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Epidemiology of perforating peptic ulcer:A population-based retrospective study over 40 years

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World Journal of Gastroenterology 2020年第35期26卷 5302-5313页

作者： Aydin Dadfar Tom-Harald edna Department of Surgery Levanger HospitalNord-Trøndelag Hospital TrustLevanger 7600Norway Institute of Clinical and Molecular Medicine Norwegian University of Science and TechnologyTrondheim 7491Norway

BACKGROUND The incidence of peptic ulcer disease has decreased during the last few decades,but the incidence of reported peptic ulcer complications has not *** peptic ulcer(PPU)is a severe form of the *** To assess trends in the incidence,presentation,and outcome of PPU over a period of 40 *** This was a single-centre,retrospective,cohort study of all patients admitted to Levanger Hospital,Norway,with PPU from 1978 to *** patients were identified in the Patient Administrative System of the hospital using International Classification of Diseases(ICD),revision 8,ICD-9,and ICD-10 codes for perforated gastric and duodenal *** reviewed the medical records of the patients to retrieve *** statistics were available for all *** incidence of PPU was analysed using Poisson regression with perforated ulcer as the dependent variable,and sex,age,and calendar year from 1978 to 2017 as *** survival analysis was performed to compare long-term survival over the four *** Two hundred and nine patients were evaluated,including 113(54%)***(22%)patients were older than 80 *** age increased from the first to the last decade(from 63 to 72 years).The incidence rate increased with increasing age,but we measured a decline in recent decades for both sexes.A significant increase in the use of acetylsalicylic acid,from 5%(2/38)to 18%(8/45),was observed during the study *** increased significantly over the 40 years of the study,with 22%(10/45)of the patients having an American Society of Anaesthesiologists(ASA)score 4-5 in the last decade,compared to 5%(2/38)in the first ***-nine percent(81/209)of the patients had one or more postoperative *** 100-day mortality and long-term survival were associated with ASA score,without significant variations between the *** Declining incidence rates occurred in recent years,but the patients were olde

关键词： Perforated peptic ulcer American Society of Anaesthesiologists classification Charlson Comorbidity Index Gastric ulcer Duodenal ulcer Epidemiology Incidence Clavien-Dindo classification of complications Mortality

The CST bounce universe model——A parametric study

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Science China(Physics,Mechanics & Astronomy) 2019年第1期62卷 9-15页

作者： Yeuk-Kwan edna Cheung Xue Song ShuYi Li YunXuan Li YiQing Zhu Department of Physics Nanjing University Institute of High Energy Physics China Academy of Sciences Department of Physics Princeton University Department of Physics Brown University California Institute of Technology ETH Zürich

A bounce universe model with a scale-invariant and stable spectrum of primordial density perturbations was constructed using a consistent truncation of the D-brane dynamics from Type IIB string theory. A coupling was introduced between the tachyon field and the adjoint Higgs field on the D3-branes to lock the tachyon at the top of its potential hill and to model the bounce process,which is known as the Coupled Scalar and Tachyon Bounce(CSTB) Universe. The CSTB model has been shown to be ghost free,and it fulfils the null energy condition; in addition, it can also solve the Big Bang cosmic singularity problem. In this paper we conduct an extensive follow-up study of the parameter space of the CSTB model. In particular we are interested in the parameter values that can produce a single bounce to arrive at a radiation-dominated universe. We further establish that the CSTB universe is a viable alternative to inflation, as it can naturally produce a sufficient number of e-foldings in the locked inflation epoch and in the post-bounce expansion to overcome the four fundamental limitations of the Big Bang cosmology, which are flatness, horizon,homogeneity and singularity, resulting in a universe of the current size.

