检索结果-南通市图书馆

Biology and therapy of urological cancer metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2016年第4期3卷 167-169页

作者： edwin m.posadas David J.mcConkey Leland W.K.Chung Guest Editor of this issue Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai medical Center Los AngelesCAUSA Guest Editor of this issue Johns Hopkins Greenberg Bladder Cancer Institute Department of Urology Brady Urological InstituteJohns Hopkins UniversityBaltimoreMDUSA Guest Editor of this issue Co-Editor in ChiefAsian Journal of UrologyUro-Oncology Research Department of medicine Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA

From the early roots of modern urology to today,genitourinary(GU)cancers have been an important part of the fields of urology and cancer *** medical science has advanced,newer clinical and basic viewpoints have impacted the thinking and practice in this important *** such,GU oncology has been consistently seen as an area of rapid evolution both in biological understanding and clinical *** cancers continue to rise in incidence ***,they represent a significant portion of cancer mortality in Asia and the western *** facts have been met with some of the boldest and most important advances in cancer biology and therapy that have reshaped this field.

关键词： metastasis mortality urinary

Cultured circulating tumor cells and their derived xenografts for personalized oncology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2016年第4期3卷 240-253页

作者： Ruoxiang Wang Gina CYChu Stefan mrdenovic Alagappan A.Annamalai Andrew E.Hendifar Nicholas N.Nissen James S.Tomlinson michael Lewis Nallasivam Palanisamy Hsian-Rong Tseng edwin m.posadas michael R.Freeman Stephen J.Pandol Haiyen E.Zhau Leland W.K.Chung Uro-Oncology Research Department of MedicineSamuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Uro-Oncology Research Department of SurgerySamuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Department of Surgery West Los Angeles VA HospitalGreater Los Angeles Veterans Affairs Healthcare SystemLos AngelesCAUSA Department of Pathology West Los Angeles VA HospitalGreater Los Angeles Veterans Affairs Healthcare SystemLos AngelesCAUSA Henry Ford Health System DetroitMIUSA Department of molecular and medical Pharmacology University of California Los AngelesLos AngelesCAUSA

Recent cancer research has demonstrated the existence of circulating tumor cells(CTCs)in cancer patient’s *** identified,CTC biomarkers will be invaluable tools for clinical diagnosis,prognosis and *** this review,we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample,to derive enough CTCs for accurate and reproducible characterization of the biophysical,biochemical,gene expressional and behavioral properties of the harvested *** of tumor cell heterogeneity,it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer *** analyzing critical steps and technical issues in ex vivo CTC culture,we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells,relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells.

关键词： Cancer metastasis Peripheral blood Circulating tumor cell ex vivo culture

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato mariam masmudi-martín manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero marta Carretero-Rey Sinforiano posadas maría E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORm),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORm in young animals and prevent ORm deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORm *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

Acceptance of COVID-19 vaccine and its related determinants in Nigeria:An online survey

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Virology 2024年第4期13卷 89-110页

作者： Eyiuche D Ezigbo Seyi S Enitan Esther N Adejumo Abiodun E Durosinmi Richard Y Akele michael O Dada Grace E Itodo Abah m Idoko Okeoghene m Edafetanure-Ibeh edwin N Okafor Adedeji A Abdulsalam Oyekan I Oyedoyin Polit U Yelpoji Ogunwola O Opeyemi Ogbuji S Nmesomachi Adesola O Oyekale Chisom B Onyeji Haemostasis and Thrombosis Unit Department of Medical Laboratory SciencesUniversity of NigeriaEnugu CampusEnuguEN 400241Nigeria Department of medical Laboratory Science School of Public and Allied HealthBabcock UniversityIlishan-RemoOG 121109Nigeria Department of medical Laboratory Science State HospitalIjebu-OdeOG 120221Nigeria Department of Biomedical Science School of Applied ScienceUniversity of BrightonBrightonES BN24ATUnited Kingdom Department of microbiology Federal Teaching Hospital LokojaLokojaKO 260006Nigeria Department of Hematology and Blood Group Serology Federal College of Veterinary and Medical Laboratory TechnologyVomPL 930101Nigeria Department of Environmental and Occupational Health Texas A and M University School of Public HealthGarlandTX 75049United States Division of Chemical Pathology Department of Medical Laboratory SciencesUniversity of NigeriaEnugu CampusEnuguEN 400102Nigeria School of molecular Bioscience Sciences College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowSCO G128QQUnited Kingdom Department of medical Laboratory Science State Hospital Ijebu-OdeIjebu-OdeOG 360101Nigeria Department of medical Laboratory Science Faculty of Health Sciences and TechnologyUniversity of JosJosPL 930103Nigeria Department of medical Laboratory Science Bola Tinubu Health and Diagnostic CenterLagosLA 100102Nigeria Department of Pathology 68 Nigerian Army Reference HospitalYabaLA 1211001Nigeria Department of medical Laboratory Science Ladoke Akintola University of TechnologyOgbomosoOS 2111105Nigeria

