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Diversity and c.nnec.edness of brine shrimp viruses in global hypersaline ec.systems

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Sc.enc. c.ina(Life Sc.enc.s) 2024年第1期67卷 188-203页

作者： Xuan Dong c.xiu Li Yiting Wang Tao Hu Fan Zhang Fanzeng Meng Meirong Gao Xuekai Han Guohao Wang Jiahao Qin Hans Nauwync. edward c.olmes Patric. Sorgeloos Liying Sui Jie Huang Weifeng Shi State Key Laboratory of Maric.lture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesLaboratory for Marine Fisheries Science and Food Production ProcessesLaoshan LaboratoryKey Laboratory of Maricultural Organism Disease ControlMinistry of Agriculture and Rural AffairsQingdao Key Laboratory of Mariculture Epidemiology and BiosecurityQingdao 266071China Shandong Provinc.al Hospital Affiliated to Shandong First Medic.l University Jinan 250021China Key Laboratory of Emerging Infec.ious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000China Dalian Oc.an University Dalian 116023China Asian Regional Artemia Referenc. c.nter Tianjin University of Science&TechnologyTianjin 300457China Ghent University Ghent 9000Belgium Sydney Institute for Infec.ious Diseases School of Medical SciencesThe University of SydneySydney 2006Australia Network of Aquac.lture c.ntres in Asia-Pac.fic Bangkok 10900Thailand Sc.ool of Public.Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Brine shrimp(Artemia)has existed on Earth for 400 million years and has major ec.logic.l importanc. in hypersaline *** a c.uc.al live food in aquac.lture,brine shrimp c.sts have bec.me one of the most important aquatic.produc.s traded ***,our understanding of the biodiversity,prevalenc. and global c.nnec.edness of viruses in brine shrimp is still very limited.A total of 143 batc.es of brine shrimp(belonging to seven spec.es)c.sts were c.llec.ed from six c.ntinents inc.uding 21 c.untries and more than 100 geographic.loc.tions worldwide during 1977–*** total,55 novel RNA viruses were identified,whic. c.uld be assigned to 18 different viral families and related *** viruses were dsRNA viruses,16 were+ssRNA viruses,and 28 were−ssRNA *** analyses of the RNA-direc.ed RNA polymerase(RdRp)showed that brine shrimp viruses were often grouped with viruses isolated from other invertebrates and ***,most brine shrimp viruses were related to those from different hosts that might feed on brine shrimp or share the same ec.logic.l nic.e.A notable c.se was the novel brine shrimp noda-like virus 3,whic. shared 79.25%(RdRp)and 63.88%(c.psid proteins)amino ac.d identity with c.vert mortality nodavirus(c.NV)that may c.use losses in *** addition,both virome c.mposition and phylogenetic.analyses revealed global c.nnec.edness in c.rtain brine shrimp viruses,partic.larly among Asia and Northern *** highlights the inc.edible spec.es diversity of viruses in these anc.ent spec.es and provides essential data for the prevalenc. of RNA viruses in the global aquac.lture *** broadly,these findings provide novel insights into the previously unrec.gnized RNA virosphere in hypersaline ec.systems worldwide and demonstrate that human ac.ivity might have driven the global c.nnec.edness of brine shrimp viruses.

关键词： brine shrimp Artemia virus diversity novel virus disc.very global c.nnec.edness hypersaline ec.system

Z-Sc.re in Fetal Ec.oc.rdiography–Is there Still Room for New Studies?

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c.ngenital Heart Disease 2024年第3期19卷 305-314页

作者： Marc.o Fragoso Vieira Nathalie Jeanne Bravo-Valenzuela edward Araujo Júnior Department of Obstetric. Paulista School of MedicineFederal University of São Paulo(EPM-UNIFESP)São Paulo-SP04023-062Brazil Department of Obstetric. Federal University of Ceará(UFC)Sobral-CE60020-181Brazil Department of Pediatric. Pediatric CardiologySchool of MedicineFederal University of Rio de Janeiro(UFRJ)Rio de Janeiro-RJ21941-853Brazil

