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Implications of Dynamic Interactions between Meteorological Patterns and Surface Water Quality on Environmental health—A Case Study of the Nairobi River

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Journal of Geoscience and Environment Protection 2024年第5期12卷 113-146页

作者： haron Safari hongbin chen edwin Kipkirui Duncan Mbuge College of Environmental Science and Engineering Tongji University Shanghai China National Engineering Research Center for Urban Pollution Control Shanghai China College of Environmental and Biosystems Engineering University of Nairobi Nairobi Kenya

Urban areas face significant challenges in maintaining water quality amidst increasing urbanization and changing climatic patterns. This study investigates the complex interplay between meteorological variables and water quality parameters in Nairobi City, focusing on the impacts of rainfall and temperature on surface water quality. Data from multiple sources, including the Water Resources Authority, Nairobi Water and Sewerage Company, and the World Bank’s Climate Change Knowledge Portal, were analyzed to assess the relationships between meteorological variables (rainfall and temperature) and water quality parameters (such as electroconductivity, biochemical oxygen demand, chloride, and ph). The analysis reveals varying impacts of rainfall and temperature on different water quality parameters. While parameters like iron and ph show strong relationships with both rainfall and temperature, others such as ammonia and nitrate exhibit moderate relationships. Additionally, the study highlights the influence of runoff, urbanization, and industrial activities on water quality, emphasizing the need for holistic management approaches. Recommendations encompass the establishment of annual publications on Nairobi River water quality, online accessibility of water quality data, development of hydrological models, spatial analysis, and fostering cross-disciplinary research collaborations. Implementing these recommendations can enhance water quality management practices, mitigate risks, and safeguard environmental integrity in Nairobi City.

关键词： Water Quality Meteorological Conditions Urban Environment Environmental health Nairobi Water Quality Parameters

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell hong chen Ying Mao Guomin Zhou Bo Liao Jinsong Wu edwin Wang Linya You Department of human Anatomy&histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MhC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

Promoting higher-valent pediatric combination vaccines in China: challenges and recommendations for action

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Infectious Diseases of Poverty 2024年第1期13卷 74-84页

作者： Jiuling Li Shu chen dwin Asturias Shenglan Tang Fuqiang Cui Global health Research Center Duke Kunshan UniversityKunshanJiangsuChina ARC Centre of Excellence in Population Ageing Research(CEPAR) Universityof New SouthWalesSydneyAustralia School of Risk and Actuarial Studies University of New South WalesSydneyAustralia Department of Pediatrics University of Colorado School of MedicineAuroraCOUSA Center for Global health Colorado School of Public HealthAuroraCOUSA Department of Epidemiology Colorado School of Public HealthAuroraCOUSA Duke Global health Institute Duke UniversityDurhamNCUSA Singhealth Duke-NUS Global health Institute Duke-NUSSingaporeSingapore Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijingChina Vaccine Research Center School of Public HealthPeking UniversityBeijingChina

Many countries have adopted higher-valent pediatric combination vaccines to simplify vaccination schedules and minimize health expenditures and social ***,China is conservative in the use of pediatric combina-tion *** reviewing and synthesizing quantitative and qualitative data,in this commentary we identify gaps and challenges to combination vaccine use and make recommendations for promoting use of higher-valent pediatric combination vaccines in *** are in four dimensions:(1)legislation and regulation,(2)immunization schedule design,(3)vaccine awareness and price,and(4)research and development *** optimize the use of combination vaccines to reduce vaccine-preventable disease burden,we make recommendations that address key challenges:(1)develop policies and regulations to strengthen enforcement of the Vaccine Administration Law and remove regulatory hurdles that hinder combination vaccine research and development,(2)establish an evi-dence-informed policy-making mechanism for combination vaccines,(3)resolve immunization schedule conflicts between monovalent and combination vaccines,and(4)implement effective interventions to increase vaccine awareness and reduce price.

关键词： Combination vaccine National immunization program Childhood immunization Vaccine-preventable disease

昆虫和线虫胰岛素/胰岛素样生长因子的生理功能研究进展

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昆虫学报 2024年第7期67卷 1006-1018页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin E.LEWIS 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室兰州730070 Department of Entomology Plant Pathology and NematologyCollege of Agricultural and Life SciencesUniversity of IdahoIdahoID 83844-229USA

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans的胰岛素信号通路研究,作为一根探针,为人类胰岛素相关疾病研究提供试验模型,对生命科学的研究具有重要意义,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫(entomopathogenic nematode,EPN)作为一种重要的生物防治因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,EPN与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对EPN的影响,必须同时关注胰岛素对线虫和寄主昆虫的影响。为了能科学系统地展开胰岛素对EPN的影响并进行深入探讨,本文就昆虫和线虫胰岛素/胰岛素样生长因子的生理功能展开综述,以期为研究胰岛素对EPN影响及EPN的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

A hybrid Ensemble Deep Learning Approach for Early Prediction of Battery Remaining Useful Life

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 177-187页

作者： Qing Xu Min Wu edwin Khoo Zhenghua chen Xiaoli Li the Institute for Infocomm Research A*STARSingapore 138632Singapore IEEE

Accurate estimation of the remaining useful life(RUL)of lithium-ion batteries is critical for their large-scale deployment as energy storage devices in electric vehicles and stationary storage.A fundamental understanding of the factors affecting RUL is crucial for accelerating battery technology ***,it is very challenging to predict RUL accurately because of complex degradation mechanisms occurring within the batteries,as well as dynamic operating conditions in practical ***,due to insignificant capacity degradation in early stages,early prediction of battery life with early cycle data can be more *** this paper,we propose a hybrid deep learning model for early prediction of battery *** proposed method can effectively combine handcrafted features with domain knowledge and latent features learned by deep networks to boost the performance of RUL early *** also design a non-linear correlation-based method to select effective domain knowledge-based ***,a novel snapshot ensemble learning strategy is proposed to further enhance model generalization ability without increasing any additional training *** experimental results show that the proposed method not only outperforms other approaches in the primary test set having a similar distribution as the training set,but also generalizes well to the secondary test set having a clearly different distribution with the training *** PyTorch implementation of our proposed approach is available at https://***/batteryrul/battery_rul_early_prediction.