关键词： bounce universe Big Bang singularity tachyon inflation flatness and horizon problems

Estimating the carbon fluxes of forests with an individual-based forest model

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Forest Ecosystems 2017年第2期4卷 133-142页

作者： edna Rodig Andreas Huth Friedrich Bohn Corinna Rebmann Matthias Cuntz UFZ-Helmholtz Centre for Environmental Research Permoserstr.1504318 LeipzigGermany University of Osnabruck BarbarastraSe 1249076 OsnabruckGermany German Centre for Integrative Biodiversity Research(iDiv)HaHe-Jena-leipzig Deutscher Platz 5e04103 LeipzigGermany INRA-Universite de Lorraine UMRU37 Ecologie et Ecophysiologie Foresti^res54280 ChampenouxFrance

Background： Capturing the response of forest ecosystems to inter-annual climate variability is a great *** this study, we tested the capability of an individual-based forest gap model to display carbon fluxes at yearly and daily time *** forest model was applied to a spruce forest to simulate the gross primary production（GPP）, respiration and net ecosystem exchange（NEE）.We analyzed how the variability in climate affected simulated carbon fluxes at the scale of the forest ***： Six years were simulated at a daily time scale and compared to the observed eddy covariance（EC） *** general, the seasonal cycle of the individual carbon fluxes was correctly described by the forest ***, the estimated GPP differed from the observed data on the days of extreme climatic *** new parameterizations were developed： one resulting from a numerical calibration, and the other resulting from a filtering *** suggest new parameter values and even a new function for the temperature limitation of ***： The forest model reproduced the observed carbon fluxes of a forest ecosystem quite *** the three parameterizations, the calibrated model version performed ***, the filtering approach showed that calibrated parameter values do not necessarily correctly display the individual functional *** concept of simulating forest dynamics at the individual base is a valuable tool for simulating the NEE, GPP and respiration of forest ecosystems.

关键词： Forest model Temperate forest Carbon fluxes Eddy covariance FORMIND

Challenges and Opportunities Modeling the Dynamic Tumor Matrisome

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Biomedical Engineering Frontiers 2023年第1期4卷 239-246页

作者： Shelly R.Peyton Manu O.Platt edna Cukierman Department of Chemical Engineering University of Massachusetts AmherstAmherstMAUSA Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlantaGAUSA Cancer Signaling&Microenvironment Program Marvin and Concetta Greenberg Pancreatic Cancer Institute.Fox Chase Cancer CenterTemple HealthPhiladelphiaPAUSA

We need novel strategies to target the complexity of cancer and,particularly,of metastatic *** an example of this complexity,certain tissues are particularly hospitable environments for metastases,whereas others do not contain fertile microenvironments to support cancer cell *** evidence that the extracellular matrix(ECM)of tissues is one of a host of factors necessary to support cancer cell growth at both primary and secondary tissue sites is *** on cancer metastasis has largely been focused on the molecular adaptations of tumor cells in various cytokine and growth factor environments on 2-dimensional tissue culture polystyrene *** imaging,conversely,has transformed our ability to watch,in real time,tumor cell invasion,intravasation,extravasation,and *** the interstitial ECM that supports all cells in the tumor microenvironment changes over time scales outside the possible window of typical intravital imaging,bioengineers are continuously developing both simple and sophisticated in vitro controlled environments to study tumor(and other)cell interactions with this *** this perspective,we focus on the cellular unit responsible for upholding the pathologic homeostasis of tumor-bearing organs,cancer-associated fibroblasts(CAFs),and their selfgenerated *** latter,together with tumoral and other cell secreted factors,constitute the“tumor matrisome”.We share the challenges and opportunities for modeling this dynamic CAF/ECM unit,the tools and techniques available,and how the tumor matrisome is remodeled(e.g.,via ECM proteases).We posit that increasing information on tumor matrisome dynamics may lead the field to alternative strategies for personalized medicine outside genomics.

关键词： invasion organs environments

Fermented soybean meal improved laying performance and egg quality of laying hens by modulating cecal microbiota,nutrient digestibility,intestinal health,antioxidant and immunological functions

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Animal Nutrition 2024年第3期18卷 309-321页

作者： Uchechukwu edna Obianwuna Lingling Huang Haijun Zhang Jing Wang Guanghai Qi Kai Qiu Shugeng Wu National Engineering Research Center of Biological Feed Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China Wilmar(Shanghai)Biotechnology Research&Development Center Co. Ltd.Shanghai 200137China

