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Surgeon preferences in the treatment of thumb carpometacarpal osteoarthritis

World Journal of Orthopedics 2024年第5期15卷 435-443页

作者： edward J Wu Bradley W Fossum Wyatt Vander Voort Christopher O Bayne Robert m Szabo Department of Orthopedic Surgery University of Minnesota Medical SchoolMinneapolisMN 55455United States Department of Orthopaedic Surgery UC Davis School of MedicineSacramentoCA 95817United States

BACKGROUND Primary thumb carpometacarpal(CmC)osteoarthritis is one of the most common conditions encountered by hand *** the vast number of operations that have been proposed,none have demonstrated results significantly superior to trapeziectomy *** The purpose of our study was to determine why surgeons opt for their technique in treating CmC *** A cross-sectional survey of active members of the American Society for Surgery of the Hand was conducted to evaluate the reasons behind their preferred technique in the treatment of isolated thumb CmC *** were contacted by email once and provided with a link to a de-identified survey consisting of 5 treatment questions and 5 demographic *** Of 950 responses were received.40.5%of surgeons preferred trapeziectomy+ligament reconstruction tendon interposition(LRTI),followed by trapeziectomy+suspensionplasty(28.2%),suture button suspension(5.9%),trapeziectomy alone(4.6%),prosthetic arthroplasty(3.2%),arthrodesis(1.1%),and other(6.6%).Proponents of trapeziectomy+LRTI cited familiarity(73.2%),exposure during fellowship(48.8%)and less proximal migration(60%)to be the main reasons affecting their *** who preferred trapeziectomy+suspensionplasty most reported simplicity(74.9%),fewer complications(45.3%),less proximal migration(43.8%),and avoidance of autogenous tissue harvest(42.7%).Advocates of suture button suspension cited avoidance of autogenous tissue harvest(80.4%),shorter immobilization(76.8%),and quicker recovery(73.2%)with their *** of trapeziectomy alone cited simplicity(97.7%),fewer complications(86.4%),and avoidance of autogenous tissue harvest(59.1%).In their comments,45%of surgeons choosing trapeziectomy alone cited evidence as an additional *** of prosthetic arthroplasty cited improved pinch strength(83.3%)and improved range of motion(63.3%),while those preferring arthrodesis cited better pinch strength(90%)and freque

关键词： Thumb carpometacarpal Osteoarthritis Trapeziectomy Ligament reconstruction tendon interposition Suspensionplasty Preferences Trends

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DEm analysis of the influence of stirrer design on die filling with forced powder feeding

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Particuology 2024年第5期88卷 107-115页

作者： Chao Zheng edward Yost Ariel R.muliadi Nicolin Govender Ling Zhang Chuan-Yu Wu School of Chemistry and Chemical Engineering University of SurreyGuildfordGU2 7XHUnited Kingdom Small molecule Pharmaceutics GenentechInc.One DNA WaySouth San FranciscoCA94080USA

Die filling is a critical stage during powder compaction,which can significantly affect the product quality and *** this paper,a forced feeder is introduced attempting to improve the filling performance of a lab-scale die filling *** die filling process is analysed with a graphics processing units(GPU)enhanced discrete element method(DEm).Various stirrer designs are assessed for a wide range of process settings(i.e.,stirrer speed,filling speed)to explore their influence on the die filling performance of free-flowing *** results show that die filing with the novel helical-ribbon(i.e.,type D)stirrer design exhibits the highest filling ratio,implying that it is the most robust stirrer design for the feeder configuration ***,die filling performance with the type D stirrer design is a function of the stirrer speed and the filling speed.A positive variation of filling ratio(ηf>0%)can be ensured over the whole range of filling speed by adjusting the stirrer speed(i.e.,increasing the stirrer speed).The approach used in this study can not only help understand how the stirrer design affects the die filling performance but also guide the optimization of feeder system and process settings.

