检索结果-南通市图书馆

抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)

在线全文

学校读者我要写书评

暂无评论

环境与职业医学 2014年第2期31卷 151-157页

作者： Nicholas j.Ashbolt Alej.ndro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anj. Coors Rita Finley William H.Gaze Thomas Heberer j.hn R.Lawrence D.G.j.akim Larsson Scott A.McEwen j.mes j.Ryan j.ns Schnfeld Peter Silley j.son R.Snape Christel Van den Eede edward Topp 王晓宇张伊人操仪 U.S.Environmental Protection Agency Office of Research and Development Unilever-Safety and Environmental Assurance Centre Department of Biological and Environmental Sciences Gothenburg University Veterinary Medicines Directorate Department of Plant and Environmental Sciences University of Copenhagen The Canberra Hospital and Canberra Clinical School Australian National University ECT Oekotoxikologie GmbH Fl?rsheim/Main Public Health Agency of Canada European Centre for Environment and Human Health Exeter University Medical School Knowledge Spa Royal Cornwall Hospital Federal Office of Consumer Protection and Food Safety Department 3: Veterinary Drugs Environment Canada Saskatoon Institute for Biomedicine The Sahlgrenska Academy University of Gothenburg Department of Population Medicine University of Guelph Environment Health and Safety GlaxoSmithKline Umweltbundesamt Federal Environment Agency MB Consult Limited Southampton University of Bradford Brixham Environmental Laboratory Pfizer Animal Health VMRD Agriculture and Agri-Food Canada London Ontario Canada

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性... 详细信息

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生"热点区域"的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的"热点区域"中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。

关键词：抗生素耐药性健康风险评估环境评估人类健康基因转移剂量反应决策分析方法耐药性细菌

在线全文

学校读者我要写书评

暂无评论

老年人尿失禁的流行病学和病因学

德国医学 1999年第6期16卷 330-332页

作者： edward j.McGuire Martin Resnick S.V.Yalla Ruth Kirschner-Hermanns Enrique Broseta Cath McGrother Christa Müller Annette Welz-Barth G.Ch.Fischer j.hann Mattelaer 李小刚 Division of Urology UT Houston Medical School6431 Fannin Suite 6018Houston Texas 77030 USA 湖北省荆州市第一人民医院

尿失禁是老年人的一个普遍问题。22%～34%的妇女声称患过尿失禁。其患病率随尿失禁程度和询问方式不同而变化很大。65岁以上妇女按尿失禁保守定义即常见的尿失禁或按限制定义即压迫性尿失禁,其患病率为10%～30%。这一患病率在长期疗养... 详细信息

尿失禁是老年人的一个普遍问题。22%～34%的妇女声称患过尿失禁。其患病率随尿失禁程度和询问方式不同而变化很大。65岁以上妇女按尿失禁保守定义即常见的尿失禁或按限制定义即压迫性尿失禁,其患病率为10%～30%。这一患病率在长期疗养院内还要高且随被检人群的年龄上升而增高。男性发病率为25%或低于妇女。

关键词：老年人尿失禁流行病学病因学

Transcriptomic analyses of localized prostate cancers of East Asian and North American men reveal race-specific luminal-basal and microenvironmental differences

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2023年第10期43卷 1164-1168页

作者： Melvin L.K.Chua Alexander K.Hakansson Enya H.W.Ong Boon Hao Hong j.ng j.ng Miao Adelene Y.L.Sim j.nice S.H.Tan Kah Min Tan Gabrielle C.j.Lee Kar Perng Low j.ffrey K.L.Tuan Terence W.K.Tan Michael L.C.Wang j.e P.S.Yeong Michael C.S.Tan Lui Shiong Lee Ravindran Kanesvaran Xin Zhao j.lian Ho Daniel E.Spratt edward M.Schaeffer Kae-j.ck Tay Yang Liu Elai Davicioni Li Yan Khor Division of Radiation Oncology National Cancer Centre SingaporeSingaporeSingapore Duke-NUS Medical School SingaporeSingapore Division of Medical Sciences National Cancer Centre SingaporeSingaporeSingapore Veracyte IncSan DiegoCAUSA Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdongP.R.China Faculty of Medicine Nursing and Health SciencesMonash UniversityVictoriaAustralia Department of Anatomical Pathology Singapore General HospitalSingaporeSingapore Department of Pathology Changi General HospitalSingaporeSingapore Department of Urology Sengkang General HospitalSingaporeSingapore Division of Medical Oncology National Cancer Centre SingaporeSingaporeSingapore Department of Radiation Oncology University Hospitals Seidman Cancer CenterCase Comprehensive Cancer CenterClevelandOHUSA Department of Urology Northwestern University Feinberg School of MedicineChicagoILUSA Department of Urology Singapore General HospitalSingaporeSingapore

