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Journal of Forestry Research 2015年第3期26卷 711-718页

作者： Marcelo Luiz Laia Acelino Couto Alfenas Sergio Hermínio Brommonschenkel Shinitiro Oda eduardo josé de melo Inaê Mariêde Araú jo Silva Janaína Fernandes Gonalves Ariadne Marques departamento de Engenharia Florestal Universidade Federal dos Vales do Jequitinhonha e Mucuri DiamantinaMinas Gerais 39100-000 Brazil departamento de Fitopatologia Universidade Federal de Viosa Viosa Minas Gerais 36570-900 Brazil Suzano Bahia Sul Celulose S/A Suzano So Paulo Brazil

Disease-resistant genes play an important role in defending against a variety of pathogens and insect pests in plants. Most of the disease-resistant genes encode pro- teins with conserved leucine rich repeat and nucleotide binding site domains. In this study, we cloned and char- acterized gene-resistant analogs （RGAs） from Eucalyptus grandis using degenerate PCR, with primers specifically targeting these two domains. The amplified fragments were cloned into the pGEM-T vector and transformed into Escherichia coli. Among the 90 clones obtained, 13 were sequenced and compared with each other and with previ- ously identified gene-resistant diseases. A BLASTX search in GenBank revealed high similarities among the con- served domains of these cloned genes with RGA genes. Some clones, however, showed no significant similarity with DNA sequences in GenBank. Southern blotting ana- lysis identified several polymorphic RFLP loci between distinct genotypes. However, none of them co-segregated with the Puccinia psidii Winter resistance gene 1 （Ppr1） in a population study.

关键词： Cloning Conserved domains RGAs Rust Eucalyptus

Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Touristic urbanization and greening of coastal dune fields:A long-term assessment of a temperate sandy barrier of Argentina

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Journal of Geographical Sciences 2025年第1期35卷 206-230页

作者： GARZO Pedro Andrés DADON josé Roberto ISLA Federico Ignacio Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICET/UNMDP) Instituto de Geología de Costas y del Cuaternario Dr.Enrique J.Schnack (IGCC-CIC/UNMDP) Universidad de Buenos Aires Facultad de Arquitectura Dise?o y Urbanismo Centro de Investigaciones Gestión de Espacios Costeros (GEC-FADU/UBA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world. However, a century ago, they were considered hazardous environments due to their great dynamic nature. As a result, stabilization practices were considered necessary. The systematic introduction of fast-growing exotic trees helped stabilize the sand, making it easier for tourism urbanization to take place, but also leading to erosion processes. This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina. This complex region includes urban resorts, afforestation zones, and protected areas. A GIS-based geospatial analysis was conducted using a large satellite database(> 350 images), and the future evolution of the vegetation was modeled. The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover, accompanied by a concurrent reduction in sandy areas. In 1986, the dune area comprised 75% more surface than vegetation, whereas in 2021, it represented 60% less than vegetation. Furthermore, the 2050 scenario suggests a potential 40% reduction of dunes in certain areas. It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance. Long-term management strategies must focus on restoring native plant communities and controlling invasive species, and avoiding new dune fixation initiatives based on the introduction of exotic species.

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

Autophagy, apoptosis and organelle features during cell exposure to cadmiumč

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BIOCELL 2013年第2期37卷 45-54页

作者： CRISTIANE DOS SANTOS VERGILIO EDÉSIO josÉTENÓRIO de melo Universidade Estadual do Norte Fluminense Centro de Biociências e BiotecnologiaLaboratório de Biologia Celular e TecidualCampos dos GoytacazesRJBrasil28013-602.

Cadmium(Cd)induces several effects in different tissues,but our knowledge of the toxic effects on organelles is insuffi *** observe the progression of Cd effects on organelle structure and function,HuH-7 cells(human hepatic carcinoma cell line)were exposed to CdCl2 in increasing concentrations(1μM–20μM)and exposure times(2 h–24 h).During Cd treatment,the cells exhibited a progressive decrease in viability that was both time-and *** treated cells displayed progressive morphological changes that included cytoplasm retraction and nuclear condensation preceding a total loss of cell *** with 10μM for 12 h led to irreversible *** these drastic and irreparable damages,treated cells(5μM for 12 h)presented a progressive loss of mitochondrial function and cytoplasm acidifi cation as well as dysfunction and disorganization of microfi laments and endoplasmic *** damages led to the induction of apoptotic events and an increase in autophagic bodies in the *** results revealed that Cd affects multiple intra-cellular targets that induce alterations in the mitochondria,cytoskeleton,endoplasmic reticulum and acidic compartments,ultimately culminating in cell death via apoptotic and autophagic pathways.

