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Open Journal of Stomatology 2019年第9期9卷 199-207页

作者： Bruna Barcelos Ferreira Victor Tieghi Neto Andréa Guedes Barreto gonç ales Denise Tostes Oliveira Fá bio sanches Magalhã es Tunes eduardo sanches gonç ales Department of Surgery Stomatology Pathology and Radiology of the Sao Paulo University Bauru School of Dentistry Bauru Brazil

The Calcifying Epithelial Odontogenic Tumor (CEOT) also called the Pindborg’s Tumor represents a rare benign epithelial odontogenic neoplasm with locally aggressive behavior. Surgical excision with a safety margin is one of the treatment options, requiring bone and soft tissue reconstruction for implant-supported rehabilitation, providing the individual with a return to adequate oral functions. The objective of the present study is to report on the case of the treatment stages and the factors involved in the rehabilitation of a 23-year-old man with a history of mandibular lesion diagnosed as CEOT. A marginal resection of the mandible lesion was performed, with posterior reconstruction with iliac crest bone graft and soft tissue graft to allow the implant-supported rehabilitation. Currently, in the postoperative control, the individual shows no signs of tumor recurrence and is rehabilitated without functional and/or aesthetic complaints. Surgical excision should be framed as a form of treatment, aiming for better resolution in the more complex cases of these invasive tumors.

关键词： Oral Pathology Bone Reconstruction Dental Implants Oral Rehabilitation

Comparative Dimensional and Microscopic Analysis of the Strength and Hardness of Internal Fixation Plates

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Open Journal of Stomatology 2020年第10期10卷 310-320页

作者： Victor Tieghi Neto eduardo Stedile Fiamoncini Matheus Falsarelli Ferreira Danilo Luiz Flumignan Luis Geraldo Vaz eduardo sanches gonçales Bauru School of Dentistry University of Sao Paulo Bauru Brazil Department of Stomatology Bauru School of Dentistry University of Sao Paulo Bauru Brazil Instituto Federal de Educaç o Ciência e Tecnologia de S&#227 o Paulo IFSP Mat&#227 o Brazil Department of Dental and Prosthetic Materials Araraquara School of Dentistry University of Sao Paulo Araraquara Brazil

The fixation stability achieved with the use of plates and screws in oral and maxillofacial surgery is a decisive factor in treatment success. The mechanical and structural properties of the internal fixation materials have direct influence on the dimensional stability and resistance of a fixation system, thus influencing treatment outcomes. This study proposed to analyze the dimensional and resistance patterns of titanium plates used for obtaining stable fixation in orthognathic surgery and craniofacial trauma. For this study, 30 conventional 2.0 mm straight four hole plates with bridge from three brands commercialized in Brazil, were subjected to macroscopic, microscopic, strength and hardness analysis. The dimensional measurements were performed using a digital caliper. Energy-dispersive X-ray spectroscopy analysis was performed by scanning electron microscopy to analyze the chemical composition of the samples. The mechanical resistance tests were performed with a universal testing machine. The samples were then submitted to Vickers hardness analysis, complying with the standards of ASTM E92. The data collected from the dimensional study was submitted to statistical analysis of the coefficient of variation, while the values obtained during the mechanical tests were analyzed by variance (ANOVA) and Tukey’s test (p 0.05). The sample groups presented different performances in resistance, hardness, size and surface, even though they were reported to be chemically similar compounds that allowed us to conclude the plates from Group 2 were more resistant than groups 1 and 3.

关键词： Fracture Fixation Internal Biocompatible Materials Compressive Strength

Giant Sialolith with 20 Years of Evolution in the Submandibular Duct

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Open Journal of Stomatology 2020年第6期10卷 115-120页

作者： Victor Tieghi Neto Rosana Mara Adami Tucunduva Andrea Guedes Barreto gonçales eduardo Stedile Fiamoncini Caio Peres Bellato Izabel Regina Fischer Rubira-Bullen eduardo sanches gonçales Department of Surgery Pathology Radiology and Stomatology Bauru School of Dentistry University of Sao Paulo Bauru Brazil

Sialolithiasis is a common disease that affects the major salivary glands, which is characterized by obstruction of the gland itself or its excretory duct due to the formation of a sialolith, resulting in decreased salivary flow. It mainly affects the submandibular glands (80% - 90%), probably because it has a long duct that surrounds the mylohyoid muscle and emerges against gravity through the Wharton’s duct. The size of the salivary calculus can vary from below 1 millimeter (mm) to a few centimeters in diameter, where most stay below 10 mm. Only 7% are greater than 15 mm and these are classified as giant calculi. This report presents a case of asymptomatic giant sialolith (approximately 60 mm in diameter) located in the duct of the right submandibular gland, with 20 years of evolution. The treatment of choice was the surgical removal of the sialolith (calculus) through the salivary duct with maintenance of the gland. Although the individual did not present complaints related to the presence of the giant calculi, its removal had a great impact on their quality of life, since a significant respiratory improvement was reported by the individual. The major difference reported was better sleep quality.

