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Addressing the Role of microRNAs in Reprogramming Leaf Growth during Drought Stress in Brachypodium distachyon

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Molecular Plant 2013年第2期6卷 423-443页

作者： edoardo Bertolini Wim Verelst David Stephen Horner Luca Gianfranceschi Viviana Piccolo Dirk Iné Mario Enrico Pè Erica Mica Institute of Life Sciences Scuola Superiore Sant'Anna Piazza Martiri della Libertà 33 56127 Pisa Italy Department of Plant Biotechnology and Bioinformatics Ghent University Technologiepark 927 9052 Ghent Belgium Department of Plant Systems Biology VIB Technologiepark 927 9052 Gtlent. Belgium Department of BioSciences University of Milan via Celoria 26 20133 Milan Italy

Plant responses to drought are regulated by complex genetic and epigenetic networks leading to rapid reprogramming of plant growth, miRNAs have been widely indicated as key players in the regulation of growth and development. The role of miRNAs in drought response was investigated in young leaves of Brachypodium dis- tachyon, a drought-tolerant monocot model species. Adopting an in vivo drought assay, shown to cause a dramatic reduction in leaf size, mostly due to reduced cell expansion, small RNA libraries were produced from proliferating and expanding leaf cells. Next-generation sequencing data were analyzed using an in-house bioinformatics pipeline allowing the identification of 66 annotated miRNA genes and 122 new high confidence predictions greatly expand- ing the number of known Brachypodium miRNAs. In addition, we identified four TAS3 loci and a large number of siRNA-producing loci that show characteristics suggesting that they may represent young miRNA genes. Most miR- NAs showed a high expression level, consistent with their involvement in early leaf development and cell identity. Proliferating and expanding leaf cells respond differently to drought treatment and differential expression analyses suggest novel evidence for an miRNA regulatory network controlling cell division in both normal and stressed condi-tions and demonstrate that drought trigger a genetic reprogramming of leaf growth in which miRNAs are deeply involved.

关键词： miRNAs drought Brachypodium leaf development.

Alginate controls heartburn in patients with erosive and nonerosive reflux disease

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World Journal of Gastroenterology 2012年第32期18卷 4371-4378页

作者： edoardo Savarino Nicola de Bortoli Patrizia Zentilin Irene Martinucci Luca Bruzzone Manuele Furnari Santino Marchi Vincenzo Savarino Division of Gastroenterology Department of Internal MedicineUniversity of Genoa16126 GenoaItaly Division of Gastroenterology Department of SurgicalOncological and Gastroenterological SciencesUniversity of Padua35128 PaduaItaly Division of Gastroenterology Department of Internal MedicineUniversity of Pisa56100 PisaItaly

AIM:To evaluate the effect of a novel alginate-based compound,Faringel,in modifying reflux characteristics and controlling ***:In this prospective,open-label study,40 patients reporting heartburn and regurgitation with proven reflux disease(i.e.,positive impedance-pH test/evidence of erosive esophagitis at upper endoscopy) underwent 2 h impedance-pH testing after eating a refluxogenic *** were studied for 1 h under basal conditions and 1 h after taking 10 mL *** both sessions,measurements were obtained in right lateral and supine decubitus *** also completed a validated questionnaire consisting of a 2-item 5-point(0-4) Likert scale and a 10-cm visual analogue scale(VAS) in order to evaluate the efficacy of Faringel in symptom *** of the treatment was assessed using a 6-point Likert scale ranging from very good(1) to very poor(6).RESULTS:Faringel decreased significantly(P < 0.001),in both the right lateral and supine decubitus positions,esophageal acid exposure time [median 10(25th75th percentil 6-16) vs 5.8(4-10) and 16(11-19) vs 7.5(5-11),respectively] and acid refluxes [5(3-8) vs 1(1-1) and 6(4-8) vs 2(1-2),respectively],but increased significantly(P < 0.01) the number of nonacid reflux events compared with baseline [2(1-3)vs 3(2-5) and 3(2-4) vs 6(3-8),respectively].Percentage of proximal migration decreased in both decubitus positions(60% vs 32% and 64% vs 35%,respectively;P < 0.001).Faringel was significantly effective in controlling heartburn,based on both the Likert scale [3.1(range 1-4) vs 0.9(0-2);P < 0.001] and VAS score [7.1(3-9.8) vs 2(0.1-4.8);P < 0.001],but it had less success against regurgitation,based on both the Likert scale [2.6(1-4) vs 2.2(1-4);P = not significant(NS)] and VAS score [5.6(2-9.6) vs 3.9(1-8.8);P = NS].Overall,the tolerability of Faringel was very good 5(2-6),with only two patients reporting modest adverse events(i.e.,nausea and bloating).CONCLUSION:Our findings demonstrate t

关键词： Impedance pH-metry Nonerosive reflux disease Erosive esophagitis Nonacid reflux Proximal reflux

Exposing vocabularies for soil as Linked Open Data

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Information Processing in Agriculture 2015年第3期2卷 208-216页