关键词： Cd cell death hepatocyte HuH-7 cells mitochondria

Thermal and salinity effects on locomotor performance of Thoropa taophora tadpoles(Anura,Cycloramphidae)

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Integrative Zoology 2020年第1期15卷 40-54页

作者： Antonio C.GALLO Cinthia ABRASILEIRO Fábio Cury de BARROS joséeduardo de CARVALHO department of Ecology and Evolutionary Biology Federal University of São PauloDiademaSão PauloBrazil

It is well known that environmental temperature influences several biological functions of ectotherms,notably in *** high permeability of anuran skin,associated with the effect of elevated environmental temperature,potentiates the dehydration process and this combination may restrict locomotor ***pa taophora is an endemic species from the Atlantic Rainforest whose tadpoles are semiterrestrial and predominantly diurnal,and are found in rocky seashores where they are exposed to sea spray and high *** this study we investigated how temperature and salinity conditions affect the locomotor performance in Thoropa taophora *** also assessed how different osmotic concentrations affect the activity of the metabolic pathways that support muscle *** measured the sprint speed of tadpoles of various sizes at different temperatures and salinities in the *** also measured the activity of the enzymes pyruvate kinase(PK),lactate dehydrogenase(LDH)and citrate synthase(CS)in different temperatures and osmotic concentrations,and calculated the thermal sensitivity and the activity constants for each *** results showed that,in general,sprint speed decreased with increasing temperature and ***,whereas the effect of increased salinity was similar in smaller and larger tadpoles,increased temperature had a higher negative impact on sprint speed of larger tadpoles,thus indicating low thermal sensitivity of small *** and LDH thermal sensitivities and LDH constant of activity decreased as the osmolality *** conclusion,the locomotor capacity of tadpoles was decreased by temperature and salinity,which may be related to a decrease in anaerobic metabolism both in terms of sensitivity and total energy turnover through enzymatic *** discuss the ecological consequences,including the potential impacts on predator escape behavior promoted by changes in metabolism and locomotor performance

关键词： amphibians energy metabolism enzyme activity sprint speed

Co-Simulation of an SRG Wind Turbine Control and GPRS/EGPRS Wireless Standards in Smart Grids

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 656-663页

作者： Andre Luiz de Oliveira Carlos eduardo Capovilla Ivan Roberto Santana Casella joséLuis Azcue-Puma Alfeu J.Sguarezi Filho University of Sao Paulo Sao Paulo 05508-010Brazil Federal University of ABC Santo Andre 09210-580Brazil

Wind energy can be considered a push-driver factor in the integration of renewable energy sources within the concept of smart *** its full deployment,it requires a modern telecommunication infrastructure for transmitting control signals around the distributed generation,in which,the wireless communication standards stand out for employing modern digital modulation and coding schemes for error correction,in order to guarantee the power plant *** some developing countries,such as Brazil,the high penetration of commercial mobile wireless standards GPRS and EGPRS(based on GSM technology)have captivated the interests of the energy sector,and they now seek to perform remote monitoring and control *** this context,this article presents a comparative performance analysis of a wireless control system for a wind SRG,when a GPRS or EGPRS data service is *** system performance is analyzed by co-simulations,including the wind generator dynamics and the wireless channel *** satisfactory results endorse the viability and robustness of the proposed system.

关键词： General packet radio service(GPRS)/enhanced GPRS(EGPRS) smart grids switched reluctance generator(SRG) wind energy wireless communications

dendritic Growth, Eutectic Features and Their Effects on Hardness of a Ternary Sn–Zn–Cu Solder Alloy

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Acta Metallurgica Sinica(English Letters) 2017年第6期30卷 528-540页

作者： Bismarck Luiz Silva Rodrigo Valenzuela Reyes Amauri Garcia joséeduardo Spinelli department of Materials Engineering Federal University of Rio Grande do Norte-UFRNNatalRN 59078-970Brazil department of Materials Engineering Federal University of Sao Carlos-UFSCarSao CarlosSP 13565-905Brazil department of Manufacturing and Materials Engineering University of CampinasUNICAMPCampinasSP 13083-860Brazil