关键词： Salivary Gland Calculi Salivary Glands Sialolithiasis

Facial Asymmetry Caused by Mandibular Osteoma: Case Report

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Open Journal of Stomatology 2019年第9期9卷 208-214页

作者： Bruna Barcelos Ferreira eduardo Stedile Fiamoncini Caio Peres Bellato Victor Tieghi Neto Denise Tostes Oliveira Osny Ferreira Junior eduardo sanches gonç ales Oral and Maxillofacial Surgery Bauru School of Dentistry S&atilde o Paulo University S&atilde o Paulo Brazil Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry S&atilde o Paulo University S&atilde o Paulo Brazil

Osteoma is a benign tumor that often affects the maxillofacial region. It exhibits slow growth and remains asymptomatic for prolonged time and may cause facial asymmetry or functional disorders when it reaches vast proportions. When osteomalacia is diagnosed it is important to check about Gardner’s Syndrome because up to 90% of patients with this syndrome may present skeletal abnormalities and osteomas. The objective of this paper is to report a case of a 54-year-old woman that related an 8-year evolution of a volume increase in the face. Clinical examination showed facial asymmetry and presence of nodular lesion located in the left region of the mandibule, painless and hard on palpation. Panoramic radiography showed radiopaque image limited to the left mandibular body and angle, suggestive of osteoma. Gastrointestinal review was requested and discarded intestinal polyps and Gardner’s Syndrome. The patient was submitted to excisional biopsy and microscopic examination of the tumor that confirmed the diagnosis of osteoma. Osteoma needs special attention due to the possible association with malignant lesions intestine and also by psychological and functional problems, when it reaches great proportions.

关键词： Osteoma Oral Surgery Mandibule

A comparative analysis of three different methods for the estimation of the basic reproduction number of dengue

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Infectious Disease Modelling 2016年第1期1卷 88-100页

作者： Rosangela Peregrina sanches eduardo Massad School of Medicine University of Sao PauloSao PauloSPBrazil London School of Hygiene and Tropical Diseases UK

The basic reproduction number,R0,is defined as the expected number of secondary cases of a disease produced by a single infection in a completely susceptible population,and can be estimated in several *** example,from the stability analysis of a compartmental model;through the use of the matrix of next generation,or from the final size of an epidemic,*** this paper we applied the method for estimating R0 of dengue fever from the initial growth phase of an outbreak,without assuming exponential growth of cases,a common assumption in many *** used three different methods of calculating R0 to compare the techniques'details and to evaluate how these techniques estimate the value of R0 of dengue using data from the city of Ribeir^ao Preto(SE of Brazil)in two *** results of the three methods are numerically different but,when we compare them using a system of differential equations developed for modeling only the first generation time,we can observe that the methods differ little in the initial growth *** conclude that the methods predict that dengue will spread in the city studied and the analysis of the data shows that the estimated values of R0 have an equal pattern overtime.

关键词： Basic reproduction number Dengue Mathematical models Likelihood-based model

Artificial Neural Networks in Risk Management: A Bibliometric Study

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Journal of Business Administration Research 2021年第1期4卷 29-36页

作者： Breno gontijo Tavares Carlos eduardo sanches da Silva Adler Diniz de Souza INATEL Nacional Institute of TelecommunicationsInformation Technology and Communications CenterAv.João de Camargo510CentroZIP:37540-000Santa Rita do SapucaíMinas Gerais StateBrazil UNIFEI Secretaria de Educação Superior do Ministério da Educação(SESU/MEC)Esplanada dos MinistériosBl“L”-3ºAndarZIP:70047-900BrasíliaDistrito Federal StateBrazil UNIFEI Federal University of ItajubaInstitute of Mathematics and ComputingBPS Ave.1303PinheirinhoZIP:37.500-903ItajubaMinas Gerais StateBrazil

This study presents a bibliometric analysis of Artificial Neural Networks in Risk *** study considered articles from the *** of Knowledge and Scopus databases,Identification of publishers,countries,periodicals and the keywords most frequently *** used the CiteSpace® software to analyze this material,which provides a set of features to support bibliometrics,including the reference *** study provides data collection on Artificial Neural Networks applied to risk *** number of works identified in this study is significant,and in the last ten years,the number of citations has *** did not identify the increase in paper count within the same period.

