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Short te.m safe.y of coronavirus dise.se.2019 vaccine. in patie.ts with solid tumors re.e.ving syste.ic the.apy

World Journal of Clinical Oncology 2022年第7期13卷 599-608页

作者： Ronald e.Cox Marie.Parish Carolyn Oxe.cis edward Mcke.na Bicky Thapa Sakti Chakrabarti Stude.t Medical College of WisconsinWauwatosaWI 53222United States Pharmacy Froedtert&the Medical College of WisconsinWauwatosaWI 53222United States De.artme.t of He.atology and Oncology Medical College of WisconsinWauwatosaWI 53222United States

BACKGROUND The.e.are.curre.tly thre. coronavirus dise.se.2019(COVID-19)vaccine. approve. by the.Unite. State. Food and Drug Administration to pre.e.t coronavirus ***,robust data are.unavailable.on the.adve.se.e.e.ts of the.vaccine. in patie.ts with solid tumor malignancie. unde.going syste.ic *** To e.aluate.the.safe.y of COVID-19 vaccine. in patie.ts with solid tumors unde.going syste.ic *** The.study include. patie.ts with solid tumors tre.te. in an acade.ic te.tiary care.ce.te. who re.e.ve. COVID-19 vaccination be.we.n January 1,2021 and August 15,2021,while.unde.going syste.ic *** me.ical re.ords we.e.acce.se. to colle.t information on patie.t characte.istics,syste.ic the.apie.,type.of vaccine.re.e.ve.,and adve.se.e.fe.ts associate. with the.vaccine.*** e.e.ts(Ae.)we.e.grade. according to Common Te.minology Crite.ia for Adve.se.e.e.ts,ve.sion *** The.analysis include. 210 patie.ts;the.me.ian age.was 70 ye.rs,and 51%of patie.ts we.e.*** most common che.othe.apy,immunothe.apy,and targe.e. the.apy administe.e. we.e.taxane.base. re.ime.s 14.2%(30/210),antiprogramme. de.th 1(PD-1)age.ts 22.8%(48/210),and antiangioge.ic age.ts 7.1%(15/210),*** most common cance.s we.e.gastrointe.tinal 43.8%(92/210),thoracic 30.4%(64/210),and ge.itourinary 17.6%(37/210).Patie.ts re.e.ve. the.following vaccine.:2 dose. of BNT162b2 by Pfize. 52%(110/210),2 dose. of mRNA-1273 by Mode.na 42%(89/210),and 1 dose.of JNJ-78436735 by Johnson&Johnson 5%(11/210).At le.st 1 Ae.attributable.to the.vaccine.was obse.ve. in 37 patie.ts 17.6%(37/210).The.total numbe. of Ae. attributable.to vaccine. was 62:Fifty-thre. grade.1 and nine.grade.*** adve.se.e.e.ts occurre. afte. the.se.ond dose.59.7%(37/62).The.most fre.ue.t grade.1 Ae. include. fatigue.17%(9/53),fe.e. 15%(8/53),inje.tion site.re.ction 13.2%(7/53),and chills 9.4%(5/53).The.most fre.ue.t grade.2 Ae. we.e.fatigue.33.3%(3/9)and ge.e.alize. we.

关键词： COVID-19 Adve.se.e.e.ts Solid tumor Che.othe.apy Immunothe.apy Targe.e. the.apy

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Tre.tme.t of hypogonadotropic male.hypogonadism: Case.base. sce.arios

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World Journal of Ne.hrology 2015年第2期4卷 245-253页

作者： Lindse. e.Crosnoe.Shiple. Osama O e.ke.any Cyrus D Rahne.a edward D Kim De.artme.t of Surge.y Division of UrologyUniversity of Tennessee Graduate School of Medicine De.artme.t of Surge.y Division of UrologyUniversity of Tennessee Graduate School of Medicine

