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Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?

World Journal of Gastroenterology 2010年第25期16卷 3144-3152页

作者： Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez eduardo maurińo Julio C Bai Small Bowel Section Department of Medicine Gastroenterology Hospital "Dr. C. Bonorino Udaondo" Caseros 2061 Ciudad de Buenos Aires Argentina Pathology Service Hospital de Gastroenter-ología "Dr. C. Bonorino Udaondo" Av. Caseros 2061 Ciudad de Buenos Aires Argentina USNMA HIGA "San Martín" La Plata B1900 Provincia de Buenos Aires Argentina Endoscopy Service Hospital de Gastroenter-ología "Dr. C. Bonorino Udaondo" Av. Caseros 2061 Ciudad de Buenos Aires Argentina Endoscopy Service HIGA "San Martín" La Plata

AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHoDS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU RoC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU RoC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CoNCLUSIoN: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects.

关键词： Celiac disease Serology Gliadin peptide antibodies Tissue transglutaminase Antigliadin antibodies Small bowel biopsy Diagnostic accuracy

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Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients

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World Journal of Gastroenterology 2019年第11期25卷 1409-1420页

作者： Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez eduardo mauri?o Elena F Verdú Julio César Bai Small Bowel Section Department of MedicineDr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1263Argentina Department of Immunology Biomedal S.L.Sevilla 41092Spain Farncombe Family Digestive Health Research Institute McMaster UniversityHamiltonON L8S4L8Canada Research Institutes Universidad del SalvadorBuenos Aires 1050Argentina

BACKGRoUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully *** To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHoDS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study *** Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. overall, 83 sets of stool and/or urine samples were *** out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary *** GIP dete

关键词： Celiac disease Follow-up Gluten-free diet Gluten immunogenic peptide excretion Rapid tests

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Risk of fracture in celiac disease:Gender,dietary compliance,or both?

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World Journal of Gastroenterology 2011年第25期17卷 3035-3042页

作者： María Inés Pinto Sánchez Adriana Mohaidle Andrea Baistrocchi Dolores Matoso Horacio Vázquez Andrea González Roberto Mazure Evangelina Maffei Guillermina Ferrari Edgardo Smecuol Adriana Crivelli Juan Andrés de Paula Juan C Gómez Silvia Pedreira eduardo maurio Julio César Bai Small Bowel Section Department of Medicine"Dr.C.Bonorino Udaondo" Gastroenterology Hospital Department of Gastroenterology German Hospital Nutritional Support Unit and Malabsortion "San Martin" HIGA1900 La PlataArgentina Department of Gastroenterology Italian Hospital

AIM:To determine the incidence of peripheral fractures in patients with celiac disease (CD) and the effect of treatment on fracture ***:We compared the incidence and risk of peripheral fractures before and after diagnosis between a cohort of 265 patients who had been diagnosed with CD at least 5 years before study entry and a cohort of 530 age-and sex-matched controls who had been diagnosed with functional gastrointestinal *** were collected through in-person interviews with an *** overall assessment window for patients was 9843 patient-years (2815 patient-years after diagnosis).RESULTS:Compared with the control group,the CD cohort showed significantly higher incidence rate and risk of first peripheral fracture before diagnosis [adjusted hazard ratio (HR):1.78,95% CI:1.23-2.56,P ociated with the classic CD presentation with gastrointestinal symptoms (P od after diagnosis,the risk of fractures was comparable between the CD cohort and controls in both sexes (HR:1.08,95% CI:0.55-2.10 for women;HR:1.57,95% CI:0.57-4.26 for men).CoNCLUSIoN:CD patients have higher prevalence of fractures in the peripheral skeleton before *** is associated with male sex and classic clinical *** fracture risk was reduced after the treatment.

