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The technique of utilizing a single gracilis functional muscle transfer to restore quadriceps function following sarcoma surgery

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Plastic and Aesthetic Research 2019年第12期6卷 37-46页

作者： Christopher M.Nguyen Imran Ratanshi jennifer L.Giuffre edward w.buchel.thomas e.j.hayakawa Section of Plastic Surgery Department of SurgeryUniversity of ManitobaWinnipeg R3A 1R9Canada The Plastic Surgery Group Fraser Health AuthoritySurreyBritish Columbia V3V 1Z2Canada

Aim:Quadriceps strength and knee extension,the most important factors limiting the ability to rise from a chair,are crucial for walking at an appropriate speed,ascending and descending stairs,and performing activities such as running,dancing,and *** of the anterior compartment of the thigh,including all four quadriceps muscles,for the treatment of a sarcoma is uncommon;however,when necessary,it is very debilitating and adversely affects a patient's quality of life without functional ***,there are a limited number of complex and difficult reconstructions to restore quadriceps function that have been described with variable *** describe a simple technique that employs a single gracilis functional muscle transfer to replace essential quadriceps ***:This is a case series describing the use of either a free or pedicled single gracilis muscle to restore quadriceps function following sarcoma ***:Four patients underwent an anterior compartment sarcoma resection that resulted in a large segmental defect and/or denervation of all four quadriceps muscles such that no quadriceps function would remain without *** four patients underwent a functional reconstruction using a single *** of the living patients achieved British Medical Research Counsel Grade 4 strength,can achieve full knee extension,are able to navigate stairs,and are able to ambulate without a *** fourth patient unfortunately was deceased in under three months following his tumor ***:Despite its small size in comparison to the quadriceps muscles,with physiotherapy and training,the gracilis muscle demonstrates the capacity to hypertrophy and replace quadriceps function following limb salvage surgery.

关键词： Knee extension re-animation functional muscle transfer free flap pedicled flap sarcoma microsurgery quadriceps reconstruction

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Power-Sharing enhancement Using Harmonized Membership Fuzzy Logic Droop Control Based Micro-Grid

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Intelligent Automation & Soft Computing 2023年第5期36卷 1395-1415页

作者： w.j.Praiselin j.Belwin edward School of electrical engineering Vellore Institute of TechnologyVellore632014TamilnaduIndia

The contribution of Renewable energy Resources(ReR)in the process of power generation is signiﬁcantly high in the recent days since it paves the way for overcoming the issues like serious energy crisis and natural *** paper deals with the renewable energy based micro-grid as it is regarded as the apt solution for integrating the ReR with the electrical *** theﬁxed droop coefﬁcients in conventional droop control approaches have caused various limitations like low power-sharing and sudden drops of grid voltage in the Direct Current(DC)side,the Harmonized Membership Fuzzy Logic(MFL)droop control is employed in this present *** proposed droop control for the hybrid PV-wind-battery system with MFL assists in achieving proper power-sharing and minimizing Total Harmonic Distortion(THD)in the emer-gency *** eradicates the deviations in voltage and frequency with itsﬂexible and robust *** THD is reduced and attains the value of 3.1%compared to the traditional droop *** simulation results of harmo-nized MFL droop control are analogized with the conventional approaches to vali-date the performance of the proposed *** addition,the experimental results provided by the Field Programmable Gate Array(FPGA)based laboratory setup built using a solar photovoltaic(PV)and wind Permanent Magnet Synchro-nous Generator(PMSG)reafﬁrms the design.

关键词： Micro-grid harmonized droop control fuzzy power-sharing total harmonic distortion

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The impact of macroalgae on mean and turbulent flow fields

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journal of Hydrodynamics 2015年第3期27卷 427-435页

作者： thomas Robert e. MCLeLLAND Stuart j. Department of Geography Environment and Earth Sciences University of Hull

In this paper, we attempt to quantify the mean and turbulent flow fields around live macroalgae within a tidal inlet in Norway. Two Laminaria digitata specimens - 0.50 m apart were selected for detailed study and a profiling ADV was used to collect 45 velocity profiles, each composed of up to seven 0.035 m-high profiles collected for 240 s at 100 Hz, at a streamwise spacing of 0.25 m and cross-stream spacing of 0.20 m. To quantify the impact of the macroalgae, measurements were repeated over a sparser grid after the region had been completely cleared of algae and major roughness elements.

