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Novel applications of statins for bone regeneration

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National Science review 2015年第1期2卷 85-99页

作者： Sarita r.Shah Caroline A.Werlang F.Kurtis Kasper Antonios G.Mikos Department of Bioengineering Rice University Department of Chemical and Biomolecular Engineering Rice University

The use of statins for bone regeneration is a promising and growing area of research. Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl, the rate-limiting enzyme of the mevalonate pathway. Because the mevalonate pathway is responsible for the synthesis of a wide variety of important biochemical molecules, including cholesterol and other isoprenoids,the efects of statins are pleiotropic. In particular, statins can greatly afect the process of bone turnover and regeneration via efects on important cell types, including mesenchymal stem cells, osteoblasts, endothelial cells, and osteoclasts. Statins have also been shown to have anti-inlammatory and antimicrobial properties that may be useful since infection can derail normal bone healing. his review will explore the pleiotropic efects of statins, discuss the current use of statins for bone regeneration, particularly with regard to biomaterials-based controlled delivery, and ofer perspectives on the challenges and future directions of this emerging area of bone tissue engineering.

关键词： tissue engineering osteogenesis statin HMG-Co A reductase local delivery

Superconducting parameter determination for (Co0.5Zn0.5Fe2O4)x/Cu0.5Tl0.5-1223 composite

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Journal of Advanced Ceramics 2016年第3期5卷 210-218页

作者： M.ME.BArAKAT N.AL-SAYYED r.AWAD A.I.ABOU-ALY Physics Department Faculty of Science Alexandria University Alexandria Egypt Physics Department Faculty of Science Beirut Arab University Beirut Lebanon

The addition of magnetic Co0.5Zn0.5Fe2O4 nanoparticles to the superconducting Cu0.5Tl0.5-1223 phase has been used to investigate the electrical resistivity behavior of the composite above the superconducting transition temperature Tc. This was studied according to the opening of spin gap and fluctuation conductivity. The results indicated that the pseudogap temperature (T*) and superconducting fluctuation temperature (Tscf) change by increasing the addition of Co0.5Zn0.5Fe2O4 nanoparticles. It was found that T* is related to hole carrier concentration P and it also depends on the antiferromagnetic fluctuation affected by magnetic nanoparticles. The excess-conductivity analysis showed four different fluctuation regions started from high temperature up to Tc, and they were denoted by short wave (sw), two-dimensional (2D), three-dimensional (3D), and critical (cr) fluctuations. The crossover temperature between 3D and 2D (T3D-2D) in the mean field region was decreased by increasing the addition of Co0.5Zn0.5Fe2O4 nanoparticles, in accordance with the decrease in Tscf with x. The coherence length at 0 K along c-axis ξc(0), effective layer thickness of the 2D system d, and inter-layer coupling strength J were estimated as a function of Co0.5Zn0.5Fe2O4 nanoparticle addition. Moreover, the thermodynamics, lower and upper critical magnetic fields, as well as critical current density have been calculated from the Ginzburg number NG. It was found that the low concentration of Co0.5Zn0.5Fe2O4 nanoparticles up to x = 0.08 wt% improves the superconducting parameters of Cu0.5Tl0.5-1223 phase. On the contrary, these parameters were deteriorated f

关键词： Co0.5Zn0.5Fe2O4 nanoparticles Cu0.5Tl0.5-1223 phase pseudogap temperature fluctuation conductivity

PrEPArATION AND CHArACTErIZATION OF AMIDATED PECTIN BASED POLYMEr ELECTrOLYTE MEMBrANES

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Chinese Journal of Polymer Science 2009年第5期27卷 639-646页

作者： r.K.Mishra A.Anis S.Mondal M.Dutt A.K.Banthia Department of Polymer Science Bundelkhand University Materials Science Center Indian Institute of Technology Department of Polymer Science Bundelkhand University

The work presents the synthesis and characterization of amidated pectin(AP) based polymer electrolyte membranes(PEM) crosslinked with glutaraldehyde(GA).The prepared membranes are characterized by Fourier transform infrared spectroscopy(FTIr),organic elemental analysis,X-ray diffraction studies(XrD),thermogravimetric analysis (TGA) and impedance *** properties of the membranes are evaluated by tensile *** degree of amidation(DA),molar and mass reaction yields(Y_M and K_N) are calcu...

关键词： Amidated pectin Proton conducting Methanol permeability Impedance spectroscopy Fuel cell.

Shifting paradigms for Nepal＇s protected areas： history, challenges and relationships

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Journal of Mountain Science 2017年第5期14卷 964-979页

作者： Babu r BHATTArAI Wendy WrIGHT Buddi S POUDEL Achyut ArYAL Bhupendra P YADAV radha WAGLE Department of National Parks and Wildlife Conservation #860KathmanduNepal Faculty of Science and Technology Federation University AustraliaVictoriaAustralia Department of Forest research and Survey #3339KthmanduNepal Institute of Mathematical and Natural Sciences Massey University#102904AucklandNew Zealand Ministry of Forests and Soil Conservation #12476 KathmanduNepal

The modern history of protected area(PA) management in Nepal dates back to 1973 when the National Parks and Wildlife Conservation Act(1973) was promulgated and Chitwan National Park was established. In the years immediately following these key events, protected area acts and regulations were strictly applied and the role of local people in managing natural resources was neglected. However with the passage of time, and with changes in the socio-political and economic characteristics of Nepal, management regimes have shifted towards a more liberal model which recognizes more clearly the contributions of people living and working within protected areas. recently, landscape level conservation models including the designation of multiple use areas have been utilized in the development of management plans for protected areas in Nepal. Conservation agencies have attempted to tackle challenges such as land use conflict, poaching and smuggling of wildlife parts and illegal harvesting of highly valued medicinal herbs through regulation, but these efforts are not always successful. We recommend a holistic conflict resolution approach which recognizes and resolves the different needs of all stakeholders.

