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Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance

Journal of Animal Science and Biotechnology 2024年第5期15卷 1820-1831页

作者： Aakilah S.Hernandez Gabriel A.Zayas eduardo E.Rodriguez Kaitlyn m.Sarlo Davila Fahad Rafiq Andrea N.Nunez Cristiane Goncalves Titto Raluca G.mateescu Department of Animal Science North Carolina State UniversityRaleighNCUSA Department of Animal Sciences University of FloridaGainesvilleFLUSA. Ruminant Diseases and Immunology Research Unit National Animal Disease CentersUnited States Department of Agriculture1920 Dayton AvenueAmesIA 50010USA. Department of Animal Science Iowa StateAmesIAUSA School of Animal Sciences and Food Engineering University of Sao PauloAv Duque de Caxias Norte 225PirassunungaSao Paulo 13635‑900Brazil

Background Thermal stress in subtropical regions is a major limiting factor in beef cattle production systems with around$369 million being lost annually due to reduced *** stress causes numerous physiological and behavioral disturbances including reduced feed intake and decreased production *** utilize various physiological mechanisms such as sweating to regulate internal *** in these traits can help identify genetic variants that control sweat gland properties and subsequently allow for genetic selection of cattle with greater *** This study used 2,401 Brangus cattle from two commercial ranches in *** phenotypes that contribute to an animal's ability to manage heat stress were calculated from skin biopsies and included sweat gland area,sweat gland depth,and sweat gland *** animals were genotyped with the Bovine GGP F250K,and BLUPF90 software was used to estimate genetic parameters and for Genome Wide Association *** Sweat gland phenotypes heritability ranged from 0.17 to 0.42 indicating a moderate amount of the phenotypic variation is due to genetics,allowing producers the ability to select for favorable sweat gland properties.A weighted single-step GWAS using sliding 10 kb windows identified multiple quantitative trait loci(QTLs)explaining a significant amount of genetic *** located on BTA7 and BTA12 explained over 1.0%of genetic variance and overlap the ADGRV1 and CCDC168 genes,*** variants identified in this study are implicated in processes related to immune function and cellular proliferation which could be relevant to heat *** of Origin Alleles(BOA)were predicted using local ancestry in admixed populations(LAmP-LD),allowing for identification of markers'origin from either Brahman or Angus ancestry.A BOA GWAS was performed to identify regions inherited from particular ancestral breeds that might have a significant impact on sweat gland pheno

关键词： GWAS Heritability Skin Thermotolerance

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Hepatic abscess induced by foreign body:Case report and literature review

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World Journal of Gastroenterology 2007年第9期13卷 1466-1470页

作者： Sofia A Santos Sara CF Alberto Elsa Cruz eduardo Pires Tomás Figueira lia Coimbra José Estevez mário Oliveira Luís Novais Joo R Deus Department of Gastroenterology Fernando Fonseca Hospital IC19 Amadora 2720-276 Portugal Department of Radiology Fernando Fonseca Hospital IC19 Amadora 2720-276 Portugal Department of Surgery Fernando Fonseca Hospital IC19 Amadora 2720-276 Portugal Department of Pathology Fernando Fonseca Hospital IC19 Amadora 2720-276 Portugal Center for the Study of Esophageal Diseases Carnaxide Portugal

Hepatic abscess due to perforation of the gastrointestinal tract caused by ingested foreign bodies is uncommon. Pre-operative diagnosis is difficult as patients are often unaware of the foreign body ingestion and symptoms and imagiology are usually non-specific. The authors report a case of 62-year-old woman who was admitted with fever and abdominal pain. Further investigation revealed hepatic abscess, without resolution despite antibiotic therapy. A liver abscess resulting from perforation and intra-hepatic migration of a bone coming from the pilorum was diagnosed by surgery. The literature concerning foreign body-induced perforation of the gastrointestinal tract complicated by liver abscess is reviewed.

