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clinical and anatomic predictors of need for repeat atrial fibrillation ablation

World Journal of cardiology 2017年第9期9卷 742-748页

作者： Yaanik Desai Mathew R Levy Shahriar Iravanian edward c clermont Heval M Kelli Robert L Eisner Mikhael F El-chami Angel R Leon David B Delurgio Faisal M Merchant Emory University School of Medicine cardiology Division Department of MedicineEmory University School of Medicine Division of cardiology Department of MedicineUniversity of Pennsylvania Department of Radiology Emory University School of Medicine

AIM To identify predictors of need for repeat procedures after initial atrial fibrillation(AF) ablation. METHODS We identified a cohort undergoing first time AF ablation at our institution from January 2004 to February 2014 who had cardiac magnetic resonance(cMR) imaging performed prior to ablation. clinical variables and anatomic characteristics(determined from cMR) were assessed as predictors of need for repeat ablation. The decision regarding need for and timing of repeat ablation was at the discretion of the treating physician. RESULTS From a cohort of 331 patients, 142 patients(43%) underwent repeat ablation at a mean of 13.6 ± 18.4 mo afterthe index procedure. Both male gender(81% vs 71%, P = 0.05) and lower ejection fraction(57.4% ± 10.3% vs 59.8% ± 9.4%, P = 0.04) were associated with need for repeat ablation. On pre-ablation cMR, mean pulmonary vein(PV) diameters were significantly larger in all four PVs among patients requiring repeat procedures. In multivariate analysis, increased right superior PV diameter significantly predicted need for repeat ablation(odds ratio 1.08 per millimeter increase in diameter, 95%cI: 1.00-1.16, P = 0.05). There were also trends toward significance for increased left and right inferior PV sizes among those requiring repeat *** Increased PV size predicts the need for repeat AF ablation, with each millimeter increase in PV diameter associated with an approximately 5%-10% increased risk of requiring repeat procedures.

关键词： Atrial 纤维性颤动脱离重复脱离心脏的磁性的回声成像肺的静脉成像

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Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems

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Science china(Life Sciences) 2024年第1期67卷 188-203页

作者： Xuan Dong cixiu Li Yiting Wang Tao Hu Fan Zhang Fanzeng Meng Meirong Gao Xuekai Han Guohao Wang Jiahao Qin Hans Nauwynck edward cHolmes Patrick Sorgeloos Liying Sui Jie Huang Weifeng Shi State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesLaboratory for Marine Fisheries Science and Food Production ProcessesLaoshan LaboratoryKey Laboratory of Maricultural Organism Disease ControlMinistry of Agriculture and Rural AffairsQingdao Key Laboratory of Mariculture Epidemiology and BiosecurityQingdao 266071China Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000China Dalian Ocean University Dalian 116023China Asian Regional Artemia Reference center Tianjin University of Science&TechnologyTianjin 300457China Ghent University Ghent 9000Belgium Sydney Institute for Infectious Diseases School of Medical SciencesThe University of SydneySydney 2006Australia Network of Aquaculture centres in Asia-Pacific Bangkok 10900Thailand School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Brine shrimp(Artemia)has existed on Earth for 400 million years and has major ecological importance in hypersaline *** a crucial live food in aquaculture,brine shrimp cysts have become one of the most important aquatic products traded ***,our understanding of the biodiversity,prevalence and global connectedness of viruses in brine shrimp is still very limited.A total of 143 batches of brine shrimp(belonging to seven species)cysts were collected from six continents including 21 countries and more than 100 geographic locations worldwide during 1977–*** total,55 novel RNA viruses were identified,which could be assigned to 18 different viral families and related *** viruses were dsRNA viruses,16 were+ssRNA viruses,and 28 were−ssRNA *** analyses of the RNA-directed RNA polymerase(RdRp)showed that brine shrimp viruses were often grouped with viruses isolated from other invertebrates and ***,most brine shrimp viruses were related to those from different hosts that might feed on brine shrimp or share the same ecological niche.A notable case was the novel brine shrimp noda-like virus 3,which shared 79.25%(RdRp)and 63.88%(capsid proteins)amino acid identity with covert mortality nodavirus(cMNV)that may cause losses in *** addition,both virome composition and phylogenetic analyses revealed global connectedness in certain brine shrimp viruses,particularly among Asia and Northern *** highlights the incredible species diversity of viruses in these ancient species and provides essential data for the prevalence of RNA viruses in the global aquaculture *** broadly,these findings provide novel insights into the previously unrecognized RNA virosphere in hypersaline ecosystems worldwide and demonstrate that human activity might have driven the global connectedness of brine shrimp viruses.

