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Estrad.ol increases cortical and.trabecular bone accrual and.bone strength in an ad.lescent male-to-female mouse mod.l of gend.r-affirming hormone therapy

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Bone Research 2024年第1期12卷 95-106页

作者： Tian Nie Varun S.Venkatesh Suzanne Golub Kathryn S.Stok Haniyeh Hemmatian Reena d.sai d.vid.J.Hand.lsman Jeffrey d.Zajac Mathis Grossmann Rachel A.d.vey d.partment of Med.cine Austin HealthUniversity of MelbourneHeidelbergVIC 3084Australia d.partment of Biomed.cal Engineering University of MelbourneParkvilleVIC 3010Australia ANZAC Research Institute University of Sydney and AndrologyConcord Repatriation General HospitalConcordNSW 2137Australia

The effects of gend.r-affirming hormone therapy on the skeletal integrity and.fracture risk in transitioning ad.lescent trans girls are *** ad.ress this knowled.e gap,we d.veloped.a mouse mod.l to simulate male-to-female transition in human ad.lescents in whom puberty is first arrested.by using gonad.trophin-releasing hormone analogs with subsequent estrad.ol *** was suppressed.by orchid.ctomy in male mice at 5 weeks of *** 3 weeks post-surgery,male-to-female mice were treated.with a high d.se of estrad.ol(~0.85 mg)by intraperitoneal silastic implantation for 12 *** includ.d.intact and.orchid.ctomized.males at 3 weeks post-surgery,vehicle-treated.intact males,intact females and.orchid.ctomized.males at 12 weeks *** to male controls,orchid.ctomized.males exhibited.d.creased.peak bone mass accrual and.a d.creased.maximal force the bone could.withstand.prior to *** treatment in orchid.ctomized.male-to-female mice compared.to mice in all control groups was associated.with an increased.cortical thickness in the mid.d.aphysis,while the periosteal circumference increased.to a level that was intermed.ate between intact male and.female controls,resulting in increased.maximal force and.*** trabecular bone,estrad.ol treatment increased.newly formed.trabeculae arising from the growth plate as well as mineralizing surface/bone surface and.bone formation rate,consistent with the anabolic action of estrad.ol on osteoblast *** d.ta support the concept that skeletal integrity can be preserved.and.that long-term fractures may be prevented.in trans girls treated.with GnRHa and.a sufficiently high d.se of *** stud. is need.d.to id.ntify an optimal d.se of estrad.ol that protects the bone without ad.erse sid. effects.

关键词： treatment treatment strength

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Sustainable oil-in-water analysis using a supercritical fluid.carbon d.oxid. extraction system d.rectly interfaced.with infrared.spectroscopy

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Journal of Environmental Sciences 2010年第9期22卷 1462-1468页

作者： edward d.Ramsey School of Chemical Engineering University of Science and Technology Liaoning

A d.rect aqueous supercritical fluid.extraction （SFE） system using carbon d.oxid. provid.s a sustainable means by which a vast range of ind.stries may continue to d.pend.on well established.infrared.（IR） techniques to d.termine oil-in-water. The SFE-IR method.provid.s an environmentally friend.y substitute for current national stand.rd.IR reference method. for measuring oil-in-water that rely on using increasingly restricted.ozone d.pleting solvents whose manufacture is being phased.out in accord.nce with international law. The SFE-IR analysis of a 500 mL water sample can be accomplished.in 15 min. A rapid.on-line SFE-IR calibration method.has been implemented. With this calibration method. SFE-IR accuracy for d.termining d.esel oil in 500 mL spiked.water samples using single wave number measurement was 86.0%-98.8% with precision （RSd. ranging from 2.5%-7.0%. Using a general purpose calculation which involves measuring infrared.absorbance values at three d.fferent wave numbers, SFE-IR method.accuracy for d.termining d.esel oil in 500 mL spiked.water samples was 83.7%-92.2% with RSd.1.0%-9.3%. d.ta is presented.that ind.cates current long established.national stand.rd.IR reference method. involving three wave number calculations should.be reviewed.since, without careful consid.ration, the inclusion of calculated.aromatic hyd.ocarbon species contributions to final oil-in-water concentration values may provid. less accurate results.

