检索结果-南通市图书馆

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell Hong Chen Ying Mao Guomin Zhou Bo Liao Jinsong Wu edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

Socio-Demographic and Clinical Characteristics of Patients Presenting with Lower Urinary Tract Symptoms Secondary to BPH, in a Tertiary Hospital

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Urology 2024年第8期14卷 447-457页

作者： Abdul-Jalilu Mohammed Muntaka edwin Mwintiereh Ta-Ang Yenli Francis Atindaana Abantanga Department of Surgery School of Medicine University for Development Studies Tamale Ghana Department of Surgery Tamale Teaching Hospital Tamale Ghana

Background: Benign prostatic hyperplasia (BPH) is the proliferation of the stromal and epithelial cells of the prostate gland, resulting in an increase in its size. This may result in obstruction of the lower urinary tract causing storage and voiding symptoms. Methods: This was a prospective cross-sectional study from August 2020 to July 2021, to evaluate the characteristic of patients presenting to the Tamale Teaching Hospital with lower urinary tract symptoms secondary to BPH. Results: The median age at presentation with LUTS secondary to BPH is 68.88 ± 11.10 years with an average prostate volume of 70 g. The average time of presentation to the hospital is 5 months, mostly with moderate to severe symptoms. Correlation between Prostate volume (PV) and age yielded a positive relationship;however, this was not statistically significant, (r = 0.028, p-value = 0.747). There was a significant positive relationship between PV and the IPSS score, (r = 0.334, p-value Conclusion: Our patients with symptomatic BPH present at age 60 years and above, with nearly all of them presenting with moderate to severe LUTS.

关键词： Benign Prostate Hyperplasia Lower Urinary Tract Symptoms Sociodemographic Characteristics

昆虫和线虫胰岛素/胰岛素样生长因子的生理功能研究进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

昆虫学报 2024年第7期67卷 1006-1018页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin E.LEWIS 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室兰州730070 Department of Entomology Plant Pathology and NematologyCollege of Agricultural and Life SciencesUniversity of IdahoIdahoID 83844-229USA

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans的胰岛素信号通路研究,作为一根探针,为人类胰岛素相关疾病研究提供试验模型,对生命科学的研究具有重要意义,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫(entomopathogenic nematode,EPN)作为一种重要的生物防治因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,EPN与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对EPN的影响,必须同时关注胰岛素对线虫和寄主昆虫的影响。为了能科学系统地展开胰岛素对EPN的影响并进行深入探讨,本文就昆虫和线虫胰岛素/胰岛素样生长因子的生理功能展开综述,以期为研究胰岛素对EPN影响及EPN的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

胰岛素/胰岛素样生长因子对昆虫和线虫的生理功能研究进展

在线全文

学校读者我要写书评

暂无评论

昆虫学报 2024年 1-13页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin E.LEWIS 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室美国爱达荷大学农学院线虫学系

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫、线虫体内均存在胰岛素样肽信号通路和及胰岛素样生长因子通路,在调控其代谢、生长发育、... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫、线虫体内均存在胰岛素样肽信号通路和及胰岛素样生长因子通路,在调控其代谢、生长发育、繁殖、胁迫抗性和寿命,且均与脊椎动物的胰岛素样肽信号通路和及胰岛素样生长因子通路高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans等的胰岛素信号通路研究,作为一根探针,在生命科学研究中为人类胰岛素相关疾病研究提供试验模型,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫作为一种重要的生防因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,EPN与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对昆虫病原线虫的影响,必须同时关注胰岛素对寄主昆虫的影响。为了能科学系统地展开胰岛素对昆虫病原线虫的影响并进行深入探讨,本文就胰岛素/胰岛素样生长因子对昆虫和线虫的生理功能展开综述,以期为研究胰岛素对昆虫病原线虫的影响及昆虫病原线虫的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

RR-SC:边缘设备中基于随机计算神经网络的运行时可重配置框架

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

计算机研究与发展 2024年第4期61卷 840-855页

作者：宋玉红沙行勉诸葛晴凤许瑞王寒华东师范大学计算机科学与技术学院上海200062

随着人工智能民主化的发展,深度神经网络已经被广泛地应用于移动嵌入式设备上,例如智能手机和自动驾驶领域等.随机计算作为一种新兴的、有前途的技术在执行机器学习任务时使用简单的逻辑门而不是复杂的二进制算术电路.它具有在资源(如... 详细信息

随着人工智能民主化的发展,深度神经网络已经被广泛地应用于移动嵌入式设备上,例如智能手机和自动驾驶领域等.随机计算作为一种新兴的、有前途的技术在执行机器学习任务时使用简单的逻辑门而不是复杂的二进制算术电路.它具有在资源(如能源、计算单元和存储单元等)受限的边缘设备上执行深度神经网络低能耗、低开销的优势.然而,之前的关于随机计算的工作都仅仅设计一组模型配置并在固定的硬件配置上实现,忽略了实际应用场景中硬件资源(如电池电量)的动态改变,这导致了低硬件效率和短电池使用时间.为了节省电池供电的边缘设备的能源,动态电压和频率调节技术被广泛用于硬件重配置以延长电池的使用时间.针对基于随机计算的深度神经网络,创新性地提出了一个运行时可重配置框架,即RR-SC,这个框架首次尝试将硬件和软件的重配置相结合以满足任务的时间约束并最大限度节省能源.RR-SC利用强化学习技术可以一次性生成多组模型配置,同时满足不同硬件配置(即不同的电压/频率等级)下的准确率要求.RR-SC得到的解具有最好的准确率和硬件效率权衡.同时,多个模型配置运行时在同一个主干网络上进行切换,从而实现轻量级的软件重配置.实验结果表明,RRSC可以在110 ms内进行模型配置的轻量级切换,以保证在不同硬件级别上所需的实时约束.同时,它最高可以实现7.6倍的模型推理次数提升,仅造成1%的准确率损失.

