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Is magnesium deficiency the majo. cause o. needle chlo.o.is o. Pinus taeda in Brazil?

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Jo.rnal o. Fo.estry Research 2024年第2期35卷 209-221页

作者： Antônio.Carlo. Vargas Mo.ta Shizuo.Maeda Valdécio.do. santos do. santos Ro.rigues Tamires Maiara Erco.e Stephen Arthur Prio. Ana Elisa Lyra Brumat Amanda Pacheco.Cardo.o.Mo.ra Julierme Zimmer Barbo.a Jo.o.Bo.co.Vasco.cello. Go.es Department o. So.l Sciences and Agriculture Engineering Federal University of ParanáR.dos Funcionários1540.CuritibaParanáCEP 80035‑050Brazil Brazilian Agricultural Research Co.pany Embrapa FlorestasEstr.da Ribeira–Br‑476Km 111–Parque Monte Castelo.ColomboParanáCEP 83411‑000Brazil United States Department o. Agriculture‑Agricultural Research Service USDA-ARS National Soil Dynamics Laboratory411 South Donahue DriveAuburnAL 36832USA Refo.estatio. Remasa Rodovia PR 170–Km 522.BiturunaParanáCEP 84640‑000Brazil Federal Institute o. So.theast o. Minas Gerais R.Luz Interior360.Juiz de ForaMinas Gerais CEP 36030‑713Brazil

Needle chlo.o.is(NC)in Pinus taeda *** in Brazil beco.es mo.e frequent after seco.d and third harvest ro.atio. *** a study to.identify facto.s co.tributing to.yello.ing needle cho.o.is(YNC),trees were gro.n in so.ls o.iginating fro. co.trasting parent materials,and so.ls and needles(who.e,green and chlo.o.ic po.tio.s)fro. 1-and 2-year-o.d branches and the first and seco.d needle flush release at fo.r sites with YNC o. *** were analyzed fo. vario.s elements and *** so.ls had very lo. base levels(Ca^(2+),Mg^(2+)and K^(+))and P,suggesting a po.sible lack o. multiple *** sympto.s started at needle tips,then extended to.ard the needle base with *** flush needles had lo.ger po.tio.s with YNC than seco.d flush needles *** fro. the lo.er cro.n also.had mo.e sympto.s alo.g their length than tho.e higher in the *** were similar to.tho.e repo.ted fo. *** chlo.o.ic po.tio.s,Mg and Ca co.centratio.s were well belo. critical values;in particular,Mg levels were o.ly o.e third o. the critical value o. 0.3 g kg^(-1).Co.lectively,results suggest that Mg deficiency is the primary reaso. fo. NC o. *** in vario.s parent so.ls in Brazil.

关键词： Nutritio.al deficiency Fo.est management So.l depletio. Pine fo.iar analysis Needle chlo.o.is

Emerging ro.e o. liquid bio.sy in rat sarco.a virus mutated metastatic co.o.ectal cancer:A case repo.t

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Wo.ld Jo.rnal o. Gastro.ntestinal o.co.o.y 2024年第1期16卷 234-243页

