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A review of potential conservation and fisheries benefits of breaching four dams in the lower Snake River(Washington,USA)

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Water Biology and Security 2022年第2期1卷 10-22页

作者： Adam J.Storch Howard A.Schaller Charles E.Petrosky Robert l.Vadas Jr. Benjamin J.Clemens Gary Sprague Norman Mercado-Silva Brett Roper Michael J.Parsley edward Bowles Robert M.Hughes Jay A.Hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.S.Fish and Wildlife Service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National Marine Fisheries Service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National Stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes Institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources Management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the Snake River Basin continue to *** assessed the rationale for breaching the four lower Snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding Sockeye Salmon(Oncorhynchus nerka),Chinook Salmon(***),steelhead(***),Bull Trout(Salvelinus confluentus),White Sturgeon(Acipenser transmontanus),and Pacific lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River System(including the Snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River System dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River System constrains survival and productivity of salmon,steelhead and Bull Trout;(6)Snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower Snake River Basin dams preclude passage of adult White Sturgeon,constraining gene flow and recruitment;(9)the lower Snake River Basin dams impede dramatically passage of adult and juvenile Pacific lamprey,and(10)Snake River Basin Pacific lamprey is at high risk of *** the four lower Snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River System can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey Salmon Steelhead White sturgeon

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Trabecular Plate loss and Deteriorating Elastic Modulus of Femoral Trabecular Bone in Intertrochanteric Hip Fractures

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Bone Research 2013年第4期1卷 346-354页

作者： Ji Wang Bin Zhou Ian Parkinson C.David l.Thomas John G.Clement Nick Fazzalari X.edward Guo Bone Bioengineering laboratory Department of Biomedical EngineeringColumbia UniversityNew YorkNew York 10027USA Bone and Joint Research lab SA Pathology and Discipline of Anatomy and PathologyUniversity of AdelaideAdelaideAustralia Section of Oral Anatomy and Surgery The Melbourne Dental SchoolUniversity of MelbourneVictoria 3010Australia

Osteoporotic hip fracture is associated with significant trabecular bone loss, which is typically characterized as low bone density by dual-energy X-ray absorptiometry （DXA） and altered microstructure by micro-computed tomography （pCT）. Emerging morphological analysis techniques, e.g. individual trabecula segmentation （ITS）, can provide additional insights into changes in plate-like and rod-like trabeculae, two major micro- structural types serving different roles in determining bone strength. Using ITS, we evaluated trabecular microstructure of intertrochanteric bone cores obtained from 23 patients undergoing hip replacement surgery for intertrochanteric fracture and 22 cadaveric controls. Micro-finite element （~FE） analyses were performed to further understand how the abnormalities seen by ITS might translate into effects on bone strength. ITS analyses revealed that, near fracture site, plate-like trabeculae were seriously depleted in fracture patients, but trabecular rod volume was maintained. Besides, decreased plate area and rod length were observed in fracture patients. Fracture patients also showed decreased elastic moduli and shear moduli of trabecular bone. These results provided evidence that in intertrochanteric hip fracture, preferential loss of plate-like trabeculae led to more rod-like microstructure and deteriorated mechanical competence adjacent to the fracture site, which increased our understanding of the biomechanical pathogenesis of hip fracture in osteoporosis.

关键词： hip fracture intertrochanteric microstructure individual trabecula segmentation finite element

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Bone density, microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women

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Bone Research 2014年第3期2卷 194-202页

作者： Bin Zhou Ji Wang Emily M Stein Zhendong Zhang Kyle K Nishiyama Chiyuan A Zhang Thomas l Nickolas Elizabeth Shane X edward Guo Bone Bioengineering laboratory Department of Biomedical Engineering Columbia University Division of Endocrinology Department of Medicine Columbia University Department of Orthopedic Surgery First Affiliated Hospital School of Medicine Shihezi University

