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Journal of Environmental Sciences 2009年第7期21卷 900-906页

作者： Ze-hua Liu Mamoru ito Yoshinori Kanjo Atsushi Yamamoto Department of Urban Engineering Graduate School of Engineering Osaka City University 3-3-138 Sugimoto Sumiyoshi-ku Osaka 558-8585 Japan Osaka City Institute of Public Health and Environmental Sciences 8-34 Tojo-cho Tennoji-ku Osaka 543-0026 Japan

An estrogen receptor （ER）/androgen receptor （AR） ligand competitive binding assay （ER/AR-binding assay） and chemical analyses were used to evaluate the endocrine disrupting chemicals （EDCs） behavior of two municipal wastewater treatment plants （WWTPs）（K and S）. In the influents, estrone （E 1）, androsterone （A）, androstenedione （AD）, BPA （bisphenol A）, NP （nonylphenol） and daidzein （DZ） were detected in high amounts with subsequent 24 h-average concentrations of 350, 1000, 29, 1300, 3900, and 5700 ng/L in K-WWTP and of 310, 620, 59, 1600, 2600, and 8400 ng/L in S-WWTP. The estrogenic （androgenic） activity as 17β-estradiol （E2） equivalents （EEQ） or testosterone （Te） equivalents （TEQ） was consequently 620 ng E2/L （570 ng Te/L） and 580 ng E2/L （800 ng Te/L） for the two WWTPs. The removal efficiencies of the above mentioned sole target chemicals were 51%-100% for K-WWTP and 55.6%-100% for S-WWTP. The removal efficiencies of EEQ were about 73% for both WWTPs, while the removal efficiencies of TEQ were 62.1% for K-WWTP and 98.4% for S-WWTP. In addition, chemical-derived EEQ were about 1.2%-52.4% of those by ER-binding assay for K-WWTP and the corresponding ratios were 1.3%-83.3% for S-WWTP, while chemical derived TEQ were less than 3% of values measured by the AR-binding assay for both WWTPs.

关键词： bioassays ER-binding AR-binding 17β-estradiol equivalents testosterone equivalents

Ultrasonic measurements of single-crystal gold under hydrostatic pressures up to 8 GPa in a Kawai-type multi-anvil apparatus

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Chinese Science Bulletin 2007年第12期52卷 1600-1606页

作者： SONG MaoShuang Akira YONEDA Eiji ito Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China Institute for Study of the Earth Interior Okayama University Misasa Tottori-ken 683-0193 Japan

Ultrasonic measurements were conducted on single-crystal gold at ambient condition and hydrostatic pressures up to 8 GPa at room temperature in a Kawai-type multi-anvil apparatus. The P-wave velocities measured at high pressures were in good agreement with Daniels and Smith’s ultrasonic study. The three independent elastic constants of gold at ambient condition were determined to be C11=192.7 GPa, C12=162.9 GPa, and C44=42.4 GPa. On the basis of an analysis of previous elastic data and the present ultrasonic data, the pressure derivatives of three elastic constants were estimated to be C1 ′1= 7.12,C 1′2 = 6.24,and C4′4 = 1.82. The calculated values of isothermal bulk modulus (KT0) and its pressure derivatives ( KT ′0) are KT0 = 166.44 GPa and KT ′0= 6.56. This indicates that Anderson et al.’s model of equation of state of gold might underestimates pressure about 1 GPa at pressure around 23 GPa and ambient temperature. Our results explained the discrepancies among the models of equation of state of gold proposed previously.

