbosch South Africa

It is suggested that unicompartmental knee replacement (UKR) offers the potential to restore normal knee kinematics better than total knee replacement (TKR) because of retaining the cruciate ligaments, and better preservation of the overall geometry. It was hypothesized that patient-specific UKR would restore normal knee kinematics even better because of a customised articular shape. A comparative kinematics study was conducted on three cadaver limbs using two different test setups, a loaded ankle rig and an unloaded ankle rig. Kinematics was compared between a patient-specific UKR and a conventional fixed-bearing UKR. Both the UKRs showed similar kinematic patterns to the normal knee using both the test apparatus. The patient-specific UKR showed good results and with the other benefits it shows potential to dramatically improve clinical outcomes of knee replacement surgery.

关键词： Tibiofemoral Kinematics Patient-Specific Knee Unicompartmental Knee Replacement

Lung cancer screening: Computed tomography or chest radiographs?

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World Journal of Radiology 2015年第8期7卷 189-193页

作者： edwin JR van Beek Saeed Mirsadraee John T Murchison Clinical Research Imaging Centre Queen’s Medical Research Institute University of Edinburgh Department of Radiology Royal Infirmary of Edinburgh

Worldwide, lung cancer is the leading cause of mortalitydue to malignancy. The vast majority of cases of lung cancer are smoking related and the most effective way of reducing lung cancer incidence and mortality is by smoking cessation. In the Western world, smoking cessation policies have met with limited success. The other major means of reducing lung cancer deaths is to diagnose cases at an earlier more treatable stage employing screening programmes using chest radiographs or low dose computed tomography. In many countries smoking is still on the increase, and the sheer scale of the problem limits the affordability of such screening programmes. This short review article will evaluate the current evidence and potential areas of research which may benefit policy making across the world.

关键词： Lung cancer Chest radiograph Computed tomography Screening Health economics