The.aim of this study is to re.ie. four case.base. sce.arios re.arding the.tre.tme.t of symptomatic hypogonadism in me.. The.article.is de.igne. as a re.ie. of publishe. lite.ature. We.conducte. a PubMe. lite.ature.se.rch for the.time.pe.iod of 1989-2014, conce.trating on 26 studie. inve.tigating the.e.fcacy of various the.ape.tic options on se.e. analysis, pre.nancy outcome., time.to re.ove.y of spe.matoge.e.is, as we.l as se.um and intrate.ticular te.toste.one.le.e.s. Our re.ults de.onstrate. thate.oge.ous te.toste.one.suppre.se. intrate.ticular te.toste.one.production, which is an absolute.pre.e.uisite.for normal spe.matoge.e.is. Ce.sation of e.oge.ous te.toste.one.should be.re.omme.de. for me. de.iring to maintain the.r fe.tility. The.apie. that prote.t the.te.tis involve.human chorionic gonadotropin （hCG） the.apy or se.e.tive.e.troge. re.e.tor modulators （Se.Ms）, but may also include.low dose.hCG with e.oge.ous te.toste.one. Off-labe. use.of Se.Ms, such as clomiphe.e.citrate. are.e.fe.tive.for maintaining te.toste.one.production long-te.m and offe. the.conve.ie.ce.of re.re.e.ting a safe. oral the.apy. At pre.e.t, routine.use.of aromatase.inhibitors is not re.omme.de. base. on a lack of long-te.m data. We.conclude. that e.oge.ous te.toste.one.supple.e.tation de.re.se. spe.m production. It was de.e.mine. that clomiphe.e.citrate.is a safe.and e.fe.tive.the.apy for me. who de.ire.to maintain fe.tility. Although le.s fre.ue.tly use. in the.ge.e.al population, hCG the.apy with or without te.toste.one.supple.e.tation re.re.e.ts an alte.native.tre.tme.t.

关键词： Hypogonadism Se.e.tive.e.troge. re.e.tor modulator Male.fe.tility Clomiphe.e Human chorionic gonadotropin

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Chambe. Size.e.fe.ts on Me.hane.e.issions from Rice.Production

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Ope. Journal of Soil Scie.ce 2015年第10期5卷 227-235页

作者： Alde. D. Smartt Kristofor R. Brye.Christophe. W. Roge.s Richard J. Norman edward e. Gbur Jarrod T. Hardke.Tre.t L. Robe.ts De.artme.t of Crop Soil and Environmental Sciences University of Arkansas Fayetteville USA De.artme.t of Plant Soil and Entomological Sciences University of Idaho Aberdeen USA Agricultural Statistics Laboratory University of Arkansas Fayetteville USA De.artme.t of Crop Soil and Environmental Sciences University of Arkansas Stuttgart USA

Quantifying me.hane.(CH4) e.issions from cultivate. rice.(Oryza sativa L.) production in the.fie.d has re.e.ve. incre.se. atte.tion re.e.tly due.to me.hane.s importance.as a gre.nhouse.gas. The.e.close.-he.dspace.chambe. te.hnique.is the.standard me.hodology for fie.d asse.sme.ts of trace.gas e.issions. Howe.e., to our knowle.ge. no dire.t comparisons of me.sure. CH4 fluxe. and e.issions from fie.d-grown rice.among diffe.ing chambe. size. have.be.n re.orte.. The.e.ore. the.obje.tive.of this study was to e.aluate.the.e.fe.t of chambe. size.[15.2- and 30.4-cm inside.diame.e. (id)] on CH4 fluxe. and se.son-long e.issions from rice.grown on a clay soil in Arkansas. Chambe. size.did not affe.t (P > 0.05) CH4 fluxe. on 10 sampling date. during the.floode. portion of the.rice.growing se.son and only affe.te. fluxe. on one.of four sampling date. afte. flood re.e.se. Total se.son-long CH4 e.issions from optimally N-fe.tilize. rice.we.e.32.6 and 35.6 kg CH4-C haǃ·se.sonǃ, which did not diffe., and from bare.clay soil we.e.0.74 and 1.75 kg CH4-C haǃ·se.sonǃ, which also did not diffe., from the.15.2- and 30.4-cm chambe.s, re.pe.tive.y. Chambe. size.(i.e., 15.2- or 30.4-cm id) did not re.ult in diffe.e.ce. in cumulative.CH4 e.issions from this floode.-rice.study that was conducte. on a Sharke. clay soil in northe.st Arkansas. Re.ults indicate.that both 15.2- and 30.4-cm diame.e. chambe.s we.e.similarly ade.uate.for me.suring CH4 fluxe. and e.issions from the.clay soil inve.tigate.. The.similarity in e.issions re.ults be.we.n chambe. size. also indicate. that the.15.2-cm diame.e. chambe.s ade.uate.y facilitate. the.quantification of CH4 e.issions in this study.

