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Delivery of essential pediatric congenital surgical care within Brazil’s universal health coverage system:a national survey of pediatric surgeons

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World Journal of Pediatric Surgery 2023年第3期6卷 136-146页

作者： Paul R Truche Abbie E Naus Fabio Botelho Julia Ferreira Alexis Bowder Luke Caddell Kathrin Zimmerman Isabella Maria de Freitas Faria Bellisa Caldas Lopes eduardo corrêa costa Fernanda Lage Lima Dantas Augusto J S A Cavalcante Carlos A L B Carvalho Simone Abib David P Mooney Nivaldo Alonso Program in Global Surgery and Social Change Harvard Medical SchoolBostonMassachusettsUSA Department of Surgery Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA Department of Pediatric Surgery McGill UniversityMontrealQuébecCanada Department of Surgery Medical College of WisconsinMilwaukeeWisconsinUSA Division of Otolaryngology-Head and Neck Surgery Department of SurgeryUniversity of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA School of Medicine UFMGBelo HorizonteMinas GeraisBrazil Department of Pediatric Surgery Instituto de Medicina Integral Professor Fernando FigueiraRecifeBrazil Department of Pediatric Surgery Hospital de Clinicas de Porto AlegrePorto AlegreBrazil Department of Pediatric Surgery Federal University of AcreRio BrancoBrazil Department of Pediatric Surgery Hospital Santa Casa de Belo HorizonteBelo HorizonteBrazil Department of Pediatric Surgery Federal University of Mato GrossoCuiabaBrazil Department of Pediatric Surgery UNIFESPSao PauloBrazil Department of Pediatric Surgery Boston Children's HospitalBostonMassachusettsUSA Department of Plastic Surgery University of São Paulo Institute of Biomedical SciencesSao PauloBrazil

Objective In this study,we assess the delivery of congenital pediatric surgical care under Brazil’s system of universal health coverage and evaluate differences in delivery between public and private *** A cross-sectional national survey of pediatric surgeons in Brazil was *** were asked which of 23 interventions identified through the Disease Control Priorities 3(Surgical Interventions for Congenital Anomalies)they perform and to report barriers faced while providing surgical *** were weighted by state and stratified by sector(public vs private).Results A sample of 352 responses was obtained and weighted to represent 1378 practicing pediatric surgeons registered in Brazil during the survey time.73%spend the majority of their time working in the public sector(‘SistemaÚnico de Saúde’and Foundation hospitals),and most of them also work in the private ***,Brazilian pediatric surgeons have the expertise to provide thoracic,abdominal,and urologic *** working mostly in the public sector were more likely to report a lack of access to essential medications(25%vs 9%,p<0.01)and a lack of access to hospital beds for surgical patients(52%vs 32%,p<0.01).Conclusions Brazilian pediatric surgeons routinely perform thoracic,abdominal,and urologic *** working in government-financed hospitals face barriers related to infrastructure,which may impact Brazilians who rely on Brazil’s universal health coverage *** that support pediatric surgeons working in the public sector may promote the workforce available to provide congenital pediatric surgical care.

关键词： pediatric survey Brazil

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Predictors of surgical complications in boys with hypospadias:data from an international registry

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World Journal of Pediatric Surgery 2023年第4期6卷 217-223页