关键词： Liver abscess Foreign body Gastrointestinal perforation

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Effect of treatment failure on the Cag A EPIYA motif in Helicobacter pylori strains from Colombian subjects

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World Journal of Gastroenterology 2017年第11期23卷 1980-1989页

作者： Javier Andres Bustamante-Rengifo Andres Jenuer matta Alvaro Jairo Pazos Luis eduardo Bravo Department of microbiology School of Basic ScienceUniversidad del Valle Registro Poblacional de Cáncer de Cali Department of PathologySchool of MedicineUniversidad del Valle Department of Biology Universidad de Narino

AIm To evaluate effect of treatment failure on cag A and vac A genotypes in Helicobacter pylori(H. pylori) isolates from *** One hundred and seventy-six participants infected with H. pylori from Colombia were treated during 14 d with the triple-standard therapy. Six weeks later, eradication was evaluated by 13C-Urea breath test. Patients with treatment failure were subjected to endoscopy control; biopsies obtained were used for histopathology and culture. DNA from H. pylori isolates was amplified using primers specific for cag A and vac A genes. The phylogenetic relationships among isolates obtained before and after treatment were established by conglomerate analysis based on random amplified polymorphic DNA(RAPD) *** Treatment effectiveness was at 74.6%. Of the par-ticipants with treatment failure, 25 accepted subjected to a second endoscopy. Prevalence of posttreatment infection was 64%(16/25) and 40%(10/25) by histology and culture, respectively. Upon comparing the cag A and vac A genotypes found before and after therapy, multiple cag A genotypes(cag A-positive and cag A-negative) were found before treatment; in contrast, cag A-negative genotypes decreased after treatment. vac A s1m1 genotype was highly prevalent in patients before and after therapy. The 3'cag A region was successfully amplified in 95.5%(21/22) of the isolates obtained before and in 81.8%(18/22) of the isolates obtained after treatment. In the isolates obtained from patients with treatment failure, it was found that 72.7%(16/22) presented alterations in the number of EPIYA motifs, compared to isolates found before *** Unsuccessful treatment limits colonization by lowvirulence strains resulting in partial and selective eradication in mixed infections, and acts on the cag A-positive strains inducing genetic rearrangements in cag A variable region that produces a loss or gain of EPIYA repetitions.

关键词： Helicobacter pylori RAPD-PCR Treatment failure EPIYA motifs 3’ cag A variable region

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Development of hepatorenal syndrome in bile duct ligated rats

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World Journal of Gastroenterology 2008年第28期14卷 4505-4511页

作者： Regina m Pereira Robson AS dos Santos eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos mauro m Teixeira Ana Cristina Sim■es e Silva Departamento de Ciências Biológicas Centro Universitário de Belo Horizonte-UNIBHAv.Mário WerneckBelo HorizonteMinas Gerais 30150-281Brazil Laboratório de Hipertenso Departamento de Fisiologia e BiofísicaInstituto de Ciências Biológicas (ICB)Universidade Federal de Minas Gerais (UFMG)Av.Antonio Carlos6627Belo HorizonteMinas Gerais 30150-281Brazil Departamento de Pediatria Faculdade de MedicinaUFMGAv.Alfredo Balena 190Belo HorizonteMinas Gerais 30150-281Brazil Departamento de Anatomia Patológica Faculdade de MedicinaUFMGAv.Alfredo Balena 190Belo HorizonteMinas Gerais 30150-281Brazil Laboratório de Imunofarmacologia Departamento de Bioquímica e ImunologiaICBUFMGAv.Antonio Carlos 6627Belo HorizonteMinas Gerais 30150-281Brazil

AIm: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. mETHODS: male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS.