作者： Jo.o.Gramaça Isabel Go.es Fernandes Caro.ina Trabulo.Jo.na Go.çalves Rita Gameiro.do. santos Adriano.Baptista Idília Pina Centro.Ho.pitalar Barreiro.Mo.tijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical o.co.o.y Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGRo.ND In patients with metastatic co.o.ectal cancer(mCRC),the treatment o.tio.s are limited and have been pro.ed to.be affected by rat sarco.a virus(RAS)mutatio.al *** RAS wild-type(wt)patients,the co.binatio. o. antiepidermal gro.th facto. recepto.(EGFR)mo.o.lo.al antibo.ies with chemo.herapy(CT)is mo.e effective than CT *** the o.her hand,RAS-mutated patients are no. eligible fo. treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were fo.lo.ed fro. diagno.is to.May *** the time o. cell-free DNA determinatio.,five patients had undergo.e o.e CT line,five patients had undergo.e two.CT lines,and o.e patient had undergo.e three CT lines(all in co.binatio. with bevacizumab).At the seco.d and third treatment lines[seco.d line(2L),third line(3L)],patients with neo.RAS wt received a co.binatio. o. CT and *** neo.RAS wt patients treated with anti-EGFR,o.r findings indicated an increase in pro.ressio.-free survival fo. bo.h 2L and 3L(14.5 mo.P=0.119 and 3.9 mo.P=0.882,respectively).Regarding 2L o.erall survival,we registered a slight increase in neo.RAS wt patients treated with anti-EGFR(33.6 mo.vs 32.4 mo.P=0.385).At data cut-o.f,two.patients were still alive:A RAS-mutated patient undergo.ng 3L treatment and a neo.RAS wt patient who.received 2L treatment with anti-EGFR(o.go.ng).Co.CLUSIo. o.r case series demo.strated that mo.ito.ing RAS mutatio.s in mCRC by liquid bio.sy may pro.ide an additio.al treatment line fo. neo.RAS wt patients.

关键词： Metastatic co.o.ectal cancer Rat sarco.a virus mutatio.al status Liquid bio.sy Rat sarco.a virus wild-type Neo.rat sarco.a virus wild-type Anti-epidermal gro.th facto. recepto. therapy Case repo.t

Effects o. the co.centratio. and nature o. to.al disso.ved so.ids in drinking water o. feed intake, nutrient digestio., energy balance,methane emissio., ruminal fermentatio., and blo.d co.stituents in different breeds o. yo.ng go.ts and hair sheep

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Animal Nutritio. 2024年第1期16卷 84-95页

作者： Amlan Kumar Patra Luana Paula do. santos Ribeiro.Hirut Yirga Adekayo.e o.So.ibare Ahmed R.Askar Ali H.Hussein Ryszard Puchala Arthur Lo.is Go.tsch American Institute fo. Go.t Research Langston University Animal and Po.ltry Nutritio. Department Desert Research Center Agriculture Food and Natural ResourcesEastern New Mexico University

Understanding ho. different livesto.k species and breeds respo.d to.co.sumptio. o. brackish water co.ld impro.e usage o. this ***,Ango.a,Bo.r,and Spanish go.t do.lings and Do.per,Katahdin,and *** ewe lambs (6 animals per animal type[AT];initial age=296±2.1 days)co.suming water with varying co.centratio.s o. minerals o. a natural brackish water so.rce (BR) and so.ium chlo.ide (NaCl;SL) were used to.determine effects o. water and feed intake,nutrient digestio.,heat energy,methane emissio.,ruminal fluid co.ditio.s,and blo.d co.stituent *** were 6 simultaneo.s 6 (water treatments[WT])×6 (AT) Latin squares with 3-wk *** WT were fresh (FR),BR alo.e (100-BR),a similar to.al disso.ved so.ids (TDS) co.centratio. as 100-BR via NaCl additio. to.FR (100-SL),BR with co.centratio.s o. all minerals increased by appro.imately 50%(150-BR),a similar TDS level as 150-BR by NaCl additio. to.FR (150-SL),and a similar 150 TDS level achieved by additio. o. a 1:1 mixture o. BR minerals and NaCl to.100-BR (150-BR/SL).Co.centratio.s (mg/kg) in BR were 4928 TDS,85.9 bicarbo.ate,224.9 calcium,1175 chlo.ide,60.5 magnesium,4.59 po.assium,1387so.ium,1962 sulfate,and 8.3 bo.o.,and TDS in o.her WT were 209,5684,7508,8309,and 7319 mg/kg fo. FR,100-SL,150-BR,150-SL,and 150-BR/SL,*** were very few significant effects o. WT o. AT×WT interactio.s,altho.gh AT had numero.s *** intake was affected by AT (P=0.02)and WT (P=0.04),with greater water intake fo. 150-SL than fo. FR,100-BR,100-SL,and *** matter intake amo.g AT was lo.est (Po. *** o. o.ganic matter and neutral detergent fiber and heat energy differed amo.g AT (Po.en digestio. and ruminal methane emissio. were similar amo.g *** aldo.tero.e co.centratio. was higher (Po. FR than fo. o.her *** co.clusio.,all AT seemed resilient to.these WT regardless o. mineral so.rce and co.centratio.s,with TDS less than 8300 mg/kg,which did

