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Oral encapsulated transforming growth factorβ1 reduces endogenous levels:Effect on inflammatory bowel disease

World Journal of Gastrointestinal Pharmacology and Therapeutics 2020年第5期11卷 79-92页

作者： Laura Hammer Stacia Furtado edith Mathiowitz Dominick L Auci Department of Research and Development TherapyXBuffaloNY 14214United States Department of Molecular Pharmacology Brown UniversityProvidenceRI 02912United States

BACKGROUND TreXTAM®is a combination of the key regulatory cytokine transforming growth factor beta(TGFβ)and all trans retinoic acid(ATRA)microencapsulated for oral delivery to immune structures of the *** is in development as a novel treatment for inflammatory bowel disease(IBD).AIM To measure TGFβlevels in blood and tissue after oral administration of encapsulated TGFβ.METHODS Animals were orally administered encapsulated TGFβby *** of drug substance in blood and in gut tissues at various times after administration were measured by *** We made the surprising discovery that oral administration of TreXTAM dramatically(approximately 50%)and significantly(P=0.025)reduced TGFβlevels in colon,but not small intestine or mesenteric lymph ***,levels in rat serum after 25 d of thrice weekly dosing with either TreXTAM,or microencapsulated TGFβalone(denoted as TPX6001)were significantly(P<0.01)reduced from baseline *** tested in the SCID mouse CD4+CD25-adoptive cell transfer(ACT)model of IBD,oral TPX6001 alone provided only a transient benefit in terms of reduced weight *** These observations suggest a negative feedback mechanism in the gut whereby local delivery of TGFβresults in reduced local and systemic levels of the active form of TGFβ.Our findings suggest potential clinical implications for use of encapsulated TGFβ,perhaps in the context of IBD and/or other instances of fibrosis and/or pathological TGFβsignaling.

关键词： Transforming growth factor beta All trans retinoic acid Ulcerative colitis Crohn’s disease Inflammatory bowel disease Regulatory T cells

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Effect of a program to control perioperative blood glucose on the incidence of nosocomial infections in patients with diabetes: A pilot study

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Journal of Diabetes Mellitus 2012年第2期2卷 238-244页

作者： Javier Ena Rosa Casan Maria Jose Carratala edith Leutscher Department of Internal Medicine Hospital Marina BaixaAlicanteSpain Division of Endocrinology and Metabolism Hospital Marina BaixaAlicanteSpain Division of Preventive Medicine Hospital Marina BaixaAlicanteSpain

Aim: To evaluate the safety and effectiveness of a pilot program to control perioperative blood glucose in patients with diabetes. Methods: A pre-post intervention study was conducted in a 280-bed hospital in Spain. In the year 2008 we implemented perioperative insulin protocols aimed at blood glucose values from 80 to 180 mg/dL. Surgical patients with diabetes admitted on year 2009 (intervention group) were compared with a control group of patients with diabetes admitted for surgery on year 2007, matched 1:1 by traditional wound class. Results: We analyzed 96 patients. Implemented protocols were followed in 48% of patients intra-operatively and 75% of patients postoperatively. Patients in the intervention group had reductions in blood glucose at surgery 150 +/- 61 mg/dL vs. 172 +/- 53 mg/dL;p = 0.05), greater proportion of target glucose values throughout hospitalization (67% vs. 55%;p = 0.07), and reductions in the incidence of nosocomial infections after controlling for confounders (Odds Ratio: 0.20;95% Confidence intervals: 0.06 - 0.72;p = 0.014) when they were compared with the control group: The incidence of hypoglycemia was similar between two groups (0.12% vs. 0.10%, p = 0.867), respectively. Conclusion: Although our protocol needs improvements to increase implementation it was useful to control blood glucose safely and for reducing nosocomial infections.

关键词： Diabetes Insulin/Administration and Dosage/Therapeutic Use Surgical Site Infection Nosocomial Infection

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Mobile Application for Research Knowledge Sharing and Dissemination: The Case of Nm-Aist Univeristy Tanzania

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Journal of Software Engineering and Applications 2022年第7期15卷 209-219页

作者： Justine M. Kemhe edith T. Luhanga Michael Kisangiri School of Computational Communication Science and Engineering The Nelson Mandela African Institution of Science and Technology Arusha Tanzania