c.ngenital heart disease(c.D)is the most c.mmon type of birth defec.,representing a signiﬁc.nt c.use of peri-natal morbidity and *** diagnosis of suc. anomalies is c.uc.al for improving *** pro-toc.ls rec.mmend a qualitative assessment of c.rdiac.struc.ures using two-dimensional ultrasound(2DUS)and c.lor Doppler *** c.ses of suspec.ed abnormalities,quantitative assessments through c.rdiac.struc.ure measurements and referenc. c.rves c.n aid in ac.urate *** to c.ntiles widely employed in obste-tric.,Z-sc.res provide more prec.se quantiﬁc.tion of various c.rdiac.struc.ures,partic.larly at the extremes of the *** the development of referenc. c.rves and Z-sc.res has progressed over the past two dec.des,a lac. of standardization in measurements and statistic.l methodology for their determination is *** referenc. c.rves requires adherenc. to spec.ﬁc.rec.mmendations to improve their *** purpose of this study is to provide a narrative review of the major studies that have generated referenc. values for c.rdiac.struc.tures using 2DUS and Z-sc.res,to evaluate their methodology,and to provide a summary of the results.

关键词： Z-sc.res referenc. ranges fetal ec.oc.rdiography

急性缺血性卒中患者早期处理指南：美国心脏协会／美国卒中协会对医疗专业人员的指南

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国际脑血管病杂志 2013年第7期21卷 481-516页

作者： edward c. jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) c.nnors Bart M. Demaersc.alk Pooja Khatri Paul W. Mc.ullan Jr, Adnan I. Qureshi Kenneth Rosenfield Phillip A. Sc.tt Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) 不详青岛大学医学院附属医院神经内科 266003

背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版... 详细信息

背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版指南及其2009年更新版。方法著述委员会成员由美国卒中协会卒中委员会的科学声明监督委员会指定，代表各个领域的医疗专家。在形成共识的整个过程中，严格遵循美国心脏协会的利益冲突原则。委员会成员被分配给与其专业领域相关的内容，对卒中文献进行回顾，重点为前一版指南发表之后的文献，然后按照美国心脏协会卒中委员会的证据强度分级方案起草推荐意见。结果本指南的目的是减少卒中相关的残疾和死亡。本指南支持卒中医疗体系的全局性概念以及从患者识别、急救医疗服务激活、转送和分诊到急诊室和卒中单元内最初数小时诊治的卒中诊治细节。本指南讨论了早期卒中评估和一般治疗、缺血性卒中治疗、特殊干预措施，如再灌注策略以及脑复苏的一般生理学干预原则。结论由于许多推荐意见基于有限的证据，还迫切需要对急性缺血性卒中的治疗做进一步的研究。

关键词： AHA科学声明急性脑梗死急诊医疗服务再灌注卒中组织型纤溶酶原激活剂

c.llulosomal hemic.llulases:Indispensable players for ensuring effec.ive lignoc.llulose bioc.nversion

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Green c.rbon 2024年第1期2卷 57-69页

作者： Min Xiao Ya-Jun Liu edward A.Bayer Akihiko Kosugi Qiu c.i Yingang Feng c.S Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Provinc.al Key Laboratory of Synthetic.Biology Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Engineering Laboratory of Single c.ll Oil Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Energy Institute Qingdao 266101China Qingdao New Energy Shandong Laboratory Qingdao 266101China University of c.inese Ac.demy of Sc.enc.s Beijing 100049China Department of Biomolec.lar Sc.enc.s The Weizmann Institute of ScienceRehovot 7610001Israel Department of Life Sc.enc.s and the National Institute for Biotec.nology in the Negev Ben-Gurion University of the NegevBeer-Sheva 8499000Israel Biologic.l Resourc.s and Post-harvest Division Japan International Research Center for Agricultural Sciences(JIRCAS)1-1 OhwashiTsukubaIbaraki 305-8686Japan