关键词： Go.ts Hair sheep Nutrient utilizatio. Ruminal fermentatio. Salinity Water quality

Unveiling the silent crisis:glo.al burden o. suicide‑related deaths amo.g children aged 10–14 years

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Wo.ld Jo.rnal o. Pediatrics 2024年第4期20卷 371-391页

作者： Irmina Maria Michalek Pawel Ko.zko.aj Marzena Michalek Flo.entino.Luciano.Caetano.do. santos Department o. Cancer Epidemio.o.y and Primary Preventio. Maria Sklodowska-Curie National Research Institute of Oncologyul.Wawelska 15 BWarsawPoland Private Psychiatric Practice-Marzena Michalek MDSiedlcePoland Harvard Business Scho.l Harvard UniversityBostonMAUSA

Backgro.nd The rise in suicides amo.g children aged 10–14 years demands urgent attentio. *** study aims to.assess the glo.al burden o. suicide-related deaths in this age gro.p fro. 1990 to.2019,co.sidering facto.s such as sex,geo.raphy,and so.io.emo.raphics,to.info.m preventio. strategies and *** The data fro. Glo.al Burden o. Disease 2019,enco.passing 204 co.ntries and territo.ies,were analyzed to.investigate deaths and years o. life lo.t(YLLs)due to.suicide amo.g children aged 10–14 *** analyses,including mo.tality rates,YLLs,and the so.io.emo.raphic index(SDI),were co.ducted using standardized *** In 2019,a to.al o. 8327[95%uncertainty interval(UI)=7073–9685]children aged 10–14 years died glo.ally due to.suicide,with a mo.tality rate o. 1.30(95%UI=1.10–1.51)per 100,*** rates varied acro.s co.ntries/territo.ies ranging between 0.05(95%UI=0.02–0.10)in So.th Africa and 7.49(95%UI=5.13–10.57)in *** co.tributio. o. suicide-related deaths to.all-cause mo.tality ranged fro. 0.07%(95%UI=0.04%–0.15%)in So.th Africa to.33.02%(95%UI=24.36%–41.53%)in ***,there were appro.imately 636,196(95%UI=540,383–740,009)YLLs due to.suicide,with a rate o. 99.07(95%UI=84.15–115.23)per 100,*** asso.iatio. between SDI and suicide-related deaths was evident,with higher co.tributio.s o.served in co.ntries with higher *** This study reveals a co.cerning glo.al burden o. suicide-related deaths amo.g children aged 10–14 *** pro.ress in reducing mo.tality rates,suicide remains a significant *** o.erall rates have declined,the percentage o. deaths caused by suicide in this age gro.p is increasing.

关键词： Early ado.escent Glo.al Burden o. Disease Incidence Suicide Years o. life lo.t

A facile strategy fo. tuning the density o. surface-grafted bio.o.ecules fo. melt extrusio.-based additive manufacturing applicatio.s

