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Expansion of endothelial surface by an increase of vessel diameter during tumor angiogenesis in experimental hepatocellular and pancreatic cancer

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World Journal of Gastroenterology 2004年第21期10卷 3171-3174页

作者： eduard Ryschich eduard Schmidt Sasa-Marcel Maksan Ernst Klar Jan Schmidt Department of Surgery University of HeidelbergHeidelbergGermany

AIM: A low vessel density is a common feature of malignant tumors. We suggested that the expansion of vessel diameter might reconstitute the oxygen and nutritient's supply in this situation. The aim of the present study was to compare the number and diameter of blood vessels in pancreatic and liver carcinoma with normal ***: Tumor induction of pancreatic (DSL6A) or hepatocellular (Morris-hepatoma) carcinoma was performed in male Lewis (pancreatic cancer) and ACI (hepatoma) rats by an orthotopic inoculation of solid tumor fragments (pancreatic cancer) or tumor cells (hepatoma). Six weeks (pancreatic cancer) or 12 d (hepatoma) after tumor implantation, the tumor microvasculature as well as normal pancreatic or liver blood vessels were investigated by intravital microscopy. The number of perfused blood vessels in tumor and healthy tissue was assessed by computer-assisted image ***: The vessel density in healthy pancreas (565±89n/mm^2) was significantly higher compared to pancreatic cancer (116±36 n/mm^2) (P<0.001). Healthy liver showed also a significantly higher vessel density (689+36 n/ram2) compared to liver carcinoma (286+32 n/mm2) (P<0.01). The comparison of diameter frequency showed a significant increase of vessel diameter in both malignant tumors compared to normal tissue (P<0.05).CONCLUSION: The expansion of endothelial cells during tumor angiogenesis is accompanied to a large extent by an increase of vessel diameter rather than by formation of new blood vessels. This may be a possible adaptive mechanism by which experimental pancreatic and hepatocellular cancers expand their endothelial diffusion surface of endothelium to compensate for inadequate neoangiogenesis.

关键词：内皮表面扩充作用导管直径肿瘤血管生成实验性肝细胞胰腺癌消化系统

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Molecular dynamics simulations of surfactant adsorption at oil/water interface under shear flow

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Particuology 2019年第3期17卷 36-43页

作者： Ying Ren Qiang Zhang Ning Yang Ji Xu Jialin Liu Ruixin Yang Christian Kunkelmann eduard Schreiner Christian Holtze Kerstin Miilheims Bernd Sachweh State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences P.O. Box 353 Beijing 100190 China Center for Mesoscience (COM) Institute of Process Engineering Chinese Academy of Sciences P.O. Box 353 Beijing 100190 China China University of Petroleum-Beijing Beijing 102249 China University of Shanghai for Science and Technology Shanghai 200093 China BASFSE 67056 Ludwigshafen am Rhein Germany BASF Advanced Chemicals Co. Ltd. Shanghai 200137 China

Surfactants are extensively used in many chemical products to improve their stability, appearance, texture, and rheology. Precise control of the emulsion droplet size distribution, which depends on the characteristics of the surfactant used, is important for target-oriented product design. A complete understand! ng of the structures and dynamics of emulsion droplets at the reactor level requires coupling of two mesoscale physical constraints, that at the interfacial level, i.e., smaller than a single droplet (Mesoscale- 1), and that at the device level, i.e., larger than a single droplet (Mesoscale-2). In this work, the structures and adsorption kinetics of Mesoscale-1 surfactant molecules were studied via coarse-grained molecular dynamics. A non-equilibrium model that could introduce stable shear flow into the simulation box was used to investigate the interfacial structures at the droplet interface under different shear rates. The configurations of the surfactant molecules and adsorption amounts were compared with those obtained without flow. The adsorption kinetics for different shear rates were compared to determine the effects of hydrodynamic interactions. The dominant mechanisms governing the dynamic structures can thus be summarized as maximization of the adsorption density at the interface and minimization of flow resistance in the bulk phase (water and/or oil molecules). A scheme for coupling between Mesoscale-1 and Mesoscale-2 is proposed. This method is promising for the incorporation of interfacial structure effects into the hydrodynamics at the reactor device level for the manipulation of chemical products.

