检索结果-南通市图书馆

journal of Materials Science & Technology 2020年第14期47卷 157-165页

作者： edward Charles Henry Crawford O’Brien Hemantha Kumar Yeddu School of Engineering Newcastle UniversityNewcastle upon TyneNE17RUUnited Kingdom

Multi-length scale modeling is performed to(i)predict the carburized case depth of SAE8620 steel gears by solving the Fick’s second law of diffusion,(ii)model the martensitic microstructure evolution in a grain inside the carburized case as well as to study the effect of stress cycling on retained austenite(RA)and martensite using a 3D phase-field model,(iii)simulate the effect of carburization and different RA contents on macroscale fatigue behavior of SAE8620 steel spur gear using the finite element *** diffusion model predicts that the case depth increases with increasing heat treatment time and *** phase-field simulations show that RA can transform to martensite during fatigue loading,where the extent of the transformation will depend on the type of stresses applied,*** in a high stress regime or low stress regime of fatigue *** transformation of martensite to austenite is also observed in low RA sample under high stress *** macroscale simulations show that the carburized case with high RA gives rise to better fatigue life compared to that with low RA.

关键词： Phase-field model Martensitic transformation Microstructure Gear steel Carburization

Guanidinoamidized Linear Polyethyleneimine for Gene Delivery

在线全文

学校读者我要写书评

暂无评论

Chinese journal of Polymer Science 2015年第6期33卷 908-919页

作者： Bo Zhang Xin-peng Ma Mei-hua Sui edward Van Kirk Willia m j.Murdoch Maciej Radosz 林能明申有青 Institute for Individualized Medicine Hangzhou First People’s Hospital Laboratory of Clinical Pharmacy Zhejiang Cancer Hospital Department of Chemical and Petroleum Engineering University of Wyoming Center for Bionanoengineering and the State Key Laboratory for Chemical Engineering Department of Chemical and Biological EngineeringZhejiang University Department of Animal Science University of Wyoming

Guanidine was introduced to low molecular weight linear polyethyleneimine （LPEI） via amide groups, to explore the effect of both guanidine degree and pendant chain length on its transfection behavior. The resulting guanidinoamidized LPEIs （GLPEIs） could dramatically reduce LPEI＇s toxicity, enhance its DNA-packaging capability, cellular uptake and therefore transfection efficiency. These polyplexes were taken up very efficiently via caveolae-mediated endocytosis and their transfection efficiencies in ovarian cancer cells were significantly improved compared to native LPEIlok polyplexes. Among these GLPEIs, LPEI-C3-G100 showed higher DNA affinity even than LPEI25k and the highest transfection efficiency, probably due to the optimization of polymer chain flexibility. Of notice, LPEI-C3-G100 polyplexes could more effectively accumulate into cytoplasm than LPEI25k, although the transfection efficiency of LPEI-C3-G100 polyplexes was not superior to that of LPEI25k polyplexes, which would be probably attributed to the more efficient release of LPEI25k polyplexes than LPEI-C3-G100 polyplexes in the cytoplasm.

关键词： Polyethyleneimine Guanidine Gene delivery Cellular uptake.

Rapid destruction of sarin surrogates by gas phase reactions with focus on diisopropyl methylphosphonate(DIMP)

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2021年第3期17卷 703-714页

作者： Elif Irem Senyurt Mirko Schoenitz edward L.Dreizin New jersey Institute of Technology NewarkNJ07102USA Tomsk State University TomskRussia

Rapid destruction of stockpiles of sarin and other chemical weapon agents(CWA)requires understanding and quantitative description of the relevant chemical *** reactions at elevated temperatures are of particular interest for prompt agent defeat *** methylphosphonate(DIMP)is a sarin surrogate particularly well suited to model sarin thermal decomposition and is often used in *** article is a review of different experimental methods addressing decomposition of gasified DIMP,respective results and their *** early decomposition products are propene,methylphosphonic acid,methyl(oxo)phosphoniumolate,and *** computational work using available kinetic data for fluorine and the phosphorus-fluorine bond predicted the decomposition under incineration *** using an isothermal flow reactor operated at 700-800 K were used to model DIMP decomposition as unimolecular reaction with results that were consistent with the earlier theoretical *** in dynamic environments was studied using DIMP supported on rapidly heated *** results showed different decomposition products and product sequences forming at different heating rates,suggesting the need for revised reaction ***,species quantification in such experiments is difficult because of inherent large temperature *** produced in a corona discharge was also reported to lead to rapid DIMP decomposition at low *** products were distinct from those observed at high *** tube experiments may be well suited to study decomposition of organophosphorus compounds like DIMP following their rapid heating in diverse ***,presently,only sarin surrogates other than DIMP have been investigated,and no intermediate reaction products,important for developing a validated mechanism,could be detected.