关键词： oil-in-water supercritical fluid.extraction infrared.spectroscopy sustainable green technology

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Assessing the impact of conceptual mineral systems uncertainty on prospectivity pred.ctions

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Geoscience Frontiers 2022年第6期13卷 182-207页

作者： Mark d.Lind.ay Agnieszka M.Piechocka Mark W Jessell Richard.Scalzo Jeremie Giraud.Guillaume Pirot edward Cripps Commonwealth Scientific and.Ind.strial Research Organisation Mineral Resources Australian Resources Research CentreWA 6151Australia Mineral Exploration Cooperative Research Centre Centre for Exploration TargetingSchool of Earth SciencesThe University of Western AustraliaPerthWA 6009Australia ARC Centre for d.ta Analytics for Resources and.Environments(d.RE) Perth and SydneyAustralia University of Syd.ey School of Mathematics and StatisticsSydneyAustralia Universitéd. Lorraine GeoRessourcesCNRS54000 NancyFrance The University of Western Australia Department of Mathematics and StatisticsPerthAustralia

The past two d.cad.s have seen a rapid.ad.ption of artificial intelligence method. applied.to mineral exploration. More recently, the easier acquisition of some types of d.ta has inspired.a broad.literature that has examined.many machine learning and.mod.lling techniques that combine exploration criteria,or ’features’, to generate pred.ctions for mineral prospectivity. Central to the d.sign of prospectivity mod.ls is a ’mineral system’, a conceptual mod.l d.scribing the key geological elements that control the timing and.location of economic mineralisation. The mineral systems mod.l d.fines what constitutes a training set, which features represent geological evid.nce of mineralisation, how features are engineered.and.what mod.lling method. are used. Mineral systems are knowled.e-d.iven conceptual mod.ls, thus all parameter choices are subject to human biases and.opinion so alternative mod.ls are ***, the effect of alternative mineral systems mod.ls on prospectivity is rarely compared.d.spite the potential to heavily influence final pred.ctions. In this stud., we focus on the effect of conceptual uncertainty on Fe ore prospectivity mod.ls in the Hamersley region, Western Australia. Four important consid.rations are tested.(1) Five d.fferent supergene and.hypogene conceptual mineral systems mod.ls guid. the inputs for five forest-based.classification prospectivity mod.ls mod.l.(2) To represent conceptual uncertainty, the pred.ctions are then combined.for prospectivity mod.l comparison.(3)Representation of three-d.mensional objects as two-d.mensional features are tested.to ad.ress commonly ignored.thickness of geological units.(4) The training d.taset is composed.of known economic mineralisation sites(d.posits) as ’positive’ examples, and.exploration d.illing d.ta provid.ng ’negative’sampling locations. Each of the spatial pred.ctions are assessed.using ind.pend.nt performance metrics common to AI-based.classification method. and.subjected.to geological pl

关键词： Uncertainty Mod.lling Prospectivity Economic geology Geological plausibility Forest-based.classification

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QUINAPRILAT INCREASES TOTAL BOd. VASCULAR COMPLIANCE IN RATS WITH MYOCARd.AL INFARCTION

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中华医学杂志(英文版) 1992年第5期105卷 382-389页

作者： Yongwei Chien edward d. Frohlich Allan A. MacPhee Barbara L. Pegram Alton Ochsner Med.cal Found.tion New Orleans LA 70121 USA

To test whether quinaprilat,a new angiotensinconverting enzyme inhibitor,has any venous effect,itsimmed.ate effects were measured.on mean circulatoryfilling pressure(MCFP),intravascular volume and.to-tal bod. vascular(i.e.,venous)compliance in consciousrats with mild.congestive heart failure ind.ced.bycoronary artery *** was d.termined.by in-flating a right atrial balloon to arrest the circulationinstantly and.*** bod. vascular compli-ance was d.rived.from total circulatory pressure-vol-ume relationships as d.termined.by seriesmeasurements of MCFP with d.fferent intravascularvolume *** 8 rats with mean infarct size of26±4%,30-minute infusion of quinaprilat(0.1mg/kg/min)d.creased.both mean arterial and.entral venous pressures by 8 mmHg and.0.7 mmHg,respectively(Pd.blood.volume remained.*** control vehicle infusion,quinaprilat increased.thetotal bod. vascular compliance(2.09±0.12 vs 2.69±0.23ml/kg/mmHg;Pd.d.creased.xtrapolated.unstressed.circulating volume(34.96±1.10 vs 28.53±2.55ml/kg;Pd.tasuggest that quinaprilat prod.ces possible venod.lationthrough immed.ately improved.total bod. vascularcompliance thereby red.cing card.ac preload.in this ratmod.l of chronic heart failure.

关键词： CONGESTIVE HEART-FAILURE CONVERTING ENZYME-INHIBITORS PRESSURE-VOLUME RELATIONSHIP ATRIAL NATRIURETIC PEPTId. CONSCIOUS RAT NITROGLYCERIN CAPTOPRIL CAPACITY THERAPY MOd.L

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Kelley's textbook of rheumatology / 7th ed

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2005年

作者： Harris edward d.

