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Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency:A case report

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World Journal of Gastroenterology 2020年第15期26卷 1841-1846页

作者： Andrew Fagbemi William G Newman Stuart G Tangye Stephen M Hughes edmund cheesman Peter D Arkwright Department of Paediatric Gastroenterology Royal Manchester Children’s HospitalManchester M199WLUnited Kingdom Department of Medical Genetics Manchester University NHS Foundation TrustManchester M139WLUnited Kingdom Evolution and Genomic Sciences University of ManchesterManchester M139WLUnited Kingdom Garvan Institute of Medical Research DarlinghurstNSW 2010Australia St Vincent’s Clinical School Faculty of MedicineUNSW AustraliaSydneyNSW 2010Australia Department of Paediatric Allergy and Immunology Royal Manchester Children’s HospitalManchester M139WLUnited Kingdom Department of Paediatric Histopathology St Mary’s HospitalManchester M139WLUnited Kingdom Lydia Becker Institute of Immunology and Inflammation University of ManchesterManchester M139WLUnited Kingdom

BACKGROUND Aminoacyl tRNA synthetases/ligases(ARSs)are highly conserved enzymes involved in attaching amino acids to tRNA promoting protein *** deficiencies of ARSs localized to the mitochondria classically present with neuropathology,the clinical features of cytosolic ARS deficiencies are more *** have previously been associated with neonatal hepatitis,but never with early-onset inflammatory bowel *** SUMMARY A nine-year-old Bangladeshi boy presented with neonatal liver failure and deranged clotting,transaminitis and *** parents were first *** older brothers and a sister were *** patient suffered from loose stools from early infancy which became more troublesome and persistent from five years old with ten bloody motions a *** endoscopies showed persistent pancolitis,which was refractory to mesalazine,corticosteroids,azathioprine,sirolimus and anti-TNF(adalimumab)therapy,but has improved recently with subcutaneous *** Genome Sequencing revealed a novel pathogenic missense variant(c.290A>G)in the cytosolic isoleucyl-tRNA synthetase gene,leading to an amino acid substitution(***97Gly).Pathogenic variants in other genes associated with inflammatory bowel disease(IBD)(ADAM17,EGFR,FOXP3,IL10RA,IL10RB,IL21R,NCF4,STAT3)were *** assays demonstrated markedly elevated IL-2,IL-5,IL-13,IL-9 and IL-10 by the patient’s CD4+T-cells,while IL-17A,IL-17F,IFNβwere lower,and TNFαnot significantly different when compared to healthy *** This case report provides evidence that recessive mutations in cytosolic isoleucyltRNA synthetase are a novel monogenic cause of IBD,which should be considered,particularly in infants and children with a history of neonatal hepatitis and very early-onset IBD poorly responsive to treatment.

关键词： Inflammatory bowel disease Hepatitis Gene Cytosolic isoleucine tRNA synthase

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Physics-informed deep learning for fringe pattern analysis

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Opto-Electronic Advances 2024年第1期7卷 4-15页

作者： Wei Yin Yuxuan Che Xinsheng Li Mingyu Li Yan Hu Shijie Feng edmund Y.Lam Qian Chen Chao Zuo Smart Computational Imaging Laboratory(SCILab) School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China Smart Computational Imaging Research Institute(SCIRI)of Nanjing University of Science and Technology Nanjing 210019China Jiangsu Key Laboratory of Spectral Imaging&Intelligent Sense Nanjing 210094China Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong Kong SAR 999077China

