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The ascent of immune checkpoint inhibitors： is the understudy ready for a leading role？

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Cancer Biology & Medicine 2017年第4期14卷 341-347页

作者： Amy L. Cummings edward B. Garon Department of Hematology and Oncology David Geffen School of Medicine at the University of California Los Angeles 90095 USA

The recent approval of pembrolizumab as second-line treatment for any solid tumor with high-level microsatellite instability or mismatch repair deficiency agnostic of tissue and origin1 has shattered a glass ceiling for immune checkpoint *** longer bound to a specific cancer diagnosis but rather a biomarker,pembrolizumab has heightened a burgeoning optimism towards the drug *** how these agents should carve out additional

关键词： PD The ascent of immune checkpoint inhibitors:is the understudy ready for a leading role PFS OS ORR IHC

Virtual screening of inorganic materials synthesis parameters with deep learning

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npj Computational Materials 2017年第1期3卷 14-22页

作者： edward Kim Kevin Huang Stefanie Jegelka Elsa Olivetti Department of Materials Science and Engineering MITCambridgeMAUSA Department of EECS and CSAIL MITCambridgeMAUSA

Virtual materials screening approaches have proliferated in the past decade,driven by rapid advances in first-principles computational techniques,and machine-learning *** comparison,computationally driven materials synthesis screening is still in its infancy,and is mired by the challenges of data sparsity and data scarcity:Synthesis routes exist in a sparse,highdimensional parameter space that is difficult to optimize over directly,and,for some materials of interest,only scarce volumes of literature-reported syntheses are *** this article,we present a framework for suggesting quantitative synthesis parameters and potential driving factors for synthesis *** use a variational autoencoder to compress sparse synthesis representations into a lower dimensional space,which is found to improve the performance of machine-learning *** realize this screening framework even in cases where there are few literature data,we devise a novel data augmentation methodology that incorporates literature synthesis data from related materials *** apply this variational autoencoder framework to generate potential SrTiO_(3) synthesis parameter sets,propose driving factors for brookite TiO_(2) formation,and identify correlations between alkali-ion intercalation and MnO_(2) polymorph selection.

关键词： synthesis variational inorganic

High energy neutron and pion-decay gamma-ray emissions from solar flares

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Chinese Journal of Astronomy and Astrophysics 2009年第1期9卷 11-40页

作者： edward L.Chupp James M.Ryan Physics Department and Space Science Center in the Institute for the Study of Earth Oceans and Space University of New Hampshire

Solar flare gamma-ray emissions from energetic ions and electrons have been detected and measured to GeV energies since 1980. In addition, neutrons produced in solar flares with 100 MeV to GeV energies have been observed at the Earth. These emissions are produced by the highest energy ions and electrons accelerated at the Sun and they provide our only direct （albeit secondary） knowledge about the properties of the accelerator（s） acting in a solar flare. The solar flares, which have direct evidence for pion-decay gamma-rays, are unique and are the focus of this paper. We review our current knowledge of the highest energy solar emissions, and how the characteristics of the acceleration process are deduced from the observations. Results from the RHESSI, INTEGRAL and CORONAS missions will also be covered. The review will also cover the solar flare capabilities of the new mission, FERMI GAMMA RAY SPACE TELESCOPE, launched on 2008 June II. Finally, we discuss the requirements for future missions to advance this vital area of solar flare physics.

关键词： Sun -- Flares -- Particle Acceleration-Meson Production

A neural network protocol for predicting molecular bond energy

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Science China Chemistry 2019年第12期62卷 1698-1703页

作者： Chao Feng edward Sharman Sheng Ye Yi Luo Jun Jiang Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China Department of Neurology University of CaliforniaIrvineCalifornia 92697USA

Molecular bond energy is a key parameter for analyzing the properties of chemical activity,stability and *** bond energy is a challenge due to the cost of first-principles simulations and unsatisfactory prediction using empirical *** we show that a neural network(NN)machine-learning method can achieve quick prediction of bond energies of organic *** atomic species and charge information as descriptors,we trained a NN protocol and applied it to predict the bond energy in a certain chemical bond that agreed with density functional theory *** protocol also provided a way to evaluate the effects of different methods of atomic charge analysis on NN *** to accurately estimate bond energies,this NN protocol provides a cost-effective tool for optimizing chemical reactions,accelerating molecular design,and other important applications.

关键词： bond energy neural network density functional theory

Bednets or Biotechnology:To Rescue Current Persons or Research for the Future?

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Fudan Journal of the Humanities and Social Sciences 2020年第4期13卷 559-572页

作者： Daniel edward Callies Institute for Practical Ethics University of CaliforniaSan DiegoUSA Encinitas USA

Malaria is still a significant cause of death and suffering throughout much of the developing ***,the global community provides significant(though,not sufficient)resources to combat the disease and the parasite that causes *** ought we to allocate these resources?One option is to purchase and distribute perhaps the best tool we have to prevent malaria:insecticide-treated *** route would see us invest in research and development of a novel biotechnology that could eradicate the disease in *** we choose to spend our money on insecticidetreated nets,we will be rescuing current individuals at risk of being infected with the ***,we can be almost certain there will be future individuals who will also need *** we instead invest in the novel biotech no logy,we could benefit countless future individuals who never have to experience the threat of ***,this would mean that some number of current individuals will die due to the lack of insecticide-treated nets that otherwise could have saved their ***,ought we to rescue current,identifiable individuals,or ought we invest in research for the sake of the future?After an exploration of the duty to rescue and cost-effectiveness analysis,I suggest we look towards the literature on intergenerational justice for a justifiable answer to the question of how we ought to allocate our malaria resources.