关键词：边缘设备随机计算运行时重配置动态硬件环境轻量级软件重配置强化学习

Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm edwin J.Yoo Ariel Isser Vivek P.Jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan P.Schneck Jordan J.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

Promoting higher-valent pediatric combination vaccines in China: challenges and recommendations for action

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2024年第1期13卷 74-84页

作者： Jiuling Li Shu Chen dwin Asturias Shenglan Tang Fuqiang Cui Global Health Research Center Duke Kunshan UniversityKunshanJiangsuChina ARC Centre of Excellence in Population Ageing Research(CEPAR) Universityof New SouthWalesSydneyAustralia School of Risk and Actuarial Studies University of New South WalesSydneyAustralia Department of Pediatrics University of Colorado School of MedicineAuroraCOUSA Center for Global Health Colorado School of Public HealthAuroraCOUSA Department of Epidemiology Colorado School of Public HealthAuroraCOUSA Duke Global Health Institute Duke UniversityDurhamNCUSA SingHealth Duke-NUS Global Health Institute Duke-NUSSingaporeSingapore Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijingChina Vaccine Research Center School of Public HealthPeking UniversityBeijingChina

Many countries have adopted higher-valent pediatric combination vaccines to simplify vaccination schedules and minimize health expenditures and social ***,China is conservative in the use of pediatric combina-tion *** reviewing and synthesizing quantitative and qualitative data,in this commentary we identify gaps and challenges to combination vaccine use and make recommendations for promoting use of higher-valent pediatric combination vaccines in *** are in four dimensions:(1)legislation and regulation,(2)immunization schedule design,(3)vaccine awareness and price,and(4)research and development *** optimize the use of combination vaccines to reduce vaccine-preventable disease burden,we make recommendations that address key challenges:(1)develop policies and regulations to strengthen enforcement of the Vaccine Administration Law and remove regulatory hurdles that hinder combination vaccine research and development,(2)establish an evi-dence-informed policy-making mechanism for combination vaccines,(3)resolve immunization schedule conflicts between monovalent and combination vaccines,and(4)implement effective interventions to increase vaccine awareness and reduce price.

关键词： Combination vaccine National immunization program Childhood immunization Vaccine-preventable disease

Nanoscale 3D ordered polymer networks

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2018年第1期61卷 25-32页

作者： edwin L. Thomas Department of Materials Science and NanoEngineering Rice University Houston TX 77030 USA

Structures having nanoscale 3D geometries are valuable as multifunctional materials, where multi-continuous microphases can synergistically influence mechanical, optical, transport and other properties. Such very high interface surface to volume ratio structures occur in a variety of materials including natural materials such as butter fly wings and sea urchin exoskeletons and in synthetic self-assembled structures such as surfactant/water systems and block polymers. Quantitative morphological characterization of such complex geometric structures is quite challenging. Unit cell sizes range from 10-300 nm with corresponding feature sizes on the 2-50 nm scale. Since these nanoscale network structures are bicontinuous, when one constituent is removed, the structure is still self supporting. Removal of one component produces a nanoporous material that may be in-filled with another component, or the surfaces of the nanopores can be coated with ultra-thin layers by atomic layer deposition to offer multiftmctional capabilities. Due to the ability to individually tailor the properties of the network（s） and matrix, for example, to create strong dielectric or impedance contrast, such spatially periodic structures are excellent for the interference of waves （electromagnetic for photonic applications and acoustic for phononic applications） that can lead to bandgaps and hence the control of wave propagation in the material. This mini-review will focus on networks formed by bottom up self assembly of block polymers. In addition to structural issues, we emphasize the special physical properties related to bi- or tri-continuous networks.

关键词： self assembly block polymer network morphologies bicontinuous

在线全文

学校读者我要写书评

暂无评论

赓续肯中友谊谱写时代新篇

当代世界 2024年第5期 76-77页

作者： [肯尼亚]埃德温·姆文达·姆威蒂肯尼亚联合民主同盟

肯中友好源远流长、生生不息。我从中国学者撰写的《郑和远航非洲与21世纪海上丝绸之路》和《非洲踏寻郑和路》两部著作中受益良多。这两本书揭示了中国著名航海家和外交家郑和在1405年至1433年的航行与非中关系的联系。郑和曾七次下西... 详细信息

肯中友好源远流长、生生不息。我从中国学者撰写的《郑和远航非洲与21世纪海上丝绸之路》和《非洲踏寻郑和路》两部著作中受益良多。这两本书揭示了中国著名航海家和外交家郑和在1405年至1433年的航行与非中关系的联系。郑和曾七次下西洋,到访包括肯尼亚拉穆和马林迪在内的东非。

关键词：郑和肯尼亚生生不息外交家航海家