BACKGROUND Vaccine hesitancy is a major challenge in the fight against the coronavirus disease 2019(COVID-19)*** the sociodemographic factors associated with vaccine acceptance among Nigerians is crucial for improving vaccine *** To assess the acceptance rate of COVID-19 vaccine and its related determinants among *** An online cross-sectional survey(observational study)was conducted between February 2021 and may 2021,using a questionnaire hosted on *** invitation to take part in the poll was sent out to participants through social networking platforms.A logistic regression was used to determine which sociodemographic factors were associated with vaccine acceptance *** A total of 1800 persons responded to the survey,a larger proportion of whom were males(53.9%)and within the age group of 21-30 years(29.4%)and earned an average income of less than$500 per month(43.3%).Only 0.56%of participants had a high perceived risk of COVID-19 infection,while only 1.11%had a perceived risk of dying from *** perception rate of the COVID-19 vaccine among participants was 51.1%,while the acceptance rate was 63.9%.There was no significant association between the COVID-19 vaccine acceptance rate and related determinants assessed,particularly age(χ²=3.049,P=0.550),sex(χ²=0.102,P=0.749),average income(χ²=3.802,P=0.875),and religion(χ²=2.819,P=0.420).Participants with chronic conditions demonstrated a higher acceptance rate compared to the general *** Despite the positive perception observed and substantial vaccine acceptance rate among the study participants,more public health interventions are still needed to enhance vaccine acceptability in Nigeria.

关键词： Acceptance COVID-19 Determinants Hesitancy Nigerians Online survey Vaccine

N-acetyl proline-glycine-proline: implications for neurological disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第6期11卷 898-899页

作者： Jeff W.Hill edwin m.Nemoto Department of Neurosurgery University of New Mexico Health Sciences Center

N-acetyl proline-glycine-proline（ac-PGP）is a matrix-derived chemoattractant,or matrikine,produced by the degradation of ***-PGP was first identified in studies of alkali eye injury in rabbits（Pfister et al.,1995）.

关键词： proline glycine acetyl neurological neuronal collagen neutrophil alkali potent chemokine

mechanical Characterisation of Densified Hardwood with Regard to Structural Applications

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable materials 2020年第9期8卷 1091-1109页

作者： Katharina müller Walter Sonderegger Oliver Kläusler michael Klippel edwin Zea Escamilla Institute of Structural Engineering(IBK) Chair of Structural Engineering–Timber StructuresSwiss Federal Institute of Technology ZurichZurich8093Switzerland Swiss Wood Solutions AG 8600 DübendorfSwitzerlandPreviously at Institute for Building Materials(IfB)Chair of Wood Materials ScienceSwiss Federal Institute of Technology ZurichZurich8093Switzerland College of Civil Engineering Nanjing Forestry UniversityNanjing210037China Sustainable Building Center for Corporate Responsibility and SustainabilityUniversity of ZurichZurich8001Switzerland

The demand for high-performance,yet eco-friendly materials is increasing on all scales from small applications in the car industry,instrument or furniture manufacturing to greater dimensions like floorings,balcony furnishings and even *** offers a good choice on all of these scales and can be modified and improved in many different *** this study,two common European hardwood species,Beech(Fagus sylvatica L.)and Ash(Fraxinus excelsior L.)were densified in radial direction by thermo-mechanical treatment and the densified product was investigated in an extensive characterisation series to determine all relevant mechanical *** in the three main directions(longitudinal,tangential,radial)and tension perpendicular to the grain(tangential,radial)were tested and compared to reference specimens with native *** and modulus of elasticity were determined in all *** addition,a Life Cycle Assessment was carried out to evaluate the environmental impact associated to the densification *** experimental investigations showed that strength and stiffness of hardwood in the longitudinal and tangential directions improve significantly by radial densification,whereas some properties in the radial direction *** Life Cycle Assessment showed that artificial wood drying has higher impact than wood ***,the transport distance of the raw material highly influences the environmental impact of the final densified *** paper then also offers an overview of possible applications in structural timber *** hardwood is a viable option as local reinforcement,where high compressive or tensile strength is *** wood densification process offers an alternative to the use of carbon-intense steel components or hardwoods from tropical forests.

