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Non-invasive home lung impedance monitoring in early post-acute heart failure discharge: Three case reports

World Journal of Clinical Cases 2019年第8期7卷 951-960页

作者： edita lycholip Egl? Palevi?iūt? Ina Thon Aamodt Ragnhild Helles? Irene Lie Anna Str?mberg Tiny Jaarsma Jelena ?elutkien? Clinic of Cardiac and Vascular Diseases Institute of Clinical Medicine Faculty of Medicine Vilnius University Center of Cardiology and Angiology Vilnius University Hospital Santaros Klinikos Faculty of Medicine Institute of Health and Society Department of Nursing Science University of Oslo Center for Patient-Centered Heart and Lung Research Department of Cardiothoracic Surgery Oslo University Hospital Departamento of Nursing Science Institute of Health and Society University of Oslo Department of Medical and Health Sciences Linkoping University Department of Social and Welfare Studies Linkoping University

BACKGROUND Patients discharged after hospitalization for acute heart failure(AHF) are frequently readmitted due to an incomplete decongestion, which is difficult to assess clinically. Recently, it has been shown that the use of a highly sensitive,non-invasive device measuring lung impedance(LI) reduces hospitalizations for heart failure(HF); it has also been shown that this device reduces the cardiovascular and all-cause mortality of stable HF patients when used in longterm out-patient follow-ups. The aim of these case series is to demonstrate the potential additive role of non-invasive home LI monitoring in the early postdischarge *** SUMMARY We present a case series of three patients who had performed daily LI measurements at home using the edema guard monitor(EGM) during 30 d after an episode of AHF. All patients had a history of chronic ischemic HF with a reduced ejection fraction and were hospitalized for 6–17 d. LI measurements were successfully made at home by patients with the help of their caregivers. The patients were carefully followed up by HF specialists who reacted to the values of LI measurements, blood pressure, heart rate and clinical symptoms. LI reduction was a more frequent trigger to medication adjustments compared to changes in symptoms or vital signs. Besides, LI dynamics closely tracked the use and dose of *** Our case series suggests non-invasive home LI monitoring with EGM to be a reliable and potentially useful tool for the early detection of congestion or dehydration and thus for the further successful stabilization of a HF patient after a worsening episode.

关键词： Heart failure Home monitoring Lung impedance Case report Pulmonary congestion

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Menstrual cycle abnormalities in women with inflammatory bowel disease and effects of biological therapy on gynecological pathology

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World Journal of Clinical Cases 2023年第21期11卷 4989-4995页

作者： Vaidota Malinauskiene Anastasija Zuzo Valentina Liakina edita Kazenaite Ieva Stundiene Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVilnius TechVilnius 10223Lithuania

Inflammatory bowel disease(IBD)is a chronic condition that affects young individuals in their reproductive *** may have long-term implications on their reproductive,sexual,and mental *** has been related to menstrual ***,the administration of biological therapy can also result in gynecological issues in addition to the disease *** purpose of this review was to present potential menstrual cycle problems in patients with IBD,as well as the impact of adalimumab and other anti-tumor necrosis factor medications on gynecological pathology.

关键词： Menstrual disorders Inflammatory bowel disease Adalimumab Infliximab Anti-tumor necrosis factor-α

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Nivolumab-induced tumour-like gastritis:A case report

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World Journal of Clinical Cases 2023年第18期11卷 4350-4359页

作者： Elena Cijauskaite edita Kazenaite Sandra Strainiene Goda Sadauskaite Benediktas Kurlinkus Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Vilnius University Hospital Santaros Clinics Center of HepatologyGastroenterology and DietologyVilnius 08661Lithuania Department of Internal Medicine and Surgery Antakalnis ClinicVilnius 10207Lithuania