关键词： brine shrimp Artemia virus diversity novel virus discovery global connectedness hypersaline ecosystem

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Z-Score in Fetal Echocardiography–Is there Still Room for New Studies?

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congenital Heart Disease 2024年第3期19卷 305-314页

作者： Marcio Fragoso Vieira Nathalie Jeanne Bravo-Valenzuela edward Araujo Júnior Department of Obstetrics Paulista School of MedicineFederal University of São Paulo(EPM-UNIFESP)São Paulo-SP04023-062Brazil Department of Obstetrics Federal University of Ceará(UFC)Sobral-CE60020-181Brazil Department of Pediatrics Pediatric CardiologySchool of MedicineFederal University of Rio de Janeiro(UFRJ)Rio de Janeiro-RJ21941-853Brazil

congenital heart disease(cHD)is the most common type of birth defect,representing a signiﬁcant cause of peri-natal morbidity and *** diagnosis of such anomalies is crucial for improving *** pro-tocols recommend a qualitative assessment of cardiac structures using two-dimensional ultrasound(2DUS)and color Doppler *** cases of suspected abnormalities,quantitative assessments through cardiac structure measurements and reference curves can aid in accurate *** to centiles widely employed in obste-trics,Z-scores provide more precise quantiﬁcation of various cardiac structures,particularly at the extremes of the *** the development of reference curves and Z-scores has progressed over the past two decades,a lack of standardization in measurements and statistical methodology for their determination is *** reference curves requires adherence to speciﬁc recommendations to improve their *** purpose of this study is to provide a narrative review of the major studies that have generated reference values for cardiac struc-tures using 2DUS and Z-scores,to evaluate their methodology,and to provide a summary of the results.

关键词： Z-scores reference ranges fetal echocardiography

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cellulosomal hemicellulases:Indispensable players for ensuring effective lignocellulose bioconversion

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Green carbon 2024年第1期2卷 57-69页

作者： Min Xiao Ya-Jun Liu edward A.Bayer Akihiko Kosugi Qiu cui Yingang Feng cAS Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Provincial Key Laboratory of Synthetic Biology Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Engineering Laboratory of Single cell Oil Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Energy Institute Qingdao 266101China Qingdao New Energy Shandong Laboratory Qingdao 266101China University of chinese Academy of Sciences Beijing 100049China Department of Biomolecular Sciences The Weizmann Institute of ScienceRehovot 7610001Israel Department of Life Sciences and the National Institute for Biotechnology in the Negev Ben-Gurion University of the NegevBeer-Sheva 8499000Israel Biological Resources and Post-harvest Division Japan International Research Center for Agricultural Sciences(JIRCAS)1-1 OhwashiTsukubaIbaraki 305-8686Japan

