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Transcatheter mitral valve repair in nonagenarians

Journal of Geriatric Cardiology 2022年第1期19卷 90-94页

作者： Pedro Luis Cepas-Guillén Isaac Pascual Eulogio Garcia Pilar Jimenez-Quevedo Alfonso Jurado-Roman Tomás Benito-González Rodrigo Estevez-Loureiro Pedro Li Dabit Arzamendi Bruno Melica eduardo infante de oliveira Pedro Martín Lorenzo Felipe Fernández-Vázquez Guillermo Galeote Luis Nombela-Franco Leire Unzue Pablo Avanzas Manel Sabate Xavier Freixa Cardiology department Cardiovascular Institute(ICCV)Hospital ClinicIDIBAPSUniversity of BarcelonaBarcelonaSpain Interventional Cardiology Unit Hospital Universitario Central de AsturiasDepartment of MedicineUniversity of OviedoOviedoSpain Servicio de Hemodinámica y Cardiología Intervencionista HM CIEC-Centro Integral de Enfermedades CardiovascularesHospital Universitario HM MontepríncipeHM HospitalesMadridSpain Facultad de Medicina Universidad CEU San PabloMadridSpain Cardiology department Cardiovascular InstituteHospital Clínico San CarlosIdISSCMadridSpain Division of Interventional Cardiology University Hospital La PazIdiPAZCIBER-CVMadridSpain department of Cardiology University Hospital of LeónLeónSpain Interventional Cardiology Unit HospitalÁlvaro CunqueiroVigoSpain Interventional Cardiology Unit Hospital Sant Pau i Santa CreuBarcelonaSpain Serviço de Cardiologia Centro Hospitalar de Vila Nova de Gaia/Espinho-EPEVila Nova de GaiaPortugal Serviço de Cardiologia Hospital de Santa MariaCentro Hospitalar Lisboa NorteCentro Académico Médico de LisboaLisboaPortugal Servicio de Cardiología Hospital Universitario de Gran Canaria Dr.NegrínLas Palmas de Gran CanariaSpain

Given the increase in life expectancy indeveloped countries,nonagenarian population will become clinically and numerically relevant in our daily routine practice in the near *** has been observed to exert a profound influence on the prevalence of severe mitral regurgitation (MR) in the population.[1]Mitral valve surgery remains the gold standard of care for patients with symptomatic severe MR.

关键词： mitral routine surgery

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Assembly structures of coastal woody species of eastern South America:Patterns and drivers

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Plant Diversity 2024年第5期46卷 611-620页

作者： eduardo Vinícius da Silva oliveira Myrna Friederichs Landim Sidney F.Gouveia Graduate Program in Ecology and Conservation Federal University of SergipeSão CristovãoSergipeBrazil National Institute of Science and Technology Ecology Evolution and Conservation of Biodiversity(INCT-EECBio)GoiâniaGoiasBrazil department of Biology Federal University of SergipeSão CristóvãoSergipeBrazil department of Ecology Federal University of SergipeSão CristóvãoSergipeBrazil

Tropical regions have provided new insights into how ecological communities are *** dry coastal communities,water stress has been hypothesized to determine plant assembly structure by favoring preadapted lineages from neighboring ecosystems,consistent with functional ***,it is unclear whether this hypothesis is sufficient to explain how coastal communities in tropical ecosystems are ***,we test whether water stress or other factors drive community assembly in woody plant communities across the coastal zone of Brazil,a tropical *** characterized functional and phylogenetic structures of these communities and determined the underlying environmental factors(e.g.,water stress,historical climate stability,edaphic constraints,and habitat heterogeneity)that drive their community *** of coastal woody species show geographically varied patterns,including stochastic arrangements,clustering,and overdispersion of species relative to their traits and phylogenetic *** complexity,water vapor pressure,and soil nutrient availability best explained the gradient in the functional *** deficit,water vapor pressure,and soil organic carbon were the best predictors of variation in phylogenetic *** results support the water-stress conservatism hypothesis on functional and phylogenetic structure,as well as the effect of habitat heterogeneity on functional structure and edaphic constraints on functional and phylogenetic *** effects are associated with increased phenotypic and phylogenetic divergence of woody plant assemblages,which is likely mediated by abiotic filtering and niche opportunities,suggesting a complex pattern of ecological assembly.

关键词： Brazil Completeness Clustering Restinga vegetation Water constraints

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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari Joséeduardo Vargas Cláudia P oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(deN)in drinking water and Veh gavage],and RIF[HFCD,deN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(P0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(P0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

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Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans,Staphylococcus aureus,and Candida spp.

