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Simultaneous quantification of 18 bioactive constituents in Ziziphus jujuba fruits by HPLC coupled with a chemometric method

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Food Science and Human Wellness 2022年第4期11卷 771-780页

作者： Tianyi Wang Sen Guo Xiameng Ren Junfeng Du Lu Bai Xueqin Cui chi-tang ho Naisheng Bai College of Food Science and Technology Northwest UniversityXi’an 710069China College of Chemical Engineering Northwest University229 Taibai North RoadXi’an 710069China Shaanxi Family Forestry Bureau Shaanxi Jiaxian Development and Reform and Science and Technology BureauYulin 719200China Department of Food Science Rutgers UniversityNew Brunswick 08901USA

The fruit of Ziziphus jujuba Mill., known as hongzao(or hong-Zao) in chinese and cultivated in china for more than 4 000 years, has shown to have hepatoprotective property. In previous study, we have isolated and identified 27 known compounds from Z. jujuba fruits, which demonstrated anti-tumor activity. In this study, a high-performance liquid chromatography-diode-array detection-mass spectrometry(HPLC-DAD-MS) method was successfully applied to the simultaneous characterization and quantitation of 18 constituents in 28 Z. jujuba samples, comprised of 12 cultivars from different regions in china, by comparing their HPLC retention times, MS spectra, UV spectra, and NMR data with those of reference compounds. The quantitative method was validated with excellent linearity(R^(2 )> 0.999 1), preferable intra-and inter-day precisions(RSD hod(hierarchical cluster analysis). In addition, these constituents showed protection against carbon tetrachloride(CCl_(4)) intoxicated Hep G2 cell lines by decreasing lactic dehydrogenase(LDH) levels. Results in this study illustrated that the content of all 18 compounds examined has significant difference and variation among cultivars and extracts. The proposed method can serve as a prerequisite for quality control of bioactive compounds in Z. jujuba products.

关键词： Ziziphus jujuba HPLC-DAD-MS Quantitative analysis Hierarchical cluster analysis HepG2 cells

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Structure variety and its effects on biological activity of tea polysaccharides

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Food Science and Human Wellness 2022年第3期11卷 587-597页

作者： Ting Hu Peng Wu Jianfeng Zhan Weixin Wang Junfeng Shen Meiyan Wang chi-tang ho Shiming Li Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization Huanggang Normal UniversityHuanggang 438000China School of Biotechnology and Food Science Tianjin University of CommerceTianjin 300134China Department of Food Science Rutgers UniversityNJ 08901USA

Tea polysaccharides(TPSs),one of the major bioactive ingredients in tea,have been widely studied due to their variety of biological activities,including antioxidant,cancer prevention,hypoglycemia,anti-fatigue,anti-coagulant,anti-obesity and immunomodulatory *** biological effectiveness of TPSs has direct relation with their structures such as monosaccharide composition,molecular weight,glycosidic linkages,conformation and others,which can be influenced by tea materials,processing methods,extraction and purification procedures among *** to the study of tea polyphenols,the exploration of TPSs in structural elucidation and biofunctionality is very *** several factors affecting the structural change of TPSs have been studied and ***,the variation of some TPS biological activity brought by the change of TPS structures has been evaluated and preliminary correlation of structure activity relationship of TPSs has been ***,this review aims to serve as a summary research report regarding the influencing factors on TPSs structures and consequential effects on the biological activities of *** hope to provide updated information and systematic references for future study and functional food development of TPSs.

关键词： Tea polysaccharides Structure variety Bioactivities Relationship Influencing factors

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Rapid qualitative and quantitative analysis of strong aroma base liquor based on SPME-MS combined with chemometrics

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Food Science and Human Wellness 2021年第3期10卷 362-369页

作者： Zongbao Sun Junkui Li Jianfeng Wu Xiaobo Zou chi-tang ho Liming Liang Xiaojing Yan Xuan Zhou School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China Department of Food Science Rutgers UniversityNew BrunswickNew Jersey 08903USA Jiangsu King’s Luck Brewery Co.Ltd. Lianshui 223411China

To objectively classify and evaluate the strong aroma base liquors(SABLs)of different grades,solid-phase microextraction-mass spectrometry(SPME-MS)combined with chemometrics were *** showed that SPME-MS combined with a back-propagation artificial neural network(BPANN)method yielded almost the same recognition performance compared to linear discriminant analysis(LDA)in distinguishing different grades of SABL,with 84%recognition rate for the test *** least squares(PLS),successive projection algorithm partial least squares(SPA-PLS)model,and competitive adaptive reweighed samplingpartial least squares(CARS-PLS)were established for the prediction of the four esters in the ***-PLS model showed a greater advantage in the quantitative analysis of ethyl acetate,ethyl butyrate,ethyl caproate,and ethyl *** results corroborated the hypothesis that SPME-MS combined with chemometrics can effectively achieve an accurate determination of different grades of SABL and prediction performance of esters.