The bioconversion of lignocellulose has attracted global attention,due to the significant potential of agricultural and forestry wastes as renewable zero-carbon resources and the urgent need for substituting fossil *** cellulosome system is a multi-enzyme complex produced by anaerobic bacteria,which comprises cellulases,hemicellulases,and associated enzymatic and non-enzymatic components that promote biomass *** enhance their efficiency in degrading recalcitrant lignocellulosic matrices,cellulosomes have been employed to construct biocatalysts for lignocellulose bioconversion,such as consolidated bioprocessing and consolidated ***,the second most abundant polysaccharides in plant cell walls,hold valuable application potential but can also induce inhibitory effects on cellulose hydrolysis,thus highlighting the indispensable roles of hemicellulases within the cellulosome *** review evaluated current research on cellulosomal hemicellulases,comparing their types,abundance,and regulation,primarily focusing on eight known cellulosome-producing species of different *** also reviewed their growth conditions,their hemicellulose-degrading capabilities,and the inhibitory effects of hemicellulose on cellulosome-based lignocellulose ***,we proposed strategies for targeted enhancement of hemicellulase in cellulosomes to improve lignocellulose bioconversion in future studies.

关键词： cellulosome Lignocellulose Hemicellulase Saccharification Biocatalyst

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Residential building performance analysis at near extreme weather conditions in Hong Kong through a thermal-comfort-based strategy

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Building Simulation 2023年第1期16卷 13-25页

作者： K.F.Fong c.K.Lee Kevin Ka-Lun Lau edward Yan Yung Ng Division of Building Science and Technology College of EngineeringCity University of Hong KongHong KongChina Department of civil Engineering and Natural Resources Lulea University of TechnologySweden School of Architecture The Chinese University of Hong KongHong KongChina

The precise building performance assessment of residential housings in subtropical regions is usually more difficult than that for the commercial premises due to the much more complicated behavior of the occupants with regard to the change in indoor *** conventional use of a fixed schedule for window opening,clothing insulation and cooling equipment operation cannot reflect the real situation when the occupants respond to the change in thermal comfort,thus affecting the appropriateness of the assessment *** rectify the situation,a new modeling strategy in which the modification of the various operation schedules was based on the calculated thermal comfort(Tc),was developed in this *** this new Tc-based strategy,the realistic building performances under different cooling provision scenarios applied to a high-rise residential building under the near extreme weather conditions were investigated and *** was found that sole provision of ventilation fans could not meet the zone thermal comfort by over 68%of the time,and air-conditioning was *** optimal use of ventilation fans for cooling could only help reduce the total cooling energy demand by less than 12%at best which could only be realistically evaluated by adopting the present *** studies were conducted which revealed that some design factors could offer opportunities for reducing the total cooling energy under the near extreme weather conditions.

关键词： predicted mean vote thermal comfort ventilation potential building performance simulation residential housings

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The acceleration of a high-charge electron bunch to 10 GeV in a 10-cm nanoparticle-assisted wakefield accelerator

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Matter and Radiation at Extremes 2024年第1期9卷 15-24页

作者： constantin Aniculaesei Thanh Ha Samuel Yoffe Lance Labun Stephen Milton edward Mccary Michael M.Spinks Hernan J.Quevedo Ou Z.Labun Ritwik Sain Andrea Hannasch Rafal Zgadzaj Isabella Pagano Jose A.Franco-Altamirano Martin L.Ringuette Erhart Gaul Scott V.Luedtke Ganesh Tiwari Bernhard Ersfeld Enrico Brunetti Hartmut Ruhl Todd Ditmire Sandra Bruce Michael E.Donovan Michael c.Downer Dino A.Jaroszynski Bjorn Manuel Hegelich University of Texas at Austin AustinTexas 78712USA SUPA Department of Physics University of StrathclydeGlasgowScotland G4 ONGUnited Kingdom Tau Systems Inc.AustinTexas 78701USA Lawrence Livermore National Laboratory LivermoreCalifornia 94550USA Los Alamos National Laboratory Los AlamosNew Mexico 87545USA Brookhaven National Laboratory UptonNew York 11973USA Ludwig-Maximilians-Universität MunichGermany

An intense laser pulse focused onto a plasma can excite nonlinear plasma *** appropriate conditions,electrons from the background plasma are trapped in the plasma wave and accelerated to ultra-relativistic *** scheme is called a laser wakefield *** this work,we present results from a laser wakefield acceleration experiment using a petawatt-class laser to excite the wakefields as well as nanoparticles to assist the injection of electrons into the accelerating phase of the *** find that a 10-cm-long,nanoparticle-assisted laser wakefield accelerator can generate 340 pc,10±1.86 GeV electron bunches with a 3.4 GeV rms convolved energy spread and a 0.9 mrad rms *** can also produce bunches with lower energies in the 4–6 GeV range.