关键词： Celiac disease Fracture risk Peripheralfractures Gluten-free diet Sex difference

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Environmental Impact Assessment Follow-Up of Seismic Survey offshore Activities in Brazil

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Journal of Environmental Protection 2024年第2期15卷 141-155页

作者： Fontes Nuno eduardo Paulo Marcelo Montaño Sao Carlos School of Engineering University of Sao Paulo Sao Carlos Brazil

Follow-up of environmental impacts is an integral part of the Environmental Impact Assessment (EIA) process, closely related to the effectiveness of the instrument. EIA follow-up has been receiving a lot of interest from scientists and practitioners, though it is recognized as one of the weakest points of EIA systems globally. Also, EIA follow-up is influenced by the context, mainly in terms of the types of projects or activities and their related impacts on the environment. Therefore, the present paper is focused on the investigation of the follow-up stage applied to the activity of seismic survey coupled with offshore oil & gas exploitation in Brazil. Research was based on a qualitative approach that included document analysis and semi-structured interviews with analysts involved in EIA processes, and sought to generate evidence of effectiveness of the EIA follow-up as conducted by the Federal Environment Agency (Ibama) in order to situate the practice of follow-up in the broader context of international best practice principles. Based on the findings, it was concluded that, due to the peculiarities of offshore seismic survey, it is necessary to promote adaptations in the procedures for monitoring impacts in order to ensure proper alignment with the principles and conceptual foundations that guide EIA practice. Specifically, the timing of the execution of the activity imposes challenges for its integration into the “conventional” cycle that has guided the monitoring of the impacts in the EIA of projects.

关键词： Environmental Impact Assessment Follow-Up Follow-Up Effectiveness oil and Gas offshore Seismic Survey

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Assembly structures of coastal woody species of eastern South America:Patterns and drivers

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Plant Diversity 2024年第5期46卷 611-620页

作者： eduardo Vinícius da Silva oliveira Myrna Friederichs Landim Sidney F.Gouveia Graduate Program in Ecology and Conservation Federal University of SergipeSão CristovãoSergipeBrazil National Institute of Science and Technology Ecology Evolution and Conservation of Biodiversity(INCT-EECBio)GoiâniaGoiasBrazil Department of Biology Federal University of SergipeSão CristóvãoSergipeBrazil Department of Ecology Federal University of SergipeSão CristóvãoSergipeBrazil

Tropical regions have provided new insights into how ecological communities are *** dry coastal communities,water stress has been hypothesized to determine plant assembly structure by favoring preadapted lineages from neighboring ecosystems,consistent with functional ***,it is unclear whether this hypothesis is sufficient to explain how coastal communities in tropical ecosystems are ***,we test whether water stress or other factors drive community assembly in woody plant communities across the coastal zone of Brazil,a tropical *** characterized functional and phylogenetic structures of these communities and determined the underlying environmental factors(e.g.,water stress,historical climate stability,edaphic constraints,and habitat heterogeneity)that drive their community *** of coastal woody species show geographically varied patterns,including stochastic arrangements,clustering,and overdispersion of species relative to their traits and phylogenetic *** complexity,water vapor pressure,and soil nutrient availability best explained the gradient in the functional *** deficit,water vapor pressure,and soil organic carbon were the best predictors of variation in phylogenetic *** results support the water-stress conservatism hypothesis on functional and phylogenetic structure,as well as the effect of habitat heterogeneity on functional structure and edaphic constraints on functional and phylogenetic *** effects are associated with increased phenotypic and phylogenetic divergence of woody plant assemblages,which is likely mediated by abiotic filtering and niche opportunities,suggesting a complex pattern of ecological assembly.