BACKGROUND Immune checkpoint inhibitors are one of the modern treatment methods for advanced ***,this group of medications is also associated with various immune-related adverse events,such as colitis or *** checkpoint inhibitor-induced gastritis is a less common adverse *** SUMMARY We describe a 64-year-old woman presenting with diarrhea,nausea,and discomfort in the upper abdominal *** patient had a history of metastatic lung cancer,which was treated with *** the first endoscopy,an infiltrating gastric tumour was ***,based on endoscopic,histological and radiological findings,nivolumab-induced gastritis was *** patient was successfully treated with three courses of *** As a consequence of the increased use of immune checkpoint inhibitors,a growing number of reported immune-related adverse events could be *** diagnosis of immune checkpoint inhibitor-induced gastritis should be considered when assessing a patient treated with nivolumab with upper gastrointestinal distress.

关键词： Nivolumab Immune checkpoint inhibitors Tumour-like gastritis Proton pump inhibitors Case report

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International visibility of Armenian domestic journals:the role of scientific diaspora

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数据与情报科学学报:英文版 2023年第2期8卷 93-117页

作者： edita Gzoyan Aram Mirzoyan Anush Sargsyan Mariam Yeghikyan Domenico AMaisano Shushanik Sargsyan Center for Scientific Information Analysis and Monitoring(CSIAM) Institute for Informatics and Automation ProblemsNational Academy of Sciences of the Republic of Armenia(IIAP NAS RA).1 Paruyr Sevak str.0014 YerevanArmenia Department of Management and Production Engineering(DIGEP) Politecnico di Torino(Italy)TurinItaly

Purpose:Nearly 122 scientific journals are currently being published in Armenia-of which only six are indexed by WoS and/or Scopus *** majority of the national journals are published in the Armenian language,solely possessing abstracts written in English,although there are also English-language and multi-language journals with articles not only in Armenian but also in other foreign *** aim of this article is to study the visibility of the(non-indexed)national Armenian journals in the WoS database through citation analy*** consideration of the existence of a relevant Armenian“diaspora”in the world,this article also attempts to estimate its impact in terms of citation ***/methodology/approach:For this end,we have identified citations to the national/domestic Armenian journals in the WoS database in comparison with the share of citations received from“diaspora”researchers(researchers of Armenian origin born in foreign countries and those originally from Armenia who have emigrated to foreign countries).Findings:Among the 116 Armenian domestic journals analyzed(not indexed by WoS),only 47 were found to be cited in *** these journals,almost 12%are citations by“diaspora”researchers,most of which concern Social Science and Humanities *** limitations:Although the surnames of Armenians end with-i(y)an,sometimes,the Diaspora Armenians,surnames are changed or modified or they are not ending with-i(y)an,in this case we may fail to identify *** implications:This study can help to build new,more deep and comprehensive relations with scientific ***/value:This study offers a new understanding of multifaced research collaboration with scientific diasporas and their role in internationalization of domestic journals.

关键词： Citation analysis National/domestic journal Armenian diaspora Scientific diaspora

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Gut microbiota contribution to hepatocellular carcinoma manifestation in non-alcoholic steatohepatitis

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World Journal of Hepatology 2022年第7期14卷 1277-1290页

作者： Valentina Liakina Sandra Strainiene Ieva Stundiene Vaidota Maksimaityte edita Kazenaite Centre of Hepatology Gastroenterology and DieteticsClinic of GastroenterologyNephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVilnius Gediminas Technical University(VILNIUS TECH)Vilnius 10223Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Therapeutic and Radiological Department Antakalnis PolyclinicVilnius 10207Lithuania Department of Pathology Forensic Medicine and PharmacologyInstitute of Biomedical SciencesFaculty of MedicineVilnius UniversityVilnius 01513Lithuania