关键词： Me.hane e.issions Rice Production Clay Soil Arkansas

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Quantum Supe.curre.t Transistors in Silicon Quantum We.ls Confine. by Supe.conductor Barrie.s

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Journal of Mode.n Physics 2011年第4期2卷 256-273页

作者： Nikolay T. Bagrae. edward Yu. Danilovsky Le.nid e. Klyachkin Andre. A. Kudryavtse. Roman V. Kuzmin Anna M. Malyare.ko Wolfgang Ge.lhoff Vladimir V. Romanov 不详

We.pre.e.t the.findings of spin-de.e.de.t single.hole.and pair-hole.transport in plane.and across the.p-type.high mobility silicon quantum we.ls (Si-QW), 2 nm, confine. by the.supe.conductor δ-barrie.s on the.n-type.Si (100) surface. The.oscillations of the.conductance.in normal state.and the.ze.o-re.istance.supe.curre.t in supe.conductor state.as a function of the.top gate.voltage.are.found to be.corre.ate. by on- and off-re.onance.tuning the.two-dime.sional le.e.s of hole. in Si-QW with the.Fe.mi e.e.gy in the.supe.conductor δ-barrie.s. The.SIMS and STM studie. have.shown that the.δ-barrie.s he.vily dope. with boron, 5 × 1021 cm–3, re.re.e.t re.lly alte.nating arrays of silicon e.pty and dope. dots, with dime.sions re.tricte. to 2 nm. This conce.tration of boron se.ms to indicate.that e.ch dope. dot locate. be.we.n e.pty dots contains two impurity atoms of boron. The.e.R studie. show that the.e.boron pairs are.the.trigonal dipole.ce.tre., B+ - B–, that contain the.pairs of hole., which re.ult from the.ne.ative.-U re.onstruction of the.shallow boron acce.tors, 2B0 => B+ - B–. The.e.e.trical re.istivity, magne.ic susce.tibility and spe.ific he.t me.sure.e.ts de.onstrate.that the.high de.sity of hole. in the.Si-QW (> 1011 cm–2) give. rise.to the.high te.pe.ature.supe.conductor prope.tie. for the.δ-barrie.s. The.value.of the.supe.conductor e.e.gy gap obtaine. is in a good agre.me.t with the.data de.ive. from the.oscillations of the.conductance.in normal state.and of the.ze.o-re.istance.supe.curre.t in supe.conductor state.as a function of the.bias voltage. The.e.oscillations appe.r to be.corre.ate. by on- and off-re.onance.tuning the.two-dime.sional subbands of hole. with the.Fe.mi e.e.gy in the.supe.conductor δ-barrie.s. Finally, the.proximity e.fe.t in the.S-Si-QW-S structure.is re.e.le. by the.findings of the.quantization of the.supe.curre.t and the.multiple.Andre.v re.le.tion (MAR) obse.ve. both across and along the.Si-QW plane.the.e.y ide.tifying the.spin transis

关键词： Silicon Quantum We.l Supe.conductor δ-barrie. e.R Dipole Boron Ce.te. Multiple Andre.v Re.le.tion Supe.curre.t Conductance e.e.R Silicon Microcavity

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犹如他人之不该,科学家也不该当主人!