关键词： SPME-MS Strong aroma base liquor(SABL) Chemometrics Grade identification Ester compounds

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Microwave heating as a universal method to transform confined molecules into armchair graphene nanoribbons

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Nano Research 2023年第7期16卷 10644-10651页

作者： Haoyuan Zhang Yingzhi Chen Kunpeng tang Ziheng Lin Xuan Li hongwei Zhang Yifan Zhang chi ho Wong chi Wah Leung Chee Leung Mak Yuan Hu Weili Cui Kecheng Cao Lei Shi State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterGuangdong Province Key Lab of Display Material and TechnologySchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China Huzhou Key Laboratory of Environmental Functional Materials and Pollution Control School of EngineeringHuzhou UniversityHuzhou 313000China Department of Industrial and Systems Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong 999077China Shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210China

Armchair graphene nanoribbons(AGNRs)with sub-nanometer width are potential materials for the fabrication of novel nanodevices thanks to their moderate direct band *** are usually synthesized by polymerizing precursor molecules on substrate ***,it is time-consuming and not suitable for large-scale *** can also be grown by transforming precursor molecules inside single-walled carbon nanotubes(SWCNTs)via furnace annealing,but the obtained AGNRs are normally *** this work,microwave heating is applied for transforming precursor molecules into *** fast heating process allows synthesizing the AGNRs in *** different molecules were successfully transformed into AGNRs,suggesting that it is a universal *** importantly,as demonstrated by Raman spectroscopy,aberrationcorrected high-resolution transmission electron microscopy and theoretical calculations,less twisted AGNRs are synthesized by the microwave heating than the furnace *** results reveal a route for rapid production of AGNRs in large scale,which would benefit future applications in novel AGNRs-based semiconductor devices.

关键词： armchair graphene nanoribbons(AGNRs) microwave heating single-walled carbon nanotubes(SWCNTs) Raman spectroscopy

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Phytochemical Analysis of Ziziphus jujuba Leaves in Six Cultivars at the Whole Life Stage by High Performance Liquid Chromatography

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Chemical Research in chinese Universities 2017年第5期33卷 702-708页

作者： CUI Xueqin MA Zhongxiao BAI Lu WU Yong GUO Sen LIU Qingchao ZHANG Li ho chi-tang BAI Naisheng College of Chemical Engineering Department of Pharmaceutical Engineering Northwest University Xi'an 710069 P. R. China Department of Food Science Rutgers University New Brunswick New Jersey 08901 USA

Leaves of Ziziphus jujuba Mill.（Z. jujuba） were used as a folk medicine to treat children suffering from typhoid fever, furuncle and ecthyma in china. The present study was to establish a high performance liquid chroma- tography-diode array detector（HPLC-DAD） method for quality control of Z. jujuba leaves. The validated method was applied to the simultaneous characterization and quantification of sixteen main constituents in thirty samples, which comprised the whole life stage of Z. ]ujuba leaves from six cultivars in Yulin, Shannxi Province, china. HPLC fin- gerprint file of Z. jujuba leaves was set up and the results indicate that the major constituents of Z. jujuba leaves are （-）-catechin（1）, quercetin-3-O-robinobioside（3）, rutin（4） and quercetin-3-O-a-L-arabinosyl-（1---~2）-a-L-rhamnoside（6） with the total contents of the nine flavonoids in respective batch ranging from 18.52 mg/g to 39.51 mg/g. In addition, the contents of compounds depend on both the season and the cultivar. During ripening of Z. jujuba leaves, flavo- noids of all the cultivars present a similar trend： initially decrease from 25th, Jun. to 5th, Aug., 2015, and then in- crease for a period of time, finally slightly fluctuate on 5th Oct. The highest contents of total flavonoids were regis- tered on 25th Jun., 2015. Different cultivars have 50%--90% variation on the content for the three classes of com- pounds. Taken together, the results demonstrate that Z. jujuba leaves have great potential to be a new health-promoting resource based on flavonoids and the best sampling time of them is in June.