Recently,the gut microbiota has been recognized as an obvious active player in addition to liver steatosis/steatohepatitis in the pathophysiological mechanisms of the development of hepatocellular carcinoma(HCC),even in the absence of *** from clinical and experimental studies shows the association of specific changes in the gut microbiome and the direct contribution to maintaining liver inflammation and/or cancerogenesis in nonalcoholic fatty liver disease-induced *** composition of the gut microbiota differs significantly in obese and lean individuals,especially in the abundance of pro-inflammatory lipopolysaccharide-producing phyla,and,after establishing steatohepatitis,it undergoes minor changes during the progression of the disease toward advanced *** studies proved that the microbiota of obese subjects can induce steatohepatitis in normally fed *** the contrary,the transplantation of healthy microbiota to obese mice relieves ***,further studies are needed to confirm these findings and the mechanisms *** this review,we have evaluated well-documented clinical and experimental research on the role of the gut microbiota in the manifestation and promotion of HCC in nonalcoholic steatohepatitis(NASH).Furthermore,a literature review of microbiota alterations and consequences of dysbiosis for the promotion of NASH-induced HCC was performed,and the advantages and limitations of the microbiota as an early marker of the diagnosis of HCC were discussed.

关键词： Gut microbiota Hepatocellular carcinoma Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Microbiome

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Effects of COVID-19 on the liver:The experience of a single center

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World Journal of Gastroenterology 2022年第39期28卷 5735-5749页

作者： Valentina Liakina Ieva Stundiene Gabriele Milaknyte Ramune Bytautiene Rosita Reivytyte Roma Puronaite Gintare Urbanoviciute edita Kazenaite Centre of Hepatology Gastroenterology and DieteticsClinic of GastroenterologyNephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVILNIUS TECHVilnius 10223Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Clinic of Cardiac and Vascular Diseases Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Institute of Data Science and Digital Technologies Faculty of Mathematics and InformaticsVilnius UniversityVilnius 01513Lithuania Department of Pathology Forensic Medicine and PharmacologyInstitute of Biomedical SciencesFaculty of MedicineVilnius UniversityVilnius 01513Lithuania

BACKGROUND The coronavirus disease 2019(COVID-19)was perhaps the most severe global health crisis in living *** respiratory symptoms,elevated liver enzymes,abnormal liver function,and even acute liver failure were reported in patients suffering from severe acute respiratory disease coronavirus 2 ***,the precise triggers of these forms of liver damage and how they affect the course and outcomes of COVID-19 itself remain *** To analyze the impact of liver enzyme abnormalities on the severity and outcomes of COVID-19 in hospitalized *** In this study,684 depersonalized medical records from patients hospitalized with COVID-19 during the 2020-2021 period were ***-19 was diagnosed according to the guidelines of the National Institutes of Health(2021).Patients were assigned to two groups:those with elevated liver enzymes(Group 1:603 patients),where at least one out of four liver enzymes were elevated(following the norm of hospital laboratory tests:alanine aminotransferase(ALT)≥40,aspartate aminotransferase(AST)≥40,gamma-glutamyl transferase≥36,or alkaline phosphatase≥150)at any point of hospitalization,from admission to discharge;and the control group(Group 2:81 patients),with normal liver enzymes during ***-19 severity was assessed according to the interim World Health Organization guidance(2022).Data on viral pneumonia complications,laboratory tests,and underlying diseases were also collected and *** In total,603(88.2%)patients produced abnormal liver test *** and AST levels were elevated by a factor of less than 3 in 54.9%and 74.8%of cases with increased enzyme levels,*** in Group 1 had almost double the chance of bacterial viral pneumonia complications[odds ratio(OR)=1.73,P=0.0217],required oxygen supply more often,and displayed higher biochemical inflammation indices than those in Group *** differences in other COVID-19 complications or underlying disea

关键词： COVID-19 SARS-CoV-2 Liver enzymes Complications Underlying disease Disease severity

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Crohn’s disease in human immunodeficiency virus-infected patient:A case report

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World Journal of Clinical Cases 2023年第17期11卷 4202-4209页