The utilization of mobile and web applications has surpassed all other platforms in terms of disseminating researchers’ knowledge among diverse communities throughout the world. The current method of disseminating researchers’ knowledge to the communities in the Arusha region in Tanzania is through meetings, workshops, and focus group discussions held by researchers, agricultural extension officers and community members after every three months or during field study. Yet the strategy is inefficient and ineffective in practice. The purpose of this study was to determine the most efficient and successful method of disseminating knowledge in communities. The study began with a qualitative phase, utilizing an interpretive technique and a qualitative multiple case study research design. The Arusha region in Tanzania was selected as a case study where different social activities were undertaken, including farming, livestock keeping, tourism activities and fishing. Individual participants were interviewed by using a semi-structured questionnaire. In addition, focus group discussions were conducted to gather more information regarding the needs of the mobile application. Through the implementation of the application, the second phase of the study led to the development of a mobile application that includes community members, agricultural extension officers, and researchers that will enable anyone to install the application on their mobile phones to access knowledge regarding activities undertaken in Arusha. According to the findings of the first phase of the research, a substantial percentage of community members own mobile phones, and hence a mobile application would be sufficient. The research also found that most researcher-community interactions occur at the data collection and intervention assessment (field trials) stages. Hence, the mobile application will benefit community members, district agricultural, irrigation, and cooperative officers (DAICO), and researchers.

关键词： Mobile Application Knowledge Sharing Knowledge Dissemination Community Based Participatory Research

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A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity

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Acta Pharmaceutica Sinica B 2018年第2期8卷 188-199页

作者： Eneida Turiján-Espinoza Rául Alejandro Salazar-González edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa Milán Diana Portales-Pérez Laboratory of Immunology and Cellular and Molecular Biology Faculty of Chemical Science UASLP Laboratory of Biopharmacy and Pharmacokinetics Faculty of Chemical Science UASLP

Arylamine N-acetyltransferase(NAT; E.C. 2.***.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins.

关键词： Arylamine N-acetyltransferase NAT Sirtuins Peripheral blood mononuclear cells Nicotinamide Resveratrol

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移动上下文感知好友推荐研究

移动上下文感知好友推荐研究

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作者： MOUKALA BOTH SUZY edith（苏芮）上海应用技术大学

学位级别：硕士

移动技术的进步使得人们可以使用社交网络服务相互连接、共享内容、获取信息并购买商品。不同的社交网络会提供不同的推荐,如朋友、商品、工作、电影、书籍等。但是,它们都需要不断建立活跃用户的信誉。这些社交网络提供某种关注用户主... 详细信息

移动技术的进步使得人们可以使用社交网络服务相互连接、共享内容、获取信息并购买商品。不同的社交网络会提供不同的推荐,如朋友、商品、工作、电影、书籍等。但是,它们都需要不断建立活跃用户的信誉。这些社交网络提供某种关注用户主要偏好或兴趣选择的推荐服务。现有系统需要很长时间来识别新用户与其他人的正确联系。大多数网站使用简单的朋友推荐算法,如流行度、相似度或者朋友的朋友是我的朋友这些方法,这些都非常直观。在接收到请求后,朋友推荐系统进入数据进行查询,并给出具有最高推荐分数的好友列表。本文建立了一个基于社交网络的朋友推荐系统。第一,该系统计算用户活跃的频率,并根据活跃频率和强度更新数据集。然后使用K-最近邻算法,可以较容易地根据用户活跃情况进行分类。第二,实现了用户的日常生活日记。通过使用具有阈值算法的K-最近邻算法来从中提取用户的生活偏好。系统使用类似的方法来计算用户之间的生活方式或偏好的相似性,并根据公共-私人图形的兴趣来确定用户的影响。本文提出的推荐系统,对小型实验和大规模模拟进行了评估。结果表明,这些建议反映了用户在选择朋友时的偏好。本文提出的一种基于上下文感知的朋友推荐的创新方法,该方法将移动计算与人的关系结合起来,以提高用户的喜好度。

关键词：好友推荐情境感知推荐系统移动数据

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欢乐屋

欢乐屋

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作者： (美)伊迪丝·华顿(edith Wharton)

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The anatomy and physiology learning system /

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2011年

作者： Applegate edith J.

ISBN: (纸本)9781437703931

Introduction to the human body -- Chemistry, matter, and life -- Cell structure and function -- Tissues and membranes -- Integumentary system -- Skeletal system -- Muscular system -- Nervous system -- Sensory system -- Endocrine system -- Cardiovascular system: the heart -- Cardiovascular system: blood vessels -- Cardiovascular system: blood -- Lymphatic system and body defense -- Respiratory syst

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Dietary Intake of Vitamin A and Macronutrients among Pregnant Women in Ngaoundere Town, Adamawa Region, Cameroon

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Food and Nutrition Sciences 2014年第21期5卷 2071-2080页

作者： Damndja Wilfred Ngaha edith N. Fombang Richard Aba Ejoh Department of Food Sciences and Nutrition National School of Agro-Industrial Sciences University of Ngaoundere Ngaoundere Cameroon College of Technology University of Bamenda Bambili Cameroon

