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Bioactive Materials 2023年第3期21卷 358-380页

作者： Nem Singh Jungryun kim Jaewon kim Kyungwoo Lee Zehra Zunbul Injun Lee Eunji kim Sung-Gil Chi Jong Seung kim department of Chemistry Korea UniversitySeoul02841South Korea department of Life Science Korea UniversitySeoul02841South Korea

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area.The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs,such as poor localization at the tumor site,high drug doses and toxicity,recurrence,and poor immune response.However,inadequate biocompatibility restricts their potential in clinical translation.Therefore,advanced nanomaterials with high biocompat-ibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of nanomedicines.Intrinsic properties of nanoscale covalent organic frameworks(nCOFs),such as suitable size,modular pore geometry and porosity,and straightforward post-synthetic modification via simple organic transformations,make them incredibly attractive for future nanomedicines.The ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted delivery.This review summarizes recently published applications of COFs in drug delivery,photo-immuno therapy,sonodynamic therapy,photothermal therapy,chemotherapy,pyroptosis,and combination therapy.Herein we mainly focused on modifications of COFs to enhance their biocompatibility,efficacy and potential clinical translation.This review will provide the fundamental knowledge in designing biocompatible nCOFs-based nano-medicines and will help in the rapid development of cancer drug carriers and theranostics.

关键词： doses medicines compatibility

Electrically controlled mRNA delivery using a polypyrrolegraphene oxide hybrid film to promote osteogenic differentiation of human mesenchymal stem cells

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Nano Research 2022年第10期15卷 9253-9263页

作者： Huijung kim Kübra Solak Yoojoong Han Yeon-Woo Cho Kyeong-Mo Koo Chang-dae kim Zhengtang Luo Hyungbin Son Hyung-Ryong kim Ahmet Mavi Tae-Hyung kim School of Integrative Engineering Chung-Ang University84 Heukseuk-roDongjak-guSeoul 06974Republic of Korea department of Nanoscience and Nanoengineering Graduate School of Natural and Applied SciencesAtatürk UniversityErzurum 25240Turkey department of Chemical and Biological Engineering Hong Kong University of Science and TechnologyKowloonHong Kong 999077China department of Pharmacology College of DentistryJeonbuk National UniversityJeonju 54896Republic of Korea department of Nanoscience and Nanoengineering Institute of ScienceAtatürk UniversityErzurum 25240Turkey department of Mathematics and Science Education Education Faculty of Kazım KarabekirAtatürk UniversityErzurum 25240Turkey

direct messenger ribonucleic acid(mRNA)delivery to target cells or tissues has revolutionized the field of biotechnology.However,the applicability of regenerative medicine is limited by the technical difficulties of various mRNA-loaded nanocarriers.Herein,we report a new conductive hybrid film that could guide osteogenic differentiation of human adipose-derived mesenchymal stem cells(hAdMSCs)via electrically controlled mRNA delivery.To find optimal electrical conductivity and mRNAloading capacity,the polypyrrole-graphene oxide(PPy-GO)hybrid film was electropolymerized on indium tin oxide substrates.We found that the fluorescein sodium salt,a molecule partially mimicking the physical and chemical properties of mRNAs,can be effectively absorbed and released by electrical stimulation(ES).The hAdMSCs cultivated on the PPy-GO hybrid film loaded with pre-osteogenic mRNAs showed the highest osteogenic differentiation under electrical stimulation.This platform can load various types of RNAs thus highly promising as a new nucleic acid delivery tool for the development of stem cell-based therapeutics.

关键词： messenger ribonucleic acid(mRNA)delivery polypyrrole graphene oxide electrical release mesenchymal stem cells

Text Sentiment Analysis Based on Multi-Layer Bi-directional LSTM with a Trapezoidal Structure

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Intelligent Automation & Soft Computing 2023年第7期37卷 639-654页

作者： Zhengfang He Cristina E.dumdumaya Ivy kim d.Machica School of Intelligent Science and Engineering Yunnan Technology and Business UniversityKunming650000China College of Information and Computing University of Southeastern PhilippinesDavao CityDavao del SurPhilippines