关键词： Surfactant adsorption Molecular dynamics simulation Mesoscale modeling Shear flow

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Use of endoscopic vacuum(E-Vac)therapy for the treatment of a cervical oesophagoileostomy leakage after a right-colon interposition for oesophageal replacement

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Gastroenterology Report 2020年第6期8卷 481-483,I0003页

作者： Sonia Fernández-Ananín Eulalia Ballester Carlos Guarner Argente Carmen Balague eduard M.Targarona Department of General and Digestive Surgery Hospital de la Santa Creu i Sant PauBarcelonaSpain Gastroenterology and Hepatology Department Hospital de la Santa Creu i Sant PauUniversidad Auto´noma de BarcelonaBarcelona

Introduction Anastomotic leakage is considered the Achilles heel after oesophagogastric resection and its therapeutic management remains a *** endoscopic options,such a clips,stents,internal drainage,fibrin glue instillation,or suturing devices,have been suggested as minimally endoscopic therapies to treat these ***,the use of endoscopic vacuum(E-Vac)therapy has proven to be useful for the healing of these adverse events and some studies have even reported its superiority to other endoscopic devices[1].The E-Vac promotes the growth of granulation tissue and increases microcirculation while providing debridement of the cavity leak in each sponge replacement by continuous negative *** describe an exceptional clinical scenario in which the use of the E-Vac allows the successful closure of a cervical oesophagoileostomy leakage and the resolution of a mediastinal abscess after an ileum and right-colon interposition for oesophageal replacement.

关键词：吻合口漏 healing sponge

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Seismic Waves in Layered Media

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Journal of Earth Science and Engineering 2014年第5期4卷 311-325页

作者： Dmytro Malytskyy eduard Kozlovskyy Carpatian Branch of Subbotin Institute of Geophysics NAS of Ukraine Lviv 79060 Ukraine

This paper is organized as follows. After a discussion of the differential equations for wave propagation in the horizontally stratified medium and of the initial and boundary conditions, the displacements are derived on the free surface of the layered medium for plane waves when a point source is located on the s-th imaginary boundary at the depth -s （physical parameters of the layers s and （s ＋ 1） are put to be identical）. Then, the source will be represented as a single force of arbitrary orientation and a general moment tensor point source. Further, ＂a primary field＂ for a point source will be introduced. Matrix method for the solution of the direct seismic problem is considered based on the matrix method of Thomson-Haskell and its modifications.

关键词： Matrix method seismic waves a point source seismic moment tensor the far-field displacements.

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Seismo-Microplasticity phenomenon in the rocks

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Natural Science 2010年第3期2卷 155-159页

作者： eduard Innokentevich Mashinskii 不详

The seismic records of borehole-to-borehole me- asurements on frequency of 200 Hz in the mi-crostrain range have been analysed. Microplas-ticity manifestations caused by seismic wave are detected on seismic records. It is the lad-der-like stepwise change in amplitude course in some parts of the seismic trace. The step dura-tion (time plateau) presents the amplitude- dependent time delay that shifts the arrival time and protracts pulse front. The microplastic process occurs owing to the anomalous re-alignment of the internal stresses on the micro-structural defects in “elastic” domain. Result is the useful contribution for improvement of the theory of wave attenuation in the rocks. It can also be used in solving the applied problems in material science, seismic prospecting, diagnos-tics etc.

关键词： Anelasticity Deformation And Time Delay Anelastic Seismic Parameters Amplitude De-pendence Of Wave Velocity And Attenuation

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预训练语言模型及其应用

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Engineering 2023年第6期25卷 51-65,M0004页

作者：王海峰李纪为 Hua Wu eduard Hovy Yu Sun Baidu Inc. Beijing 100193China College of Computer Science and Technology Zhejiang UniversityHangzhou 310058China Language Technologies Institute Carnegie Mellon UniversityPittsburghPA 15213USA

预训练语言模型(pre-trained languages model,PTLM)在自然语言处理(natural language processing,NLP)领域取得了令人瞩目的成功,并由此引发了下游任务从监督学习到预训练-微调范式的转变。在此之后,一系列预训练模型的创新研究涌现出... 详细信息