关键词： Chemical weapon agent Agent defeat Thermal decomposition Incineration Prompt reactions

Silvicultural alternatives to conventional even-aged forest man-agement-what limits global adoption?

在线全文

学校读者我要写书评

暂无评论

Forest Ecosystems 2015年第2期2卷 123-138页

作者： Klaus j Puettmann Scott McG Wilson Susan C Baker Pablo j Donoso Lars Dr?ssler Girma Amente Brian D harvey Thomas Knoke Yuanchang Lu Susanna Nocentini Francis E Putz Toshiya Yoshida jürgen Bauhus Department of Forest Ecosystems and Society Oregon State University Consultant Forester and Forest Ecologist School ofBiological Sciences University of Tasmania Department of Forests and Society Faculty of Forest Sciences and Natural Resources Universidad Austral de Chile Southern Swedish Forest Research Centre Swedish Agricultural University Haramaya University Institut de recherche sur les forêts Université du Québec en Abitibi-Témiscamingue 445 Boulevard de l’Université Institute of Forest Management TUMSchool of Life Sciences Weihenstephan Technische Universit?t München Department of Forest Management and Statistics IFRIT Chinese Academy of Forestry Department of Agricultural Food and Forestry Systems University of Florence Department of Biology University of Florida Uryu Experimental Forest Field Science Center for Northern Biosphere Hokkaido University Chair of Silviculture Faculty of Environment and Natural Resources University of FreiburgTennenbacherstr

Background： The development of forestry as a scientific and management discipline over the last two centuries has mainly emphasized intensive management operations focused on increased commodity production, mostly wood. This conventionar＇ forest management approach has typically favored production of even-aged, single-species stands. While alternative management regimes have generally received less attention, this has been changing over the last three decades, especially in countries with developed economies. Reasons for this change include a combination of new information and concerns about the ecological consequences of intensive forestry practices and a willingness on the part of many forest owners and society to embrace a wider set of management objectives. Alternative silvicultural approaches are characterized by a set of fundamental principles, including avoidance of clearcutting, an emphasis on structural diversity and small-scale variability, deployment of mixed species with natural regeneration, and avoidance of intensive site-preparation methods. Methods： Our compilation of the authors＇ experiences and perspectives from various parts of the world aims to initiate a larger discussion concerning the constraints to and the potential of adopting alternative silvicultural practices. Results： The results suggest that a wider adoption of alternative silvicultural practices is currently hindered by a suite of ecological, economic, logistical, informational, cultural, and historical constraints. Individual contexts display their own unique combinations and relative significance of these constraints, and accordingly, targeted efforts, such as regulations and incentives, may help to overcome specific challenges. Conclusions： In a broader context, we propose that less emphases on strict applications of principles and on stand structures might provide additional flexibility and facilitate the adoption of alternative silvicultural regimes in a broader set of circumstanc

关键词： Silvicultural alternatives adoption

A spectrum of pathological changes induced by SARS-COV-2:An observational study in a cohort of pregnant women from Mizoram,India

在线全文

学校读者我要写书评

暂无评论

Gynecology and Obstetrics Clinical Medicine 2023年第2期3卷 106-111页

作者： Vanremmawii Lalrinfela harvey Vanlalpek Lalduhchhungi Zothansangi Hmingthanzuali Ralte Department of Obstetrics and Gynaecology Zoram Medical CollegeIndia Department of Pathology Zoram Medical CollegeIndia

Background:Maternal infection by SARS-CoV-2 may lead to adverse pregnancy outcomes and causes pathological changes in the ***,consensus regarding characteristic pathological features is *** the placental histopathology in a cohort of women from Mizoram,India,was conducted to relate the SARS-CoV-2 infection's effectswith pregnancy and its *** and methods:The characteristics of 72 pregnant women diagnosed positive for SARS-CoV-2 who eventually delivered at Zoram Medical College Hospital,Mizoram,neonates'well-being,and histopathological features of placentas were ***:Of 72 women in this study,59(81.9%)gave birth at full *** these births,5 were normal vaginal deliveries,while the remaining 67(93.1%)were delivered via cesarean *** reasons for cesarean delivery were either related to SARS-CoV-2 infection(n=49),existing obstetric problems(n=15)or fetal-distress(n=5).All deliveries resulted in live births of COVID-negative babies,with 80.6%(n=58)of the newborns having a birth weight of over 2.5 *** scores ranged from 4 to 6 in 61(84.7%)of the babies,and 10 neonates required resuscitation,of which 8 were managed in the neonatal intensive care unit(NICU).The placental histopathology showed increased fibrin thrombi in 8 cases(11.1%),while 20 cases(28%)showed focal infarction,microcalcification levels were elevated in 16 cases(22.2%),and a small percentage of cases(1.4%)exhibited small fibrotic villi and inter-villus *** chorioangiosis was detected in 28(38.9%)of the cases,while avascular villi were seen in 6 ***-stained liquor was observed in a single *** hemorrhage was found in 42 cases,whileintervillous inflammation and increased syncytial knots were present in 14 and 5 cases,*** placenta pathology of 10 neonates who required resuscitation/NICU admission was not significantly different from that of the 62 neonates who did not require ***,