Dear editor,Prostate cancer(PCa)remains a maj.r healthcare burden in men globally[1].Most patients present with localized disease,and treatment is recommended based on risk classification systems like the National Comprehensive Cancer Network(NCCN)[2].However,these methods are imprecise for estimating metastasis-free survival and prostate cancer-specific mortality and thus biomarkers that can predict tumor aggression are needed[3–5].Several studies have since characterized the molecular landscape of localized PCa in White[4,5]and Black/African-American men[6],but data is lacking in Asian *** Chinese Prostate Cancer Genome and Epigenome Atlas(CPGEA)reported on the genomic and epigenomic landscape of 208 PCa of men from China[7].Comparative analyses between the CPGEA cohort and data from The Cancer Genome Atlas(TCGA)revealed higher frequencies of Forkhead box A1(FOXA1)and chromodomain-helicase DNA-binding 1(CHD1)mutations,and lower frequencies of phosphatase and tensin homolog(PTEN)mutations and transmembrane protease serine 2-E26 transformationspecific related gene(TMPRSS2-ERG)fusion in Chinese compared with White men[7].These preliminary findings highlight the presence of race-specific differences in molecular phenotypes of PCa.

关键词： landscape Atlas editor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

七氟醚抑制脑干吸气前运动神经元的作用机制

国外医学（麻醉学与复苏分册） 2005年第4期26卷 249-252页

作者： Astrid G.Stucke edward j.Zuperku Viseslav Tonkovic-Capin Mirko Krolo Francis A.Hopp j.hn P.Kampine Eckehard A.E.Stuth Zhongcong Xie 许鹏程曾因明 Research Fellow in Anesthesiology Associate Professor of Anesthesiology Research Professor of Anesthesiology Associate Professor of Anesthesiology Biomedical Engineer Associate Professor of Anesthesiology Professor and Chairman of Anesthesiology Associate Professor of Anesthesiology 哈佛大学麻省总医院江苏省麻醉学重点实验室

研究背景:位于延髓尾部腹侧髓质的神经元是与吸气相关的前运动神经元,它们是支配呼吸肌如膈肌、肋间外肌、肋间内肌等运动神经元的上一级神经元.这些神经元的兴奋状态由NMDA受体,AM-PA受体调控,也受抑制性AGBAA能神经调节.作者在去大脑... 详细信息

研究背景:位于延髓尾部腹侧髓质的神经元是与吸气相关的前运动神经元,它们是支配呼吸肌如膈肌、肋间外肌、肋间内肌等运动神经元的上一级神经元.这些神经元的兴奋状态由NMDA受体,AM-PA受体调控,也受抑制性AGBAA能神经调节.作者在去大脑狗的模型上探讨七氟醚对这些突触机制的影响。

关键词：前运动神经元七氟醚脑干 NMDA受体兴奋状态 PA受体神经调节突触机制膈肌

在线全文

学校读者我要写书评

暂无评论

留给子孙的理财经

大众理财顾问 2010年第7期 92-92页

作者： edward j.Ledford 康会欣

有一天醒来，我们会发现和父辈的共同之处比想像得要多得多，一个典型的实例就是有着相似的理财生命周期。学会如何理财，更重要的是什么时候开始理财，将对我们及家人产生深远影响。在理财生命周期的前期阶段，可以虚心学习和采取积极... 详细信息