预训练语言模型(pre-trained languages model,PTLM)在自然语言处理(natural language processing,NLP)领域取得了令人瞩目的成功,并由此引发了下游任务从监督学习到预训练-微调范式的转变。在此之后,一系列预训练模型的创新研究涌现出来。本文系统性、全面的回顾了自然语言处理的代表性工作和最新进展,并按照类别系统性的介绍了自然语言处理领域的预训练模型。首先我们简要介绍了预训练模型,以及不同的模型特点和框架。之后,我们介绍并分析了预训练模型的影响和挑战以及下游任务中的应用。最后,我们简要总结并阐述了预训练模型未来的研究方向。

关键词：自然语言处理语言模型预训练影响和挑战范式的转变

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The Challenges of the Engineering Inspection of Pipelines and Heat Engines by Temperature Deformation and Stress

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Journal of Power and Energy Engineering 2016年第1期4卷 40-46页

作者： eduard А. Mikaelian Saif A. Mouhammad Gubkin Russian State University of Oil and Gas Moscow Russia Physics Department Faculty of Science Taif University Taif Saudi Arabia

Pipelines and engines are studied under the thermal stress during operation. With the calculated ratios obtained, it is possible to settle practical issues in operation in order to increase the reliability and safety of equipment. To this end, it is first necessary to investigate the thermal mode of the pipeline, the engine for the planned period by the operations control centre. At the same time, the equipment with the average temperature at a certain time of the year exceeding the design value should be identified. In addition, the equipment concerning the nature of jamming should be studied at the sections specified in such a way. In case of identifying the jammed sections based on the above calculated ratios by thermal deformation and stressing the necessary value of movement of the sections, it should be determined that the actual voltage does not exceed the permissible level.

关键词： Thermal Stress Deformation Jamming in Pipes Equipment Thermal Stress Characteristics

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Phosphorus:Distributed Control Plane Approach for Photonic Grids

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China Communications 2011年第3期8卷 1-11页

作者： eduard Escalona Georgios Zervas Reza Nejabati Dimitra Simeonidou High Performance Networks Group University of Essex

G2MPLS is a Network Control Plane(NCP) architecture that implements the concept of Grid Network Services(GNS) required for implementing photonic *** provides part of the functionalities related to the selection,co-allocation and maintenance of both Grid and network resources through a set of seamless procedures at the user-to-network and inter-domain boundaries.G2MPLS' main features and procedures are presented in this document,as well as the considerations to deploy it and facilitate its dissemination.

关键词： Photonic Grids Grid Network Service Network Control Plane GMPLS G2MPLS

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Moving toward Semantics for Language Processing:Recent Advances in Resource Construction and Application

Moving toward Semantics for Language Processing:Recent Advan...

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IEEE自然语言处理与知识工程国际学术会议

作者： eduard Hovy USC Information Sciences Institute

＜正＞Research in natural language processing over the past decade has produced amazing results using statistical methods. But increasingly there are signs that continued quality improvement for language processing applications （including QA, summarization, information extraction, and possibly even machine translation） require deeper and richer representations, possibly even （shallow） semantics of text meaning. But how can one define large-scale shallow semantic representations, and create shallow semantic content resources, that are stable and large enough to be adequate for the needs of statistically based NLP applications? In this talk I describe recent work at various locations, focusing on the resource components required （including ISI’s symbol definition ontology Omega and the BBN-UPenn-Colorado-ISI large corpus OntoBank of （shallow） meaning representations） and the resources and methods one needs to build them （including existing ontologies, human annotation procedures, and a verification methodology, as embodied in a pilot project called Learning by Reading that involves various prominent researchers）. This work is bringing together the NLP and KE/KR communities after a separation of some 40 years, and poses challenges for each side: dealing with large amounts of possibly incorrect knowledge is not something KE/KR has comfortable with, and dealing with requirements that knowledge be formalized and consistent is not something that large-scale NLP has been comfortable with. But should these challenges be resolved, the research discussed in this talk will enable numerous experiments on the wide-scale use of （shallow） semantics, to the benefit of NLP applications of all kinds.

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RISK OF INVESTMENTS IN TO BONDS

RISK OF INVESTMENTS IN TO BONDS

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作者： eduard Rau Altai Academy of Economics and Law

This article considers main types of risks with which investors face at operations bonds.

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