Antinutritional factors in feedstuffs may limit their utilization in livestock production,but fermentation process can be used to improve feed quality;however,studies on fermented soybeans for laying hens remain *** investigated the effect of fermented soybean meal(FSBM)at various inclusion levels as a partial replacement for soybean meal(SBM)on egg production,egg quality,amino acid digestibility,gut morphology and microbiota,antioxidant capacity and immune response of young laying hens.A total of 360 Hy-line Brown laying hens aged 18 weeks were selected and divided into 5 groups of 6 replicates each and 12 birds per *** control group received a basal diet while the trial group received the basal diet with FSBM included at 2.5%,5.0%,7.5%and 10.0%,respectively,for 12 *** findings revealed that the nutritional value of FSBM was higher compared to that of SBM in terms of reduced content of trypsin inhibitors and increased contents of crude protein,amino acids and *** enhanced egg production(P<0.05),feed-to-egg ratio(P<0.05),and albumen quality(albumen height and Haugh unit)(P<0.05).Furthermore,FSBM improved apparent fecal amino acid digestibility(P<0.05),gut morphology(increased villus height,villus width,villus height-to-crypt depth ratio and decreased crypt depth)(P<0.05),antioxidant capacity(reduced malondialdehyde and increased catalase,total superoxide dismutase,glutathione peroxidase and total antioxidant capacity)(P<0.05)and immune function(increased concentrations of IgG,IgA,and IgM;increased levels of transforming growth factor beta and Toll-like receptor 2;and reduced levels of interleukin 1βand tumor necrosis factor alpha)(P<0.05).Further analysis showed that FSBM altered the composition of the gut microbiota favoring beneficial *** findings suggest that probiotic fermentation improved the nutritional value of *** inclusion of FSBM in the diets of laying hens at 2.5%or 5.0%improved amino acid digestibility,gut

关键词： Fermented soybean meal Laying hen Egg production Egg quality Immune response

Resting-state functional connectivity in lifelong musicians

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Psychoradiology 2023年第1期3卷 154-161页

作者： Cyrus Eierud Andrew Michael David Banks edna Andrews Linguistics Program Duke UniversityDurhamNC 27708USA Duke Institute for Brain Sciences Duke UniversityDurhamNC 27708USA Department of Statistical Science Duke UniversityDurhamNC 27708USA Center for Cognitive Neuroscience Duke UniversityDurhamNC 27708USA

Background:It has been postulated that musicianship can lead to enhanced brain and cognitive reserve,but the neural mechanisms of this effect have been poorly *** professional musicianship in conjunction with novel brain imaging techniques offers a unique opportunity to examine brain network differences between musicians and matched ***:In this study we aim to investigate how resting-state functional networks(FNs)manifest in lifelong active *** will evaluate the FNs of lifelong musicians and matched healthy controls using resting-state functional magnetic resonance ***:We derive FNs using the data-driven independent component analysis approach and analyze the functional network con-nectivity(FNC)between the default mode(DMN),sensory-motor(SMN),visual(VSN),and auditory(AUN)*** examine whether the linear regressions between FNC and age are different between the musicians and the control ***:The age trajectory of average FNC across all six pairs of FNs shows significant differences between musicians and *** show an increase in average FNC with age while controls show a decrease(P=0.013).When we evaluated each pair of FN,we note that in musicians FNC values increased with age in DMN–AUN,DMN–VSN,and SMN–VSN and in controls FNC values decreased with age in DMN–AUN,DMN–SMN,AUN–SMN,and SMN–***:This result provides early evidence that lifelong musicianship may contribute to enhanced brain and cognitive *** of this study are preliminary and need to be replicated with a larger number of participants.

关键词： resting-state fMRI lifelong musicianship default mode network sensory-motor network functional network connectivity cognitive reserve

Primary esophageal diffuse large B cell lymphoma presenting with tracheoesophageal fistula: A rare case and review

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World Journal of Gastrointestinal Oncology 2017年第10期9卷 431-435页

作者： Jirapat Teerakanok Judy Park DeWitt edna Juarez Kyaw Zin Thein Irfan Warraich Department of Internal Medicine Texas Tech University Health Sciences Center School of Medicine Texas Tech University Health Sciences Center Department of Pathology Texas Tech University Health Sciences Center

Primary non-Hodgkin lymphomas in the esophagus are rare. Tracheoesophageal fistulas mainly arise from solid esophageal carcinoma or mediastinal malignancies. Our patient presented with cough, dysphagia and weight loss, and upon initial computed tomography imaging and esophagogastroduodenoscopy, a malignant mass in the middle third of esophagus with tracheoesophageal fistula was found. The location of the mass and presence of malignant tracheoesophageal fistula were strongly suggestive of squamous cell carcinoma. However, tumor biopsy revealed diffuse large B-cell lymphoma. This case report details a rare incident of a primary diffuse large B-cell lymphoma presented as tracheoesophageal fistula and reviews previous literature.