有一天醒来，我们会发现和父辈的共同之处比想像得要多得多，一个典型的实例就是有着相似的理财生命周期。学会如何理财，更重要的是什么时候开始理财，将对我们及家人产生深远影响。在理财生命周期的前期阶段，可以虚心学习和采取积极主动的行动。

关键词：财经生命周期积极主动理财

Adaptivity and A Posteriori Error Control for Bifurcation Problems Ⅰ:The Bratu Problem

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Communications in Computational Physics 2010年第9期8卷 845-865页

作者： K.Andrew Cliffe edward j.C.Hall Paul Houston Eric T.Phipps Andrew G.Salinger School of Mathematical Sciences University of NottinghamUniversity ParkNottingham NG72RDUK Computer Science Research Institute Sandia National LaboratoriesAlbuquerqueNew MexicoUSA

This article is concerned with the numerical detection of bifurcation points of nonlinear partial differential equations as some parameter of interest is *** particular,we study in detail the numerical approximation of the Bratu problem,based on exploiting the symmetric version of the interior penalty discontinuous Galerkin finite element method.A framework for a posteriori control of the discretization error in the computed critical parameter value is developed based upon the application of the dual weighted residual(DWR)*** experiments are presented to highlight the practical performance of the proposed a posteriori error estimator.

关键词： Bifurcation theory Bratu problem a posteriori error estimation adaptivity discontinuous Galerkin methods

Muscarinic stimulation rescues β1-adrenergic response in transgenic mouse heart overexpressing β2-adrenoceptor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

郑州大学学报(医学版) 2000年第1期35卷 18-27页

作者： ZHANG Shengj.n 1) ,CHENG Heping 1) ,ZHOU Yingying 1) ,WANG Dingj. 1) ,Bruce Ziman 1) ,Harold Spurgoen 1) , Robert j.Lefkowitz 2) ,edward G.Lakatta 1) ,Walter j.Koch 3) ,XIAO Ruiping 1) 1)Laboratory of Cardiovascular Sciences,Gerontology Research Center,National Institute on Aging,Baltimore,Maryland 21224 2)Dept.of Medicine and Howard Hughes Medical Institute,Duke University Medical Center,Durham,NC 3)Dept.of Surgeon,Duke University Medical Center,Durham,NC

Cardiac specific overexpression of human β 2 adrenergic receptor (β 2 AR) in transgenic mice (TG4) enhances the basal cardiac function due to a ligand independent,spontaneous β 2 AR ***,agonist mediated stimulation of either β 1 AR or β 2 AR fails to induce contractile response in this transgenic *** the unresponsiveness of β 2 AR has been attributed to an efficient coupling of the receptor to pertussis toxin (PTX) sensitive G proteins (G i),mechanisms underlying the loss of β 1 AR response is *** the present study,we demonstrated that,unlike β 2 AR,β 1 AR contractile response was not restored by PTX treatment,although G i protein abundance was significantly elevated in TG4 relative to non transgenic ***,the loss of β 1 AR function was not attributable to β adrenergic receptor kinase (βARK) mediated receptor desensitization,as evidenced by the unaltered βARK1 activity in TG4 *** contrast,preincubation of cells with a muscarinic receptor agonist,carbachol (CCh),or a β 2 AR inverse agonist,ICI 118,551 (ICI),largely restored the contractile response to β 1 AR stimulation by norepinephrine plus an α 1 adrenergic antagonist,*** cases were associated with a significant reduction in the baseline cAMP accumulation and contractility,and the rescued β 1 AR positive inotropic effect was completely reversed by a β 1 AR antagonist,CGP ***,we conclude that overexpression of β 2 AR in the moure heart causes a loss of β 1 AR contractile response,likely through a cAMP/protein kinase A(PKA) dependent heterologous receptor desensitization,independent of G i protein or β*** of the spontaneous β 2 AR activation by either muscarinic stimulation or the β 2 AR inverse agonist ICI can resensitize the β 1 AR contractile respinse in TG4 ventricular myocytes.