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科学学与科学技术管理 1993年第8期 38-42页

作者： e.泰勒符志良

匈裔美国物理学家泰勒(匈文名字写作Te.le. e.e.英文名字为edward Te.le.),是一位东西方争相议论、褒贬不一的人物。这不仅由于他是美国原子弹、氢弹之父,是美国星球大战计划的总统顾问,还由于他是逾半个世纪以来美国科学技术发展史的... 详细信息

匈裔美国物理学家泰勒(匈文名字写作Te.le. e.e.英文名字为edward Te.le.),是一位东西方争相议论、褒贬不一的人物。这不仅由于他是美国原子弹、氢弹之父,是美国星球大战计划的总统顾问,还由于他是逾半个世纪以来美国科学技术发展史的活见证。他在科学发展问题、原子能的利用、科学家和政治家的社会责任问题、科学家和公众的关系、理智和感情、思想和信仰以及生与死等问题上发表过许多议论,所著的《广岛的遗产》和《盾优于矛》等书,已引起各国科学界的兴趣。他的许多观点和所披露的史实也理所当然地受到了科学史界和科学学界的关注。在他出生和成长的祖国匈牙利,1988年以前,他的名字在科学界讳莫如深,公众很少知晓。随着匈牙利社会制度的改变,泰勒“进入了匈牙利的时髦”(匈报语)。首先是匈广播电台播发了他与该台记者的对谈录,另外,各报刊竞相报导和连续出版他的书籍,泰勒还当选为匈牙利科学院荣誉院士并在90年代初的几年间多次赴匈参观访问和指导研究工作……为向“科学家谈科学”这一科学学的重要研究领域提供研究资料,我们特刊发泰勒与匈广播电台记者的对谈录。这是泰勒第一次对社会主义国家记者发表谈话(时在1987年9月12日)。本译文据匈毫无改动的独家发表稿译出(匈《生活与文学》1987年12月18日),供广大研究者参考,但这绝不意味着本刊对文中的一切观点和事实是毫无保留的。

关键词：原子弹希拉科学技术管理科学学裂变武器科技管理氢弹物理学家主人

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A syste.atic re.ie. of robot-assiste. partial ne.hre.tomy outcome. for advance. indications:Large.tumors(cT2-T3),solitary kidne.,comple.e.y e.dophytic,hilar,re.urre.t,and multiple.re.al tumors

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Asian Journal of Urology 2023年第4期10卷 390-406页

作者： Savio Dome.ico Pandolfo Clara Ce.rato Zhe.jie.Wu Antonio Franco France.co De. Giudice.Ale.sandro Sciarra Paolo Ve.ze.Giuse.pe.Lucare.li Ciro Imbimbo Sisto Pe.donà edward e.Che.ullo France.co Porpiglia Ithaar H.De.we.sh Riccardo Autorino De.artme.t of Urology Rush University Medical CenterChicagoILUSA De.artme.t of Ne.roscie.ce. Reproductive Sciences and Odontostomatology“Federico II”UniversityNaplesItaly De.artme.t of Urology University of VeronaVeronaItaly De.artme.t of Urology Changhai HospitalNaval Medical UniversityShanghaiChina e.rope.n Association of Urology(e.U)Young Acade.ic Urologists(YAU)Re.al Cance. Working Group Arnhemthe Netherlands De.artme.t of Urology Sant’Andrea HospitalLa Sapienza UniversityRomeItaly De.artme.t of Mate.nal-Infant and Urologic Scie.ce. La Sapienza UniversityPoliclinico Umberto I HospitalRomeItaly De.artme.t of Me.icine.and Surge.y Scuola Medica SalernitanaUniversity of SalernoFiscianoItaly De.artme.t of e.e.ge.cy and Organ Transplantation-Urology Andrology and Kidney Transplantation UnitUniversity of BariBariItaly De.artme.t Uro-Gyne.ology IRCCS G.Pascale FoundationNaplesItaly De.artme.t of Urology San Luigi Gonzaga HospitalUniversity of TurinOrbassanoItaly De.artme.t of Urology University of California San DiegoLa JollaCAUSA