关键词： Hepatorenal syndrome Bile duct ligation Renal function Renin angiotensin system

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Carbon nanodots:A metal-free,easy-to-synthesize,and benign emitter for light-emitting electrochemical cells

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Nano Research 2022年第6期15卷 5610-5618页

作者： Yongfeng Liu Shi Tang Xiuyu Wu Nicolas Boulanger eduardo Gracia-Espino Thomas Wågberg Ludvig Edman Jia Wang Department of Physics UmeåUniversitySE-90187 UmeåSweden LunaLEC AB Linnaeus väg 24SE-90187 UmeåSweden College of Physical Science and Technology Yangzhou UniversityYangzhou 225009China

Light-emitting electrochemical cells(LECs)can be fabricated with cost-efficient printing and coating methods,but a current drawback is that the LEC emitter is commonly either a rare-metal complex or an expensive-to-synthesize conjugated ***,we address this issue through the pioneering employment of metal-free and facile-to-synthesize carbon nanodots(CNDs)as the emitter in functional LEC ***-shaped(average diameter=4.4 nm)and hydrophilic CNDs,which exhibit narrow cyan photoluminescence(peak=485 nm,full width at half maximum=30 nm)with a high quantum yield of 77%in dilute ethanol solution,were synthesized with a catalyst-free,one-step solvothermal process using low-cost and benign phloroglucinol as the sole starting *** propensity of the planar CNDs to form emission-quenching aggregates in the solid state was inhibited by the inclusion of a compatible 2,7-bis(diphenylphosphoryl)-9,9’-spirobifluorene host compound,and we demonstrate that such pristine host-guest CND-LECs turn on to a peak luminance of 118 cd·m^(−2)within 5 s during constant current-density driving at 77 mA·cm^(−2).

关键词： carbon nanodot light-emitting electrochemical cell phloroglucinol sustainable synthesis solution-based fabrication

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A Fragmentation mechanism of Homemade Explosive TmDD Using DART-mS and Isotopic Labeling

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火炸药学报 2018年第1期41卷 16-20,30页

作者： Alexander Pedroza Zarate Fredy Colpas-Castillo Daniel J.Alcazar Franco Wilman A.Cabrera-Lafaurie eduardo A.Espinosa-Fuentes Department of Chemistry Universidad de Cartagena Facultad de Ciencias Exactas Cartagena Colombia Department of Natural and Exact Science Corporación Universidad de la Costa (CUC) Barranquilla Colombia Department of Civil and Environmental Sciences Corporación Universidad de la Costa (CUC) Barranquilla Colombia

A fragmentation mechanism and characterization for the first time using Direct Analysis in Real Time- Time of Flight-mass Spectrometry(DART-TOF-mS)of the tetramethylene diperoxide dicarbamide(TmDD)compound were *** mS-spectrum may support other research about devices and detection in real *** mass spectrum of TmDD obtained using DART ionization in the positive-ion detection mode exhibited a strong peak at m/z254representing an ammonium adduct([TmmD·NH_4]~+).There was another peak at m/z237,which represented the protonated molecule([TmDD·H]~+)of *** two peaks corroborated the identity of the *** DART-mS spectra of the TmDD-isotopomer successfully corroborated the respective molecular tails. The principal fragmentation residues also showed coherence according to the number of isotopically labeled atoms on the TmDD *** contrast with other organic peroxides analyzed by this technique,TmDD exhibited substantial *** theoretical modeling results showed that the fragmentation mechanism of the TmDD ion adduct is strongly dependent of the TmDD ring flexibility and the hydrogen bonding formed between the nitrogen and oxygen atoms and the atmospheric proton.

关键词： direct analysis in real time Time of Flight-mass Spectrometry TmDD isotopomers

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The detrimental effects of lipopolysaccharideinduced neuroinflammation on adult hippocampal neurogenesis depend on the duration of the pro-inflammatory response

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Neural Regeneration Research 2019年第5期14卷 817-825页

作者： martha Pérez-Domínguez Evangelina ávila-mu?oz eduardo Domínguez-Rivas Angélica Zepeda Departamento de medicina Genómica y Toxicología Ambiental Instituto de Investigaciones Biomédicas.Universidad Nacional Autónoma de MéxicoCDMX