关键词： Bibliometric study Artificial neural networks Risk management I.S.I.Web of knowledge Scopus

Natural products,PGC-1α,and Duchenne muscular dystrophy

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Acta Pharmaceutica Sinica B 2020年第5期10卷 734-745页

作者： Ipek Suntar[ Antoni Sureda Tarun Belwal Ana sanches Silva Rosa Anna Vacca Devesh Tewari eduardo Sobarzo-Sánchez Seyed Fazel Nabavi Samira Shirooie Ahmad Reza Dehpour Suowen Xu Bahman Yousefi Maryam Majidinia Maria Daglia Giuseppe D’Antona Seyed Mohammad Nabavi Department of Pharmacognosy Faculty of PharmacyGazi UniversityEtilerAnkara 06330Turkey Research Group in Community Nutrition and Oxidative Stress Health Research Institute of the Balearic Islands(IdISBa)and CIBEROBN(Physiopathology of Obesity and Nutrition)University of Balearic IslandsPalmaBalearic Islands E-07122Spain G.B.Pant National Institute of Himalayan Environment and Sustainable Development AlmoraUttarakhand 263643India National Institute for Agricultural and Veterinary Research(INIAV) VairaoVila do CondePortugal Center for Study in Animal Science(CECA) ICETAUniversity of PortoPortoPortugal Institute of Biomembranes Bioenergetics and Molecular BiotechnologiesNational Council of ResearchBari 70126Italy Department of Pharmacognosy School of Pharmaceutical SciencesLovely Professional UniversityPhagwaraPunjab 144411India Laboratory of Pharmaceutical Chemistry Faculty of PharmacyUniversity of Santiago de CompostelaSantiagode Compostela 15782Spain Department of Organic Chemistry Faculty of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Applied Biotechnology Research Center Baqiyatallah University of Medical SciencesTehran ***Iran Pharmaceutical Sciences Research Center Health InstituteKermanshah University of Medical SciencesKermanshah ***Iran Department of Pharmacology Faculty of MedicineTehran University of Medical SciencesTehran ***Iran Experimental Medicine Research Center Tehran University of Medical SciencesTehran ***Iran The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Molecular Medicine Research Center Tabriz University of Medical SciencesTabriz 516615731Iran Drug Applied Research Center Tabriz University of Medical SciencesTabriz 516615731Iran Solid Tumor Research Center Urmia University of Medical SciencesUrmia 571478334Iran Department of Pharmacy University of Naples FedericoⅡNaples 80138Italy International Research Center for Foo

Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription ***γcoactivator 1(PGC-1)coactivators possess an extensive range of biological effects in different tissues,and play a key part in the regulation of the oxidative metabolism,consequently modulating the production of reactive oxygen species,autophagy,and mitochondrial *** to these findings,a large body of studies,aiming to establish the role of PGC-1 in the neuromuscular system,has shown that PGC-1 could be a promising target for therapies targeting neuromuscular *** these,some evidence has shown that various signaling pathways linked to PGC-1αare deregulated in muscular dystrophy,leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species(ROS)*** the light of these results,any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular ***-1αis influenced by different patho-physiological/pharmacological *** products have been reported to display modulatory effects on PPARγactivation with fewer side effects in comparison to synthetic *** together,this review summarizes the current knowledge on Duchenne muscular dystrophy,focusing on the potential effects of natural compounds,acting as regulators of PGC-1α.

关键词： Muscular dystrophy Natural product Peroxisome proliferator-activated receptor Y coactivator la PPARγactivation Reactive oxygen species Mitochondrial oxidative phosphorylation

Adenomatoid odontogenic tumour displacing multiple teeth in an adolescent

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Open Journal of Stomatology 2012年第2期2卷 146-148页

作者： Kellen Cristine Tjioe Denise Tostes Oliveira Marcelo Lupion Poleti Osny Ferreira Jr. eduardo Sant’Anna eduardo sanches goncales Department of Stomatology Bauru School of DentistryUniversity of Sao PauloBauruSao PauloBrazil

Adenomatoid odontogenic tumor is an unusual benign neoplasm which shares clinical and radiographic characteristics with odontogenic cystic lesions denoting a distinct behavior. This paper reports a case of a 12-year-old boy with a bony consistence tumefaction involving the area from teeth 12 to 17. Radiographically, the lesion was characterized by a well-circum- scribed unilocular radiolucent area displacing maxillary canine, first and second premolars. The final diagnosis was adenomatoid odontogenic tumour. The lesion was enucleated concomitantly with the removal of the canine tooth under general anesthesia. The patient was submitted to orthodontic treatment and has been followed-up for four years. Clinical and radiographic features are discussed in this report.

关键词： Odontogenic Tumor Adenomatoid Odontogenic Tumor Oral Surgery