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Severe cyclophosphamide-related hyponatremia in a patient with acute glomerulonephritis

World Journal of Nephrology 2017年第4期6卷 217-220页

作者： Pasquale Esposito Maria Valentina Domenech Nicoletta Serpieri Marta Calatroni Ilaria Massa Alessandro Avella edoardo la porta Luca Estienne Elena Caramella Teresa Rampino Department of Nephrology Dialysis and TransplantationFondazione IRCCS Policlinico "San Matteo" and University of Pavia

Cyclophosphamide is frequently used to treat cancer,autoimmune and renal diseases,such as rapidly progressive *** side effects are well-known,including bone marrow depression,infections,alopecia,sterility,bladder malignancy and hemorrhagic ***,in some cases cyclophosphamide use has been related to the onset of hyponatremia,by development of a syndrome of inappropriate ***,severe hyponatremia has been previously reported in patients treated with high-dose or moderate-dose of intravenous cyclophosphamide,while only few cases have been reported in patients treated with low ***,we discuss a case of a syndrome of inappropriate antidiuresis followed to a single low-dose of intravenous cyclophosphamide in a patient with a histological diagnosis of acute glomerulonephritis,presenting as acute kidney *** cyclophosphamide administration(500 mg IV),while renal function gradually improved,the patient developed confusion and *** examinations showed serum sodium concentration dropped to 122 mmol per liter associated with an elevated urinary osmolality of 199 mO sm/kg,while common causes of acute hyponatremia were *** was successfully treated with water restriction and hypertonic saline solution infusion with the resolution of the electrolyte *** case,together with the previous ones already reported,highlights that electrolyte profile should be strictly monitored in patients undergoing cyclophosphamide therapy in order to early recognize the potentially lifethreatening complications of acute water retention.

关键词：环磷酰胺癌症治疗方法临床分析

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