Adult hippocampal neurogenesis is a finely tuned process regulated by extrinsic factors. Neuroinflammation is a hallmark of several pathological conditions underlying dysregulation of neurogenesis. In animal models, lipopolysaccharide(LPS)-induced neuroinflammation leads to a neurogenic decrease mainly associated to the early inflammatory response. However, it is not well understood how the neuroinflammatory response progresses over time and if neurogenesis continues to be diminished during the late neuroinflammatory response. moreover, it is unknown if repeated intermittent administration of LPS along time induces a greater reduction in neurogenesis. We administered one single intraperitoneal injection of LPS or saline or four repeated injections(one per week) of LPS or saline to young-adult mice. A cohort of new cells was labeled with three 5-bromo-2-deoxyuridine injections(one per day) 4 days after the last LPS injection. We evaluated systemic and neuroinflammation-associated parameters and compared the effects of the late neuroinflammatory response on neurogenesis induced by each protocol. Our results show that 1) a single LPS injection leads to a late pro-inflammatory response characterized by microglial activation, moderate astrocytic reaction and increased interleukin-6 levels. This response correlates in time with decreased neurogenesis and 2) a repeated intermittent injection of LPS does not elicit a late pro-inflammatory response although activated microglia persists. The latter profile is not accompanied by a continued longterm hippocampal neurogenic decrease. Hereby, we provide evidence that the neuroinflammatory response is a dynamic process that progresses in a milieu-dependent manner and does not necessarily lead to a neurogenic decrease, highlighting the complex interaction between the immune system and neurogenesis.

关键词： dentate gyrus subgranular zone inflammation microglia astrocytes IL-6 cytokines cell proliferation neural progenitor cells immature neurons long-term short-term adult hippocampal neurogenesis

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Cryopreservation of Cyrtopodium hatschbachii Pabst (Orchidaceae) immature seeds by encapsulation-dehydration

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BIOCELL 2012年第1期36卷 31-36页

作者： mAURO RODRIGO SURENCISKI eduardo ALBERTO FLACHSLAND GRACIELA TERADA LUIS AmADO mROGINSKI AND HEBE YOLANDA REY Instituto de Botánica del Nordeste(IBONE) CONICET–UNNEFacultad de Ciencias Agrarias(UNNE)C.C.209(3400)CorrientesArgentina

The aim of the present study was to investigate the efficiency of the encapsulation-dehydration technique for cryopreservation of Cyrtopodium hastchbachii Pabst *** seeds of this species were cryopreserved by an encapsulation-dehydration *** of five immature pods,120 days after pollination,were encapsulated in 3%calcium alginate matrix and pretreated in liquid medium supplemented with 0.08 m sucrose(24 h),0.15 m sucrose(24 h),0.25 m sucrose(48 h),0.5 m sucrose(24 h)and 0.75 m sucrose(24 h)in shaker at 60 *** beads were dehydrated 5 h in silicagel and immersed in liquid nitrogen for 12 *** beads were thawed at 30℃ for 1 min,rehydrated using the same liquid mediums[0.75 m sucrose(24 h),0.5 m sucrose(24 h),0.25 m sucrose(48 h)and 0.15 m sucrose(24 h)]and cultivated in half strength murashige&Skoog medium(1962)with the addition of 2 g/L activated *** four percent of seeds survived and developed into acclimatized plants after being *** this work,the encapsulation-dehydration technique was employed for first time in Cyrtopodium hatschbachii.

关键词： cryoconservation liquid nitrogen calcium alginate activated charcoal sucrose

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Preclinical models of idiosyncratic drug-induced liver injury(iDILI):moving towards prediction

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3685-3726页

作者： Antonio Segovia-Zafra Daniel E.Di Zeo-Sanchez Carlos Lopez-Gomez Zeus Perez-Valdes eduardo Garcıa-Fuentes Raul J.Andrade m.Isabel Lucena marina Villanueva-Paz Unidad de Gestio´n Clı´nica de Gastroenterologı´a Servicio de Farmacologıa ClınicaInstituto de Investigacio´n Biomedica de Malaga-IBIMAHospital Universitario Virgen de la VictoriaUniversidad de MalagaMalaga 29071Spain Centro de Investigacion Biomedica en Red en el Area Tematica de Enfermedades Hepaticas y Digestivas(CIBERehd) Madrid 28029Spain Platform ISCIII de Ensayos Clınicos UICEC-IBIMAMalaga 29071Spain Unidad de Gestion Clınica de Aparato Digestivo Instituto de Investigacion Biomedica de Malaga(IBIMA)Hospital Universitario Virgen de la VictoriaMalaga 29010Spai