关键词： dealiasing laminaria digitata turbulence vectrino profiler velocity profile

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ensemble learning framework for landslide susceptibility mapping:Different basic classifier and ensemble strategy

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Geoscience Frontiers 2023年第6期14卷 170-190页

作者： Taorui Zeng Liyang wu Dario Peduto thomas Glade Yuichi S.hayakawa Kunlong Yin Institute of Geological Survey China University of GeosciencesWuhan 430074China eNGAGe—Geomorphic Systems and Risk Research Department of Geography and Regional ResearchUniversity of Vienna1010 ViennaAustria Faculty of engineering China University of GeosciencesWuhanChina Department of Civil engineering University of Salerno84084 SalernoFiscianoItaly Faculty of environmental earth Science Hokkaido UniversityHokkaido 060-0810Japan

The application of ensemble learning models has been continuously improved in recent landslide susceptibility research,but most studies have no unified ensemble ***,few papers have discussed the applicability of the ensemble learning model in landslide susceptibility mapping at the township *** study aims at defining a robust ensemble framework that can become the benchmark method for future research dealing with the comparison of different ensemble *** this purpose,the present work focuses on three different basic classifiers:decision tree(DT),support vector machine(SVM),and multi-layer perceptron neural network model(MLPNN)and two homogeneous ensemble models such as random forest(RF)and extreme gradient boosting(XGBoost).The hierarchical construction of deep ensemble relied on two leading ensemble technologies(i.e.,homogeneous/heterogeneous model ensemble and bagging,boosting,stacking ensemble strategy)to provide a more accurate and effective spatial probability of landslide *** selected study area is Dazhou town,located in the jurassic red-strata area in the Three Gorges Reservoir Area of China,which is a strategic economic area currently characterized by widespread landslide *** on a long-term field investigation,the inventory counting thirty-three slow-moving landslide polygons was *** results show that the ensemble models do not necessarily perform better;for instance,the Bagging based DT-SVM-MLPNNXGBoost model performed worse than the single XGBoost *** the eleven tested models,the Stacking based RF-XGBoost model,which is a homogeneous model based on bagging,boosting,and stacking ensemble,showed the highest capability of predicting the landslide-affected ***,the factor behaviors of DT,SVM,MLPNN,RF and XGBoost models reflected the characteristics of slow-moving landslides in the Three Gorges reservoir area,wherein unfavorable lithological conditions and intense human engineering activitie

关键词： Three Gorges Reservoir Area Landslide susceptibility mapping ensemble learning framework Uncertainty research

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The impact of iodinated X-ray contrast agents on formation and toxicity of disinfection by-products in drinking water

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journal of environmental Sciences 2017年第8期29卷 173-182页

作者： Clara H.jeong edward j.Machek Morteza Shakeri Stephen e.Duirk thomas A.Ternes Susan D.Richardson elizabeth D.wagner Michael j.Plewa Molecular and environmental Toxicology Center School of Medicine and Public Health University of Wisconsin-Madison Madison WI USA Department of Civil engineering University of Akron Akron OH USA Department of water Chemistry Federal Institute of Hydrology Koblenz Germany Department of Chemistry and Biochemistry University of South Carolina Columbia SC USA Department of Crop Sciences and the Safe Global water Institute University of Illinois at Urbana-Champaign Urbana IL USA

The presence of iodinated X-ray contrast media（ICM） in source waters is of high concern to public health because of their potential to generate highly toxic disinfection by-products（DBPs）. The objective of this study was to determine the impact of ICM in source waters and the type of disinfectant on the overall toxicity of DBP mixtures and to determine which ICM and reaction conditions give rise to toxic by-products. Source waters collected from Akron,OH were treated with five different ICMs, including iopamidol, iopromide, iohexol,diatrizoate and iomeprol, with or without chlorine or chloramine disinfection. The reaction product mixtures were concentrated with XAD resins and the mammalian cell cytotoxicity and genotoxicity of the reaction mixture concentrates was measured. water containing iopamidol generated an enhanced level of mammalian cell cytotoxicity and genotoxicity after disinfection. while chlorine disinfection with iopamidol resulted in the highest cytotoxicity overall, the relative iopamidol-mediated increase in toxicity was greater when chloramine was used as the disinfectant compared with chlorine. Four other ICMs（iopromide, iohexol, diatrizoate, and iomeprol） expressed some cytotoxicity over the control without any disinfection, and induced higher cytotoxicity when chlorinated. Only iohexol enhanced genotoxicity compared to the chlorinated source water.