关键词：单晶体黄金超声波测量高温高压实验流体静力学状态方程

Influence of collagen fibre orientation on the frictional properties of articular cartilage

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Biosurface and Biotribology 2021年第2期7卷 90-97页

作者： Seido Yarimitsu Kei ito Hiromichi Fujie Graduate School of Systems Design Tokyo Metropolitan UniversityHachiojiTokyoJapan

Articular cartilage has a unique collagen fibre network structure that exhibits both anisotropy and depth *** fibre orientation in a cross-section parallel to the articular cartilage surface may affect the lubrication properties of articular *** effect of collagen fibre orientation on the frictional properties of articular cartilage was examined through finite element analysis of the ***,a three-dimensional fibre-reinforced poroelastic biphasic model was used to determine the influence of collagen fibril orientation on the frictional properties of articular *** simulations reveal that collagen fibre orientation has a significant influence on the deformation behaviour of articular cartilage in front of and behind the contact *** coefficient of dynamic friction was lower in the direction parallel to the collagen fibre orientation than in the direction perpendicular to the collagen fibre orientation,regardless of the indenter speed.

关键词： friction fibre deformation

Challenging situation of coronary artery anomaly associated with ischemia and/or risk of sudden death

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World Journal of Cardiology 2024年第4期16卷 173-176页

作者： Shigenori ito Division of Cardiology Sankuro HospitalToyota 471-0035Japan

Coronary artery anomaly is known as one of the causes of angina pectoris and sudden death and is an important clinical entity that cannot be *** incidence of coronary artery anomalies is as low as 1%-2%of the general population,even when the various types are *** anomalies are practically challenging when the left and right coronary ostium are not found around their normal positions during coronary angiography with a *** there is atherosclerotic stenosis of the coronary artery with an anomaly and percutaneous coronary intervention(PCI)is required,the suitability of the guiding catheter at the entrance and the adequate back up force of the guiding catheter are *** level of PCI risk itself should also be considered on a caseby-case *** this case,emission computed tomography in the R-1 subtype single coronary artery proved that ischemia occurred in an area where the coronary artery was not visible to the naked *** follow-up would be crucial,because sudden death may occur in single coronary *** prevent atherosclerosis with full efforts is also important,as the authors indicated admirably.

关键词： Coronary artery anomaly Single coronary artery Ischemia Sudden death Percutaneous coronary intervention Coronary vessel anomalies Myocardial ischemia Sudden cardiac death

The Sensitivity Analysis for the Flow Past Obstacles Problem with Respect to the Reynolds Number

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Advances in Applied Mathematics and Mechanics 2012年第1期4卷 21-35页

作者： Kazufumi ito Zhilin Li Zhonghua Qiao Center for Research in Scientific Computation&Department of Mathematics North Carolina State UniversityRaleighNC 27695-8205USA School of Mathematical Sciences Nanjing Normal UniversityNo.1 Wenyuan RoadYadong New DistrictNanjing 210046China Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong

In this paper,numerical sensitivity analysis with respect to the Reynolds number for the flow past obstacle problem is *** carry out such analysis,at each time step,we need to solve the incompressible Navier-Stokes equations on irregular domains twice,one for the primary variables;the other is for the sensitivity variables with homogeneous boundary *** Navier-Stokes solver is the augmented immersed interface method for Navier-Stokes equations on irregular *** of the most important contribution of this paper is that our analysis can predict the critical Reynolds number at which the vortex shading begins to develop in the wake of the *** interesting experiments are shown to illustrate how the critical Reynolds number varies with different geometric settings.

关键词： Navier-Stokes equations sensitivity analysis flow past cylinder embedding technique immersed interface method irregular domain augmented system projection method fluid-solid interaction

Hypoxia-inducible factor 1 alpha and vascular endothelial growth factor overexpression in ischemic colitis

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World Journal of Gastroenterology 2005年第10期11卷 1535-1539页

作者： Tomoyuki Okuda Takeshi Azuma Masahiro Ohtani Ryuho Masaki Yoshiyuki ito Yukinao Yamazaki Shigeji ito Masaru Kuriyama Second Department of Internal Medicine Department of Endoscopic Medicine Department of Internal Medicine