Recently,deep learning has yielded transformative success across optics and photonics,especially in optical *** neural networks (DNNs) with a fully convolutional architecture (e.g.,U-Net and its derivatives) have been widely implemented in an end-to-end manner to accomplish various optical metrology tasks,such as fringe denoising,phase unwrapping,and fringe ***,the task of training a DNN to accurately identify an image-to-image transform from massive input and output data pairs seems at best naive,as the physical laws governing the image formation or other domain expertise pertaining to the measurement have not yet been fully exploited in current deep learning *** this end,we introduce a physics-informed deep learning method for fringe pattern analysis (PI-FPA) to overcome this limit by integrating a lightweight DNN with a learning-enhanced Fourier transform profilometry (Le FTP) *** parameterizing conventional phase retrieval methods,the Le FTP module embeds the prior knowledge in the network structure and the loss function to directly provide reliable phase results for new types of samples,while circumventing the requirement of collecting a large amount of high-quality data in supervised learning *** by the initial phase from Le FTP,the phase recovery ability of the lightweight DNN is enhanced to further improve the phase accuracy at a low computational cost compared with existing end-to-end *** results demonstrate that PI-FPA enables more accurate and computationally efficient single-shot phase retrieval,exhibiting its excellent generalization to various unseen objects during *** proposed PI-FPA presents that challenging issues in optical metrology can be potentially overcome through the synergy of physics-priors-based traditional tools and data-driven learning approaches,opening new avenues to achieve fast and accurate single-shot 3D imaging.

关键词： optical metrology deep learning physics-informed neural networks fringe analysis phase retrieval

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On the use of deep learning for phase recovery

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Light(Science & Applications) 2024年第2期13卷 190-235页

作者： Kaiqiang Wang Li Song Chutian Wang Zhenbo Ren Guangyuan Zhao Jiazhen Dou Jianglei Di George Barbastathis Renjie Zhou Jianlin Zhao edmund Y.Lam Department of Electrical and Electronic Engineering The University of Hong KongHong Kong SARChina School of Physical Science and Technology Northwestern Polytechnical UniversityXi’anChina Department of Biomedical Engineering The Chinese University of Hong KongHong Kong SARChina School of Information Engineering Guangdong University of TechnologyGuangzhouChina Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

Phase recovery(PR)refers to calculating the phase of the light field from its intensity *** exemplified from quantitative phase imaging and coherent diffraction imaging to adaptive optics,PR is essential for reconstructing the refractive index distribution or topography of an object and correcting the aberration of an imaging *** recent years,deep learning(DL),often implemented through deep neural networks,has provided unprecedented support for computational imaging,leading to more efficient solutions for various PR *** this review,we first briefly introduce conventional methods for ***,we review how DL provides support for PR from the following three stages,namely,pre-processing,in-processing,and *** also review how DL is used in phase image ***,we summarize the work in DL for PR and provide an outlook on how to better use DL to improve the reliability and efficiency of ***,we present a live-updating resource(https://***/kqwang/phase-recovery)for readers to learn more about PR.

关键词： networks phase optics

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Effect of Lateritic Stone Aggregate and Coconut Husk Fiber on the Properties of Concrete

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Open Journal of Civil Engineering 2024年第2期14卷 240-257页

作者： edmund Borbi Humphrey Danso Emmanuel Appiah-Kubi Department of Construction Technology and Management Education Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development Kumasi Ghana Department of Architecture and Civil Engineering Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development Kumasi Ghana

Natural stone aggregate forms the bulk volume of concrete and has contributed to the increased cost of concrete production. This has led to the search for alternate aggregates such as lateritic stone for concrete production. This paper investigates the engineering properties of concrete produced with lateritic aggregate (LA) as the coarse aggregate replacement and coconut husk fibre (CHF) as reinforcement. Natural stone aggregate was replaced by LA at 0%, 10%, 20%, 30%, 40%, and 50%, with 0.25% constant CHF by weight. A mix proportion of 1:1.5:3 with a water-cement ratio of 0.6 was used for producing concrete. A total of 162 specimens (90 cubes and 72 beams) were prepared and tested at the 7, 14, 21, and 28 days of curing. The highest compressive strength was 43.36 N/mm2 (10% LA replacement) as compared to the control of 41.51 N/mm2. The 10% LA replacement obtained the highest flexural strength of 5.35 N/mm2 as compared with the 5.29 N/mm2 for the control. The water absorption of the concrete increased from 2.8% (control) to 3.57% (50% replacement LA). Scanning electron microscopy (SEM) revealed micro gaps between CHF and LA concrete. The study, therefore, concludes that the use of LA and CHF positively influenced the strength properties of concrete. 10% LA replacement of coarse aggregate and 0.25% CHF is recommended to practitioners for use.