作者： Kathryn Scougall Jillian Bryce Federico Baronio Rachel L Boal Jose Roberto Castera Sebastián Castro Tim Cheetham eduardo correa costa Feyza Darendeliler Justin H Davies Mirjam Dirlewanger Gabriella Gazdagh Evgenia Globa Gil Guerra-Junior Tulay Guran Gloria Herrmann Paul-Martin Holterhus Ahsen KaragözlüAkgül Renata Markosyan Kenneth McElreavey Marcio Lopes Miranda Anna Nordenstrom Stuart O’Toole Sukran Poyrazoglu Gianni Russo Valerie Schwitzgebel Marianna Stancampiano Michael Steigert S Faisal Ahmed Angela K Lucas-Herald University of Glasgow GlasgowUK IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola BolognaItaly Great North Children's Hospital Newcastle Upon TyneUK Hospital de Ninos Ricardo Gutiérrez Buenos AiresArgentina Hospital de Clinicas de Porto Alegre Porto AlegreBrazil Istanbul University IstanbulTurkey Southampton Children's Hospital SouthamptonUK University Hospital of Geneva GenevaSwitzerland Ukrainian Research Center of Endocrine Surgery Endocrine Organs and Tissue Transplantation KyivUkraine State University of Campinas CampinasBrazil Marmara University IstanbulTurkey University Medical Centre UlmGermany University Hospital of Schleswig-Holstein Campus Kiel/Christian-Albrechts-University of Kiel KielGermany Marmara University Faculty of Medicine IstanbulTurkey Yerevan State Medical University Endocrinology Clinic YerevanArmenia Institut Pasteur ParisFrance Karolinska University Hospital StockholmSweden Royal Hospital for Children GlasgowUK IRCCS Ospedale San Raffaele MilanoItaly Graubunden Cantonal Hospital ChurSwitzerland

Background Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their *** Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development(l-DSD)*** regressions,fisher's exact tests and spearman's correlation tests were performed on the data to assess associations between clinical factors and complication *** Of the 551 eligible boys,data were available on 160(29%).Within the cohort,the median(range)External Masculinization Score(EMS)was 6(2,9).All presented with one or more additional genital malformation and 61(38%)presented with additional extragenital *** of androgen action,androgen synthesis and gonadal development were diagnosed in 28(18%),22(14%)and 9(6%)boys,*** remaining 101(62%)patients were diagnosedas having non-specific 46,XY Disorders of Sex ***(50%)boys had evidence of abnormal biochemistry,and gene variants were identified in 42(26%).Median age at first hypospadias surgery was 2 years(0,9),and median length of follow-up was 5 years(0,17).Postsurgical complications were noted in 102(64%)*** were no significant associations with postsurgical *** Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative *** clinical factors were significantly associated with complication *** complication rates with no observable cause suggest the involvement of other factors which need investigation.

关键词： complications surgical involvement

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Movement behaviors and their association with depressive symptoms in Brazilian adolescents:A cross-sectional study

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Journal of Sport and Health Science 2022年第2期11卷 252-259页

作者： Bruno Goncalves Galdino da costa Jean-Philippe Chaput Marcus Vinicius Veber Lopes Luis eduardo Argenta Malheiros Kelly Samara Silva Research Centre in Physical Activity and Health Federal University of Santa CatarinaFlorianopolis88040-900Brazil Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada

Background:Physical activity,sleep,and sedentary behaviors compose 24-h movement behaviors and have been independently associated with depressive ***,it is not clear whether it is the movement behavior itself or other contextual factors that are related to depressive *** objective of the present study was to examine the associations between self-reported and accelerometer-measured movement behaviors and depressive symptoms in ***:Cross-sectional data from 610 adolescents(14-18 years old)were *** answered questions from the Center for Epidemiological Studies Depression scale and reported time spent watching videos,playing videogames,using social media,time spent in various physical activities,and daytime ***-worn accelerometers were used to measure sleep duration,sleep efficiency,sedentary time,and physical ***-effects logistic regressions were ***:Almost half of the adolescents(48%)were classified as being at high risk for depression(score≥20).No significant associations were found between depressive symptoms and accelerometer-measured movement behaviors,self-reported non-sport physical activity,watching videos,and playing ***,higher levels of self-reported total physical activity(odd ratio(OR)=0.92,95%confidence interval(95%CI):0.86-0.98)and volume of sports(OR=0.88,95%CI:0.79-0.97),in minutes,were associated with a lower risk of depression,while using social media for either 2.0-3.9 h/day(OR=1.77,95%CI:1.58-2.70)or>3.9 h/day(OR=1.67,95%CI:1.10-2.54),as well as higher levels of daytime sleepiness(OR=1.17,95%CI:1.12-1.22),were associated with a higher risk of ***:What adolescents do when they are active or sedentary may be more important than the time spent in the movement behaviors because it relates to depressive *** daytime sleepiness,promoting sports,and limiting social media use may benefit adolescents.