关键词： β-adrenergic receptor subtypes muscarinic receptor receptor desensitization β-adrenergic receptor kinases inhibitory G proteins cardiac myocytes

Rapid Airfoil Design for Uncooled High Pressure Turbine Blades

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

j.urnal of Environmental Science and Engineering(B) 2018年第5期7卷 193-208页

作者： Niloofar Moradi edward Vlasic Hany Moustapha Francois Garnier Turbine Design Department Pratt and Whitney Canada (P&WC) Longueuil (Québec) J4G1A1 Canada Mechanical Engineering Department Engineering School (ETS) University of Quebec Montréal (Québec) H3C1K3 Canada

The aero-engine design process is highly iterative,multidisciplinary in nature and *** success of any engine design depends on best exploiting and considering the interactions among the numerous traditional engineering disciplines such as aerodynamics and *** emphasis has been placed lately on system integration,cross disciplines leveraging of tools and multi-disciplinary-optimization at the preliminary design *** paper investigates the automation of the airfoil generation process,referred to as Rapid Airfoil3D(RAF-3D),for uncooled high pressure turbine blades at the preliminary design *** approach uses the TAML(Turbine Aero Mean Line)program in parallel with a database of previously designed P&WC airfoils,in-house design rules and best practices to define a pre-detailed airfoil shape which can be fed back to other analytical groups for pre-detail analyses,such as for structural integrity and *** airfoil shapes have been aerodynamically validated using an in-house three dimensional Reynolds averaged Navier-Stokes ***-3D will shorten the turnaround time for Pratt&Whitney turbine aerodynamics group to provide a preliminary3D airfoil shape to turbine structures group by up to a factor of ***,the preliminary assessments of stress and vibration specialists will be more accurate as their assessments will be based on an airfoil that has had inputs from all functional groups even though it is"first pass"design.

关键词： Optimization turbine blade preliminary design CFD(Computational Fluid Dynamics)

手术前口服普瑞巴林用于缓解妇科小手术术后疼痛的随机安慰剂对照实验

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

麻醉与镇痛 2008年第5期4卷 49-53页

作者： Michael j. Paech Raymond Goy Sebastian Chua Karen Scott Tracey Christmas Dorota A. Doherty 彭宇(译) 蒋宗滨(校) Pharmacology and Anaesthesiology Unit School of Medicine and Pharmacology The University of Western Australia Department of Anaesthesia and Pain Medicine King Edward Memorial Hospital for Women Research Design and Biostatistics Unit Women and Infants Research Foundation Perth Western Australia Australia 不详

背景尽管普瑞巴林能有效治疗神经病理性疼痛，但是否能有效控制手术后疼痛仍证据不足。我们的研究目的是调查分析普瑞巴林对发生急性内脏痛的日间手术患者的镇痛效果。假设是普瑞巴林和安慰剂的镇痛效果差异无显著性。方法对90例行子宫... 详细信息

背景尽管普瑞巴林能有效治疗神经病理性疼痛，但是否能有效控制手术后疼痛仍证据不足。我们的研究目的是调查分析普瑞巴林对发生急性内脏痛的日间手术患者的镇痛效果。假设是普瑞巴林和安慰剂的镇痛效果差异无显著性。方法对90例行子宫手术的妇科小手术妇女进行随机双盲平行安慰剂对照试验。患者在手术前约1小时口服普瑞巴林100mg（PG组）或安慰剂（C组）。观察结果是患者在恢复室和手术后24小时的疼痛评分。结果两组患者在恢复室的疼痛评分（PG组的中位数、四分位间距分别为16和0～36；C组中位数、四分位间距分别为10和6．5—36，P=0．80）和此后所经历的疼痛差异无显著性；两组患者恢复室内芬太尼用量（PG组为42％，C组为27％，P=0．12）或手术后24小时恢复质量（PG组和c组的中位数、四分位间距分别为17、17—18小时和18、16．5～18，P=O．75）差异也无显著性。出院后轻度头晕、视觉障碍和行走困难的发生率普瑞巴林组明显高于安慰剂组。结论只进行单纯子宫操作的妇科小手术患者，手术前服用单次剂量普瑞巴林100mg不能减轻其手术后急性疼痛以及改善其恢复质量。

关键词：手术后疼痛随机安慰剂妇科小手术普瑞巴林术前口服对照实验神经病理性疼痛缓解