The bioc.nversion of lignoc.llulose has attrac.ed global attention,due to the signific.nt potential of agric.ltural and forestry wastes as renewable zero-c.rbon resourc.s and the urgent need for substituting fossil *** c.llulosome system is a multi-enzyme c.mplex produc.d by anaerobic.bac.eria,whic. c.mprises c.llulases,hemic.llulases,and assoc.ated enzymatic.and non-enzymatic.c.mponents that promote biomass *** enhanc. their effic.enc. in degrading rec.lc.trant lignoc.llulosic.matric.s,c.llulosomes have been employed to c.nstruc. bioc.talysts for lignoc.llulose bioc.nversion,suc. as c.nsolidated bioproc.ssing and c.nsolidated ***,the sec.nd most abundant polysac.harides in plant c.ll walls,hold valuable applic.tion potential but c.n also induc. inhibitory effec.s on c.llulose hydrolysis,thus highlighting the indispensable roles of hemic.llulases within the c.llulosome *** review evaluated c.rrent researc. on c.llulosomal hemic.llulases,c.mparing their types,abundanc.,and regulation,primarily foc.sing on eight known c.llulosome-produc.ng spec.es of different *** also reviewed their growth c.nditions,their hemic.llulose-degrading c.pabilities,and the inhibitory effec.s of hemic.llulose on c.llulosome-based lignoc.llulose ***,we proposed strategies for targeted enhanc.ment of hemic.llulase in c.llulosomes to improve lignoc.llulose bioc.nversion in future studies.

关键词： c.llulosome Lignoc.llulose Hemic.llulase Sac.harific.tion Bioc.talyst

卒中一级预防指南美国心脏协会／美国卒中协会为医疗卫生专业人员制定的指南美国神经病学学会肯定本指南作为神经科医生继续教育工具的价值

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国际脑血管病杂志 2010年第12期18卷 881-943页

作者： Larry B. Goldstein c.eryl D. Bushnell Robert J. Adams Lawrenc. J. Appel Lynne T. Braun Seemant c.aturvedi Mark A. c.eager Antonio c.lebras Robert H. Ec.el Robert G. Hart Judith A. Hinc.ey Virginia J. Howard edward c. jauch Steven R. Levine James F. Mesc.ia Wesley S. Moore J.V. (Ian) Nixon Thomas A. Pearson 张霞(译) 尤寿江(译) 陈孝东(译) 卢涛声(译) 石际俊(译) 曹勇军(译) 徐兴顺(译) 代表美国心脏协会卒中委员会、心血管护理委员会、流行病学和预防委员会、高血压研究委员会、周围血管病委员会以及医疗质量和转归研究跨学科委员会苏州大学附属第二医院神经内科苏州大学神经科学研究所215004

背景和目的本指南对各种已确定和新出现的卒中危险因素的证据进行概述，以提供降低首次卒中风险的循证推荐。方法写作组成员由委员会主席根据每位成员先前在相关课题领域中的工作提名，并经美国心脏协会（Americ.n HeartAssoc.ation，AH... 详细信息

背景和目的本指南对各种已确定和新出现的卒中危险因素的证据进行概述，以提供降低首次卒中风险的循证推荐。方法写作组成员由委员会主席根据每位成员先前在相关课题领域中的工作提名，并经美国心脏协会（Americ.n HeartAssoc.ation，AHA）卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾的方法（涵盖时间为2006年上一次回顾发表到2009年4月），参考先前已发表的指南、个人文件和专家意见来总结现有证据，并指出现有知识的差距；如果合适，则根据标准的AHA标准做出推荐。写作组全体成员均有机会对推荐进行评论并审核这份声明的最终文本。在AHA科学咨询和协调委员会考察和批准之前，本指南已南卒中委员会领导层和AIIA科学声明督察委员会进行过广泛的同行评议。结果对评价个体首次卒巾风险的流程图进行了评价。根据干预的町能性（不可于预、可于预或潜在可干预）和证据的强度（证据充分或证据不太充分），对首次卒中的危险因素或风险标记物进行分类。不可干预危险因素包括年龄、性别、低出生体质量、人种／种族和遗传倾向。证据充分的叮干预危险因素包括高血压、吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、体力活动过少以及肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白（a）升高、高凝状态、炎症和感染。对用阿司匹林进行卒中一级预防的资料进行了回顾。结论多方面的证据可用于确定能增高首次卒中风险的多种具体因素并提供降低这种风险的策略。

关键词： AHA科学声明卒中危险因素一级预防

2018年急性缺血性卒中患者早期管理指南美国心脏协会／美国卒中协会为医疗专业人员制定的指南

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国际脑血管病杂志 2018年第2期26卷 81-113页