关键词： Discrete element method Die filling Forced feeding Stirrer design GPU computing

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Integrated Single-cell multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 67-88页

作者： manickam Ashokkumar Wenwen mei Jackson J.Peterson Yuriko Harigaya David m.murdoch David m.margolis Caleb Kornfein Alex Oesterling Zhicheng Guo Cynthia D.Rudin Yuchao Jiang edward P.Browne Department of medicine University of North Carolina at Chapel HillChapel HillNC 27599USA HIV Cure Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Biostatistics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Genetics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of medicine Duke UniversityDurhamNC 27708USA Department of Computer Science Duke UniversityDurhamNC 27708USA Department of Statistics Texas A&M UniversityCollege StationTX 77843USA Department of Biology Texas A&M UniversityCollege StationTX 77843USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA

Despite the success of antiretroviral therapy,human immunodeficiency virus(HIV)cannot be cured because of a reservoir of latently infected cells that evades *** understand the mechanisms of HIV latency,we employed an integrated single-cell RNA sequencing(scRNA-seq)and single-cell assay for transposase-accessible chromatin with sequencing(scATAC-seq)approach to simultaneously profile the transcriptomic and epigenomic characteristics of~125,000 latently infected primary CD4^(+)T cells after reactivation using three different latency reversing *** expressed genes and differentially accessible motifs were used to examine transcriptional pathways and transcription factor(TF)activities across the cell *** identified cellular transcripts and TFs whose expression/activity was correlated with viral reactivation and demonstrated that a machine learning model trained on these data was 75%-79%accurate at predicting viral ***,we validated the role of two candidate HIV-regulating factors,FOXP1 and GATA3,in viral *** data demonstrate the power of integrated multimodal single-cell analysis to uncover novel relationships between host cell factors and HIV latency.

关键词： HIV latency reversal Primary CD4þT cell Single-cell multiomics HIV-regulating factor machine learning

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Application of Connected Truck Data to Evaluate Spatiotemporal Impact of Rest Area Closures on Ramp Parking

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Journal of Transportation Technologies 2024年第3期14卷 289-307页

作者： Jijo K. mathew Jairaj Desai edward D. Cox Darcy m. Bullock Lyles School of Civil Engineering Purdue University West Lafayette IN USA Indiana Department of Transportation Indianapolis IN USA

Ensuring adequate access to truck parking is critical to the safe and efficient movement of freight traffic. There are strict federal guidelines for commercial truck driver rest periods. Rest areas and private truck stops are the only places for the trucks to stop legally and safely. In locations without sufficient parking areas, trucks often park on interstate ramps, which create safety risks for other interstate motorists. Historically, agencies have employed costly and time intensive manual counting methods, camera surveillance, and driver surveys to assess truck parking. Connected truck data, available in near real-time, offers an efficient alternative to practitioners to assess truck parking patterns and identify areas where there may be insufficient safe parking spaces. This paper presents a case study of interstate I-70 in east central Indiana and documents the observed spatiotemporal impacts of a rest area closure on truck parking on nearby interstate ramps. Results showed that there was a 28% increase in parking on ramps during the rest area closure. Analysis also found that ramps closest to the rest area were most impacted by the closure, seeing a rise in truck parking sessions as high as 2.7 times. Parking duration on the ramps during rest area closure also increased drastically. Although it was expected that this would result in increased parking by trucks on adjacent ramps, this before, during, after scenario provided an ideal scenario to evaluate the robustness of these techniques to assess changing parking characteristics of long-haul commercial trucks. The data analytics and visualization tools presented in this study are scalable nationwide and will aid stakeholders in informed data-driven decision making when allocating resources towards improving the nations commercial vehicle parking infrastructure.

关键词： Connected Truck Data Rest Areas Exit Ramps Truck Parking Commercial Vehicles

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Inhibition of m2 tumor-associated macrophages polarization by modulating the Wnt/β-catenin pathway as a possible liver cancer therapy method

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World Journal of Gastroenterology 2024年第40期30卷 4399-4403页

作者： Vladislav V Tsukanov Julia L Tonkikh edward V Kasparov Alexander V Vasyutin Clinical Department of the Digestive System Pathology of Adults and Children Federal Research Center“Krasnoyarsk Science Center”of the Siberian Branch of the Russian Academy of SciencesScientific Research Institute of Medical Problems of the NorthKrasnoyarsk 660022Russia