Hispanic Americans of Caribbean origin are a fast-growing subset of the US population, but there are no studies on bone density, microstructure and biomechanical integrity in this minority group. In this study, we aimed to compare Caucasian and Caribbean Hispanic postmenopausal American women with respect to these characteristics. Thirty-three Caribbean Hispanics were age-matched to thirty-three Caucasian postmenopausal women. At the lumbar spine, the Hispanic women had significantly lower areal bone mineral density （aBMD）. At the radius by high-resolution peripheral quantitative computed tomography （HR-pQCT）, there were minimal differences between Hispanic and Caucasian women. At the tibia, Hispanic women had lower trabecular volumetric bone density and trabecular number, and higher trabecular separation. Individual trabecula segmentation （ITS） analyses indicated that at the tibia, Hispanic women not only had significantly lower bone volume fraction, but also had significantly lower rod bone volume fraction, plate trabecular number, rod trabecular number and lower plate-plate, plate-rod and rod-rod junction densities compared to Caucasian women. The differences in bone quantity and quality contributed to lower whole bone stiffness at the radius, and both whole bone and trabecular bone stiffness at the tibia in Hispanic women. In conclusion, Hispanic women had poorer bone mechanical and microarchitectural properties than Caucasian women, especially at the load-bearing distal tibia.

关键词： bone DXA Bone density microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women

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心理需要的满足与工作满意度：哪一个能够更好地预测工作绩效？

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管理评论 2012年第6期24卷 98-104,132页

作者：张剑张微 edward l.Deci 北京科技大学东凌经济管理学院北京100083 University of Rochester New York 14627-0266

以自我决定理论为理论基础,通过对112名员工与其相应主管进行问卷调研,验证了:(1)工作满意度与工作绩效之间存在中低度相关;(2)基本心理需要对工作绩效各维度具有显著影响;(3)基本心理需要的满足对工作绩效的预测效果较工作满意度更好... 详细信息

以自我决定理论为理论基础,通过对112名员工与其相应主管进行问卷调研,验证了:(1)工作满意度与工作绩效之间存在中低度相关;(2)基本心理需要对工作绩效各维度具有显著影响;(3)基本心理需要的满足对工作绩效的预测效果较工作满意度更好。进而发现心理需要满足的中介作用,揭示工作满意度通过心理需要满足对工作绩效产生影响这一作用机制,并对所得结果的管理实践意义进行了探讨。

关键词：自我决定理论心理需要满足工作满意度工作绩效

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An Introduction to Algorithmic Trading : Basic to Advanced Strategies

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丛书名： Wiley trading series

2011年

作者： edward leshik Jane Cralle

ISBN: (纸本)9780470689547;9780470979358;9781119975090

Interest in algorithmic trading is growing massively – it''s cheaper, faster and better to control than standard trading, it enables you to ‘pre-think''the market, executing complex math in real time and take the required decisions based on the strategy defined. We are no longer limited by human ‘bandwidth''. The cost alone (estimated at 6 cents per share manual, 1 cent per share algorithmic) is a sufficient driver to power the growth of the industry. According to consultant firm, Aite Group llC, high frequency trading firms alone account for 73% of all US equity trading volume, despite only representing approximately 2% of the total firms operating in the US markets. Algorithmic trading is becoming the industry lifeblood. But it is a secretive industry with few willing to share the secrets of their success. The book begins with a step-by-step guide to algorithmic trading, demystifying this complex subject and providing readers with a specific and usable algorithmic trading knowledge. It provides background information leading to more advanced work by outlining the current trading algorithms, the basics of their design, what they are, how they work, how they are used, their strengths, their weaknesses, where we are now and where we are going. The book then goes on to demonstrate a selection of detailed algorithms including their implementation in the markets. Using actual algorithms that have been used in live trading readers have access to real time trading functionality and can use the never before seen algorithms to trade their own accounts. The markets are complex adaptive systems exhibiting unpredictable behaviour. As the markets evolve algorithmic designers need to be constantly aware of any changes that may impact their work, so for the more adventurous reader there is also a section on how to design trading algorithms. All examples and algorithms are demonstrated in Excel on the accompanying CD ROM, including actual algorithmic examples which have been used

关键词： Stocks--Mathematical models Program trading (Securities) Algorithms Investment analysis

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New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells

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Open Journal of Medicinal Chemistry 2022年第1期12卷 1-13页

作者： edward C. lisic Sarah N. Grossarth Sarah B. Bowman Jessica l. Hill Michael W. Beck Joseph E. Deweese Xiaohua Jiang Department of Chemistry Tennessee Technological University Cookeville TN USA Department of Biological Physical and Human Sciences Freed Hardeman University Henderson TN USA

The new ligand, 2-acetylpyrazine-tertbutylthiosemicarbazone (APZ-tBTSC), and its Cu(II), Pd(II) and Pt(II) complexes have been synthesized. This ligand coordinates to the metal ions in a tridentate monoanionic fashion forming monometallic complexes with the formula [M(APZ-tBTSC)Cl]. The ligand and the three metal complexes [Cu(APZ-tBTSC)Cl], [Pd(APZ-tBTSC)Cl], and [Pt(APZ-tBTSC)Cl] were tested for anti-proliferative biological behavior with a panel of seven microbes, and the copper and palladium complexes were found to be highly active against Gram positive bacteria. The 4 compounds were also tested in human topoisomerase IIα DNA relaxation assays and all three metal complexes had topoisomerase inhibition at a concentration between 4 - 6 micro-molar. The 4 compounds were also tested for activity with the HEK293T cell line and also the breast cell cancer line, MDA-MB-231. The most effective compound for activity against the HEK293T cell line was the [Cu(APZ-tBTSC)Cl] complex, and the MDA-MB-231 breast cancer cell line was the [Pt(APZ-tBTSC)Cl] complex.

关键词： Topoisomerase Breast Cancer α-(N)-Heterocyclic Thiosemicarbazones

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The influence of physiological environment on the targeting effect of aptamer-guided gold nanoparticles

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Nano Research 2019年第1期12卷 129-135页

作者： Ding Ding Yinling Zhang edward A.Sykes long Chen Zhuo Chen Weihong Tan Molecular Science and Biomedicine laboratory(MBl) State Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical Engineering and College of Life SciencesHunan UniversityChangsha 410082China School of Medicine Queens University81 Barrie StreetKingstonONK7L 3N6Canada Faculty of Science and Technology University of MacaoAvenida da UniversidadeMacao Taipa 999078China Department of Chemistry Departments of Physiology and Functional GenomicsCenter far Research at the Bio/Nano InterfaceUF Health Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleFlorida 32611USA Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200240China

Aptamer guided nano medicine shows great promise in targeted cancer *** the loss of targeting capacity duri ng in vivo or clinical trials has largely hindered its popularity and there are no systematic studies to elucidate the ***,we investigated such loss of targeting capacity by examining how the physiological milieu affected targeting *** functionalized gold nanoparticle(AuNP)was chosen as the model and exposed to human blood serum that is used to mimic physiological *** light scattering(DlS),flow cytometry and label-free liquid chromatography tan dem mass spectrometry(lC-MS/MS)were employed to determi ne variations of NPs'surface chemistry and biological identities changes after serum *** showed that the targeting ability loss was caused by protein corona blocking,replacement and enzymatic cleavage of surface aptamer targeting ***,the aggregation issue is critical for the smaller *** of the protein corona profile indicated the accumulation of immune-related proteins on the surface of aptamer-conjugated NPs,which could induce immune response,resulting in rapid clearanee of NPs.

关键词： targeting effect aptamer nanomedicine physiological environment

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Meso-Scale VOC-Mixture Analyzer with Tunable Separation and Microsensor Array Detection

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稀有金属材料与工程 2006年第A3期35卷 61-64页

作者： Qiongyan Zhong William H. Steinecker edward T. Zellers Department of Environmental Health Sciences University of Michigan 109 S. Observatory St. Ann Arbor MI 48109-2029 USA Department of Chemistry University of Michigan 109 S. Observatory St. Ann Arbor MI 48109-2029 USA

A novel portable instrument developed for field determinations of complex mixtures of volatile organic compounds (VOCs) is *** key features of the instrument are a miniature multi-stage adsorbent preconcentrator/focuser,two series-coupled separation columns with pressure and temperature tunable retention control,and an integrated array of four chemiresistor (CR) sensors coated with Au-thiolate monolayer-protected nanoparticles (MPN).MPN-CR array response patterns are used with retention times to identify eluting *** is used as the carrier *** of 20 common indoor air contaminants gave lODs in the range of 0.05 ng/g～0.53 ng/g for a 1 l sample *** of preliminary analyses of characteristic VOCs generated from *** as well as vapor-phase markers of environmental tobacco smoke (ETS) at low-or sub-ng/g levels are presented.