Sentiment analysis,commonly called opinion mining or emotion artificial intelligence(AI),employs biometrics,computational linguistics,nat-ural language processing,and text analysis to systematically identify,extract,measure,and investigate affective states and subjective data.Sentiment analy-sis algorithms include emotion lexicon,traditional machine learning,and deep learning.In the text sentiment analysis algorithm based on a neural network,multi-layer Bi-directional long short-term memory(LSTM)is widely used,but the parameter amount of this model is too huge.Hence,this paper proposes a Bi-directional LSTM with a trapezoidal structure model.The design of the trapezoidal structure is derived from classic neural networks,such as LeNet-5 and AlexNet.These classic models have trapezoidal-like structures,and these structures have achieved success in the field of deep learning.There are two benefits to using the Bi-directional LSTM with a trapezoidal structure.One is that compared with the single-layer configuration,using the of the multi-layer structure can better extract the high-dimensional features of the text.Another is that using the trapezoidal structure can reduce the model’s parameters.This paper introduces the Bi-directional LSTM with a trapezoidal structure model in detail and uses Stanford sentiment treebank 2(STS-2)for experiments.It can be seen from the experimental results that the trapezoidal structure model and the normal structure model have similar performances.However,the trapezoidal structure model parameters are 35.75%less than the normal structure model.

关键词： Text sentiment Bi-directional LSTM Trapezoidal structure

Machine-learned metrics for predicting the likelihood of success in materials discovery

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npj Computational Materials 2020年第1期6卷 539-547页

作者： Yoolhee kim edward kim Erin Antono Bryce Meredig Julia Ling Citrine Informatics Redwood CityCA 94063USA

Materials discovery is often compared to the challenge of finding a needle in a haystack.While much work has focused on accurately predicting the properties of candidate materials with machine learning(ML),which amounts to evaluating whether a given candidate is a piece of straw or a needle,less attention has been paid to a critical question:are we searching in the right haystack?We refer to the haystack as the design space for a particular materials discovery problem(i.e.,the set of possible candidate materials to synthesize),and thus frame this question as one of design space selection.In this paper,we introduce two metrics,the predicted fraction of improved candidates(PFIC),and the cumulative maximum likelihood of improvement(CMLI),which we demonstrate can identify discovery-rich and discovery-poor design spaces,respectively.A combined classification system,composed of the CMLI and PFIC metrics,is then used to identify optimal design spaces with high precision,and thus show the potential to significantly accelerate ML-driven materials discovery.

关键词： likelihood predicting searching

Suggestion of Maintenance Criteria for Electric Railroad Facilities Based on Fuzzy TOPSIS

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Computers, Materials & Continua 2022年第3期70卷 5453-5466页

作者： Sunwoo Hwang Joouk kim Hagseoung kim Hyungchul kim Youngmin kim Innovative Transportation and Logistics Research Center Korea Railroad Research InstituteUiwang16105Korea Smart Electrical&Signaling division Korea Railroad Research InstituteUiwang16105Korea department of Systems Engineering Ajou UniversitySuwon16499Korea

This paper is on the suggestion of maintenance items for electric railway facility systems.With the recent increase in the use of electric locomotives,the utilization and importance of railroad electrical facility systems are also increasing,but the railroad electrical facility system in Korea is rapidly aging.To solve this problem,various methodologies are applied to ensure operational reliability and stability for railroad electrical facility systems,but there is a lack of detailed evaluation criteria for railroad electrical facility system maintenance.Also,maintenance items must be selected in a scientific and systematic method.Therefore,railroad electrical facility systems are selected for study.design StructureMatrix(dSM)is utilized to establish considerations tailored to the maintenance characteristics,and the Fuzzy-TOPSIS methodology is utilized for determining the maintenance detail evaluation item baseline weights,a multi-criteria decision-making problem.Studies show that degradation,insulation items have the highest weight of 14.63%,and capacity items have the lowest weight of 5.34%.The results of this may be contributed to the underlying research in carrying out maintenance activities to ensure the reliability and safety of railroad electrical facility systems.