作者： Giovanni L’Abate Caterina Caracciolo Valeria Pesce Guntram Geser Vassilis Protonotarios edoardo A.C.Costantini Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria(CREA) Agrobiology and Pedology Research CentreFirenzeItaly Global Forum on Agricultural Research RomeItaly Food and Agriculture Organization of the United Nations RomeItaly University of Alcala Alcala de HenaresSpain Salzburg Research SalzburgAustria

Standards to describe soil properties are well established,with many ISO specifications and a few international thesauri available for specific ***,in recent years,the European directive on "Infrastructure for Spatial Information in the European Community(INSPIRE)"has brought together most of the existing standards into a well defined ***,the adoption of these standards so far has not reached the level of semantic interoperability,defined in the paper,which would facilitate the building of data services that reuse and combine data from different *** paper reviews standards for describing soil data and reports on the work done within the EC funded agINFRA project to apply Linked Data technologies to existing standards and data in order to improve the interoperability of soil *** main result of this work is ***,an RDF vocabulary for soil concepts based on the UML INSPIRE model was ***,a KOS(Knowledge Organization System)for soil data was published and mapped to existing relevant KOS,based on the analysis of the SISI database of the CREA of *** work also has a methodological value,in that it proposes and applies a methodology to standardize metadata used in local scientific databases,a very common situation in the scientific ***,this work aims at contributing towards a wider adoption of the INSPIRE directive,by providing an RDF version of it.

关键词： Agriculture Soil Knowledge Organization Systems Vocabularies Resource Description Framework Linked Open Data INSPIRE

基于辅助粒子滤波的汽车轮胎参数和行驶状态估计

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农业机械学报 2015年第4期46卷 282-288,301页

作者：包瑞新 edoardo Sabbioni 于会龙张涛辽宁石油化工大学机械工程学院抚顺113001 米兰理工大学机械工程学院米兰20156

单独的轮胎魔术公式参数通常需要通过昂贵的试验设备和大量的试验数据才能够确定,之后这些参数在设计阶段将被应用于车辆模型来模拟车辆的操纵动力学行为。建立了包含定常统计特性噪声的汽车动力学模型,利用龙格-库塔方法模拟模型,引入... 详细信息

单独的轮胎魔术公式参数通常需要通过昂贵的试验设备和大量的试验数据才能够确定,之后这些参数在设计阶段将被应用于车辆模型来模拟车辆的操纵动力学行为。建立了包含定常统计特性噪声的汽车动力学模型,利用龙格-库塔方法模拟模型,引入辅助粒子滤波技术,通过二次加权操作,较好地实现了轮胎参数的估计,并最终代入动力学方程,实现了车辆侧向力等参数的估计。同时进行了场地试验。结果表明,辅助粒子滤波技术改善了标准粒子滤波算法的精度,验证了算法的有效性。

关键词：车辆动力学模型魔术公式辅助粒子滤波龙格-库塔方法

Clinical correlates of enlarged prostate size in subjects with sexual dysfunction

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Asian Journal of Andrology 2014年第5期16卷 767-773,I0011页

作者： Giovanni Corona Mauro Gacci Elisa Maseroli Giulia Rastrelli Linda Vignozzi Alessandra Sforza Gianni Forti edoardo Mannucci Mario Maggi Endocrinology Unit Maggiore-Bellaria Hospital Medical Department Azienda-Usl Bologna Bologna Italy Department of Urology Sexual Medicine and Andrology Unit Department of Clinical Physiopathology Endocrinology Unit Department of Clinical Physiopathology University of Florence Florence Italy Diabetes Agency Careggi Hospital Florence Italy

Digito-rectal examination （DRE） of the prostate provides useful information on the state of prostate growth and on the presence of suspected peripheral nodules. The aim of this study is to describe the clinical and biochemical correlates of finding an enlarged prostate size at DRE in subjects with sexual dysfunction （SD）. A consecutive series of 2379 patients was retrospectively studied. The analysis was focused on a subset of subjects （n = 1823; mean age 54.7± 11.4） selected for being free from overt prostatic diseases. Several parameters were investigated. After adjusting for confounders, the presence of an enlarged prostate size at DRE was associated with a higher risk of metabolic syndrome （HR = 1.346 （1,129-1.759）; P = 0.030）, type 2 diabetes mellitus （HR = 1.489 （1.120-1.980）; P = 0.006）, increased LDL cholesterol （〉100mgdl^-1; HR = 1.354 （1.018-1.801）; P = 0.037） and increased mean blood pressure （BP） values （HR = 1.017 （1.007-1.027） for each mmHg increment; P = 0.001）. Accordingly, enlarged prostate size was also associated with a higher risk of arteriogenic erectile dysfunction （ED）, as well as with other andrological conditions, such as varicocele and premature ejaculation （PE）. PSA levels were significantly higher in subjects with enlarged prostate size when compared to the rest of the sample （HR = 3.318 （2.304; 4.799） for each log unit increment in PSA levels; P 〈 0.0001）. Arteriogenic ED, according to different criteria, was also associated with increased PSA levels. In conclusion, our data support the need to examine prostate size either by clinical （DRE） or biochemical （PSA） inspection in subjects with SD, in order to have insights into the nature of the SD and the metabolic and cardiovascular （CV） background of the patient.