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World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle Nagai de Lima Thaís Cristine Pereira Lara Steffany de Carvalho Letícia Ferreira dos Santos Carlos eduardo Rocha oliveira Lucas de Paula Ramos Maria Cristina Marcucci Amjad Abu Hasna Luciane Dias de oliveira department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil department of Restorative dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon Schoenanthus and Pelargonium graveolens essential oils against Streptococcus mutans,Staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).RESULTS *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei Staphylococcus aureus Streptococcus mutans

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Combined Oxidative Phosphorylation deficiency-20-Exome as a Diagnostic Implement

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Journal of Biosciences and Medicines 2024年第6期12卷 7-12页

作者： Paulo Roberto Matos-Neto Lucas Antonissen Lima Verde Airton Ferreira da Ponte-Filho Luís eduardo oliveira Matos Amandha Espavier Trés Paulo Roberto Lacerda Leal Gerardo Cristino-Filho Regina Coeli de Carvalho Porto Carneiro Faculty of Medicine Federal University of Cear Sobral Cear Brazil department of Neurosurgery Federal University of Cear Sobral Cear Brazil department of Neuropediatrics Federal University of Cear Sobral Cear Brazil

Mitochondrial disorders are phenotypically varied, with serious clinical repercussions. Among them, there is the deficiency of combined oxidative phosphorylation of type 20, which occurs due to a defect in the VARS2 gene. This article presents a case of a 2-year-old female with progressive myoclonic epilepsy and psychomotor regression, with refractoriness to multiple anticonvulsants. The diagnosis was only made after the examination was carried out. Therefore, this article highlights the aspects of this rare disease and the importance of the exome for the diagnosis of rare conditions.

关键词： Oxidative Phosphorylation Epilepsy Exome Mitochondrial defect VARS2

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To Open the Mouth,to Show the Tongue:Anthropophagic Gestures in Brazilian Art

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Journal of Foreign Languages and Cultures 2021年第2期5卷 143-151,155,156页

作者： eduardo Jorge de oliveira Andre Masseno University of Zurich

This essay seeks to articulate a detailed reading through two anatomical selections-the mouth and tongue-in Brazilian art from the end of the *** reading is part of a shift in the matrix of Oswald de Andrade’s“Anthropophagic Manifesto,”originally published in the Re vista de Antropofagia in 1928,whose interpretations spread in Brazil during the second half of the 20th *** study mobilises elements of the manifesto and its resonance in the works of artists such as Anna Maria Maiolino,Lygia Pape,Paulo Bruscky,and Lenora de Barros.

关键词： mouth tongue Anthropophagic Manifesto Oswald de Andrade Brazilian art

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Foodborne outbreaks in Brazil associated with fruits and vegetables:2008 through 2014

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Food Quality and Safety 2018年第4期2卷 173-181页

作者： Susana de oliveira Elias Luana Tombini decol eduardo Cesar Tondo departamento de Ciências dos Alimentos-Universidade Federal do Rio Grande do Sul Instituto de Ciência e Tecnologia de Alimentos-Av.Bento Gonçalves9500 Prédio 43212 Agronomia CEP:91505-970-Porto Alegre-RS-Brasil

Objectives:Foodborne disease outbreaks linked to fruits and vegetables have been increasing in occurrence worldwide;therefore,the aim of this study was to identify the reported foodborne outbreaks associated with fruit and vegetable consumption in Brazil from 2008 to *** And Limitations:Thirty produce related outbreaks resulted in 2926 illnesses,347 hospitalizations,and no *** bacterial pathogens were identified as etiological *** these,Salmonella was the most frequent(30 per cent of outbreaks)followed by Staphylococcus aureus(23.3 per cent),Escherichia coli(10 per cent),Bacillus cereus(6.6 per cent),and thermotolerant coliforms(3.3 per cent),whereas etiological agents could not be determined for 26.6 per cent of *** most common food vehicles implicated in outbreaks were generically named as fruits and vegetables(46.6 per cent of outbreaks).The term salad was used generically and specifically like salads(two outbreaks),raw/cooked salads(four outbreaks),vegetable salad,tropical salad,Caesar salad,and raw salad of cabbage and *** one outbreak was related exclusively to fruit(fruit pulp),whereas other outbreaks were related to cooked carrot,lettuce,cucumber,watermelon/cabbage,and chard/*** sources and issues related to the future control of produce-related foodborne disease outbreaks are discussed.

关键词： produce pathogens Salmonella foodborne illness disease surveillance notification

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Partition coefficient prediction of Baker's yeast invertase in aqueous two phase systems using hybrid group method data handling neural network

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Chinese Journal of Chemical Engineering 2017年第5期25卷 652-657页

作者： Carlos eduardo de Araújo Padilha Sérgio Dantas de oliveira Júnior Domingos Fabiano de Santana Souza Jackson Araújo de oliveira Gorete Ribeiro de Macedo Everaldo Silvino dos Santos Laboratory of Biochemical Engineering Chemical Engineering DepartmentFederal University of Rio Grande do Norte (UFRN)

A hybrid GMDH neural network model has been developed in order to predict the partition coefficients of invertase from Baker's yeast. ATPS experiments were carried out changing the molar average mass of PEG(1500–6000 Da), p H(4.0–7.0), percentage of PEG(10.0–20.0 w/w), percentage of MgSO_4(8.0–16.0 w/w), percentage of the cell homogenate(10.0–20.0 w/w) and the percentage of MnSO_4(0–5.0 w/w) added as cosolute. The network evaluation was carried out comparing the partition coefficients obtained from the hybrid GMDH neural network with the experimental data using different statistical metrics. The hybrid GMDH neural network model showed better fitting(AARD = 32.752%) as well as good generalization capacity of the partition coefficients of the ATPS than the original GMDH network approach and a BPANN model. Therefore hybrid GMDH neural network model appears as a powerful tool for predicting partition coefficients during downstream processing of biomolecules.