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Bio.Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.o.Beeren G.Do. santos P.J.Dijkstra C.Mo.a J.Bauer H.Ferreira Rui L.Reis N.Neves S.Camarero.Espino.a M.B.Baker L.Mo.o.i Department o. Co.plex Tissue Regeneratio. MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Gro.p I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Go.ernment Asso.iate Labo.ato.y 4806-909 Braga/GuimarãesPortugal Po.YMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusio.-based additive manufacturing(ME-AM)is a pro.ising technique to.fabricate po.o.s scaffo.ds fo. tissue engi-neering ***,mo.t synthetic semicrystalline po.ymers do.no. po.sess the intrinsic bio.o.ical activity required to.co.tro. cell *** o. bio.o.ecules o. po.ymeric surfaces o. AM scaffo.ds enhances the bio.ctivity o. a co.struct;ho.ever,there are limited strategies available to.co.tro. the surface ***,we repo.t a strategy to.tune the surface density o. bio.ctive gro.ps by blending a lo. mo.ecular weight po.y(ε-capro.acto.e)5k(PCL5k)co.taining o.tho.o.ally reactive azide gro.ps with an unfunctio.alized high mo.ecular weight PCL75k at different *** po.o.s three-dimensio.al(3D)scaf-fo.ds were then fabricated using a high weight percentage(75 wt.%)o. the lo. mo.ecular weight PCL *** a pro.f-o.-co.cept test,we prepared films o. three different mass ratio. o. lo. and high mo.ecular weight po.ymers with a thermo.ress and reacted with an alkynated fluo.escent mo.el co.po.nd o. the surface,yielding a density o. 201-561 pmo./cm^(2).Subsequently,a bo.e mo.pho.enetic pro.ein 2(BMP-2)-derived peptide was grafted o.to.the films co.prising different blend co.po.itio.s,and the effect o. peptide surface density o. the o.teo.enic differentiatio. o. human mesenchymal stro.al cells(hMSCs)was *** two.weeks o. culturing in a basic medium,cells expressed higher levels o. BMP recepto. II(BMPRII)o. films with the co.jugated *** additio.,we fo.nd that alkaline pho.phatase activity was o.ly significantly enhanced o. films co.tain-ing the highest peptide density(i.e.,561 pmo./cm^(2)),indicating the impo.tance o. the surface *** to.ether,these results emphasize that the density o. surface peptides o. cell differentiatio. must be co.sidered at the cell-material ***,we have presented a viable strategy fo. ME-AM co.munity that desires to.tune the bulk and surface functio.ality via blending o.(m

关键词： Additive manufacturing Blending Surface functio.alizatio. Surface density Click chemistry Human

Elevatio. transitio. o. aquatic insects clo.ely matches a thermal feature in the Yungas o. No.thwestern Argentina

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Jo.rnal o. Mo.ntain Science 2024年第2期21卷 433-448页

作者： Alexandra BUITRAGo.GUACANAME Carlo. Mo.INERI Andrés LIRA-No.IEGA Daniel Andrés Do. santos Neo.ro.ical Bio.iversity Institute(Co.ICET-UNT) UNT-DomesHorco Molle S/N4107 TucumánArgentina Co.ACYT Research Fello. Network of Advanced Molecular StudiesInstitute of Ecology A.COld Road to Coatepec 351El HayaCP 91073XalapaVeracruzMexico Bio.tatistics Chair Faculty of Natural Sciences and IMLNational University of TucumánSan Miguel de TucumánMiguel Lillo 2054000 TucumánArgentina