关键词： microsensor gas chromatography nanoparticle sensor array portable ETS

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Fecal volatile components elicit aggregation in the oriental migratory locust, *** manilensis （Orthoptera： Acrididae）

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Insect Science 2011年第2期18卷 166-174页

作者： Wang-Peng Shi Hong-li Sun Nyndat edward Yu-Hua Yan Key laboratory for Biological control of Ministry of Agriculture China Agricultural University Beijing China International Centre of Insect Physiology and Ecology Nairobi Kenya

The aggregation components from fecal volatiles of the oriental mi- gratory locust, locusta migratoria manilensis were identified with gas chromatographic/electroantennographic detector （GC-EAD）, GC-MS （mass spectrometry） analyses and behavioral bioassays. Both last instar nymphs and adults of the oriental migratory locust have similar aggregation pheromones in their volatiles. A total of 11 electrophysiologically active compounds, namely, hexanal, cyclohexanol, heptanal, phenol, 2,5-dimethyl- pyrazine, benzyl alcohol, benzaldehyde, guaiacol, nonanal, 2,6,6-trimethyl-2-cyclohexene- 1,4-dione and decyl aldehyde were identified in the fecal volatiles of 2-day-old immature adult male locusts. Only hexanal, nonanal, benzaldehyde, cyclohexanol and 2,5-dimethyl- pyrazine elicited significant aggregation responses in immature 2-day-old adult males. However, adult males had significantly lower behavioral responses to synthetics of five single compounds than the blend of cyclohexanol, 2,5-dimethyl-pyrazine, benzaldehyde, nonanal, hexanal in ratios of 100 ： 100 ： 2 ： 60 ： 30 in the range of 30 60 μg/ml. We propose that it is the blend of these five compounds that plays a key role in eliciting and sustaining aggregation in gregarious oriental migratory locusts. These results also showed that the aggregation pheromones of the oriental migratory locust are significantly different from those found in the desert locust.

关键词： aggregation behavior aggregation pheromone gregarious locusts locustamigratoria manilensis

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Quantifying defects in thin films using machine vision

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npj Computational Materials 2020年第1期6卷 737-742页

作者： Nina Taherimakhsousi Benjamin P.Macleod Fraser G.l.Parlane Thomas D.Morrissey edward P.Booker Kevan E.Dettelbach Curtis P.Berlinguette Department of Chemistry The University of British Columbia2036 Main MallVancouverBC V6T 1Z1Canada Stewart Blusson Quantum Matter Institute The University of British Columbia2355 East MallVancouverBC V6T 1Z4Canada Department of Chemical&Biological Engineering The University of British Columbia2360 East MallVancouverBC V6T 1Z3Canada Canadian Institute for Advanced Research(CIFAR) MaRS Innovation Centre661 University Ave.Suite 505TorontoON M5G 1M1Canada

The sensitivity of thin-film materials and devices to defects motivates extensive research into the optimization of film *** research could be accelerated by automated experiments that characterize the response of film morphology to synthesis *** imaging can resolve morphological defects in thin films and is readily integrated into automated experiments but the large volumes of images produced by such systems require automated *** approaches to automatically analyzing film morphologies in optical images require application-specific customization by software experts and are not robust to changes in image content or imaging ***,we present a versatile convolutional neural network(CNN)for thin-film image analysis which can identify and quantify the extent of a variety of defects and is applicable to multiple materials and imaging *** CNN is readily adapted to new thin-film image analysis tasks and will facilitate the use of imaging in automated thin-film research systems.

关键词： film thin image

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