关键词： Disinfection by-products Iodo-DBPs Iodinated X-ray contrast media

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IKKi: a novel regulator of Act1, IL-17 signaling and pulmonary inflammation

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Cellular & Molecular Immunology 2011年第6期8卷 447-449页

作者： Noula Shembade edward w Harhaj Department of Microbiology and Immunology Sylvester Comprehensive Cancer CenterThe University of MiamiMiller School of MedicineMiamiFLUSA

TH17 inflammatory helper cells constitute an important subset of T lymphocytes that secrete the cytokine interleukin 17(IL-17)and thereby drive inflammation in response to microbial *** of TH17 cells,characterized by increased IL-17 production,is a hallmark of many inflammatory and autoimmune diseases such as asthma,multiple sclerosis and rheumatoid arthritis.1 The adaptor molecule and e3 ubiquitin ligase Act1 is a key signaling molecule downstream of the IL-17 receptor(IL-17R)that triggers activation of the NF-kB and mitogen-activated protein kinase(MAPK)signaling pathways,which in turn coordinate the induction of cytokine and chemokine genes that are central to the inflammatory response.2 However,the details of IL-17 signaling and precisely how Act1 is regulated have been poorly *** a recent issue of Nature Immunology,Bulek et *** identified the kinase I kappa B kinase i(IKKi,also known as IKKe)as a critical regulator of Act1 and IL-17 signaling.

关键词： Act1 inflammation cytokine

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Understanding Contaminant Veins in Squeeze Casting and Semi-solid Metalworking Processes

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特种铸造及有色合金 2003年第Z1期23卷 230-234,238页

作者： edward j. Vinarcik, P.e. engineer Voctorie Co.8218 Medicine Bow Run Fort WayreIdiana 46825 U.S A

when commercializing the semi-solid metalworking processes, component producers looked to conventional die-casting to identify potential defects and control component quality. Several defects were expected including cold shuts, cold flows, flash, drags, warping, and gas entrapment, just to name a few. efforts were taken to avoid these defects. A new defect type, contaminant veins, has surfaced unique to semi-solid metalworking. Although, semi-solid metalworking has proven to be successful, component producers have been reluctant to report defects for fear of giving this emerging processes a bad reputation. Nonetheless, this defect must be understood to avoid future problems.

关键词： Contaminant Veins Squeeze Casting Semi-solid Casting

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The Behaviour of LNG Carrier Moored to a jetty exposed to waves,Swell,Unsteady wind and Current

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China Ocean engineering 1999年第1期14卷 81-92页

作者： j. e. w. wICHeRS Maritime Research Institute Netherlands

Most terminals for tankers are piers and sea islands, while other types include single point moorings and multiple-buoy moorings. The LNG and LPG carrier moored to the jetty is a very common terminal for transfer of gas in open seas. It is important to estimate the motions and line tensions of the LNG carrier when it moors to a jetty in metocean environment. Normally, the motions of the LNG carrier would be restricted by the loading arm, which is connected to LNG carrier's manifold. An example of 125,000 m(3) LNG carrier moored to a jetty exposed to a set of environment conditions is given. A mathematical model which is based on the equations of motion in the time domain is used to the analysis of LNG moored to an offshore jetty exposed to waves, swell, wind and current. By means of a time domain computer program TeRMSIM computations are carried out to determine and optimize the lay-out and / or orientation of the jetty and mooring gear in terms of forces in mooring lines and fenders and the envelope of motions of the loading arms. The purpose of this study is to determine the sensitivity of the mooring system and carrier motions to the combinations of wind waves with and without swell, steady wind and wind spectra. The results can be consulted by the designer in the design of jetties.

关键词： mooring system dynamic response time domain analysis jetty

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Advances in shape measurement in the digital world

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Particuology 2016年第3期14卷 19-31页

作者： Xiaodong jia edward j. Garboczi School of Chemical and Process engineering University of Leeds Leeds IS2 9JT. UK Material Measurement Laboratory National Institute of Standards and Technology Boulder CO 80305. USA

The importance of particle shape in terms of its effects on the behaviour of powders and other particulate systems has long been recognised, but particle shape information has been rather difficult to obtain and use until fairly recently, unlike its better-known counterpart, particle size. However, advances in computing power and 3D image acquisition and analysis techniques have resulted in major progress being made in the measurement, description and application of particle shape information in recent years. Because we are now in a digital era, it is fitting that many of these advanced techniques are based on digital technology. This review article aims to trace the development of these new techniques, highlight their contributions to both academic and practical applications, and present a perspective for future developments.

关键词： Particle shape Digital methods Shape measurement Spherical harmonics X-ray tomography

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