关键词： Hardwood densification high-performance construction materials thermo-mechanical treatment mechanical characterisation life cycle assessment timber structures

Socio-ecological dynamics and challenges to the governance of Neglected Tropical Disease control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2017年第1期6卷 302-314页

作者： edwin michael Shirin madon Eck Institute for Global Health Department of Biological SciencesUniversity of Notre DameNotre DameUSA Department of International Development London School of Economics and Political ScienceLondonUK Department of management London School of Economics and Political ScienceLondonUK

The current global attempts to control the so-called“Neglected Tropical Diseases(NTDs)”have the potential to significantly reduce the morbidity suffered by some of the world’s poorest ***,the governance of these control programmes is driven by a managerial rationality that assumes predictability of proposed interventions,and which thus primarily seeks to improve the cost-effectiveness of implementation by measuring performance in terms of pre-determined ***,we argue that this approach has reinforced the narrow normal-science model for controlling parasitic diseases,and in doing so fails to address the complex dynamics,uncertainty and socio-ecological context-specificity that invariably underlie parasite *** suggest that a new governance approach is required that draws on a combination of non-equilibrium thinking about the operation of complex,adaptive,systems from the natural sciences and constructivist social science perspectives that view the accumulation of scientific knowledge as contingent on historical interests and norms,if more effective control approaches sufficiently sensitive to local disease contexts are to be devised,applied and *** the core of this approach is an emphasis on the need for a process that assists with the inclusion of diverse perspectives,social learning and deliberation,and a reflexive approach to addressing system complexity and incertitude,while balancing this flexibility with stability-focused *** derive and discuss a possible governance framework and outline an organizational structure that could be used to effectively deal with the complexity of accomplishing global NTD *** also point to examples of complexity-based management structures that have been used in parasite control previously,which could serve as practical templates for developing similar governance structures to better manage global NTD *** results hold important wider implications for global health po

关键词： Neglected tropical diseases Lymphatic filariasis Schistosomiasis malaria Smallpox Socio-ecological dynamics Complex dynamical systems Normal science paradigm Organizational theory Complexity-based governance

Tracking materials science data lineage to manage millions of materials experiments and analyses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational materials 2019年第1期5卷 460-468页

作者： edwin Soedarmadji Helge S.Stein Santosh K.Suram Dan Guevarra John m.Gregoire Joint Center for Artificial Photosynthesis California Institute of TechnologyPasadenaCAUSA Toyota Research Institute Los AltosCA 94022USA

In an era of rapid advancement of algorithms that extract knowledge from data,data and metadata management are increasingly critical to research *** materials science,there are few examples of experimental databases that contain many different types of information,and compared with other disciplines,the database sizes are relatively *** these issues are the challenges in managing and linking data across disparate synthesis and characterization experiments,which we address with the development of a lightweight data management framework that is generally applicable for experimental science and *** years of managing experiments with this system has yielded the materials Experiment and Analysis Database(mEAD)that contains raw data and metadata from millions of materials synthesis and characterization experiments,as well as the analysis and distillation of that data into property and performance metrics via software in an accompanying open source *** unprecedented quantity and diversity of experimental data are searchable by experiment and analysis attributes generated by both researchers and data processing *** search web interface allows users to visualize their search results and download zipped packages of data with full annotations of their *** enormity of the data provides substantial challenges and opportunities for incorporating data science in the physical sciences,and mEAD’s data and algorithm management framework will foster increased incorporation of automation and autonomous discovery in materials and chemistry research.

关键词： linking distillation autonomous

Hypertension and obesity in living kidney donors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2021年第6期11卷 180-186页

作者： mahmoud m mohamed Ahmed Daoud Syed Quadri michael J Casey mariah Aurora posadas Salas Vinaya Rao Tibor Fülöp Karim m Soliman Department of medicine Division of NephrologyUniversity of TennesseeMemphisTN 38163United States Department of medicine Division of NephrologyCairo UniversityCairo 11562Egypt Department of medicine Division of NephrologyMedical University of South CarolinaCharlestonSC 29425United States medicine Service Ralph H.Johnson VA Medical CenterCharlestonSC 29401United States

Over the past few decades,the shortage in the kidney donor pool as compared to the increasing number of candidates on the kidney transplant waitlist led to loosening of kidney donors’acceptance *** and obesity represent risk factors for chronic kidney disease,both in native kidneys and those in kidney transplant *** great progress has been made in kidney transplantation from living donors to benefit the recipient survival and quality of life,progress has been slow to fully risk-characterize the *** review critically reassesses the current state of understanding regarding the risk of endstage kidney disease in those donors with obesity,hypertension or *** risk assessment tools need to be developed urgently to fully understand the risk glomerular filtration rate compensation failure in the remaining kidney of the donors.

关键词： Living donor Kidney Obesity Hypertension Living kidney donors