作者： Ausra Vinikaite Benediktas Kurlinkus Dominyka Jasinskaite Sandra Strainiene Audrone Buineviciute Goda Sadauskaite Vytautas Kiudelis edita Kazenaite Lithuanian University of Health Sciences Faculty of MedicineKaunas 44307Lithuania Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Center of Hepatology Gastroenterology and DietologyVilnius University Hospital Santaros ClinicsVilnius 08661Lithuania Department of Internal Medicine and Surgery Antakalnis ClinicVilnius 10207Lithuania Department of Gastroenterology Lithuanian University of Health SciencesKaunas 44307Lithuania

BACKGROUND Inflammatory bowel disease(IBD)is an autoimmune condition treated with immunosuppressive ***,the need for immune system suppression becomes questionable when infection with the human immunodeficiency virus(HIV)occurs simultaneously and impacts the course of *** reported case represents the clinical course,prescribed treatment and its effect,as well as clinical challenges faced by physicians in a combination of such *** also present a comprehensive literature review of similar *** SUMMARY A 49-year-old woman suffering from a newly diagnosed Crohn’s disease was hospitalized due to exacerbated symptoms(abdominal pain,fever,and weight loss).During her hospital stay,she tested positive for *** conservative treatment,the patient improved and was *** the outpatient clinic,her HIV infection was confirmed as stage C3,and antiretroviral treatment was initiated *** notwithstanding,soon the patient was rehospitalized with pulmonary embolism and developed a series of complications because of the subsequent coexistence of IBD and *** intensive and meticulous treatment,the patient’s condition has improved and she remains in *** The paucity of studies and data on the coexistence of HIV and IBD leaves clinicians doubting the optimal treatment options.

关键词： Crohn’s disease Inflammatory bowel disease Human immunodeficiency virus Immunocompromised patient Case report

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Metastatic multifocal melanoma of multiple organ systems:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10136-10145页

作者： Vaidota Maksimaityte Rosita Reivytyte Gabriele Milaknyte Ugnius Mickys Gintare Razanskiene Domantas Stundys edita Kazenaite Jonas Valantinas Ieva Stundiene Institute of Clinical Medicine Faculty of MedicineVilnius UniversityVilnius 01513Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Institute of Biomedical Sciences Faculty of MedicineVilnius UniversityVilnius 01513Lithuania

BACKGROUND Malignant melanoma is becoming more common among middle-aged individuals all over the *** metastasis can be found in various organs,although metastases to the spleen and stomach are *** we present a rare metastatic multifocal melanoma,clinically and histologically mimicking lymphoma,with metastases of multiple *** SUMMARY A 46-year-old Caucasian male with a history of nodular cutaneous malignant melanoma was presented with nausea,general weakness,shortness of breath,abdominal enlargement,and night *** abdominal ultrasound revealed enlarged liver and spleen with multiple *** tomography demonstrated multiple lesions in the lungs,liver,spleen,subcutaneous tissue,bones and a pathological lymphadenopathy of the *** biopsy and the biopsy from the enlarged lymph node were *** cells showed diffuse or partial positivity for melanocytic markers,such as microphthalmia-associated transcription factor,S100,HMB45 and *** tumor harbored BRAF V600E mutation,demonstrated by immunohistochemical labelling for BRAF V600E and detected by real-time polymerase chain reaction *** combined all the findings,a diagnosis was made of a metastatic multifocal melanoma of the stomach,duodenum,liver,spleen,lungs,lymph nodes and *** patient refused treatment and died a week *** This case report highlights the clinical relevance of rare metastatic multifocal melanoma of multiple organ systems.

关键词： Metastatic melanoma Gastrointestinal tract Nodular Multifocal BRAF V600E Case report

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A randomized retrospective clinical study on the choice between endodontic surgery and immediate implantation

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Frigid Zone Medicine 2022年第2期2卷 90-93页

作者： Garegin Movsesyan edita Margaryan Marianna Arakelyan Mikhail Stepanov Training and Clinical Center«FODERIS» Moscow 121467Russia Department of Therapeutic Dentistry Institute of DentistryI.M.SechenovFirst Moscow State Medical University(Sechenov University)Moscow 119991Russia Department of Surgical Dentistry I.M.Sechenov Institute of DentistryFirst Moscow State Medical University(Sechenov University)Moscow 119991Russia