关键词： Placental pathology SARS-COV-2 Pregnancy outcome Mizo women

SYNTHESIS AND BIOSYNTHESIS OF β-LACTAM ANTIBIOTICS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国抗生素杂志 1985年第2期10卷 114-124页

作者： edward Abraham England Sir William Dunn School of pathology University of Oxford

In 1928 Fleming observed the antibacterial action of penicillin at ***’s Hospital, London, on a plate seeded with staphylococci that had been contaminated with a strain of penicillium *** than ten years later H. W. Florey and E. Chain and their colleagues at Oxford University showed that crude preparations of penicillin had chemotherapeutic properties which seemed at the time to be almost miraculous. This marked the beginning of investigations that were to lead to the widespread use of β-lactam antibiotics in medicine.

关键词： LACTAM ANTIBIOTICS SYNTHESIS AND BIOSYNTHESIS OF

Remote monitoring of implantable defibrillators is associated with fewer inappropriate shocks and reduced time to medical assessment in a remote and rural area

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World journal of Cardiology 2021年第3期13卷 46-54页

作者： Kara Callum Claudia Graune Elizabeth Bowman edward Molden Stephen j Leslie Department of Cardiology NHS HighlandInverness IV23UJUnited Kingdom

BACKGROUND Implantable cardioverter defibrillators(ICDs)and cardiac resynchronisation therapy with defibrillators(CRT-D)reduce mortality in certain cardiac patient ***,inappropriate shocks pose a problem,having both adverse physical and psychological effects on the *** advances in device technology now allow remote monitoring(RM)of devices to replace clinic follow up *** allows real time data to be analysed and actioned and this may improve patient *** To determine if RM in patients with an ICD is associated with fewer inappropriate shocks and reduced time to medical *** This was a single centre,retrospective observational study,involving 156 patients implanted with an ICD or CRT-D,followed up for 2 years post *** appropriate and inappropriate shocks were recorded along with cause for inappropriate shocks and time to medical *** RM was associated with fewer inappropriate shocks(13.6%clinic vs 3.9%RM;P=0.030)and a reduced time to medical assessment(15.1±6.8 vs 1.0±0.0 d;P<0.001).CONCLUSION RM in patients with an ICD is associated with improved patient outcomes.

关键词： Implantable cardioverter defibrillator Inappropriate shocks Remote monitoring Cardiac patients Heart failure Arrythmia

Data and curiosity:Working with mentor Donald ***

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Science 2022年第1期35卷 29-33页

作者： edward Garnero School of Earth and Space Exploration Arizona State University Tempe AZ 85287USA

I arrived at Caltech in june 1986,with interests in both mineral physics and seismology.I was excited to either study mineral physics with Professor Tom Ahrens,or investigate great earthquakes with Hiroo *** arriving,I decided seismology would be my path.I was particularly interested in Hiroo’s work on earthquake size,from some papers I read as an undergraduate(Kanamori,1978,1983).

关键词： earthquake seismology excited

Building a sustainable organizational energy evaluation system in the Asia Pacific

在线全文

学校读者我要写书评

暂无评论

Global Energy Interconnection 2019年第5期2卷 379-386页

作者： edward Vine Lawrence Berkeley National Laboratory

In the face of climate change and with the vision for the future of humanity represented by the Sustainability Development Goals,sustainability has become associated with the major and rapid transformation of global systems and the resilience of transformed systems to adapt over *** dynamic view of transformation has implications for both the design of tran sformatio nal energy in itiatives and their *** there is an urge nt n eed to evaluate the scale,scope,nature,and sufficiency of transformation toward planetary sustainability,a framework(model)is proposed to determine the most effective en ergy evaluati on capacity buildi ng strategies for achievi ng various in dividual and group level outcomes,most effective strategies for certain types of participants,and design of different strategies to maximize their impact in a sustainable ***,a new energy evaluation organization is identified,which is expected to lead us into this new era.

关键词： Energy evaluation Energy efficiency Building capacity Asia Pacific Renewable energy

Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice

在线全文

学校读者我要写书评

暂无评论

Bone Research 2017年第2期5卷 95-108页

作者： Eric E Beier Tzong-jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta j edward Puzas Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester NY USA Department of Environmental and Occupational Medicine Rutgers University Piscataway NJ USA and Center for Musculoskeletal Research University of Rochester School of Medicine and Dentistry Rochester NY USA

Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in ***, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone.

关键词： Sclerostin prenatal negative