The problem of liver cancer is becoming increasingly important due to the epi-demic of metabolic diseases and persistent high alcohol *** deter-mines great attention to the development and improvement of methods for early diagnosis and treatment of liver *** et al presented a study in the World Journal of Gastroenterology,in which they showed that the use of the traditional Chinese medicine Calculus bovis(CB)can suppress tumor growth in mice by inhibiting m2 tumor-associated macrophages(TAm)through modulating the activity of the Wnt/β-catenin *** interaction of CB components with the Wnt/β-catenin pathway,m2 TAm polarization,and tumor dynamics were studied using network pharmacology,transcriptomics,and molecular *** is now generally accepted that the polarization of TAm and the differentiation of the functions of m1 and m2 phagocytes are of great importance for the progression of *** is assumed that m2 TAm promote proliferation and migration of tumor *** to medicinally influence the Wnt/β-catenin pathway in order to modulate phagocyte polarization now belong to one of the most promising areas of immunotherapy of oncological ***,the work of the Chinese authors deserves attention and further development.

关键词： Liver cancer Treatment Calculus bovis Tumor-associated macrophages m2 tumor macrophage polarization Wnt/β-catenin pathway

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历史和记忆的分与合:一个观念史的分析

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华中师范大学学报（人文社会科学版） 2024年第1期63卷 111-120页

作者：王晴佳上海外国语大学全球文明史研究所上海200083 美国罗文大学历史系新泽西州08028

随着记忆研究在近年的兴起,中文学界出现了“历史记忆”这一名称,含有将两者等同的意思。与之相对照,历史和记忆在西方学术中一直存在某种张力——史学在西方的诞生与对抗记忆的目的相关,之后历史和记忆长期处于一种分离的关系。以兰克... 详细信息

随着记忆研究在近年的兴起,中文学界出现了“历史记忆”这一名称,含有将两者等同的意思。与之相对照,历史和记忆在西方学术中一直存在某种张力——史学在西方的诞生与对抗记忆的目的相关,之后历史和记忆长期处于一种分离的关系。以兰克为代表的近代科学史学,其理论前提是区别“过去”与“现在”,并从后者的立场考察、重构前者,而记忆则常常将两者混为一体。二战之后,兰克史学面临一系列挑战,记忆研究的兴盛便是其中之一。从莫里斯·阿布瓦赫写作《集体记忆》到皮埃尔·诺拉主编《记忆之场》,西方学者试图用记忆来补充和修正历史研究和书写的传统,改进和扩大历史学的方法和范围,促成其内容的更新和革新。但历史研究和记忆研究在近年的合流,仍没有改变两者之间的根本差异。

关键词：近代史学记忆研究历史记忆《记忆之场》莫里斯·阿布瓦赫皮埃尔·诺拉

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Venous thromboembolism prophylaxis in hospitalized elderly patients： Time to consider a ＇mUST＇ strategy

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Journal of Geriatric Cardiology 2011年第2期8卷 114-120页

作者： Kwok m Ho edward Litton Department of Intensive Care medicine Royal Perth Hospital and School of Population Health University of Western Australia Perth WA 6000 Australia

Venous thromboembolism （VTE） is the commonest cause of preventable death in hospitalized patients. Elderly patients have higher risk of VTE because of the high prevalence of predisposing co-morbidities and acute illnesses. Clinical diagnosis of VTE in the elderly patient is particularly difficult and, as such, adequate VTE prophylaxis is of pivotal importance in reducing the mortality and morbidities of VTE. Omission of VTE prophylaxis is, however, very common despite continuous education. A simple way to overcome this problem is to implement universal VTE prophylaxis for all hospitalized elderly patients instead of selective prophylaxis for some patients only according to individual＇ s risk of VTE. Although pharmacological VTE prophylaxis is effective for most patients, a high prevalence of renal impairment and drug interactions in the hospitalized elderly patients suggests that a multimodality approach may be more appropriate. mechanical VTE prophylaxis, including calf and thigh compression devices and/or an inferior vena cava filter, are often underutilized in hospitalized elderly patients who are at high-risk of bleeding and VTE. Because pneumatic compression devices and thigh length stockings are virtually risk free, mechanical VTE prophylaxis may allow early or immediate implementation of VTE prophylaxis for all hospitalized elderly patients, regardless of their bleeding and VTE risk. Although the cost-effectiveness of this multimodality Universal STat （＇mUST＇） VTE prophylaxis approach for hospitalized elderly patients remains uncertain, this strategy appears to offer some advantages over the traditional ＇selective and single-modal＇ VTE prophylaxis approach, which often becomes ＇hit or miss＇ or not implemented promptly in many hospitalized elderly patients. A large clustered randomized controlled trial is, however, needed to assess whether early, multimodality, universal VTE prophylaxis can improve important clinical outcomes of hospitalized elderly patients.