关键词： Brazil Completeness Clustering Restinga vegetation Water constraints

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How far have we come?Review of main public policies to reduce landslide impacts in Brazil

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Journal of Mountain Science 2024年第9期21卷 2891-2904页

作者： Bianca Carvalho VIEIRA Tiago Damas MARTINS Telma Mendes da SILVA Joséeduardo BoNINI Department of Geography University of São PauloAvenida Professor Lineu Prestes 05508-000Brazil Cities Institute Federal University of São PauloAvenida Jacu-Pêssego 08260-001Brazil Department of Geography Federal University of Rio de JaneiroAvenida Athos da Silveira Ramos 21941-916Brazil

During the rainy season in Brazil,landslides can have catastrophic consequences,including loss of life,damage to urban infrastructure and significant economic ***,more than eight million people in Brazil live in disaster-prone *** objective of this article is to present a chronological review of the principal policies and programmes at the national,state,and municipal levels,with an emphasis on their key actions aimed at mitigating the impact of disasters related to natural hazards,particularly *** analysis was based on official records of public policies from the national,state,and municipal *** results show that several initiatives were initially developed at the local and regional ***,it was not until the late 1980s that a comprehensive organisation of civil protection at the national level emerged as a response *** is possible to highlight three phases(understanding,coexistence,and prevention)of institutional action focused on risk management in the face of *** the growing knowledge of risk scenarios,disasters continue to occur in Brazil on an annual basis,revealing several obstacles to reducing their impact,particularly given the social and economic disparities between Brazilian regions and the applicability of public policies that must overcome the limitations of each municipality.

关键词： Disasters Risk Mitigation Prevention Legislation Civil Defense Natural Hazards

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Low-Cost and Biodegradable Thermoelectric Devices Based on van der Waals Semiconductors on Paper Substrates

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Energy & Environmental Materials 2024年第1期7卷 201-206页

作者： Gulsum Ersu Carmen Munuera Federico J.Mompean Daniel Vaquero Jorge Quereda João Elias F.S.Rodrigues Jose A.Alonso eduardo Flores Jose R.Ares Isabel J.Ferrer Abdullah M.Al-Enizi Ayman Nafady Sruthi Kuriakose Joshua o.Island Andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Nanotechnology Group USAL-NanolabUnivesidad de SalamancaSalamanca Junta de Castilla y León 37007Spain GISC Departamento de Física de MaterialesUniversidad Complutense de MadridMadrid E-28040Spain Departamento de Física Aplicada Centro de Investigación y Estudios AvanzadosMérida 97310Mexico MIRE Group Departamento de Física de MaterialesUniversidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Physics and Astronomy University of Nevada Las VegasLas Vegas NV 89154USA

We present a method to fabricate handcrafted thermoelectric devices on standard office paper *** devices are based on thin films of WS_(2),Te,and BP(P-type semiconductors)and TiS_(3)and TiS_(2)(N-type semiconductors),deposited by simply rubbing powder of these materials against *** thermoelectric properties of these semiconducting films revealed maximum Seebeck coefficients of(+1.32±0.27)mV K^(-1)and(-0.82±0.15)mV K^(-1)for WS_(2)and TiS_(3),***,Peltier elements were fabricated by interconnecting the P-and N-type films with graphite electrodes.A thermopower value up to 6.11 mV K^(-1)was obtained when the Peltier element were constructed with three *** findings of this work show proof-of-concept devices to illustrate the potential application of semiconducting van der Waals materials in future thermoelectric power generation as well as temperature sensing for low-cost disposable electronic devices.

关键词： paper-based electronics Seebeck effect semiconductors thermoelectrics van der Waals materials

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BSN:The First Light Curve Analysis of the Total Eclipse Binary System EL Tuc

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Research in Astronomy and Astrophysics 2024年第10期24卷 66-75页

作者： Elham Sarvari eduardo Fernández Lajús Atila Poro Independent researcher TehranIran Instituto de Astrofísica de La Plata(CCT La Plata-CoNICET-UNLP) La PlataArgentina BSN Project &Astronomy Department of the Raderon AI Lab.BurnabyBCCanada