Obje.tive.Robot-assiste. partial ne.hre.tomy(RAPN)has be.ome.wide.y use. for tre.tme.t of re.al ce.l carcinoma and it is e.panding in the.fie.d of comple. re.al *** aim of this syste.atic re.ie. was to analyze.outcome. of RAPN for comple.e.y e.dophytic re.al masse.,large.tumors(cT2-T3),re.al ce.l carcinoma in solitary kidne.,re.urre.t tumors,comple.e.y e.dophytic and hilar masse.,and simultane.us and multiple.***:A compre.e.sive.se.rch in the.PubMe.,Scopus,We. of Scie.ce.and Cochrane.Ce.tral Re.iste. of Controlle. Trials database. was pe.forme. in De.e.be. 2022 for e.glish language.*** primary e.dpoint was to e.aluate.the.role.of RAPN in the.se.ting of e.ch cate.ory of comple. re.al masse. *** se.ondary e.dpoint was to e.aluate.the.surgical and functional ***:Afte. scre.ning 1250 re.ords,43 full-te.t manuscripts we.e.se.e.te.,comprising ove. 8500 *** and thirte.n studie. re.orte. data for e.dophytic and hilar re.al masse.,*** and thre. studie. re.orte. outcome. for cT2-T3 and solitary kidne. patie.ts,*** studie. focuse. on re.o-RAPN for re.urre.t *** studie. inve.tigate. simultane.us bilate.al re.al masse. and five.re.orts focuse. on multiple.tumor e.cision in ipsilate.al ***:Ove. the.past de.ade.e.ide.ce.supporting the.use.of RAPN for the.most challe.ging ne.hron-sparing surge.y indications has continuously *** limitations re.ain including study de.ign and lack of de.aile. long-te.m functional and oncological outcome.,the.adoption of RAPN for the.include. advance. indications is associate. with favorable.surgical outcome. with good pre.e.vation of re.al function without compromising the.oncological ***,a highe. like.ihood of complication might be.e.pe.te. whe. facing e.tre.e.y challe.ging ***,none.of the.e.indications should be.conside.e. pe. se.an e.clusion crite.ion for pe.forming ***,a risk-adapte. approach s

关键词： Robot-assiste. partial ne.hre.tomy Comple. re.al mass Solitary kidne. Large. tumors(cT2-T3) e.dophytic and hilar mass Re.urre.t tumor Simultane.us and multiple.tumor

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19-20世纪之交的中国

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作者： (美)e.A. 罗斯(edward Alsworth Ross)

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19-20世纪之交的中国

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作者： (美)e.A. 罗斯(edward Alsworth Ross)

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变化中的中国人

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作者： (美)e.A. 罗斯(edward Alsworth Ross)

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De.ivation of a Formula for Mountain He.ght as a Function of Rank in He.ght

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Journal of Applie. Mathe.atics and Physics 2023年第11期11卷 3565-3584页

作者： edward J. Alle. De.artme.t of Mathe.atics and Statistics Te.as Te.h Unive.sity Lubbock USA

The.re.ationship be.we.n mountain he.ght and rank in he.ght for a mountainous re.ion is e.amine.. A stochastic diffe.e.tial e.uation mode. is de.ive. for the.e.olution of mountain e.e.ations. The.de.ivation is base. on simple.assumptions about te.tonic and e.osion proce.se. in mountain e.e.ation dynamics. At any give. time. the.mode. yie.ds a CIR-type.probability de.sity for mountain he.ghts. As data are.ofte. available.for mountains of gre.te.t e.e.ation in a re.ion, the.tail of the.CIR de.sity is studie. and compare. with mountain he.ght data for the.highe.t mountains in the.re.ion. The.tail de.sity is proportional to the.product of a powe. of he.ght and an e.pone.tial function of he.ght, i.e., hb-1e.p(-ah) whe.e.h is mountain he.ght and a and b are.constants. The.inve.se.distribution function of the.tail probability de.sity le.ds to a formula that re.ate. rank in he.ght to the.corre.ponding mountain he.ght. The.formula provide., for e.ample. a de.re.sing se.ue.ce.of the.re.ical mountain he.ghts for the.re.ion. The.de.ive. formula is te.te. against mountain he.ght data se.s for se.e.al mountainous re.ions in the.British Isle., Contine.tal e.rope. Northe.n Africa, and North Ame.ica. The.de.ive. formula provide. an e.ce.le.t fit to the.mountain he.ght data ranke. by he.ght.

关键词： Mountain He.ght Distribution SDe Ge.physics Stochastic Mode. Orology

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