关键词： Flavonoid High performance liquid chromatography-diode array detector(HPLC-DAD) Quality control Ziziphus jujuba leaf

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Multifunctional health-promoting effects of oolong tea and its products

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Food Science and Human Wellness 2022年第3期11卷 512-523页

作者： Shuzhen Wang Ting Zeng Shuang Zhao Yu Zhu Changchun Feng Jianfeng Zhan Shiming Li chi-tang ho Alexander Gosslau Huanggang Normal University College of Life ScienceHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive UtilizationHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie MountainsHubei Zhongke Research Institute of Industrial TechnologyHuanggang 438000China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Department of Food Science Rutgers UniversityNJ 08901USA Department of Science(Biology) City University of New YorkNY 10007USA

Oolong tea,partially fermented from Camellia sinensis leaves,exhibits significant antioxidative,anti-inflammatory,and anti-cancer activities as indicated in several in vitro and in vivo ***,studies on health promoting effects of oolong tea and its characteristic compounds are *** potential efficacy of bioactives derived from oolong tea and their roles as promising anticancer agents,their cardio-protective benefits during hypoxic conditions,effects in treating allergic disorders,potential prebiotic activities,improvement of blood lipid status in human beings,effectivity as oral hypoglycemic agent in the treatment of type 2 diabetes,and their potentials to reduce the risk of obesity have been discussed in this *** promising studies mainly gained from animal studies might broaden the consumption and usage of the phenolic-enriched oolong tea and its products in food and pharmaceutical ***,potential health beneficial effects of oolong tea in humans should be further complemented by large-sized,randomized double-blind and placebo-controlled trials to consolidate potential therapeutic applications.

关键词： Oolong tea Anticancer potential Antioxidative activity Microbiota modulating activities Synergistic effects

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Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury(TBI)in rats

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Food Science and Human Wellness 2020年第3期9卷 229-236页

作者： Guang Cheng Zhiwei Yue Liwen Wang Yutaka Miyauchi Michiko Suzawa Shiming Li chi-tang ho Hui Zhao Naiyao Chen Department of Hematology and tangshan Key Laboratory Translational Medical CenterNorth China University of Science and TechnologyTangshanHebei 063000China Tianjin Key Laboratory of Food and Biotechnology School of Biotechnology and Food ScienceTianjin University of CommerceTianjin 300134China Miyauchi Citrus Research Center TakasakiGunmaJapan Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Huanggang Normal UniversityHuanggangHubei 438000China Department of Food Science RutgersThe State University of New JerseyNew BrunswickNew Jersey 08901United States

Traumatic brain injury(TBI)is closely related to neuro-inflammatory response and causes a complex pathological process and serious *** this study,we explored whether the formatted citrus peel extract gold lotion(GL)could have a therapeutic effect on rats suffered *** rat model was prepared by the electric Cortical Contusion Impactor(eCCI)*** against TBI by GL was assessed by the behavioral,organizational of rats and the molecular markers in the brain injury *** results showed that GL could reduce nerve damage and neurological *** mechanisms probably due to that GL could not only reduce the associated damage markers including GFAP,OX-42,TNF-α,COX-2,NF-κB and TLR4 but also promote the expression of VEGF which is responsible for protecting neuronal cells in the injury *** findings revealed that GL could be a promising preparation for TBI prevention.

关键词： Citrus peel Cognitive Traumatic brain injury Inflammation Gold lotion

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5-Demethylnobiletin and its major metabolites:efficient preparation and mechanism of their anti-proliferation activity in HepG2 cells

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Food Science and Human Wellness 2022年第5期11卷 1191-1200页

作者： Yanping Xin Ting Zheng Man Zhang Ruiqiang Zhang Siyue Zhu Dongli Li Denggao Zhao Yanyan Ma chi-tang ho Qingrong Huang School of Biotechnology and Health Sciences Wuyi UniversityJiangmen 529020China International Healthcare Innovation Institute(Jiangmen) Jiangmen 529020China Department of Food Science Rutgers UniversityNew Jersey 08901USA