We conducted the first light curve study of the binary star EL Tuc within the Binary Systems of South and North project's *** photometric observations were made using standard multiband BVR_cI_c filters at an observatory in *** presented a new ephemeris for EL Tuc and a linear fit to the o–C diagram,utilizing our extracted times of minima and additional *** employed the PHysics of Eclipsing BinariEs Python code and the Markov chain Monte Carlo approach for the system's light curve *** target system's light curve solution required a cold starspot on the hotter *** conclude that EL Tuc is a total contact binary system with a low mass ratio of q=0.172±0.002,an orbital inclination of i=83°.74±0°.40,and a fillout factor of f=53.7%±1.6%.We used the P-a relationship and the Gaia Data Release 3 parallax method to determine the absolute parameters of EL Tuc to compare the precision of our *** system was classified as W-type based on the mass and effective temperature of the companion *** positions of the systems were depicted on the M-L,M-R,T-M,and *** relationship between the spectroscopic and photometric mass ratios of binaries was discussed.

关键词： (stars:)binaries:eclipsing stars:individual(EL Tuc) line:identification

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ProTSA: A Testing Process for Automotive Software Domain

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Journal of Software Engineering and Applications 2024年第7期17卷 571-615页

作者： Renato Rafael Arcanjo Luiz eduardo Galvão Martins Dirceu Lavoiser Fernandes Graci Department of Inovation and Science Federal University of Sao Paulo (UNIFESP) Sao Jose dos Campos Brazil Department of Automotive Electronics Faculty of Technology of Sao Paulo (Fatec) Santo Andre Brazil

This study evaluates the development of a testing process for the automotive software domain, highlighting challenges stemming from the absence of adequate processes. The research demonstrates the application of Design Science Research methodology in developing, an automotive software testing process—ProTSA, using six functional testing modules. Additionally, the study evaluates the benefits of implementing ProTSA in a specific original Equipment Manufacturer (oEM) using an experimental single-case approach with industry professionals’ participation through a survey. The study concludes that combining testing techniques with effective communication and alignment is crucial for enhancing software quality. Furthermore, survey data indicates that implementing ProTSA leads to productivity gains by initiating tests early, resulting in time savings in the testing program and increased productivity for the testing team. Future work will explore implementing ProTSA in cybersecurity, over-the-air software updates, and autonomous vehicle testing processes. .

关键词： Verification and Validation Automotive Software Automotive Systems

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How inflammation influences psychiatric disease

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World Journal of Psychiatry 2024年第3期14卷 342-349页

作者： eduardo Ferat-osorio JoséLuis Maldonado-García Lenin Pavón División de Investigación Clínica de la Coordinación de Investigación en Salud Instituto Mexicano del Seguro SocialMexico City 06720Mexico Departamento de Bioquímica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacán 04510Ciudad de MéxicoMexico Departamento de Inmunología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Laboratorio de Psicoinmunología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico

Recent studies highlight the strong correlation between infectious diseases and the development of neuropsychiatric *** this editorial,we comment on the article“Anti-infective therapy durations predict psychological stress and laparoscopic surgery quality in pelvic abscess patients”by Zhang et al,published in the recent issue of the World Journal of Psychiatry 2023;13(11):*** discussion highlighted the potential consequences of anxiety,depression,and psychosis,which are all linked to bacterial,fungal,and viral infections,which are relevant to the impact of inflammation on the sequelae in mental health as those we are observing after the coronavirus disease 2019 *** focus specifically on the immune mechanisms triggered by inflammation,the primary contributor to psychiatric ***,pathophysiological mechanisms such as organ damage,post-injury inflammation,and infectioninduced endocrine alterations,including hypocortisolism or autoantibody formation,significantly contribute to the development of chronic low-grade inflammation,promoting the emergence or development of psychiatric alterations in susceptible *** inflammation can have long-term effects on patients,a multidisciplinary treatment plan can avoid complications and debilitating health issues,and it is crucial to recognize and address the mental health implications.

关键词： Inflammation infection Depression Pelvic inflammatory disease Psychiatric complication

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