关键词： acceleration nanoparticle charge

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Six psychotropics for pre-symptomatic ＆ early Alzheimer＇s (McI), Parkinson＇s, and Huntington＇s disease modification

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Neural Regeneration Research 2016年第11期11卷 1712-1726页

作者： edward c. Lauterbach Psychiatry and Neurology Mercer University School of Medicine Macon GA USA

The quest for neuroprotective drugs to slow the progression of neurodegenerative diseases （NDDs）, including Alzheimer＇s disease （AD）, Parkinson＇s disease （PD）, and Huntington＇s disease （HD）, has been largely unrewarding. Preclinical evidence suggests that repurposing quetiapine, lithium, valproate, fluoxetine, donepezil, and memantine for early and pre-symptomatic disease-modification in NDDs may be promising and can spare regulatory barriers. The literature of these psychotropics in early stage and pre-symptomatic AD, PD, and HD is reviewed and propitious findings follow. Mild cognitive impairment （McI） phase of AD： salutary human randomized controlled trial findings for low-dose lithium and, in selected patients, donepezil await replication. Pre-symptomatic AD： human epidemiological data indicate that lithium reduc- es AD risk. Animal model studies （AMS） reveal encouraging results for quetiapine, lithium, donepezil, and memantine. Early PD： valproate AMS findings show promise. Pre-symptomatic PD： lithium and valproate AMS findings are encouraging. Early HD： uncontrolled clinical data indicate non-progression with lithium, fluoxetine, donepezil, and memantine. Pre-symptomatic HD： lithium and valproate are auspicious in AMS. Many other promising findings awaiting replication （valproate in McI; lithium, valproate, fluoxetine in pre-symptomatic AD; lithium in early PD; lithium, valproate, fluoxetine in pre-symptomatic PD; donepezil in early HD; lithium, fluoxetine, memantine in pre-symptomatic HD） are reviewed. Dose- and stage-dependent effects are considered. Suggestions for signal-enhancement in human trials are provided for each NDD stage.

关键词： drug repositioning neuroprotective agents psychotropic drugs neurodegenerative diseases mildcognitive impairment humans animals animal models

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Identification of bovine coronavirus in a Daurian ground squirrel expands the host range of Betacoronavirus 1

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Virologica Sinica 2023年第2期38卷 321-323页

作者： Lin Xu Wei Liu Mengyu Bie Tao Hu Dong Yan Zhishu Xiao edward c.Holmes Weifeng Shi School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan250117China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTai'an271000China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing100101China University of chinese Academy of Sciences Beijing100049China Anti-plague Institute of Hebei Province Zhangjiakou075000China Sydney Institute for Infectious Diseases School of Medical SciencesThe University of SydneySydneyNSW 2006Australia

Dear Editor,Bovine coronavirus(BcoV)is a member of the species Betacoronavirus 1 in the genus Betacoronavirus,subgenus *** members of the species Betacoronavirus 1 comprise porcine hemagglutinating encephalomyelitis virus(PHEV),human coronavirus Oc43(HcoVOc43),equine coronavirus(EcoV),and rabbit coronavirus HKU14(RbcoV HKU14)(corman et al.,2018).BcoV is known to infect a wide range of mammals including domestic and wild ruminants,causing enteritis and pneumonia(Saif,2010).BcoV is ubiquitous in cattle worldwide,even in the respiratory and intestinal samples of healthy individuals,causing major economic losses to the beef and dairy cattle industries(Vlasova and Saif,2021).Importantly,it has been suggested that HcoV-Oc43 originated in rodents,and that the major host of BcoV–cattle–acts as intermediate host(Kin et al.,2016;Forni et al.,2017;corman et al.,2018;cui et al.,2019).