5-Demethylnobile tin(5-DMN),a hydroxylated polymethoxyflavone(OH-PMF)identified in aged citrus peels,has demonstrated health benefiting effects in previous studies.5-DMN undergoes biotransformation in vivo,yielding 5,3’-didemethylnobiletin(5,3’-DDMN),5,4’-didemethylnobiletin(5,4’-DDMN)and5,3’,4’-tridemethylnobiletin(5,3’,4’-TDMN).however,the anti-cancer effects of 5-DMN and its in vivo metabolites against HepG2 cells remain *** this study,an efficient chemical synthetic method was developed to obtain 5-DMN and its 3 metabolites,and their molecular structures were confirmed by;H NMR and ***,cell cycle arrestment,apoptosis and caspase-3 expression were investigated to evaluate the anti-liver cancer effects of these OH-PMFs on HepG2 *** results showed that all 4 compounds inhibited the proliferation of HepG2 cells in a concentration-dependent *** anti-proliferative activity was exerted through inducing G2/M phase arrestment,cell apoptosis and promoting expression of a key apoptotic protein called cleaved *** results indicated that 5,3’-DDMN and5,3’,4’-TDMN showed a stronger inhibitory activity on cell proliferation than 5-DMN,followed by 5,4’-*** expression of cleaved caspase-3 was the highest in cells treated with 5,4’-DDMN,implying that the apoptosis induced by other OH-PMFs might be mediated by other apoptotic execution *** research reveals the application potential and scientific evidence for the production and functionality of OH-PMFs.

关键词： Hydroxylated polymethoxyflavones Chemical synthesis HepG2 Cell cycle Apoptosis

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The effects of the extract of oolong tea and its metabolites from Andraca theae in high fat diet induced obese Wistar rat

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Food Science and Human Wellness 2018年第2期7卷 120-124页

作者： Yen-Chen Tung Tsung-Hai Hsieh Meei-Ju Yang Wei-Lun Hung chi-tang ho Min-Hsiung Pan Institute of Food Science and Technology National Taiwan UniversityTaipei 106Taiwan Tea Research and Extension Station Taoyuan 326Taiwan Citrus Research and Education Center Department of Food Science and Human NutritionUniversity of FloridaLake AlfredFL33850USA Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA

Obesity is a critical health issue *** a long time,the concept of drinking tea for health and pleasure is widely *** strain of Andraca theae lives on the tea leaf and the bioactivity of its metabolites in the feces is unknown ***,the objective of this study was to investigate whether the extract of tea(Taiwan Tea Experiment Station No.12(TE))and its metabolites from Andraca theae(TME)could prevent obesity in the high fat diet-induced obese *** results showed that TE had higher concentrations of epigallocatechin gallate(EGCG)and caffeine than that from *** significantly decreased abdominal adipose tissue,especially epididymal fat via increasing preadipocyte factor 1(Pref-1),SRY(sex determining region Y)-box 9(SOX-9)and decreasing peroxisome proliferator-activated receptorγ(PPARγ),CCAAT/enhancer binding protein(C/EBP)β,C/EBPαand C/EBPβprotein *** together,these results suggest that the content of tea polyphenols in TE play an important role for alleviating abdominal fat.

关键词： Tea Andraca theae High fat diet Obesity

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Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice

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Food Science and Human Wellness 2012年第1期1卷 65-73页

作者： Min-Hsiung Pan Shiming Li ching-Shu Lai Yutaka Miyauchi Michiko Suzawa chi-tang ho Department of Seafood Science National Kaohsiung Marine UniversityKaohsiung 811TaiwanChina Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA Miyauchi Citrus Research Center 324-10 Shigoka-MachiTakasakiGunma 370-0845Japan

The inhibitory effects of a formulated product from citrus peel extract,Gold Lotion(GL),on 12-O-tetradecanoylphorbol 13-acetate(TPA)-induced expression of inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)in mouse skin was reported in this *** is found that in the TPA-induced skin inflammation model,the topical application of GL effectively inhibited the transcriptional activation of iNOS and its mRNA and protein in mouse *** is also discovered that GL significantly inhibited TPA-induced mouse skin inflammation by decreasing inflammatory gene ***,GL dramatically inhibited 7,12-dimethylbenez[a]anthracene(DMBA)/TPA-induced skin tumor formation and reduced tumor incidence,tumor weight and tumor multiplicity of papillomas at 20 *** essence,these in vivo data have revealed that GL is an effective anti-tumor agent that functions by down-regulating the protein levels of COX-2,ornithine decarboxylase(ODC),and vascular endothelial growth factor(VEGF)in mouse skin,suggesting that GL is a novel functional natural product capable of preventing inflammation-associated tumorigenesis.©2012 Production and hosting by Elsevier *** behalf of Beijing Academy of Food Sciences.

关键词： Inhibition Skin cancer Citrus flavonoids Inflammation Tumorigenesis

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