关键词： Concrete Coarse Aggregate Compressive Strength Flexural Strength Natural Stone Aggregate SEM

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Fast and robust phase retrieval for masked coherent diffractive imaging

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Photonics Research 2022年第3期10卷 758-768页

作者： Li Song edmund Y.Lam Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong KongChina

Conventional phase retrieval algorithms for coherent diffractive imaging(CDI)require many iterations to deliver reasonable results,even using a known mask as a strong constraint in the imaging setup,an approach known as masked *** paper proposes a fast and robust phase retrieval method for masked CDI based on the alternating direction method of multipliers(ADMM).We propose a plug-and-play ADMM to incorporate the prior knowledge of the mask,but note that commonly used denoisers are not suitable as regularizers for complex-valued latent images ***,we develop a regularizer based on the structure tensor and Harris corner *** with conventional phase retrieval methods,our technique can achieve comparable reconstruction results with less time for the masked ***,validation experiments on real in situ CDI data for both intensity and phase objects show that our approach is more than 100 times faster than the baseline method to reconstruct one complex-valued image,making it possible to be used in challenging situations,such as imaging dynamic ***,phase retrieval results for single diffraction patterns show the robustness of the proposed ADMM.

关键词： coherent phase retrieval

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Nicotinic acetylcholine signaling is required for motor learning but not for rehabilitation from spinal cord injury

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Neural Regeneration Research 2023年第2期18卷 364-367页

作者： Yue Li edmund R.Hollis II Burke Neurological Institute White PlainsNYUSA Feil Family Brain and Mind Research Institute Weill Cornell MedicineNew YorkNYUSA Current address:Department of Neuroscience University of Rochester Medical CenterRochesterNYUSA

Therapeutic intervention for spinal cord injury is limited,with many approaches relying on strengthening the remaining substrate and driving recovery through rehabilitative *** compared with learning novel compensatory strategies,rehabilitation focuses on resto ring movements lost to *** rehabilitation of previously learned movements after spinal cord injury requires the molecular mechanisms of motor learning,or if it engages previously trained motor circuits without requiring novel learning remains an open *** this study,mice we re randomly assigned to receive intrape ritoneal injection with the pan-nicotinic,non-competitive antagonist mecamylamine and the nicotinicα7 subunit selective antagonist methyllycaconitine citrate salt or vehicle(normal saline)prior to motor learning assays,then randomly reassigned after motor learning for rehabilitation study *** rvical spinal co rd dorsal column lesion was used as a model of in complete *** of this study showed that nicotinic acetylcholine signaling was required for motor learning of the single pellet-reaching task but it was dispensable for the rehabilitation of the same task after *** findings indicate that critical diffe rences exist between the molecular mechanisms supporting compensatory motor learning strategies and the restoration of behavior lost to spinal cord injury.

关键词： acetylcholine basal forebrain corticospinal tract dorsal column lesion mecamylamine methyllycaconitine motor control rehabilitation rotarod single pellet-reaching task

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Enhancement and validation of building integrated PV system:3D modelling,techno-economics and environmental assessment

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Energy and Built Environment 2022年第4期3卷 444-466页

作者： edmund Jin Wen Thoy Yun Ii Go School of Engineering and Physical Sciences Heriot-Watt University Malaysia.1Jalan Venna P5/2Precinct 562200 PutrajayaWilayah Persekutuan PutrajayaMalaysia