关键词： Malaria Gene drive Cost-efFectiveness analysis Intergenerational justice Rule of rescue

Network coding-aware cache replacement policy in on-demand broadcast environments

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Journal of Harbin Institute of Technology(New Series) 2012年第5期19卷 92-100页

作者：陈君 LEE Victor C S CHAN edward School of Information Management Wuhan UniversityWuhan 430072China Dept.of Computer Science City University of Hong KongHong KongChina

Network coding has been proved to be an effective technique in improving the performance of data broadcast systems because clients requesting different data items can be served simultaneously in one broadcast. Previous studies showed that its efficiency is highly related to the content of clients' cache. However, existing data broadcast systems do not take network coding information into account when making cache replacement decisions. In this paper, we propose two networks coding-aware cache replacement policies called DLRU and DLRU-CP to supplement network coding assisted data broadcast in on-demand broadcast environments. In DLRU, both data access and decoding contribution are taken into account to make replacement decisions. DLRU-CP is based on DLRU but allows clients to retrieve decodable data items that have not been requested yet. The performance gain of our proposed cache replacement policies over traditional cache replacement policy is shown in the simulation results, which demonstrate conclusively that the proposed policies can effectively reduce the overall response time.

关键词： Network coding cache replacement on-demand broadcast mobile computing

Mitigation of Hypoxic Ecosystems Using Hemolymph Analysis of Callinectes sapidus and Procambarus clarkii in Relation to Spartina Grasses

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Open Journal of Ecology 2016年第8期6卷 484-495页

作者： Natalie Bush edward Bush Christopher Green Julie anderson Pamela Blanchard Nathan Bush Jennifer Conover St. Joseph’s Academy Baton Rouge LA USA LSU AgCenter Baton Rouge LA USA LSU AgCenter Aquaculture Research Station Baton Rouge LA USA LSU AgCenter and Louisiana Sea Grant Baton Rouge LA USA Health and Human Resources Baton Rouge LA USA Department of Mathematics Texas A & M University College Station TX USA Louisiana Universities Marine Consortium Chauvin LA USA

In the past 80 years, Louisiana has lost over one million acres in land, affecting plants and crustaceans that live in these environments. The first objective of this research was to determine the relationship between diffused oxygen in water and time with the behavioral and physiological health of Callinectes sapidus (blue crab) and Procambarus clarkii (crawfish). After 24 hours, manual dexterity, or the amount of time it takes for a crustacean to flip itself over increased under hypoxic conditions. Hemolymph was extracted and tested for lactate, glucose, and protein. Crawfish were also exposed to this same procedure. An additional crawfish study comparing Spartina plants to assimilate oxygen for aeration compared to mechanical aeration was conducted. The hypoxic groups for all three studies at the 0.05 level had a significantly greater manual dexterity time and greater amounts of lactate and glucose. The protein was significantly higher in hypoxia-exposed crawfish. Time and aeration affect the health of crustaceans, and plants were shown to effectively provide normoxic oxygen levels at a similar level as mechanical aeration. These studies support the importance of marsh grasses for the coast and crustacean viability.

关键词： Coastal Restoration Barrier Island Mitigation Marine Ecology

基于农村内源性发展模式的新型夯土建筑策略——以“一专一村”西南农村地区项目为例

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建筑学报 2024年第1期 105-111页

作者：万丽吴恩融迟辛安柏文峰周来香港中文大学建筑学院中国香港999077 昆明理工大学建筑与城市规划学院昆明650500

提出内源性发展理念与当地生土建筑相结合的农村建设思路,以“一专一村”计划的一系列新型夯土建筑实践为例,从与环境和谐相处、发掘本土价值、尊重当地人的主体性、引入外部智力资源几个方面进行深入分析,总结出“科学方法、适宜技术... 详细信息

提出内源性发展理念与当地生土建筑相结合的农村建设思路,以“一专一村”计划的一系列新型夯土建筑实践为例,从与环境和谐相处、发掘本土价值、尊重当地人的主体性、引入外部智力资源几个方面进行深入分析,总结出“科学方法、适宜技术”的创新思路及“本土材料、本土技术、本土工匠”的组织原则,探讨系统性、跨学科、跨部门联动,提升乡村发展内生动力的建造模式。

关键词：内源性发展内生动力夯土建筑可持续发展

Multimodality image registration and fusion using neural network

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Journal of Harbin Institute of Technology(New Series) 2003年第3期10卷 235-240页

作者： Mostafa G Mostafa Aly A Farag edward Essock Computer Vision and Image Processing Laboratory Dept. of Electrical and Computer Engineering University of Louisville Louisville KY 40292 USAComputer Vision and Image Processing Laboratory Dept. of Electrical and Computer Engineering University of Louisville Louisville KY 40292 USADept. of Psychology University of Louisville Louisville kY 40292 USA

Multimodality image registration and fusion are essential steps in building 3-D models from remotesensing data. We present in this paper a neural network technique for the registration and fusion of multimodali-ty remote sensing data for the reconstruction of 3-D models of terrain regions. A FeedForward neural network isused to fuse the intensity data sets with the spatial data set after learning its geometry. Results on real data arepresented. Human performance evaluation is assessed on several perceptual tests in order to evaluate the fusionresults.

关键词： data fusion image registration image interpolation neural network, 3-D model building