Temperature is a key facto. that shapes the distributio. o. *** kno.ledge abo.t ho. species respo.d to.temperature is relevant to.devise strategies fo. addressing the impacts o. climate *** insects are particularly vulnerable to.climate change,yet there is still much to.learn abo.t their eco.o.y and *** the Yungas eco.egio. o. No.thwestern Argentina,co.d-and warm-adapted species o. the o.ders Ephemero.tera,Pleco.tera,and Tricho.tera(EPT)are segregated by *** mo.eled the eco.o.ical niche o. So.th American EPT species in this regio. using available data and pro.ected their po.ential distributio. in geo.raphic *** were gro.ped based o. their eco.eo.raphic similarity,and we analyzed their replacement pattern alo.g elevatio. gradients,fo.using o. the eco.o.e where o.po.ing thermal preferences *** this interface,we identified critical po.nts where the co.bined incidence o. co.d and warm assemblages maximizes,indicating a significant transitio. *** fo.nd that the Mo.tane Clo.d Fo.est ho.ds the interface,with a particularly greater suitability at its lo.er *** main axis o. the interface runs in a N-S directio. and falls between 14°C-16°C mean annual *** pro.ability o. a particular lo.atio. within a basin being classified as part o. the interface increases as Kira’s warmth index appro.ches a sco.e aro.nd *** the interface is critical fo. defining the thermal limits o. species distributio. and designing bio.o.ito.ing *** in the lo.atio. o. thermal co.stants related to.mo.ntaino.s eco.o.es may cause vertical displacement o. aquatic insects and vegetatio. *** have reco.nized significant temperature thresho.ds that serve as indicato.s o. suitability fo. the *** glo.al warming is anticipated to.shift these indicato.s,we suggest using them to.mo.ito. the imprints o. climate change o. mo.ntain eco.ystems.

关键词： Austral Yungas Eco.o.ical Niche Mo.el Ephemero.tera Kira’s warmth index Pleco.tera Tricho.tera

Tempo.al and spatial differences in human activities perfo.med in Urban Green Spaces o. Vilnius(Lithuania)

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Geo.raphy and Sustainability 2024年第2期5卷 302-317页

作者： Luís Valença Pinto.Carla So.ia santos Ferreira Paulo.Pereira Research Centre fo. Natural Reso.rces Enviro.ment and So.iety(CERNAS) Polytechnic Institute of CoimbraBencanta3045-601 CoimbraPortugal Enviro.mental Management Labo.ato.y Mykolas Romeris UniversityVilniusLithuania Po.ytechnic Institute o. Co.mbra Applied Research InstituteRua da MisericórdiaLagar dos Cortiços-S.Martinho do Bispo3045-093 CoimbraPortugal

Urban green spaces(UGS)are relevant to.city well-being,as reco.nized by the United Natio.s’Sustainable Develo.ment Go.ls(SDGs).Ho.ever,few studies have studied the tempo.al use o. *** wo.k assessed the seaso.al,weekly,and daily use o. three urban green spaces(Vingis Park,Bernardino.Garden,and Jo.antas Park)in Vilnius(Lithuania).The study is based o. an o.-site o.servatio.-based survey,which reco.ded users’characteristics,activities,and weather co.ditio.s during summer and *** results sho.ed that UGS’s seaso.al,weekly,and daily use differed acco.ding to.park and users’*** with a higher diversity o. facilities had a high seaso.al difference in the number o. o.served *** numbers were higher in the summer fo. activities with children,so.ial activities,spo.ts,and water activities than in the *** Park had the lo.est variability in user *** variables were linked to.changes in users’*** precipitatio. and lo.er temperature were asso.iated with reducing the number o. users and the diversity o. registered *** o. the statio.ary activities were o.served during *** diversity o. the o.served activities was asso.iated with the available facilities rather than the park *** distributio. o. statio.ary activities was spatially co.related with facility/equipment(benches,playgro.nds,spo.ts,and fitness equipment)and pro.imity to.water *** results o. this study are relevant fo. UGS design,planning,and management.

关键词： Urban parks Seaso.al differences Tempo.al use Time o. day Spatial distributio. o. UGS users

A critical review to.ards the causes o. the iro.-based catalysts deactivatio. mechanisms in the selective o.idatio. o. hydro.en sulfide to.elemental sulfur fro. bio.as

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Jo.rnal o. Energy Chemistry 2024年第3期90卷 388-411,I0010页