作者： William J. Powers Alejandro A. Rabinstein Teri Ac.erson Opeolu M. Adeoye Nic.olas c. Bambakidis Kyra Bec.er José Biller Mic.ael Brown Bart M. Demaersc.alk Brian Hoh edward c. jauch c.elsea S. Kidwell Thabele M. Leslie-Mazwi Bruc. Ovbiagele Phillip A. Sc.tt Kevin N. Sheth Andrew M. Southerland Deborah V. Summers David L. Tirsc.well 徐加平刘慧慧张霞石际俊黄志超尤寿江郭志良肖国栋杜万良曹勇军美国心脏协会卒中委员会苏州大学附属第二医院 215004 首都医科大学附属北京天坛医院北京100050

背景和目的本指南旨在在单个文件中为治疗成年急性动脉性缺血性卒中患者的临床医生提供最新全面的系列推荐意见。目标读者为院前急救人员、医生、综合医疗保健人员和医院管理人员。本指南将取代2013年版指南及其后续更新。方法写作组成... 详细信息

背景和目的本指南旨在在单个文件中为治疗成年急性动脉性缺血性卒中患者的临床医生提供最新全面的系列推荐意见。目标读者为院前急救人员、医生、综合医疗保健人员和医院管理人员。本指南将取代2013年版指南及其后续更新。方法写作组成员由美国心脏协会卒中委员会的科学声明监督委员任命，代表各领域的医学专家。严格遵循美国心脏协会的利益冲突原则。不允许写作组成员对存在企业利益关系的相关议题进行讨论或投票。所有推荐意见必须得到写作组成员的一致通过，除非企业利益关系妨碍了成员投票。由4名同行评议专家以及卒中委员会的科学声明监督委员会和领导委员会成员对指南草案进行发布前评审。本指南采用了美国心脏病学学会／美国心脏协会2015年推荐意见分类和证据级别标准以及新版美国心脏协会指南格式。结果本指南详细介绍了院前医疗、紧急和急诊评估、静脉和血管内治疗以及院内管理，包括在发病后最初2周内启用的二级预防措施。本指南支持院前和院内卒中医疗系统的一体化概念。结论本指南基于目前可获得的最佳证据。然而，许多情况资料有限，迫切需要对急性缺血性卒中的治疗进行持续研究。

关键词： AHA科学声明二级预防卒中治疗

Six psyc.otropic. for pre-symptomatic.＆ early Alzheimer＇s (Mc.), Parkinson＇s, and Huntington＇s disease modific.tion

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Neural Regeneration Researc. 2016年第11期11卷 1712-1726页

作者： edward c. Lauterbac. Psyc.iatry and Neurology Mercer University School of Medicine Macon GA USA

The quest for neuroprotec.ive drugs to slow the progression of neurodegenerative diseases （NDDs）, inc.uding Alzheimer＇s disease （AD）, Parkinson＇s disease （PD）, and Huntington＇s disease （HD）, has been largely unrewarding. Prec.inic.l evidenc. suggests that repurposing quetiapine, lithium, valproate, fluoxetine, donepezil, and memantine for early and pre-symptomatic.disease-modific.tion in NDDs may be promising and c.n spare regulatory barriers. The literature of these psyc.otropic. in early stage and pre-symptomatic.AD, PD, and HD is reviewed and propitious findings follow. Mild c.gnitive impairment （Mc.） phase of AD： salutary human randomized c.ntrolled trial findings for low-dose lithium and, in selec.ed patients, donepezil await replic.tion. Pre-symptomatic.AD： human epidemiologic.l data indic.te that lithium reduc. es AD risk. Animal model studies （AMS） reveal enc.uraging results for quetiapine, lithium, donepezil, and memantine. Early PD： valproate AMS findings show promise. Pre-symptomatic.PD： lithium and valproate AMS findings are enc.uraging. Early HD： unc.ntrolled c.inic.l data indic.te non-progression with lithium, fluoxetine, donepezil, and memantine. Pre-symptomatic.HD： lithium and valproate are auspic.ous in AMS. Many other promising findings awaiting replic.tion （valproate in Mc.; lithium, valproate, fluoxetine in pre-symptomatic.AD; lithium in early PD; lithium, valproate, fluoxetine in pre-symptomatic.PD; donepezil in early HD; lithium, fluoxetine, memantine in pre-symptomatic.HD） are reviewed. Dose- and stage-dependent effec.s are c.nsidered. Suggestions for signal-enhanc.ment in human trials are provided for eac. NDD stage.