Background:Periapical endodontic surgery(PES)for root amputation and tooth replacement by immediate implant placement are two possible treatment options for bone lesions in the root apex of a tooth that has previously undergone endodontic *** methods are performed when the effectiveness of orthograde canal revision is questionable or when such treatment cannot be *** effectiveness of these methods varies from study to ***:clinical evaluation of the efficacy of periapical endodontic surgery for root amputation and immediate implant placement with simultaneous tooth extraction in the proximate and long-term *** and methods:The study included 183 patients between the ages of 24 and *** were divided into 2 groups;group I-endodontic surgery was performed to resect the apex of the tooth root(108 patients)and group II-an operation to install an implant with simultaneous tooth extraction(75 patients).In group I,in 36 cases,PES was performed in the area of the first molars and premolars,and 72 cases in the area of incisors and *** group II,75 patients received 231 ***:In all 108 patients of group I in the postoperative period and within 1 month,the wounds healed without *** none of the 36 operated premolars and molars,there was no definitive elimination of the radiographic bone loss(Rude grade 2 and 3)after 12 *** the area of incisors and canines,complete healing was observed only in 37.5%of cases(I class according to Rud).In group II,out of 184 implants installed immediately after tooth extraction,one was removed one month after *** other cases,all implants were successfully integrated with the subsequent fabrication of prosthetic ***:The complex“implant(installed in the socket of the tooth immediately after its removal)-bone-soft tissues-prosthetic construction”is stable over time in terms of functional and aesthetic parameters,preservation o

关键词： periapical pathological lesion immediate implantation delayed implantation apicoectomy endodontic surgery

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Scientometric Implosion that Leads to Explosion: Case Study of Armenian Journals

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Journal of Data and Information Science 2020年第3期5卷 187-196页

作者： Shushanik Sargsyan edita Gzoyan Aram Mirzoyan Viktor Blaginin Center for Scientific Information Analysis and Monitoring(CSIAM) Institute for Informatics and Automation ProblemsNational Academy of Sciences of the Republic of Armenia(IIAP NAS RA)0014 YerevanArmenia Yerevan State Medical University after Mkhitar Heratsi Medical Physics Department0025 YerevanArmenia Center on Scientometrics and Ranking Researches.Ural State University of Economics 620014 YekaterinburgRussia

Purpose: The purpose of this study is to introduce a new concept and term into the scientometric discourse and research—scientometric implosion—and test the idea on the example of the Armenian journals. The article argues that the existence of a compressed scientific area in the country makes pressure on the journals and after some time this pressure makes one or several journals explode—break the limited national scientific area and move to the international arena. As soon as one of the local journals breaks through this compressed space and appears at an international level, further explosion happens, which makes the other journals follow the same ***/methodology/approach: Our research is based on three international scientific databases—WoS, Scopus, and RISC CC, from where we have retrieved information about the Armenian journals indexed there and citations received by those journals and one national database—the Armenian Science Citation Index. Armenian Journal Impact Factor(ArmJIF) was calculated for the local Armenian journals based on the general impact factor formula. Journals were classified according to Gl?nzel and Schubert(2003). Findings: Our results show that the science policy developed by the scientific authorities of Armenia and the introduction of ArmJIF have made the Armenian journals comply with international standards and resulted in some local journals to break the national scientific territory and be indexed in international scientific databases of RISC, Scopus, and WoS. Apart from complying with technical requirements, the journals start publishing articles also in foreign languages. Although nearly half of the local journals are in the fields of social sciences and humanities, only one journal from that field is indexed in international scientific databases. Research limitation: One of the limitations of the study is that it was performed on the example of only one state and the second one is that more time passage is needed to firmly

关键词： Sceintometric implosion Armenian Journal Impact Factor(ArmJIF) National scientific databases Armenian Science Citation Index(ASCI) International scientific databases

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