关键词： U14 rabbit

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Flight characteristics Analysis Based on QAR Data of a Jet Transport During Landing at a High-altitude Airport

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chinese Journal of Aeronautics 2012年第1期25卷 13-24页

作者： c.edward Lan WU Kaiyuan YU Jiang Department of Aerospace Engineering The University of KansasKansas 66045USA china Aerodynamics Research and Development center Mianyang 622661China Scientific Research Base Civil Aviation Flight University of ChinaGuanghan 618307China

Flight data of a twin-jet transport aircraft in revenue flight are analyzed for potential safety problems. Data from the quick access recorder （QAR） are first filtered through the kinematic compatibility analysis. The filtered data are then organized into longitudinal- and lateral-directional aerodynamic model data with dynamic ground effect. The dynamic ground effect requires the radio height and sink rate in the models. The model data are then refined into numerical models through a fuzzy logic algorithm without data smoothing in advance. These numerical models describe nonlinear and unsteady aerodynamics and are used in nonlinear flight dynamics simulation. For the jet transport under study, it is found that the effect of crosswind is significant enough to excite the Dutch roll motion. Through a linearized analysis in flight dynamics at every instant of time, the Dutch roll motion is found to be in nonlinear oscillation without clear damping of the amplitude. In the analysis, all stability derivatives vary with time and hence are nonlinear functions of state variables. Since the Dutch roll motion is not damped despite the fact that a full-time yaw damper is engaged, it is concluded that the design data for the yaw damper is not sufficiently realistic and the contribution of time derivative of sideslip angle to damping should be considered. As a result of nonlinear flight simulation, the vertical wind acting on the aircraft is estimated to be mostly updraft which varies along the flight path before touchdown. Varying updraft appears to make the descent rate more difficult to control to result in a higher g-load at touchdown.

关键词： jet transport unsteady aerodynamics nonlinear aerodynamics flight dynamics flight safety quick access recorder data

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Extraction of 17β-estradiol in water using non-imprinted polymer submicron particles in membrane filters

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Journal of Environmental Sciences 2010年第11期22卷 1820-1825页

作者： Yiyan Li edward P. c. Lai Institute of Environmental Science Carleton University 1125 Colonel By Drive Ottawa Ontario K1S 5B6 Canada. Department of chemistry Carleton University 1125 Colonel By Drive Ottawa Ontario K1S 5B6 Canada

17β-Estradiol （E2） is an endocrine disrupting chemical of harm to both animals and human beings at a low concentration level （ng/L）. It cannot be completely removed by wastewater treatments, and is often detected in both environment and drinking waters. The purpose of this feasibility study, towards environmental engineering in the field of water analysis and treatment, was to remove E2 by extraction using non-imprinted polymer （NIP） submicron particles. Experimental results showed that 0.5 mg/L of E2 could be completely extracted by adding 10 mg of NIP particles directly into 10 mL of water. However, the extraction efficiency decreased to 64% for 100 mL of water. prefilling the NIP particles inside a membrane filter showed a potential for water treatment of a large volume, requiring no effort to distribute the particles uniformly in the water. High extraction efficiency （80 ± 10）% for E2 was achieved for 100 mL of water. A total mass of 0.29 mg E2 was extracted from 1000 mL of water containing 0.8 mg/L E2 （by using only 10 mg of NIP particles）. Both efficiency and mass capacity can be increased, by scaling up the amount of NIP particles, towards environmental engineering applications.

关键词： 17β-estradiol non-imprinted polymer submicron particles membrane filter pollution abatement technology

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