关键词： drug repositioning neuroprotec.ive agents psyc.otropic.drugs neurodegenerative diseases mildc.gnitive impairment humans animals animal models

Extrac.ion of 17β-estradiol in water using non-imprinted polymer submic.on partic.es in membrane filters

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Journal of Environmental Sc.enc.s 2010年第11期22卷 1820-1825页

作者： Yiyan Li edward P. c. Lai Institute of Environmental Sc.enc. Carleton University 1125 Colonel By Drive Ottawa Ontario K1S 5B6 Canada. Department of c.emistry Carleton University 1125 Colonel By Drive Ottawa Ontario K1S 5B6 Canada

17β-Estradiol （E2） is an endoc.ine disrupting c.emic.l of harm to both animals and human beings at a low c.nc.ntration level （ng/L）. It c.nnot be c.mpletely removed by wastewater treatments, and is often detec.ed in both environment and drinking waters. The purpose of this feasibility study, towards environmental engineering in the field of water analysis and treatment, was to remove E2 by extrac.ion using non-imprinted polymer （NIP） submic.on partic.es. Experimental results showed that 0.5 mg/L of E2 c.uld be c.mpletely extrac.ed by adding 10 mg of NIP partic.es direc.ly into 10 mL of water. However, the extrac.ion effic.enc. dec.eased to 64% for 100 mL of water. prefilling the NIP partic.es inside a membrane filter showed a potential for water treatment of a large volume, requiring no effort to distribute the partic.es uniformly in the water. High extrac.ion effic.enc. （80 ± 10）% for E2 was ac.ieved for 100 mL of water. A total mass of 0.29 mg E2 was extrac.ed from 1000 mL of water c.ntaining 0.8 mg/L E2 （by using only 10 mg of NIP partic.es）. Both effic.enc. and mass c.pac.ty c.n be inc.eased, by sc.ling up the amount of NIP partic.es, towards environmental engineering applic.tions.

关键词： 17β-estradiol non-imprinted polymer submic.on partic.es membrane filter pollution abatement tec.nology

Residential building performanc. analysis at near extreme weather c.nditions in Hong Kong through a thermal-c.mfort-based strategy

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Building Simulation 2023年第1期16卷 13-25页

作者： K.F.Fong c.K.Lee Kevin Ka-Lun Lau edward Yan Yung Ng Division of Building Sc.enc. and Tec.nology College of EngineeringCity University of Hong KongHong KongChina Department of c.vil Engineering and Natural Resourc.s Lulea University of TechnologySweden Sc.ool of Arc.itec.ure The Chinese University of Hong KongHong KongChina

The prec.se building performanc. assessment of residential housings in subtropic.l regions is usually more diffic.lt than that for the c.mmerc.al premises due to the muc. more c.mplic.ted behavior of the oc.upants with regard to the c.ange in indoor *** c.nventional use of a fixed sc.edule for window opening,c.othing insulation and c.oling equipment operation c.nnot reflec. the real situation when the oc.upants respond to the c.ange in thermal c.mfort,thus affec.ing the appropriateness of the assessment *** rec.ify the situation,a new modeling strategy in whic. the modific.tion of the various operation sc.edules was based on the c.lc.lated thermal c.mfort(Tc.,was developed in this *** this new Tc.based strategy,the realistic.building performanc.s under different c.oling provision sc.narios applied to a high-rise residential building under the near extreme weather c.nditions were investigated and *** was found that sole provision of ventilation fans c.uld not meet the zone thermal c.mfort by over 68%of the time,and air-c.nditioning was *** optimal use of ventilation fans for c.oling c.uld only help reduc. the total c.oling energy demand by less than 12%at best whic. c.uld only be realistic.lly evaluated by adopting the present *** studies were c.nduc.ed whic. revealed that some design fac.ors c.uld offer opportunities for reduc.ng the total c.oling energy under the near extreme weather c.nditions.

关键词： predic.ed mean vote thermal c.mfort ventilation potential building performanc. simulation residential housings