关键词： Deep learning early prediction lithium-ion battery remaining useful life(RUL)

Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of Yin Yang 1 in the brain?

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Neural Regeneration Research 2019年第7期14卷 1148-1151页

作者： Zhefan Stephen chen ho Yin edwin Chan School of Life Sciences Faculty of ScienceThe Chinese University of Hong Kong Gerald Choa Neuroscience Centre The Chinese University of Hong Kong

Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including *** controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous ***,YY1 also mediates the transcription of genes that are required for neuronal *** impairment of the transcriptional function of YY1 causes neuronal *** review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative *** expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic *** the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis neurodegeneration protein aggregates recruitment protein degradation subcellular localization transcriptional regulation Yin Yang 1

high-Q lithium niobate microring resonators using lift-off metallic masks [Invited]

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Chinese Optics Letters 2021年第6期19卷 44-49页

作者： Ke Zhang Zhaoxi chen hanke Feng Wing-han Wong edwin Yue-Bun Pun cheng Wang Department of Electrical Engineering City University of Hong KongKowloonHong KongChina State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong KongChina

high-Q lithium niobate(LN) optical micro-resonators are an excellent platform for future applications in optical communications, nonlinear optics, and quantum optics. To date, high-Q factors are typically achieved in LN using either dielectric masks or femtosecond laser ablation, while the more standard and commonly available lift-off metallic masks are often believed to lead to rough sidewalls and lowered Q factors. here, we show that LN microring resonators with strong light confinement and intrinsic Q factors over 1 million can be fabricated using optimized lift-off metallic masks and dry etching processes, corresponding to a waveguide propagation loss of ~0.3 d B=cm. The entire process is fully compatible with wafer-scale production and could be transferred to other photonic materials.

关键词： lithium niobate optical resonators microstructure fabrication

Design and fabrication of 1-D semiconductor nanomaterials for high-performance photovoltaics

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Science Bulletin 2016年第5期61卷 357-367页

作者： Ning han Zaixing Yang Lifan Shen hao Lin Ying Wang edwin Y.B.Pun Yunfa chen Johnny C.ho State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of SciencesBeijing 100190 China CAS Center for Excellence in Urban Atmospheric Environment Xiamen 361021 China Department of Physics and Materials Science City University of Hong Kong Hong Kong China State Key Laboratory of Millimeter Waves City University of Hong Kong Hong Kong China Shenzhen Research Institute City University of Hong KongShenzhen 518057 China Department of Electronic Engineering City University of Hong Kong Hong Kong China

To date, the cost-effective utilization of solar energy by photovoltaics for large-scale deployment remains challenging. Further cost minimization and efficiency maximization, through reduction of material consumption, simplification of device fabrication as well as optimization of device structure and geometry, are required. The usage of 1D nanomaterials is attractive due to the outstanding light coupling effect, the ease of fabrication, and integration with one-dimensional(1-D) semiconductor materials. The light absorption efficiency can be enhanced significantly, and the corresponding light-toelectricity conversion efficiency can be as high as their bulk counterparts. Also, the amount of active materials used can be reduced. This review summarizes the recent development of 1-D nanomaterials for photovoltaic applications, including the anti-reflection, the light absorption,the minority diffusion, and the semiconductor junction properties. With solid progress and prospect shown in the past 10 years, 1-D semiconductor nanomaterials are attractive and promising for the realization of high-efficiency and low-cost solar cells.

关键词： One-dimensional nanomaterials Photovoltaics Solar cells Light absorption Minority diffusion length Semiconductor junction

一种面向体系结构的自适应软件构件分派模型及算法

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计算机研究与发展 2011年第12期48卷 2300-2307页

作者：陈洪龙李仁发李蕊 edwin Sha 湖南大学计算机与通信学院长沙410082 美国德州大学达拉斯分校计算机科学系德克萨斯州李察逊75083-0688 国防科学技术大学计算机学院长沙410073

自适应演化软件是近年来软件工程领域的研究热点,而以体系结构为中心的自适应演化尤其受到重视.针对当前演化中对非功能性约束关注的不足,着重对面向体系结构的自适应演化框架中构件的分派优化问题进行研究.首先详细描述了基于体系结构... 详细信息

自适应演化软件是近年来软件工程领域的研究热点,而以体系结构为中心的自适应演化尤其受到重视.针对当前演化中对非功能性约束关注的不足,着重对面向体系结构的自适应演化框架中构件的分派优化问题进行研究.首先详细描述了基于体系结构模型的构件分派问题,并建立能够满足嵌入式软件构造机制中非功能性约束的分派模型,接着证明该分派问题为NP完全问题,最后提出一种启发式分派算法找出近似最优解,实验表明,与贪婪和整线性规划算法相比,该算法具有多目标均衡的优势;而与整线性规划算法相比,虽然不能保证找到最优解,但具有较大的计算时间优势.

关键词：自适应软件在线演化软件体系结构模型构件分派关键路径