Idiosyncratic drug-induced liver injury(iDILI) encompasses the unexpected harms that prescription and non-prescription drugs,herbal and dietary supplements can cause to the *** remains a major public health problem and a major cause of drug *** the lack of biomarkers for iDILI prediction,diagnosis and prognosis,searching new models to predict and study mechanisms of iDILI is *** of the major limitations of iDILI preclinical assessment has been the lack of correlation between the markers of hepatotoxicity in animal toxicological studies and clinically significant ***,major advances in the understanding of iDILI susceptibility and pathogenesis have come from the study of well-phenotyped iDILI ***,there are many gaps for explaining all the complexity of iDILI susceptibility and ***,there is a need to optimize preclinical human in vitro models to reduce the risk of iDILI during drug ***,the current experimental models and the future directions in iDILI modelling are thoroughly discussed,focusing on the human cellular models available to study the pathophysiological mechanisms of the disease and the most used in vivo animal iDILI *** also comment about in silico approaches and the increasing relevance of patient-derived cellular models.

关键词： Drug-induced liver injury Preclinical models mechanisms Oxidative stress mitochondrial damage Immune response Personalized medicine

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Non-linear modeling of kinetic and equilibrium data for the adsorption of hexavalent chromium by carbon nanomaterials:Dimension and functionalization

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Chinese Journal of Chemical Engineering 2019年第4期27卷 912-919页

作者： miguel de la Luz-Asunción eduardo E.Pérez-Ramírez Ana L.martínez-Hernández Victor m.Castano Víctor Sánchez-mendieta Carlos Velasco-Santos Facultad de Quimica Universidad Autonoma del Estado de Mexico Km. 12 de la carretera Toluca-Atlacomulco C.P. 50200 San Cayetano Toluca Estado de Mexico Mexico Tecnologico Nacional de mexico-Instituto Tecnologico de Queretaro Division de Estudios de Posgrado e Investigacion Av. Tecnologico s/n esq. GraL Mariano Escobedo Col. Centro Historico C.P. 76000 Santiago de Queretaro Queretaro Mexico Centro de Fisica Aplicada y Tecnologia Avanzada Universidad Nacional Autonoma de Mexico Boulevard Juriquilla 3001 Queretaro 76230 Mexico

The adsorption capacities for the removal of hexavalent chromium from aqueous solutions by six carbon nanomaterials have been evaluated. Single-walled and multi-walled carbon nanotubes as received and after oxidation treatment, graphene oxide and reduced graphene oxide are the materials with different dimension and functionalization compared in this research. Carbon nanotubes have been modified using hydrogen peroxide as oxidizing agent under microwave radiation. The oxidation treatment on carbon nanotubes has a positive effect increasing the adsorbent–adsorbate interaction. Rate-controlling mechanisms and equilibrium data are analyzed using non-linear models. Non-linear method is proposed as the most suitable method for determining the kinetic and equilibrium parameters. The values of adsorption energy(E) obtained from the Dubinin–Radushkevich isotherm,have been found around 0.371 and 0.870 k J·mol-1, indicating physical adsorption. Therefore, the pseudo-second order model represents better the kinetic experimental data. The results show that the Langmuir isotherm provides a slightly better fit to the experimental data compared with the Freundlich isotherm, indicating homogeneous distribution of active sites on carbon nanomaterials and monolayer adsorption. The separation factors RLare found in the range of 0–1, suggesting that the adsorption process is suitable for all adsorbents. The mechanisms for hexavalent chromium removal have been proposed as electrostatic interactions and hydrogen bonding.

关键词： Carbon nanotubes Graphene Adsorption Hexavalent chromium Kinetic

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