关键词： age bundle of care deep vein thrombosis prevention pulmonary embolism

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ANALYSIS AND ImPROVEmENT OF LEAD TImE FOR JOB SHOP UNDER mIXED PRODUCTION SYSTEm

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Chinese Journal of mechanical Engineering 2006年第4期19卷 487-491页

作者： CHE Jianguo HE Zhen edward m Knod Department of Industrial Engineering Tianjin University Tianjin 300072 China Department of management Western Illinois University Macomb 61466 USA

Firstly an overview of the potential impact on work-in-process （WIP） and lead time is provided when transfer lot sizes are undifferentiated from processing lot sizes. Simple performance examples are compared to those from a shop with one-piece transfer lots. Next, a mathematical programming model for minimizing lead time in the mixed-model job shop is presented, in which one-piece transfer lots are used. Key factors affecting lead time are found by analyzing the sum of the longest setup time of individual items among the shared processes （SLST） and the longest processing time of individual items among processes （LPT）. And lead time can be minimized by cutting down the SLST and LPT. Reduction of the SLST is described as a traveling salesman problem （TSP）, and the minimum of the SLST is solved through job shop scheduling. Removing the bottleneck and leveling the production line optimize the LPT. If the number of items produced is small, the routings are relatively short, and items and facilities are changed infrequently, the optimal schedule will remain valid. Finally a brief example serves to illustrate the method.

关键词： Lead time Work-in-process(WIP) mixed production system Job shop scheduling problem Traveling salesman problem(TSP)

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High energy neutron and pion-decay gamma-ray emissions from solar flares

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Chinese Journal of Astronomy and Astrophysics 2009年第1期9卷 11-40页

作者： edward L.Chupp James m.Ryan Physics Department and Space Science Center in the Institute for the Study of Earth Oceans and Space University of New Hampshire

Solar flare gamma-ray emissions from energetic ions and electrons have been detected and measured to GeV energies since 1980. In addition, neutrons produced in solar flares with 100 meV to GeV energies have been observed at the Earth. These emissions are produced by the highest energy ions and electrons accelerated at the Sun and they provide our only direct （albeit secondary） knowledge about the properties of the accelerator（s） acting in a solar flare. The solar flares, which have direct evidence for pion-decay gamma-rays, are unique and are the focus of this paper. We review our current knowledge of the highest energy solar emissions, and how the characteristics of the acceleration process are deduced from the observations. Results from the RHESSI, INTEGRAL and CORONAS missions will also be covered. The review will also cover the solar flare capabilities of the new mission, FERmI GAmmA RAY SPACE TELESCOPE, launched on 2008 June II. Finally, we discuss the requirements for future missions to advance this vital area of solar flare physics.

关键词： Sun -- Flares -- Particle Acceleration-meson Production

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SOmE RECENT DEVELOPmENTS IN THE STUDY OF ANCIENT GREEK LAW

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Journal of Ancient Civilizations 2018年第2期33卷 187-266,284页

作者： edward m. Harris University of Durham University of Edinburgh

The laws of the Greek city-states and the Hellenistic Kingdoms dealt with all aspects of life in the community.1 The laws regulated the main political institutions of the community and gave rules to its officials about how to conduct public business. meetings of the Council and Assembly were run according to public statutes, and decrees submitted for approval had to conform to legal norms. All public officials were subject to a legal review of their conduct and could be prosecuted in court or punished by special magistrates.

关键词： ANCIENT GREEK LAW Greek city-states Hellenistic Kingdoms

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