关键词： Partitioning Invertase Aqueous Two Phase System GMDH Neural network

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Recovery of polyphenols from camu-camu(Myrciaria dubia ***)depulping residue by cloud point extraction

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Chinese Journal of Chemical Engineering 2018年第12期26卷 2471-2476页

作者： Carlos eduardo de Araujo Padilha Juliana Chris Silva de Azevedo Francisco Caninde de Sousa Junior Sergio Dantas de oliveira Junior Domingos Fabiano de Santana Souza Jackson Araujo de oliveira Gorete Ribeiro de Macedo Everaldo Silvino dos Santos Laboratory of Biochemical Engineering Chemical Engineering department Federal University of Rio Grande do Notre(UFRN)NatalRNBrazil Laboratory of Food Bioactive Compounds and Dairy Technology Chemical Engineering DepartmentFederal University of Rio Grande do Notre(UFRN)NatalRNBrazil

In this study the potential of cloud point extraction formed by a non-ionic surfactant was used in order to separate polyphenols from industrial residues of camu-camu. The effects of operational conditions of the cloud point extraction(CPE) on the polyphenol recovery and volumetric ratio were investigated. The results showed a maximum recovery of 95.71% that was obtained using 7.0 wt% Triton X-114, native pH(3.25), and 80 wt%polyphenol extract at 30 °C. The use of cloud point extraction was successful to recover the polyphenols from agroindustrial residue since it is a simple as well as of low-cost technique.

关键词： Cloud point extraction Recovery Polyphenols Camu-camu depulping residue

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Evaluation of physicochemical properties as supporting information on quality control of raw materials and veterinary pharmaceutical formulations

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Journal of Pharmaceutical Analysis 2018年第3期8卷 168-175页

作者： Sara da Silva Anacleto Marcella Matos Cordeiro Borges Hanna Leijoto de oliveira Andressa Reis Vicente eduardo Costa de Figueiredo Marcone Augusto Leal de oliveira Barbara Juliana Pinheiro Borges Marcelo Antonio de oliveira Warley de Souza Borges Keyller Bastos Borges departamento de Ciencias Naturals Universidade Federal de Sao Joao del-Rei Campus Dom Bosco Praca Dora Helvecio 74 Fabricas 36301-160 Sao Joao del-Rei Minas Gerais Brazil departamento de Quimica Universidade Federal do Espirito Santo Avenida Fernando Ferrari 514 Goiabeiras 29075-910 Vitdria Espirito Santo Brazil Laboratorio de Analise de Toxicantes e Farmacos Faculdade de Ciencias Farmaceuticas Universidade Federal de Alfenas Rua Gabriel Monteiro da Silva 700 Centro 37130-000 Alfenas Minas Gerais Brazil departamento de Quimica Universidade Federal de Juiz de Fora Rua Jose Lourenco Kelmer s/n 36036-330 Juiz de Fora Minas Gerais Brazil Centro de Ciencias da Saude Universidade Federal do Espirito Santo Avenida Marechal Campos 1468 Maruipe 29.043-900 Vitori Espirito Santo Brazil Centro Universitario Norte do Espirito Santo Universidade Federal do Espirito Santo Br 101 Norte Km 67 Sao Mateus Espirito Santo Brazil

This study aimed to show that the physicochemical proprieties obtained by Fourier transform infrared spectroscopy （FTIR）, thermogravimetry （TG）, and scanning electronic microscopy （SEM） can be useful tools for evaluating the quality of active pharmaceutical ingredients （APIs） and pharmaceutical products. In addition, a simple, sensitive, and efficient method employing HPLC-DAD was developed for simulta- neous determination of lidocaine （LID）, ciprofloxacin （CFX） and enrofloxacin （EFX） in raw materials and in veterinary pharmaceutical formulations. Compounds were separated using a Gemini Cm （250 mm×4.6 mm, 5μm） Phenomenex column, at a temperature of 25℃, with a mobile phase containing 10 mM of phosphoric acid （pH 3.29）： acetonitrile （85.7：14.3, v/v） and a flow rate of 1.5 mL/min. Physicochemical characterization by TG, FTIR, and SEM of raw materials of LID, CFX, and EFX provided information useful for the evaluation, differentiation, and qualification of raw materials. Finally, the HPLC method was proved to be useful for evaluation of raw material and finished products, besides satisfying the need for an analytical method that allows simultaneous determination of EFX, CFX, and LID, which can also be extended to other matrices and applications.

关键词： HPLC Physicochemical characterization Quality control Veterinary pharmaceutical formulation Raw material

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