关键词： Accelerometry Depression Physical activity Sedentary behavior Sleep

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Numerical Study on the Effect of Submerged Depth on the Horizontal Plate Wave Energy Converter

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China Ocean Engineering 2014年第5期28卷 687-700页

作者： Flávio Medeiros SEIBT eduardo costa COUTO Elizaldo Domingues dos SANTOS Liércio André ISOLDI Luiz Alberto Oliveira ROCHA Paulo Roberto de Freitas TEIXEIRA Graduate Program of Ocean Engineering Universidade Federal do Rio Grande96203-900 Rio Grande RS Brazil Mechanical Engineering Department Universidade Federal do Rio Grande do Sul90050-170 Porto Alegre RS Brazil

The growing search for clean and renewable energy sources has given rise to the studies of exploring sea wave energy. This paper is concerned with the numerical evaluation of the main operational principle of a submerged plate employed for the conversion of wave energy into electrical one. The numerical model used to solve the conservation equations of mass, momentum and transport of volume fraction is based on the finite volume method （FVM）. In order to tackle with the flow of mixture of air-water and its interaction with the device, the multiphase model volume of fluid （VOF） is employed. The purpose of this study is the evaluation of a numerical model for improvement of the knowledge about the submerged plate wave energy converter, as well as the investigation of the effect of the distance from the plate to the bottom of the sea （HP） on the performance of the converter. The simulations for several distances of the plate from the seabed show that the optimal efficiency is 64%, which is obtained for HP=0.53 m （88% of the depth）. This efficiency is 17% larger than that found in the worst case （HP=0.46 m, 77% of the depth）.

关键词： numerical simulation submerged plate wave energy conversion efficiency

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Ileal loop interposition:an alternative biliary bypass technique

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Hepatobiliary & Pancreatic Diseases International 2010年第6期9卷 654-657页

作者： Felipe JF Coimbra Alessandro L Diniz Heber SC Ribeiro Wilson L costa Jr. eduardo NP Lima AndréL Montagnini Abdominal Surgery Department Hospital do Cncer A.C.CamargoRua Professor Antnio Prudente 211LiberdadeSo PauloSP 01509-010Brazil Nuclear Medicine Imaging Department Hospital do Cncer A.C.CamargoRua Professor Antnio Prudente 211LiberdadeSo PauloSP 01509-010Brazil

BACKGROUND:Obstructive jaundice is a common condition in advanced digestive *** procedures can improve quality of life and allow patients to attempt a systemic *** anastomosis is still the procedure of choice for patients in many *** a surgical bypass is not possible,biliary drainage can be done by placing endoscopic or transparietal stents,which are less durable methods even when an expandable stent is employed. METHODS:A 47-year-old male with an excellent clinical status and a previous cholecystectomy and an exploratory laparotomy for advanced gastric cancer was referred with obstructive jaundice.A preoperative CT scan showed a dilated bile duct and a small mass at the distal hepatic *** other signs of metastasis were found.A surgical bilioenteric anastomosis was *** surgery,a distal choledochal obstruction and a mesenteric retraction by a lymph node mass prevented the jejunum to ascend for a bilioenteric anastomosis. Surgically,an alternative bilioenteric bypass was performed by means of an ileal loop interposition between the bile duct and the jejunum. RESULT:The recovery of the patient was uneventful and his bilirubin levels normalized after one *** patient was then referred for systemic chemotherapy. CONCLUSIONS:This alternative biliary bypass can be safely and easily performed,and may be a good alternative for patients already referred for surgery because of a better life expectancy and when the jejunum is not an alternative.

关键词： biliary bypass ileal loop interposition biliary cancer

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Volatile organic compound emission and biochemical properties of degraded Ultisols ameliorated by no tillage and liming

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Pedosphere 2020年第5期30卷 597-606页