关键词： Electrical facility system railroad maintenance fuzzy method

Multi-Bandgap Monolithic Metal Nanowire Percolation Network Sensor Integration by Reversible Selective Laser-Induced Redox

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Nano-Micro Letters 2022年第3期14卷 216-228页

作者： Junhyuk Bang Yeongju Jung Hyungjun kim dongkwan kim Maenghyo Cho Seung Hwan Ko Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National University1 Gwanak‑roGwanak‑guSeoul 151‑742Republic of Korea department of Mechanical Engineering Seoul National University1 Gwanak‑roGwanak‑guSeoul 08826Republic of Korea Institute of Advanced Machines and design Institute of Engineering ResearchSeoul National UniversitySeoul 08826Republic of Korea

Active electronics are usually composed of semiconductor and metal electrodes which are connected by multiple vacuum deposition steps and photolithography patterning.However,the presence of interface of dissimilar material between semiconductor and metal electrode makes various problems in electrical contacts and mechanical failure.The ideal electronics should not have defective interfaces of dissimilar materials.In this study,we developed a novel method to fabricate active electronic components in a monolithic seamless fashion where both metal and semiconductor can be prepared from the same monolith material without creating a semiconductor-metal interface by reversible selective laser-induced redox(rSLIR)method.Furthermore,rSLIR can control the oxidation state of transition metal(Cu)to yield semiconductors with two different bandgap states(Cu_(2)O and CuO with bandgaps of 2.1 and 1.2 eV,respectively),which may allow multifunctional sensors with multiple bandgaps from the same materials.This novel method enables the seamless integration of single-phase Cu,Cu_(2)O,and CuO,simultaneously while allowing reversible,selec-tive conversion between oxidation states by simply shining laser light.Moreover,we fabricated a flexible monolithic metal-semiconduc-tor-metal multispectral photodetector that can detect multiple wavelengths.The unique monolithic characteristics of rSLIR process can provide next-generation electronics fabrication method overcoming the limitation of conventional photolithography methods.

关键词： Monolithic integration Seamless interface Multi-bandgap nanowire Laser-induced redox Multispectral photodetector

Rapid synthesis of MoS_(2)-Ag nanocomposites via photoreduction for optical tuning and surface-enhanced Raman scattering applications

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Journal of Materiomics 2023年第2期9卷 229-234页

作者： Yoonkyung Lee Eunpa kim Hyeongkeun kim Kyunghoon kim School of Mechanical Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Samsung Electronics Semiconductor R&DAdvanced Manufacturing Engineering TeamPyeongtaek17786Republic of Korea Korea Electronics Technology Institute Seongnam13509Republic of Korea

Semiconductoremetal nanocomposites have been widely investigated to modify the intrinsic properties of materials used for optoelectronic devices and sensing applications.In this study,a method for rapid synthesis of MoS_(2)-Ag nanocomposites via laser-assisted photoreduction was proposed.For the photoreduction process,we used AgNO_(3)solution as a metal source.Under laser irradiation,Ag ions were easily reduced on MoS_(2)by photo-generated electrons from MoS_(2).The optical properties of MoS_(2)-Ag nanocomposites were easily controlled by simple adjustment of the photoreduction time.To investigate the surface-enhanced Raman scattering(SERS)effect of the MoS_(2)-Ag nanocomposites,the SERS spectra of methylene blue(MB)on MoS_(2)-Ag nanocomposites were measured,and the nanocomposites were found to enhance the Raman scattering intensity of MB up to~106.Therefore,the laser-assisted photoreduction method has great potential for rapid synthesis and optical tuning of semiconductoremetal nanocomposites.

关键词： Molybdenum disulfide(MoS2) Silver(Ag) Photoreduction Optical tuning Surface-enhanced Raman scattering(SERS)

Vacuolar protein sorting protein 41(VPS41) at an intersection of endosomal traffic in neurodegenerative disease

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Neural Regeneration Research 2019年第7期14卷 1210-1212页

作者： edward F.Griffin kim A.Caldwell Guy A.Caldwell department of Biological Sciences The University of Alabama departments of Neurology and Neurobiology University of Alabama at Birmingham School of Medicine Center for Neurodegeneration and Experimental Therapeutics University of Alabama at Birmingham School of Medicine Nathan Shock Center of Excellence for Basic Research in the Biology of Aging University of Alabama at Birmingham

Alzheimer’s and Parkinson’s diseases are neurodegenerative disorders pathologically classified by the accumulation of amyloidogenic proteins into insoluble inclusions within the brain.Specifically,amyloid plaques in the brains of Alzheimer’s disease patients are comprised of amyloid-β(Aβ)peptide,the product of sequential cleavage of the amyloid precursor protein byβ-andγ-secretases.Similarly,α-synuclein is a major component of Lewy bodies associated with Parkinson’s disease.