The incorporation of photovoltaic elements in buildings have been gaining more mileage in recent *** integrated photovoltaic(BIPV)technologies are on the rise in terms of efficiency and longevity,with a compound annual growth rate(CAGR)of 15.7%since *** costs of production and raw materials of BIPV have reached a level that is economically beneficial for building developers to adopt the ***,the lack of infras-tructure as compared to traditional means of energy production has impeded the maturing of such *** issue of conversion efficiency and module degradation have been addressed but not completely resolved by the scientific *** attractive governmental incentives such as net energy metering(NEM)and better returns of investments are shifting the tide as of late,what remains to be seen is the mass adoption of BIPV technology in residential and commercial *** work aims to develop an optimal layout for photo-voltaic panels in the university building precise 3D modelling and solar energy resource *** method adopted is based on energy production capability of a 3D modelled BIPV system which will be carried out in three *** are i)Assessment of geographical location and meteorological data,ii)Development of 3D model and orientation analytics and(iii)Development of optimal PV *** systems were considered for this study,which is the roof and two systems on the Southern Faç*** proposed rooftop BIPV design is expected to provide 49.27%of the building’s energy consumption while reducing CO_(2)emissions by 20155.32 tonnes throughout the lifespan of the system’s *** paper serves as a pioneering study on the feasibility of a BIPV system through the incorporation of building geometry for computations on incident solar *** the reduction of electricity imported from the grid,the adoption of the BIPV system also serves as an incremental step towards achi

关键词： Facade Energy yield Performance ratio Payback Building geometry

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Characterization of time-and size-dependent particle emissions and decay from cooking oil fumes in residence:Impacts of various intervention measures

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Building Simulation 2023年第7期16卷 1149-1158页

作者： Jianbang Xiang Linmin Hu Jiayuan Hao Siqing Wu Jianping Cao edmund Seto School of Public Health(Shenzhen) Sun Yat-sen UniversityShenzhenGuangdong 518107China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China Division of Environmental Health University of Southern CaliforniaLos AngelesCA 90032USA School of Medicine Sun Yat-sen UniversityShenzhenGuangdong 518107China School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong 510006China Department of Environmental and Occupational Health Sciences University of WashingtonSeattleWA 98195USA

The dynamic characteristics of cooking-related particle size distributions in real-world settings are not fully *** a real-world campaign in a naturally-ventilated apartment in the northwest US,this study investigates the temporal profiles of size-resolved particle number concentrations(PNCs)ranging from 0.3 to 10µm from frying cooking *** cooking scenarios included various combinations of window ventilation,venting range hood(VRH)use,and portable air cleaner(PAC)*** a standardized pan-frying protocol throughout seven scenarios,real-time PNCs of 16-size bins were measured in the *** PNCs were empirically compared among size bins,periods,and *** most abundant size ranges of cooking-related particles were 0.3–0.579µm in number(45%–71%of the total)and 2.685–5.182µm in mass(48%–57%of the total).Compared with the scenario without any cooking-fume mitigating measures,keeping the kitchen windows open reduced the mean PNCs during and within 1-h after cooking for PM_(0.3-2.5),PM_(2.5-10),and PM_(0.3-10)by 78%,92%,and 79%,*** contrast,utilizing a VRH during cooking reduced the corresponding levels by 21%,69%,and 25%,*** with running the VRH,using a PAC in the kitchen led to additional reductions of 84%,88%,and 84%,***,the removal efficiencies of the three strategies generally increased with particle sizes.