作者： Laura GIAGNONI Cosimo TAITI Paloma LEON corrado costa Paolo MENESATTI Rafael ESPEJO Clara GOMEZ-PACCARD Chiquinquira HONTORIA eduardo VAZQUEZ Marta BENITO Stefano MANCUSO Giancarlo RENELLA Department of Agriculture FoodEnvironment and Forestry(DAGRI)University of FlorenceP.le delle Cascine 18Florence 50144(Italy) Departamento de Production Agraria E.T.S.I.AgrondmicaAlimentaria y de BiosistemasUniversidad Politecnica de MadridAvda.Complutense s/nMadrid 28040(Spain) Consiglio per la Ricerca in Agricoltura e I'Analisi dell'Economia Agraria(CREA)-Unita di Ricerca per ilngegneria Agraria via della Pascolare 16Monterotondo ScaloRM 00015(Italy) Department of Soil Biogeochemistry and Soil Ecology University of BayreuthDr.Hans-Frisch-Strafie 1-3Bayreuth 95448(Germany) University of Padua Department of AgronomyFoodNatural ResourcesAnimals and Environment(DAFNAE)Viale dell'Universita 16Legnaro 35020(Italy)

TTie Ultisols in the Rana de Canamero area in Southwest Spain showed aluminum(Al)phytotoxicity,and the clearance of natural vegetation and decades of intensive conventional agriculture caused the deplation of soil organic matter(SOM).Therefore,we studied the long-term effects of no tillage and liming using sugar beet foam(SF)and red gypsum(RG),alone or in combination,on the restoration of Ultisols affected by acidification,Al phytotoxicity,and SOM *** measured the main soil chemical properties,soil microbial biomass,soil enzyme activities involved in carbon,nitrogen,phosphorus,and sulfur mineralization,and the emission of volatile organic compounds(VOCs).The results indicated that liming effectively neutralized the soil acidity in the long term and,in combination with no tillage,significantly increased soil microbial biomass and enzyme ***-three VOCs were detected using the proton transfer reaction-time of flight(PTR-ToF)technique,and both liming and tillage changed the VOC emission *** greatest difference in VOC emission pattern was observed between no-tilled un-amended soils and tilled lime-amended soils,suggesting the activation of different metabolic pathways within the microbial communities of soils under different *** in VOC emission patterns could be attributed to the decomposition of carbohydrates,which were also sustained by the higher enzyme activities in the lime-amended soils.

关键词： carbohydrate decomposition degraded soils long-term field trial soil acidity soil enzyme activities soil microbial biomass soil restoration

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Beneficial effects of Pleurotus albidus supplementation on body weight and food intake in healthy C57BL/6 mice

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Journal of Future Foods 2021年第1期1卷 98-103页

作者： Paola Quevedo da costa Mariana Parron Paim eduardo Echer dos Reis Patrick Tirck Marli Camassola Paulo Cavalheiro Schenke Department of Physiology and Pharmacology Universidade Federal de PelotasCampus Capao do Leao 96900-010 Pelotas.Brazjl Department of Physiology Universidade Federal do Rio Grande do SulCampus Centro 90050-170 Porto AlegreBrazil Enzymes and Biomass Laboratory Institute of BiotechnologyUniversidade de Caxias do SulRua Francisco Getúlio Vargas 113095070-560Caxias do SulRSBrazil

The current investigation intended to check the influence of Pleurotus albidus extract supplementation on body weight,food intake,glycemia,serum lipids,and oxidative stress *** male C57BL/6 mice were partitioned into two experimental groups:control and *** supplementation was performed by gavage(500 mg/kg)for 20 uninterrupted *** this period,all animals received water and food ad libitum and they had their food ingestion and body weight monitored ***,mice underwent an insulin sensitivity test,followed by euthanasia and biochemical *** supplementation decreased the body weight and food intake,but it did not change other parameters in healthy *** work showed for the first time that the *** extract supplementation presents a promising potential on body weight and food intake control.

关键词： Blood glucose Glutathione peroxidase Insulin Pleurotus Triglycerides

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Pathogenesis and clinical management of arboviral diseases

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World Journal of Virology 2025年第1期14卷 9-50页

作者： Victoria Cenci Dietrich Juan Marcos Caram costa Marina Maria Gomes Leite Oliveira Carlos eduardo Oliveira Aguiar Luis Guilherme de Oliveira Silva Marcel Silva Luz Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(DENV)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFV),chikungunya virus(CHIKV),and Zika virus(ZIKV),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(DENV,ZIKV,YFV,and CHIKV)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections Dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

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Intravenous vs intraperitoneal mesenchymal stem cells administration:What is the best route for treating experimental colitis?