关键词： Protected area National Park Conservation Management Development history Nepal

A Heuristic for the Job Scheduling Problem with a Common Due Window on Parallel and Non-Identical Machines

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Journal of Systems Engineering and Electronics 2001年第2期12卷 6-11页

作者： Huang Decai College of information Engineering, Zhejiang University of Technology,Hangzhou 310014, P. r. China College of Information Engineering Zhejiang University of Technology Hangzhou 310014 P. R. China

In this paper, we give a mathematical model for earliness-tardiness job scheduling problem with a common due window on parallel and non-identical machines. Because the job scheduling problem discussed in the paper contains a problem of minimizing make-span, which is NP-complete on parallel and uniform machines, a heuristic algorithm is presented to find an approximate solution for the scheduling problem after proving an important theorem. Two numerical examples illustrate that the heuristic algorithm is very useful and effective in obtaining the near-optimal solution.

关键词： Common due window Job scheduling Earliness-tardiness JIT.

Blow-up for Doubly Degenerate Nonlinear Parabolic Equations

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Acta Mathematica Sinica,English Series 2008年第9期24卷 1525-1532页

作者： Ming Yu CHEN School of Science,Quanzhou Nomal University,Quanzhou,Fujian 362000,P,r.China School of Science Quanzhou Nomal University Quanzhou Fujian 362000 P. R. China

In this paper, we give a complete picture of the blow-up criteria for weak solutions of the Dirichlet problem of some doubly degenerate nonlinear parabolic equations.

关键词： doubly degenerate parabolic equation weak solution blow up global existence first eigenvalue

FL-FN-MOGA Based Traffic Signal Control

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Journal of Systems Engineering and Electronics 2003年第3期14卷 14-23页

作者： Wei Wu & Zhang Yi Department of Automation, Tsinghua University, Beijing 100084, P. r. China Department of Automation Tsinghua University Beijing 100084 P. R. China

In this paper, a traffic signal control method based on fuzzy logic (FL), fuzzy-neuro (FN) and multi-objective genetic algorithms (MOGA) for an isolated four-approach intersection with through and left-turning movements is presented. This method has an adaptive signal timing ability, and can make adjustments to signal timing in response to observed *** 'urgency degree' term, which can describe the different user's demand for green time is used in decision-making by which strategy of signal timing can be determined. Using a fuzzy logic controller, we can determine whether to extend or terminate the current signal phase and select the sequences of phases. In this paper, a method based on fuzzy-neuro can be used to predict traffic parameters used in fuzzy logic controller. The feasibility of using a multi-objective genetic algorithm ( MOGA) to find a group of optimizing sets of parameters for fuzzy logic controller depending on different objects is also demonstrated. Simulation results show that the proposed methed is effecfive to adjust the signal timing in response to changing traffic conditions on a real-time basis, and the controller can produce lower vehicle delays and percentage of stopped vehicles than a traffic-actuated controller.

关键词： Traffic signal control Fuzzy logic Fuzzy-neuro Multi-objective genetic algorithms.

Area Comparison, Superharmonic Functions, and Applications

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Acta Mathematica Sinica,English Series 2001年第2期17卷 207-216页

作者： Yi Hu YANG Department of Applied Mathematics, Tongji University, Shanghai 200092 P. r. China Department of Applied Mathematics Tongji University Shanghai 200092 P. R. China

In this paper, we study some geometrical and analytic properties of manifolds with non- negative sectional curvature at, infinity. Then, we apply these results to the study of harmonic maps.

关键词： Area comparison Superharmonic functions Harmonic maps

Effects of LIDAr DEM resolution in hydrodynamic modelling: model sensitivity for cross-sections

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International Journal of Digital Earth 2013年第1期6卷 3-27页

作者： M.Podhorányi J.Unucka P.Bobál V.ríhová Institute of geoinformatics faculty of mining and geologyvsb-technical university of ostravaostravaczech republic Institute of geological engineering faculty of mining and geology of vsb-technical universityostravaczech republic

With the development of science and technology the entire Earth,together with all of its phenomena,is gradually becoming an object of computer *** several years,this process has also affected water components,which are essential for the development of humans and economies on ***,monitoring of its resources and movement across the Earth’s surface is the main object of investigation of several research *** recent years,hydraulic modelling has experienced significant development that meets water and computer connection *** study consequently dealt with hydraulic modelling and uncertainties in the data that may affect the resulting flood *** analysed the effect of cross-sections generated and the subsequent inundation areas in Digital Elevation Models of different *** basic DEM was constructed from data obtained by the LIDAr *** results were obtained using a one-dimensional(1-D)model,HEC-rAS,and its extension,*** Olsˇe and Stona´vka river junction,located in the northeast region of the Czech republic,was selected for *** resolutions selected for the study to generate cross-sections and the subsequent inundation areas were 1 m,5 m and 10 *** resulting cross-sections were confronted with the actual surveyed cross-sections.

关键词： digital flood cross-sections LIDAr hydrodynamic model HEC-rAS river topography