关键词： commissural axon guidance pathologically

Boosting overall water splitting by incorporating sulfur into NiFe(oxy)hydroxide

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Journal of Energy Chemistry 2022年第1期31卷 364-371,I0010页

作者： Chiho kim Seong Hyun kim Seunghun Lee Ilyeong Kwon Seong Hyun kim Shinho kim Changgyu Seok Yoo Sei Park Yangdo kim department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea BK21 Four Innovative Graduate Education Program for Global High-tech Materials&PartsPusan National UniversityBusan 46241Republic of Korea department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH).Pohang 37673Republic of Korea

developing highly active and cost-effective electrocatalysts for enhancing the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is a significant challenge for overall water splitting.Sulfur-incorporated nickel iron(oxy)hydroxide(S-NiFeOOH)nanosheets were directly grown on commercial nickel foam using a galvanic corrosion method and a hydrothermal method.The incorporation of sulfur into NiFeOOH enhanced the catalytic activity for the HER and OER in 1 M KOH electrolyte.The enhanced catalytic activity is attributed to the change in the local structure and chemical states due to the incorporation of sulfur.High performance for overall water splitting was achieved with an alkaline water electrolyzer.This was realized by employing S-NiFeOOH as a bifunctional electrocatalyst,thereby outperforming a water electrolyzer that requires the usage of precious metal electrocatalysts(i.e.,Pt/C as the HER electrocatalyst and IrO_(2) as the OER electrocatalyst).Moreover,when driven by a commercial silicon solar cell,an alkaline water electrolyzer that uses S-NiFeOOH as a bifunctional electrocatalyst generated hydrogen under natural illumination.This study shows that S-NiFeOOH is a promising candidate for a large-scale industrial implementation of hydrogen production for overall water splitting because of its low cost,high activity,and durability.In addition,the solar-driven water electrolyzer using S-NiFeOOH as a bifunctional electrocatalyst affords the opportunity for developing effective and feasible solar power systems in the future.

关键词： Overall water splitting Hydrogen production Sulfur incorporated NiFe(oxy)hydroxide Electrocatalysts Solar-driven water splitting

Nanocrystalline Iron Pyrophosphate-Regulated Amorphous Phosphate Overlayer for Enhancing Solar Water Oxidation

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Nano-Micro Letters 2022年第12期14卷 387-400页

作者： Chengkai Xia Yuankai Li Minyeong Je Jaekyum kim Sung Min Cho Chang Hyuck Choi Heechae Choi Tae-Hoon kim Jung Kyu kim School of Chemical Engineering Sungkyunkwan University(SKKU)2066 Seobu-roJangan-guSuwon 16419Republic of Korea Theoretical Materials and Chemistry Group Institute of Inorganic ChemistryUniversity of CologneGreinstr.650939 CologneGermany department of Chemistry Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea department of Materials Science and Engineering Engineering Research CenterChonnam National UniversityGwangju 61186Republic of Korea

A rational regulation of the solar water splitting reaction pathway by adjusting the surface composition and phase structure of catalysts is a substantial approach to ameliorate the sluggish reaction kinetics and improve the energy conversion efficiency.In this study,we demonstrate a nanocrystalline iron pyrophosphate(Fe_(4)(P_(2)O_(7))_(3),FePy)-regulated hybrid overlayer with amorphous iron phosphate(FePO_(4),FePi)on the surface of metal oxide nanostructure with boosted photoelectrochemical(PEC)water oxidation.By manipulating the facile electrochemical surface treatment followed by the phosphating process,nanocrystalline FePy is localized in the FePi amorphous overlayer to form a heterogeneous hybrid structure.The FePy-regulated hybrid overlayer(FePy@FePi)results in significantly enhanced PEC performance with long-term durability.Compared with the homogeneous FePi amorphous overlayer,FePy@FePi can improve the charge transfer efficiency more significantly,from 60% of FePi to 79%of FePy@FePi.Our density-functional theory calculations reveal that the coexistence of FePi and FePy phases on the surface of metal oxide results in much better oxygen evolution reaction kinetics,where the FePi was found to have a typical down-hill reaction for the conversion from OH*to O_(2),while FePy has a low free energy for the formation of OH*.

关键词： Water oxidation Photoelectrochemical cell Metal pyrophosphate Electrochemical surface treatment