AIM: To examine the etiology and pathophysiology in human ischemic colitis from the viewpoint of ischemic factors such as hypoxia-inducible factor 1 alpha (HIF-1 alpha and vascular endothelial growth factor (VEGF). METHODS: Thirteen patients with ischemic colitis and 21 normal controls underwent colonoscopy. The follow-up colonoscopy was performed in 8 patients at 7 to 10 d after the occurrence of ischemic colitis. Biopsy samples were subjected to real-time RT-PCR and immunohistochemistry to detect the expression of HIF-1 alpha and VEGF. RESULTS: HIF-1 alpha and VEGF expression were found in the normal colon tissues by RT-PCR and immunohistochemistry. HIF-1 alpha and VEGF were overexpressed in the lesions of ischemic colitis. Overexpressed HIF-1 alpha and VEGF RNA quickly decreased to the normal level in the scar regions at 7 to 10 d after the occurrence of ischemic colitis. CONCLUSION: Constant expression of HIF-1 alpha and VEGF in normal human colon tissue suggested that HIF-1 alpha and VEGF play an important role in maintaining tissue integrity. We confirmed the ischemic crisis in ischemic colitis at the molecular level, demonstrating overexpression of HIF-1 alpha and VEGF in ischemic lesions. These ischemic factors may play an important role in the pathophysiology of ischemic colitis.

关键词： Ischemic colitis HIF-1 alpha VEGF

Functional relationship between p53 and RUNX proteins

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Journal of Molecular Cell Biology 2019年第3期11卷 224-230页

作者： Suk-Chul Bae Arun Mouli Kolinjivadi Yoshiaki ito Department of Biochemistry School of Medicineand Institute for Tumour ResearchChungbuk National UniversityCheongju 28644South Korea Cancer Science Institute of Singapore National University of SingaporeSingapore 117599Singapore

RUNX genes belong to a three-membered family of transcription factors,which are well established as master regulators of *** them,aberrations in RUNX3 expression are frequently observed in human malignancies primarily due to epigenetic silencing,which is often *** the G1 phase of the cell cycle,RUNX3 regulates the restriction(R)-point,a mechanism that decides cell cycle *** at the R-point or loss of RUNX3 results in premature entry into S phase,leading to a proliferative *** of Runxl and Runx2 induce immortalization of mouse embryo *** a consequence,RUNX loss induces pre-cancerous lesions independent of oncogene activation.p53 is the most extensively studied tumour suppressor.p53 plays an important role to prevent tumour progression but not tumour ***,upon oncogene activation,early inactivation of RUNX genes and subsequent mutation of p53 appear to result in tumour initiation and ***,transcription-independent DNA repairing roles of RUNX3 and p53 are *** evolutionarily old genes,it appears that the primordial function of p53 is to protect genome integrity,a function that likely extends to the RUNX gene as *** this review,we examine the mechanism and sequence of actions of these tumour suppressors in detail.

关键词： RUNX tumour suppressor p53

Coupled simulation of BES-CFD and performance assessment of energy recovery ventilation system for office model

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Journal of Central South University 2012年第3期19卷 633-638页

作者： Yunqing FAN T.Hayashi K.ito Interdisciplinary Graduate School of Engineering Science(IGSES) Kyushu University

Thermal comfort and indoor air quality as well as the energy efficiency have been recognized as essential parts of sustainable building assessment. This work aims to analyze the energy conservation of the heat recovery ventilator and to investigate the effect of the air supply arrangement. Three types of mixing ventilation are chosen for the analysis of coupling ANSYS/FLUENT （a computational fluid dynamics （CFD） program） with TRNSYS （a building energy simulation （BES） software）. The adoption of mutual complementary boundary conditions for CFD and BES provides more accurate and complete information of indoor air distribution and thermal performance in buildings. A typical office-space situated in a middle storey is chosen for the analysis. The office-space is equipped with air-conditioners on the ceiling. A heat recovery ventilation system directly supplies flesh air to the office space. Its thermal performance and indoor air distribution predicted by the coupled method are compared under three types of ventilation system. When the supply and return openings for ventilation are arranged on the ceiling, there is no critical difference between the predictions of the coupled method and BES on the energy consumption of HVAC because PID control is adopted for the supply air temperature of the occupied zone. On the other hand, approximately 21% discrepancy for the heat recovery estimation in the maximum between the simulated results of coupled method and BES-only can be obviously found in the floor air supply ventilation case. The discrepancy emphasizes the necessity of coupling CFD with BES when vertical air temperature gradient exists. Our future target is to estimate the optimum design of heat recovery ventilation system to control CO2 concentration by adjusting flow rate of flesh air.