This paper examines the risk of Vitamin A deficiency among selected pregnant women in Ngaoundere, Adamawa Region, Cameroon. A total of one hundred (100) pregnant women attending ante natal visits at the Regional Hospital in Ngaoundere were involved in a survey conducted in 2012 which used a 24-hour dietary recall to assess their dietary intake. Food models were used to assist memory and portion sizes of food taken. Carotenoids were quantified in the meals commonly consumed, as well as proteins, sugar, fibers and oil, nutrients intervening in carotenoids absorption and vitamin A metabolism. The results indicated that the dietary intake of vitamin A was inadequate with 37.5% of the selected pregnant women exposed to acute vitamin A deficiency, while 20% of them were exposed to the severe form. The daily consumption of vitamin A was about 539.09 ± 43.09 μg, corresponding to a contribution of 67.39% to the vitamin A requirement of the pregnant women. The dietary intake of macronutrients was also inadequate with a daily consumption of 57.28 ± 12 g for oils, 177.88 ± 29 g for sugars, 47.34 ± 11 g for proteins and 11.28 ± 3 g for fibers corresponding respectively to a contribution of 63.6%, 70.8%, 78.90% and 45.1% of these nutrients requirement in these women. Given that over 50% of the women surveyed were exposed to vitamin A deficiency, there is a need for urgent intervention programs in the area to alleviate this situation.

关键词： Vitamin A Intake Dietary Intake Vitamin a Deficiency Pregnant Women Ngaoundere

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Spanish Version of Test MIS (*) with Delayed Memory Recall Normative Values and Results in a Population with Mild Cognitive Impairment

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Advances in Alzheimer's Disease 2015年第2期4卷 45-61页

作者： Labos edith Trojanowski Sofía Seinhart Daniel Schapira Marcelo Renato Alejandro Laboratory of Cognitive Functions Research-Faculty of Medicine University of Buenos Aires Buenos Aires Argentina Italian Hospital of Buenos Aires Buenos Aires Argentina

Background: Cognitive impairment becomes more common with ageing and may benefit from intervention. In a Spanish speaking population, detection of cognitive impairment by a general practitioner in Primary Care can be a problem, as many of the standard tests target English speaking populations. The Memory Impairment Screen (MIS-A) is a validated test using English words to detect Alzheimer’s Disease (AD) and other dementias. We have modified this test to suit a Spanish speaking population and added a new component, delayed recall. We have called our new test the Memory Impairment Screen with Delayed Recall (MIS-D). Objectives: 1) To test a Spanish version of MIS-A and MIS-D. 2) To assess the discriminative validity of MIS-D as a screening tool for the amnestic variant of Mild Cognitive Impairment (aMCI) in a group of Spanish speaking people aged 65 years old and over. Methods: A case-control study of a cohort of 739 native Spanish speaking residents of Buenos Aires aged 65 years old and over, of whom 436 were healthy controls and 303 had a diagnosis of aMCI. Measurements: Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NVP) were estimated for MIS-D and MIS-A. Results: Normative values for MIS-A and MIS-D were obtained from the control population. Both age and education significantly affected these values (p < 0.0001). Control participants showed significant differences for both modalities, MIS-A and MIS-D. The cut-off for MIS-A should be 7.5 and for MIS-D, 5.5. Comparison between control population and aMCI population using ROC curve gave a result of 5.5 in MIS-D, with 97% specificity and 76% sensitivity. Conclusion: MIS-D was positively predictive of aMCI, with 97% specificity and 76% sensitivity in a sample of Spanish speaking patients aged 65 years old and over in Buenos Aires.

关键词： Amnestic Mild Cognitive Impairment Memory Test Delayed Recall

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Mass Transfer around a Rising CO2 Bubble in an Air Lift Column Applied to Aquaculture

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Natural Resources 2020年第5期11卷 205-217页

作者： Djimako Bongo edith Kadjagaba Nekoulnang Djetounako Clarisse Jean-Yves Champagne National Institute of Science and Technology of Abéché Abéché Chad Faculty of Exact and Applied Sciences University of N’Djamena N’Djamena Chad Laboratory of Fluid Mechanics and Acoustics INSA-Lyon Lyon France

He mentioned in the 18th century the possibility of injecting gas bubbles into a column of liquid to create a displacement of this liquid due to the rise of bubbles. This system takes the name of Air Lift and the first publications around this process appear at the beginning of the 20th century. There are many economic and ecological interests: CO2 from industrial production is valued because it is consumed by algae, which once they reach maturity can be converted into fuel. It is therefore a very good energy balance thanks to a low consumption of gray energy and the system is simple to set up. In this study, we will delve deeper into the description of the bubble column and the theory that accompanies it. We will then describe our experiences and the work done.

关键词： Mass Transfer PLIF PIV Transverse Velocity CO2

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