The present investigation is based on the results of a directionally solidified （DS） Sn-9 wt%Zn-2 wt%Cu alloy, including primary/secondary/tertiary dendrite arm spacings of the Sn-rich matrix, the morphologies of the eutectic mixture and the corresponding interphase spacing, the nature and proportion of the Cu-Zn intermetallic compound （IMC）. The main purpose is to establish interrelations of these microstructure features with experimental solidification thermal parameters, such as cooling rates and growth rates （v）, macrosegregation and hardness. Such interrelations are interesting for both industry and academy since they represent a tool permitting the preprogramming of final properties based on the design of the microstructure. In the case of Sn-Zn-Cu alloys, hardly anything is known about the combined effects of the length scale of the microstructure and fraction and distribution of the primary IMC on hardness. The alloy microstructure is composed of a β-Sn dendritic region, surrounded by a eutectic mixture of α-Zn and β-Sn phases and the γ-Cu5Zn8 IMC. The eutectic interphase spacing varies in the range 1.2-3.6 μm, with the α-Zn phase having a globular morphology for ν 〉 0.5 mm/s and a needle-like morphology for ν 〈 0.3 mm/s. A modified Hall-Petch-type experimental expression relating hardness to the interphase spacing is proposed.

关键词： Sn-Zn-Cu solder alloy Solidification Microstructure Eutectic morphology Hardness

Leaf water potential and gas exchange of eucalypt clonal seedlings to leaf solar protectant

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Journal of Forestry Research 2019年第1期30卷 57-64页

作者： Talita Miranda Teixeira Xavier josé eduardo Macedo Pezzopane Ricardo Miguel Penchel josé Ricardo Macedo Pezzopane departamento de Ciências Florestais e da Madeira Universidade Federal do Espírito Santo Fibria Celulose S.A Rodovia General Euryale Jesus Zerbini Embrapa Pecuária Sudeste

This experiment was carried out in acclimatized greenhouses with seedlings of two hybrid clones of Eucalyptus urophylla×Eucalyptus grandis. A sunscreen protector consisting of 62.5% calcium carbonate was sprayed on the seedlings at weekly intervals. Water stress was induced by suspending irrigation until the soil reached 30% available water and water was then replaced so that it returned to field capacity. Gas exchange and leaf water status were measured after 50 days. The experiment was set up in a 4×2 factorial randomized block design in four distinct environments:(1) temperatures less than 21.2℃ and vapor pressure deficit of 0.15 kPa;(2) intermediate temperatures of 24.2℃ and vapor pressure deficit of 0.69 kPa;(3) high temperatures of 27.0℃ and high vapor pressure deficit of 1.4 kPa; and,(4) high temperature of 27.0℃ and vapor pressure deficit below 1.10 kPa. Two leaf sun protector treatments were used, with five replications each. High atmospheric demand acted as a stress factor for the seedlings during the initial growth *** of leaf sunscreen protector provided beneficial effects in maintaining optimum water status and gas exchanges of the plants under water stress.

关键词： Eucalyptus urophylla×Eucalyptus grandis Calcium carbonate Water stress Atmospheric demand

Gravitational waves from compact objects

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Research in Astronomy and Astrophysics 2010年第11期10卷 1071-1099页

作者： josé Antonio de Freitas Pacheco University of Nice-Sophia Antipolis Observatoire de la Cote d'Azur Laboratoire Cassiopée-UMR 6202 BP 4229-F606304-Nice Cedex 4-France

Large ground-based laser beam interferometers are presently in operation both in the USA （LIGO） and in Europe （VIRGO） and potential sources that might be detected by these instruments are revisited. The present generation of detectors does not have a sensitivity high enough to probe a significant volume of the universe and, consequently, predicted event rates are very low. The planned advanced generation of interferometers will probably be able to detect, for the first time, a gravitational sig- nal. Advanced LIGO and EGO instruments are expected to detect few （some）： binary coalescences consisting of either two neutron stars, two black holes or a neutron star and a black hole. In space, the sensitivity of the planned LISA spacecraft constellation will allow the detection of the gravitational signals, even within a ＂pessimistic＂ range of possible signals, produced during the capture of compact objects by supermassive black holes, at a rate of a few tens per year.

关键词： gravitational waves -- neutron stars -- black holes