来源：畅想之星图书光盘版（南... 评论

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Relationships between testate amoeba communities and.water quality in Lake d.nghu, a large alkaline lake in Wuhan, China

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Frontiers of Earth Science 2013年第2期7卷 182-190页

作者： Yangmin QIN Bertrand.FOURNIER Enrique LARA Yansheng GU Hongmei WANG Yongd. CUI Xiaoke ZHANG edward A. d. MITCHELL State Key Laboratory of Biogeology and.Environmental Geology China University of Geosciences Wuhan 430074 China State Key Laboratory of Loess and.Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'an 710075 China Laboratory of Soil Biology University of Neuchatel Rue Emile Argand 11 CH-2000 Neuchatel Switzerland Institute of Hyd.obiology Chinese Academy of Sciences Wuhan 430072 China

The mid.le Yangtze Reach is one of the most d.veloped.regions of China. As a result, most lakes in this area have suffered.from eutrophication and.serious environmental pollution d.ring recent d.cad.s. The aquatic biod.versity in the lakes of the area is thus currently und.r significant threat from continuous human activities. Testate amoebae （TA） are benthic （rarely planktonic） microorganisms characterized.by an agglutinated.or autogenous shell. Owing to their high abund.nce, preservation potential in lacustrine sed.ments, and.d.stinct response to environmental stress, they are increasingly used.as ind.cators for monitoring water quality and.reconstructing palaeoenvironmental changes. However this approach has not yet been d.veloped.in China. This stud. presents an initial assessment of benthic TA assemblages in eight lakes of Lake d.nghu in the region of Wuhan, China. Testate amoeba community structure was most strongly correlated.to water pH. In more alkaline cond.tions, communities were d.minated.by Centropyxis aculeata, d.fflugia oblonga, Pontigulasia compressa, Pon. elisa and.Lesquereusia mod.sta. These results are consistent with previous stud.es and.show that TA could.be useful for reconstructing past water pH fluctuations in China. To achieve this, the next step will be to expand.the d.tabase and.build.transfer function mod.ls.

关键词： testate amoebae (TA) water quality water pH Lake d.nghu China

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The Process and.Benefits of d.veloping Prototype Climate Services——Examples in China

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Journal of Meteorological Research 2020年第5期34卷 893-903页

作者： Chris d.HEWITT Nicola GOLd.NG Peiqun ZHANG Tyrone d.NBAR Philip E.BETT Joanne CAMP Timothy d.MITCHELL edward POPE Met Office Exeter EX 13PBUK University of Southern Queensland Toowoomba QLD 4350Australia Beijing Climate Center/National Climate Center China Meteorological AdministrationBeijing 100081China

Changes in climate pose major challenges to society, and.so d.cision-makers need.actionable climate information to inform their planning and.policies to make society more resilient to climatic changes. Climate services are being d.veloped.to provid. such actionable climate information. The successful d.velopment and.use of climate services benefits greatly from close engagement between d.velopers, provid.rs, and.users of the services. The Climate Science for Service Partnership China(CSSP China) is a China–UK collaboration fostering closer engagement between climate scientists, provid.rs of climate services, and.users of climate services. We d.scribe the process within CSSP China of co-d.veloping climate services through trials with users to revise and.improve a prototype. Examples are provid.d.covering various scientific capabilities, user need., and.parts of China. The d.velopment process is yield.ng many benefits, such as increasing the engagement between provid.rs and.users, making users more aware of how climate information can be of use in their d.cision-making, giving the climate service provid.rs a better und.rstand.ng of the users’ requirements for climate information, and.shaping future scientific research and.d.velopment. In ad.ition to the benefits, we also d.cument some challenges that have emerged. along with ways of alleviating them. We have two key recommend.tions from our experiences: make the time and.space for effective engagement between the users and.d.velopers of any climate service;bring the need. of the users in to the d.sign and.d.livery of the climate service as early as possible and.throughout the d.velopment cycle.

关键词： climate services prototypes user engagement

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Arabinosylation of a Yariv-Precipitable Cell Wall Polymer Impacts Plant Growth as Exemplified.by the Arabid.psis Glycosyltransferase Mutant ray1

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Molecular Plant 2013年第4期6卷 1369-1372页

作者： Sascha Gille Vaishali Sharma edward E.K. Baid.o Jay d. Keasling Henrik Vibe Scheller Markus Pauly Energy Biosciences Institute University of California Berkeley CA 94720 USA Joint BioEnergy Institute Emeryville CA 94608 USA Physical Biosciences d.vision Lawrence Berkeley National Laboratory Berkeley CA 94720 USA d.partment of Chemical and.Biomolecular Engineering Department of Bioengineering University of California Berkeley CA 94720 USA d.partment of Plant and.Microbial Biology University of California Berkeley CA 94720 USA

d.ar Ed.tor, Plant cells are encased.by cell walls--rigid.yet highly d.namic composite structures, which consist of cellulose, hemicelluloses, pectic polysaccharid.s, glycoproteins, and.the polyphenol lignin （Somerville et al., 2004）. Biosynthesis of the wall polysaccharid.s is facilitated.by d.nor- and.acceptor- substrate-specific glycosyltransferases catalyzing the transfer of the sugar moiety from a nucleotid. sugar to form a specific glycosid.c linkage. Glycosyltransferases have been grouped.into families based.on primary structure, one of which is fam- ily GT77 （***/GT77_***）.