关键词： Non-Hodgkin lymphoma Tracheoesophageal fistula Esophageal cancer Esophageal lymphoma

Risk factors of admission for acute colonic diverticulitis in a population-based cohort study: The North Trondelag Health Study, Norway

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World Journal of Gastroenterology 2016年第48期22卷 10663-10672页

作者： Aras Jamal Talabani Stian Lydersen Eivind Ness-Jensen Birger Henning Endreseth Tom-Harald edna Department of Surgery Levanger Hospital North Trondelag Hospital Trust Regional Centre for Child and Youth Mental Health and Child Welfare - Central Norway Faculty of Medicine Norwegian University of Science and Technology HUNT Research Centre Department of Public Health and General Practice Faculty of Medicine Norwegian University of Science and Technology Upper Gastrointestinal Surgery Department of Molecular Medicine and Surgery Karolinska Institutet Karolinska University Hospital Clinic of Medicine St. Olav’s Hospital Trondheim University Hospital Clinic of Surgery St. Olav’s Hospital Trondheim University Hospital Institute of Cancer Research and Molecular Medicine Norwegian University of Science and Technology Unit for Applied Clinical Research Institute of Cancer Research and Molecular Medicine Norwegian University of Science and Technology

AIM To assess risk factors of hospital admission for acute colonic *** The study was conducted as part of the second wave of the population-based North Trondelag Health Study(HUNT2), performed in North Trondelag County, Norway, 1995 to 1997. The study consisted of 42570 participants(65.1% from HUNT2) who were followed up from 1998 to 2012. Of these, 22436(52.7%) were females. The cases were defined as those 358 participants admitted with acute colonic diverticulitis during follow-up. The remaining participants were used as controls. Univariable and multivariable Cox regression analyses was used for each sex separately after multiple imputation to calculate *** Multivariable Cox regression analyses showed that increasing age increased the risk of admission for acute colonic diverticulitis: Comparing with ages 70 years, HR = 6.19, P < 0.001. In males the corresponding values were HR = 1.85, P = 0.004 and 2.56, P < 0.001. In patients with obesity(body mass index ≥ 30) the HR = 2.06, P < 0.001 in females and HR = 2.58, P < 0.001 in males. In females, present(HR = 2.11, P < 0.001) or previous(HR = 1.65, P = 0.007) cigarette smoking increased the risk of admission. In males, breathlessness(HR = 2.57, P < 0.001) and living in rural areas(HR = 1.74, P = 0.007) increased the risk. Level of education, physical activity, constipation and type of bread eaten showed no association with admission for acute colonic *** The risk of hospital admission for acute colonic diverticulitis increased with increasing age, in obese individuals, in ever cigarette smoking females and in males living in rural areas.

关键词： Acute colonic diverticulitis North Trondelag Health Study Risk factors Multivariable Cox regression analysis Multiple imputation

The Makings of an Icon： Analysis of Photograph of Israeli Soldiers

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Journalism and Mass Communication 2015年第6期5卷 298-308页

作者： edna Barromi Perlman University of Haifa Haifa Israel Kibbutz College of Education Technology and Arts Tel Aviv Israel

This study analyses an iconic photograph of Israeli paratroopers, photographed in Jerusalem in 1967. It explores how visual and formal structural components in the image function in this photograph and how they contribute to the process of creating an icon. It explores the mechanisms that exist in visual icons and addresses the question of why some press photographs turn into iconic images while other do not, and if there is a connection between the visual structural elements in the images and the way they are perceived by the public. The study discusses how this visual logic correlates with other elements such as public opinion and myths.

关键词： Photographs icons symbols Israel soldiers myths Zionism