关键词： benign prostatic hyperplasia metabolic syndrome enlarged prostate size testosterone

Lumen-apposing metal stents for malignant biliary obstruction: Is this the ultimate horizon of our experience?

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World Journal of Gastroenterology 2019年第29期25卷 3857-3869页

作者： Andrea Anderloni edoardo Troncone Alessandro Fugazza Annalisa Cappello Giovanna Del Vecchio Blanco Giovanni Monteleone Alessandro Repici Digestive Endoscopy Unit Division of Gastroenterology Humanitas Research Hospital Milan 20089 Italy Department of Systems Medicine University of Rome “Tor Vergata” Rome 00133 Italy Digestive Endoscopy Unit Division of Gastroenterology Humanitas University Milan 20089 Italy

In the last years, endoscopic ultrasonography (EUS) has evolved from a purely diagnostic technique to a more and more complex interventional procedure, with the possibility to perform several type of therapeutic interventions. Among these, EUS-guided biliary drainage (BD) is gaining popularity as a therapeutic approach after failed endoscopic retrograde cholangiopancreatography in distal malignant biliary obstruction (MBO), due to the avoidance of external drainage, a lower rate of adverse events and re-interventions, and lower costs compared to percutaneous trans-hepatic BD. Initially, devices created for luminal procedures (e.g., luminal biliary stents) have been adapted to the new trans-luminal EUSguided interventions, with predictable shortcomings in technical success, outcome and adverse events. More recently, new metal stents specifically designed for transluminal drainage, namely lumen-apposing metal stents (LAMS), have been made available for EUS-guided procedures. An electrocautery enhanced delivery system (EC-LAMS), which allows direct access of the delivery system to the target lumen, has subsequently simplified the classic multi-step procedure of EUS-guided drainages. EUS-BD using LAMS and ECLAMS has been demonstrated effective and safe, and currently seems one of the most performing techniques for EUS-BD. In this Review, we summarize the evolution of the EUS-BD in distal MBO, focusing on the novelty of LAMS and analyzing the unresolved questions about the possible role of EUS as the first therapeutic option to achieve BD in this setting of patients.

关键词： Interventional endoscopic ultrasonography Endoscopic ultrasonography-guided biliary drainage Endoscopic ultrasonography-guided choledocho-duodenostomy Biliary metal stent Lumen-apposing metal stent

Detection of a possible superluminous supernova in the Epoch of Reionization

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Science Bulletin 2017年第10期62卷 675-678页

作者： Jeremy Mould Tim Abbott Jeff Cooke Chris Curtin Antonios Katsianis Anton Koekemoer edoardo Tescari Syed Uddin Lifan Wang Stuart Wyithe Centre for Astrophysical & Supercomputing Swinburne University Hawthorn 3122 Australia Cerro Tololo lnteramerican Observatory NOAO La Serena Chile Space Telescope Science Institute Baltimore MD 21218 USA Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China Texas A&M University College Station 7X 77843 USA University of Melbourne School of Physics Melbourne 3010 Australia Departamento de Astronornia Universidad de Chile Los Condes Santiago. Chile

The Epoch of Reionization(EoR)poses a number of puzzles,including the sufficiency of ionizing radiation,the rapid production of supermassive black holes and the early appearance of abundant metals in larger *** the first of these,solutions focus on the main sequence evolution of massive stars,but the second and third puzzles involve the terminal phase of stellar evolution,

关键词：超新星再电离大质量恒星检测光度恒星演化电离辐射 EOR

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把哲学引入公共行政:一项研究议程

公共行政评论 2020年第4期13卷 58-68,206页

作者： [英]edoardo Ongaro 丁淑娟(译) 英国开放大学欧洲公共行政联合会 Public Policy and Administration期刊东莞理工学院法律与社会工作学院(知识产权学院)

一、引言与逻辑基础本文的核心观点是哲学知识对深入理解公共治理、公共行政体制和公共服务管理重要议题具有积极显著的贡献。将哲学知识引入公共行政(这并非意味从"象牙塔"退却)具有重大现实意义。本文旨在系统地勾勒和评述将哲学思想... 详细信息

一、引言与逻辑基础本文的核心观点是哲学知识对深入理解公共治理、公共行政体制和公共服务管理重要议题具有积极显著的贡献。将哲学知识引入公共行政(这并非意味从"象牙塔"退却)具有重大现实意义。本文旨在系统地勾勒和评述将哲学思想引入公共行政领域的研究轮廓和进展,并介绍四种相互补充的研究途径。为论证将哲学思想引入公共行政的重要性,我们以公共治理安排的"合法性"为例。

关键词：公共行政公共治理公共服务管理哲学知识研究议程哲学思想核心观点逻辑基础

A NIGHT AT THE OPERA Your Quintessential Guide to Xiqu

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城市漫步（上海版、英文） 2019年第6期 36-45页

作者： edoardo Donati Fogliazza 不详

It's no overstatement that xiqu,the general term for Chinese drama,is the pride and joy of Chinese *** back centuries,the imperial art form has been adapted and reimagined time and time again,with various styles birth... 详细信息

关键词： process. has Your