关键词： cooking oil fumes size-resolved particles venting range hood window ventilation portable air cleaner

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Supersonically sprayed self-aligne d rGO nanosheets and ZnO/ZnMn_(2)O_(4)nanowires for high-energy and high-power-density supercapacitors

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Journal of Materials Science & Technology 2023年第6期137卷 193-204页

作者： Chanwoo Park edmund Samuel Byeong-Yeop Kim Seongpil An Hae-Seok Lee Sam S.Yoon School of Mechanical Engineering Korea UniversitySeoul 02841Republic of Korea Energy Environment Policy and Technology Graduate School of Energy and Environment(KU-KIST Green School)Korea UniversityRepublic of Korea SKKU Advanced Institute of Nanotechnology(SAINT)and Department of Nano Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

Core-shell-type bimetallic oxide and carbon composites comprising zinc oxide(ZnO)nanospheres and zinc manganese oxide(ZnMn_(2)O_(4))nanowires were produced by a hydrothermal method,and supersoni-cally sprayed together with reduced graphene oxide(rGO)nanosheets onto Ni foil to fabricate flexible *** supersonic impact facilitated the exfoliation of the rGO nanosheets,thereby increasing the surface area and adhesion of the composite particles to the *** rGO nanosheets were vertically aligned during the supersonic impact and formed localized zones,enabling optimal accommodation of the ZnO/ZnMn_(2)O_(4)*** localization,with the addition of rGO,reduced the agglomeration of ZnO/ZnMn_(2)O_(4)*** molar concentration of MnSO_(4)used in the synthesis of ZnO/ZnMn_(2)O_(4)was varied from 0.05 to 0.15 mol/L to determine the optimal MnSO_(4)concentration that would result in the highest energy storage *** unique nanostructure of ZnO/ZnMn_(2)O_(4)and the self-alignment of rGO sheets facilitated a favorable environment for high energy storage capability with a specific capaci-tance of 276.3 mF·cm^(−2)at a current density of 0.5 mA·cm^(−2)and an energy density of 98.2μWh·cm^(−2)at a power density of 1600μW·cm^(−2).The width of the potential window was increased to 1.2 V,imply-ing a significant increase in the energy storage capability of the *** retention of 88%was achieved after 10,000 charge/discharge cycles for the supercapacitor fabricated using an optimal MnSO_(4)concentration(0.10 mol/L)during the composite synthesis.

关键词： ZnO/ZnMn_(2)O_(4)nanowires rGO nanosheets Hydrothermal method Supersonic spraying Supercapacitor

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Wearable sensors and supercapacitors using electroplated-Ni/ZnO antibacterial fabric

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Journal of Materials Science & Technology 2022年第5期100卷 254-264页

作者： Taegun Kim Chanwoo Park edmund P.Samuel Yong-Il Kim Seongpil An Sam S.Yoon School of Mechanical Engineering Korea UniversitySeoul 02841Republic of Korea KU-KIST Green School Korea UniversitySeoul 136-713Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT)and Department of Nano Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

Herein,nickel nanocones and zinc oxide nanosheets were electroplated onto a fabric to produce multifunctional(wearable,stretchable,washable,hydrophobic,and antibacterial)materials with sensing,heating,and supercapacitive *** these functionalities are integrated into a one-layered fabric that can be used as a portable intelligent electronic textile for potential application in healthcare monitoring,smart sportswear,and energy *** nickel enhances the electrical conductivity and thus increases the electron charge transfer for supercapacitor *** integration of ZnO with the Ni-plated fabric provides pseudocapacitance via redox reactions with the *** resistance of the Ni/ZnO fabric changes in response to external stimuli such as temperature and *** voltage is applied,the fabric generates heat through Joule heating,demonstrating its potential application as winter *** superior mechanical durability of the fabric was confirmed through bending and stretching *** hydrophobic surface prevents viruses contained in liquid droplets from infiltrating the *** addition,bacterial growth is inhibited because of the antibacterial properties of the Ni/ZnO fabric and because of Joule *** one-layered fabric integrated with such multiple functionalities is expected to be applicable in the development of next-generation portable and wearable electronic textiles in various industries.

关键词： Multifunctional conductive fabric Fabric supercapacitor Fabric heater Thermal and strain sensors Electroplating

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