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World Journal of Gastroenterology 2014年第48期20卷 18228-18239页

作者： Fabiany da costa Goncalves Natália Schneider Fernanda Otesbelgue Pinto Fabíola Schons Meyer Fernanda Visioli Bianca Pfaffenseller Patrícia Luciana da costa Lopez eduardo Pandolfi Passos Elizabeth Obino Cirne-Lima Luíse Meurer Ana Helena Paz Centro de Pesquisa Experimental do Hospital de Clínicas de Porto Alegre Porto Alegre 90035-903Rio Grande do SulBrazil Programa de Pós-Gradua??o:Ciências em Gastroenterologia e Hepatologia Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Faculdade de Odontologia Universidade Federado Rio Grande do SulPorto Alegre 90035-003Rio Grande doSulBrazil

AIM:To investigate the therapeutic effects of mesenchymal stem cells(MSCs)transplanted intraperitoneally andintravenously in a murine model of ***:MSCs were isolated from C57BL/6 mouse adipose *** cultures were analyzed according to morphology,cellular differentiation potential,and surface molecular *** acute colitis was induced in C57BL/6 mice by oral administration of2%dextran sulfate sodium(DSS)in drinking water ad libitum from days 0 to *** mice were treated with1×106 MSCs via intraperitoneal or intravenous injection on days 2 and *** disease activity index was determined daily based on the following parameters:weight loss,stool consistency and presence of blood in the feces and *** compare morphological and functional differences in tissue regeneration between different MSC injection modalities,mice were euthanized on day 8,and their colons were examined for length,weight,and histopathological *** responses were determined by measuring the levels of different serum cytokines using a CBA Th1/Th2/Th17 *** rates were evaluated by terminal deoxynucleotidyl transferase-mediated d UDPbiotin nick end labeling ***:Intravenous infusion of MSCs was more effective than intraperitoneal treatment(P<0.001)in reducing the clinical and histopathologic severity of colitis,which includes weight loss,diarrhea and *** histological evaluation demonstrated decreased colonic inflammation based on reduced crypt loss and reduced infiltration of inflammatory *** therapeutic effect was most likely mediated by the down-regulation of pro-inflammatory cytokines[interleukin(IL)-6 and tumor necrosis factor(TNF)];and by the up-regulation of anti-inflammatory cytokines(IL-10 and IL-4).Intravenous transplantation alsoinduced high levels of IFN that lead to activation of the immunosuppressive activity of the MSCs,which did not occur with intraperitoneal transplantation(P=0.006).An increase in a

关键词： Ulcerative colitis Dextran sulfate sodium Inflammatory bowel disease Mesenchymal stem cell Cell transplantation Intravenous injection Immunomodulation

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Functional N-Representability in 2-Matrix,1-Matrix,and Density Functional Theories

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Journal of Modern Physics 2013年第3期4卷 391-400页

作者： eduardo V.Ludena F.Javier Torres Cesar costa Prometheus Program SenescytQuitocuador Grupo Ecuatoriano para el Estudio Experimental y Teorico de Nanosistemas(GETNano) Universidad San Francisco de Quito(USFQ)Edificion NewtonOficina N102C Diego de Robles y Via InteroceanicaQuitoEcuador Grupo de Quimica Computacional y Teorica(QCT-USFQ) Universidad San Francisco de Quito(USFQ)Diego de Robles y Via InteroceanicaC.P.17-1200-841QuitoEcuador Departamento de Fisica Escuela Politecnica Nacional(EPN)Ladron de Guevara E11-256QuitoEcuador

The N-representability conditions on the reduced second-order reduced density matrix (2-RDM), impose restrictions not only in the context of reduced density matrix theory (RDMT), but also on functionals advanced in one-matrix theory such as natural orbital functional theory (NOFT), and on functionals depending on the one-electron density such as those of density functional theory (DFT). We review some aspects of the applications of these N-representability conditions in these theories and present some conclusions.

关键词： N-Representability DFT D1-Matrix Theory D2-Matrix Theory

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