关键词： Yariv-Precipitable Exemplified Arabid.psis Glycosyltransferase

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The significance of clinical practice guid.lines on ad.lt varicocele d.tection and.management

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Asian Journal of And.ology 2016年第2期18卷 269-275,J0006,J0007页

作者： Anand.Shrid.arani Ryan C Owen Osama O Elkelany edward d.Kim d.partment of Urology University of Tennessee College of Medicine Chattanooga TN 37403 USA d.vision of Urology Department of Surgery University of Tennessee Graduate School of Medicine Knoxville TN 37920 USA.

Varicoceles are the most common correctable etiology of male factor infertility. However, the d.tection and.management of varicoceles have not been stand.rd.zed. This has led.to d.cad.s of d.bate regard.ng the effect of varicocele on male infertility and.subsequently whether repair lead. to an improved.fertility status. The current bod. of evid.nce investigating the role of varicocele and.varicocelectomy is weak and.conflicting. The stance taken by the AUA and.ASRM suggests that there is insufficient outcomes d.ta to support evid.nced.based.guid.lines, citing evid.nce used.to provid. current recommend.tions are generally of a low quality level. On the other hand. the EAU Guid.lines give a level la of evid.nce for management of varicoceles that are clinically palpable, associated.with subnormal semen analyses and.having otherwise unexplained.fertility. Besid.s aid.ng with clinical varicocele d.tection and.management, clinical practice opinion statements and.guid.lines aim to d.rect and.strengthen the infrastructure of future stud.es. We review the current status of opinion statements and.guid.lines in varicocele and.management d.tection with focus on their application in practice.

关键词： guid.lines varicocele varicocele d.tection varicocele management varicocelectomy

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End.scopic biliary treatment of unresectable cholangiocarcinoma: A meta-analysis of survival outcomes and.systematic review

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World.Journal of Gastrointestinal End.scopy 2023年第3期15卷 177-190页

作者： Jeffrey Rebhun Claire M Shin Uzma d.Sid.iqui edward Villa d.partment of Gastroenterology Oregon Health and Sciences UniversityPortlandOR 97239United States d.partment of Med.cine University of Illinois at ChicagoChicagoIL 60612United States Center for End.scopic Research and.Therapeutics University of ChicagoUniversity of Chicago MedicineChicagoIL 60637United States d.partment of Gastroenterology and.Hepatology Northshore University Health SystemEvanstonIL 60201United States

BACKGROUNd.End.scopic rad.ofrequency ablation(ERFA),percutaneous rad.ofrequency ablation(PRFA),and.photod.namic therapy(Pd.),when used.in conjunction with conventional biliary stenting,have d.monstrated.a survival benefit in patients with unresectable *** To compare pooled.survival outcomes,ad.erse event rates,and.mean stent patency for those und.rgoing these *** A comprehensive literature review of published.stud.es and.abstracts from January 2011 to d.cember 2020 was performed.comparing survival outcomes in patients und.rgoing ERFA with stenting,biliary stenting alone,PRFA with stenting,and.Pd. with stenting for unresectable cholangiocarcinoma(CCA).RESULTS d.ta from four stud.es d.monstrated.a pooled.mean survival favoring ERFA as compared.to biliary stenting alone(12.0±0.9 mo vs 6.8±0.3 mo,Pd.med.an survival time(13 mo vs 8 mo,Pd.PRFA with stenting groups d.monstrated.statistical superiority to biliary stenting alone(Pd.P=0.004,respectively).However,when comparing ERFA to PRFA,pooled.d.ta d.monstrated.overall higher mean survival in the ERFA with stenting cohort as compared.to PRFA with stent cohort(12.0+0.9 mo vs 8.1+2.1 mo,Pd.ta from two stud.es d.monstrated.a pooled.med.an survival favoring ERFA with stenting as compared.to Pd. with stenting(11.3 mo vs 8.5 mo,P=0.02).CONCLUSION While further prospective,rand.mized.stud.es are need.d.to assess efficacy of ERFA,our metaanalysis d.monstrated.that this technique offers end.scopists a reasonable palliative method.by which to treat patients with unresectable CCA that results in longer survival as compared.to biliary stenting alone,percutaneous rad.ofrequency ablation with biliary stenting,and.Pd. with biliary stenting as well as an acceptable ad.erse event profile based.on available published.d.ta.

关键词： End.scopic rad.ofrequency ablation Percutaneous rad.ofrequency ablation Photod.namic therapy Cholangiocarcinoma Meta-analysis Systematic review

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