关键词： building energy simulation computational fluid dynamics (CFD) FLUENT TRNSYS energy saving

Guadalupian (Middle Permian) Radiolarian and Sponge Spicule Faunas from the Bancheng Formation of the Qinzhou Allochthon,South China

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Journal of Earth Science 2013年第2期24卷 145-156页

作者： ito Tsuyoshi 张磊冯庆来 Matsuoka Atsushi State Key Laboratory for Geological Processes and Mineral Resources China University of Geosciences Graduate School of Science and Technology Niigata University Department of Geology Faculty of ScienceNiigata University

The Gujingling （古井岭） Section in Xiaodong （小董）, Guangxi （广西） Zhuang Autonomous Region, China, consists of cherts and siliceous siltstones, which belongs to the Bancheng （板城）Formation of the Qinzhou （钦州） allochthon. Three successive radiolarian assemblage-zones related to the Guadalupian （Middle Permian） appear in the section in the following ascending order： Pseudoalbaillella sp. aff. Pseudoaibailleila longicornis-Pseudoalbaillella fusiformis, Follicucuilus monacanthus, and Follicucuilus scholasticus-Foilicucullus porrectus. The radiolarian content in this section is generally greater than that of sponge spicules. The radiolarian fauna commonly consists of abundant Albaillellaria and spherical radiolaria with minor Latentifistularia and Entactinaria. The sponge fauna is composed mainly of hexactinellids with minor demosponges. These siliceous fossil faunal features, comparable with those in a deep basin of the western belt of the Phosphoria Basin in the western United States, indicate that the Bancheng Formation in the Gujingling Section was deposited in a basin deeper than 1 000 m. The siliceous siltstones in the section are characterized by inclusion of silt-sized quartz and no inclusion of sand-sized materials, suggesting that the Gujingling Section was located at least a few hundred kilometers from the South China Block in the Guadalupian.

关键词： radiolarian fossil sponge spicule Guadalupian (Middle Permian) Bancheng Formation Qinzhou allochthon paleobathymerry.

A Blowdown Cryogenic Cavitation Tunnel and CFD Treatment for Flow Visualization around a Foil

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Journal of Thermal Science 2005年第4期14卷 346-351页

作者： Yutaka ito Kazuya SAWASAKI Naoki TANI Takao NAGASAKI Toshio NAGASHIMA Tokyo Institute of Technology G3-334259Nagatsuta-choMidori-kuYokohama226-8502Japan Honda Motor Co.Ltd. 2-1-1Minami-AoyamaMinato-kuTokyo107-8556Japan Japan Aerospace Exploration Agency 2-1-1SengenTsukuba305-8505Japan University of Tokyo 7-3-1HongoBunkyo-kuTokyo113-8656Japan

Cavitation is one of the major problems in the development of rocket engines. There have been few experimental studies to visualize cryogenic foil cavitation. Therefore a new cryogenic cavitation tunnel of blowdown type was built. The foil shape is “piano-convex”. This profile was chosen because of simplicity, but also of being similar to the one for a rocket inducer impeller. Working fluids were water at room temperature, hot water and liquid nitrogen. In case of Angle of Attack （AOA）=8°, periodical cavity departure was observed in the experiments of both water at 90℃ and nitrogen at -190℃ under the same velocity 10 m/sec and the same cavitation number 0.7. The frequencies were observed to be 110 and 90 Hz, respectively, and almost coincided with those of vortex shedding from the foil. Temperature depression due to the thermodynamic effect was confirmed in both experiment and simulation especially in the cryogenic cavitation.

关键词： cavitation tunnel cryogen CFD visualization simulation foil.