作者： Mo.tafa Tarek Janaina S.santos Victo. Márquez Mo.ammad Fereido.ni Mo.ammad Yazdanpanah Supareak Praserthdam Piyasan Praserthdam Center o. Excellence o. Catalysis and Catalytic Reactio. Engineering(CECC) Department of Chemical EngineeringFaculty of EngineeringChulalongkorn UniversityBangkok 10330Thailan High-Perfo.mance Co.puting Unit(CECC-HCU) Center of Excellence on Catalysis and Catalytic Reaction Engineering(CECC)Chulalongkorn UniversityBangkok 10330Thailand

Hydro.en sulfide(H_(2)S) no. o.ly presents significant enviro.mental co.cerns but also.induces severe co.ro.io. in industrial equipment,even at lo. *** vario.s techno.o.ies,the selective o.idatio. o. hydro.en sulfide(So._(2)S) to.elemental sulfur(S) has emerged as a sustainable and enviro.mentally friendly *** to.its unique pro.erties,iro. o.ide has been extensively investigated as a catalyst fo. So._(2)S;ho.ever,rapid deactivatio. has remained a significant *** causes o. iro. o.ide-based catalysts deactivatio. mechanisms in So._(2)S,including sulfur o. sulfate depo.itio.,the transfo.matio. o. iro. species,sintering and excessive o.ygen vacancy fo.matio.,and active site lo.s,are tho.o.ghly examined in this *** fo.using o. the deactivatio. mechanisms,this review aims to.pro.ide valuable insights into.enhancing the stability and efficiency o. iro.-based catalysts fo. So._(2)S.

关键词： Selective o.idatio. o. H_(2)S Iro.-based Catalysts Mechanism o. deactivatio. Sulfur o. sulfate depo.itio. Transfo.matio. o. iro. species Sintering SDG 7

Artemisia vulgaris Induces Tumo.-Selective Ferro.to.is and Necro.to.is via Lyso.o.al Ca^(2+) Signaling

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Chinese Jo.rnal o. Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas do. santos Zamario.i Michele Ro.ana Maia santos Ado.fo.Garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira So.aya S Smaili Maria Cristina Marcucci Carlo. Ro.ha o.iveira Gustavo.JS Pereira Claudia Binco.etto Department o. Pharmaco.o.y Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Gro.p o. Phyto.o.plexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department o. Bio.ciences and o.al Diagno.is Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

o.jective To.evaluate the chemical co.po.itio. and effects o. Artemisia vulgaris(AV)hydro.lco.o.ic extract(HEAV)o. breast cancer cells(MCF-7 and SKBR-3),chro.ic myelo.d leukemia(K562)and NIH/3T3 *** Phyto.hemical analysis o. HEAV was do.e by high-perfo.mance liquid chro.ato.raphy-mass(HPLC)*** and cell death studies were perfo.med using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necro.tatin-1(Nec-1)were used to.assess the mo.e o. HEAV-induced cell death and aceto.ymethylester(BAPTA-AM)was used to.verify the invo.vement o. cyto.o.ic calcium in this *** calcium measurements were made using *** HEAV decreased the viability o. MCF-7,SKBR-3 and K562 cells(Po. HEAV-treated K562 cells was reduced co.pared to.HEAV-expo.ed fibro.lasts(Po. K562 cells with HEAV induced cell death primarily by late apo.to.is and necro.is in assays using annexin V-FITC/7-AAD(Po. Nec-1 and Fer-1 increased the viability o. K562 cells treated with HEAV relative to.cells expo.ed to.HEAV alo.e(Po. lyso.o.es in K562 cells(Po.e,BAPTA-AM,an intracellular Ca^(2+)chelato.,decreased the number o. no.-viable cells treated with HEAV(Po.clusio.s HEAV is cyto.o.ic and activates several mo.alities o. cell death,which are partially dependent o. lyso.o.al release o. Ca^(2+).These effects may be related to.artemisinin and caffeo.lquinic acids,the main co.po.nds identified in HEAV.

关键词： Artemisia vulgaris necro.to.is ferro.to.is late apo.to.is Ca^(2+)signaling