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Usefulness of coronary flow reserve measured by transthoracic coronary Doppler ultrasound in the elderly

Journal of Geriatric Cardiology 2017年第7期14卷 436-441页

作者： Danijela Trifunovic edina cenko Concetta Torromeo Beatrice Ricci Michele Schiariti Marija Zdravkovic Zorana Vasiljevic Olivia Manfrini Department of Cardiology University Clinical Center of Serbia Belgrade Serbia School of Medicine University of Belgrade Belgrade Serbia Department of Experimental Diagnostics and Specialty Medicine University of Bologna Bologna Italy Department of Cardiovascular Respiratory Nephrological Anesthesiological and Geriatric Sciences Sapienza University of Rome Italy Department of Cardiology University Hospital Medical Center "Bezanijska kosa" Belgrade Serbia

The left anterior descending (LAD) coronary artery is the main vessel of human coronary circulation, and life-threatening consequences are seen when flow in this area is impaired Noninvasive measurement of coronary flow reserve (CFR),defined as the ratio of maximal to baseline coronary blood flow, has been repeatedly shown to be a feasible technique by ultrasound transthoracic Doppler (TTD) both in the LAD and, with some limitations, in the posterior descending (PD) coronary artery. CFR by TTD offers two important pieces of information: information about patency and flow through the large epicardial coronary artery proximal to the site of CFR assessment and information about the functional integrity of coronary microcirculation distal to the site of CFR assessment. CFR by TTD is a valuable research tool for investigating the pathophysiology of coronary circulation. However, CFR by TTD is also an important clinical decision-making instrument, enabling functional assessment of epicardial coronary stenosis, particularly in cases of anatomically borderline stenosis, i.e., 50%-70% of cases. CFR by TTD enables insight downstream into coronary microvascular function that might be impaired due to primary coronary microvascular disease, as a consequence of myocardial diseases with extramural compression and microvascular remodeling and rarefaction (in left ventricular hypertrophy, dilated or hypertrophic cardiomyopathy, or aortic stenosis), or as a consequence of microvascular obstruction due to micro-embolization by plaque and thrombus debris during percutaneous coronary interventions.

关键词：冠状动脉多普勒超声血流量老年人应用储备多普勒技术 LAD

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Hepatitis B virus infection and hepatocellular carcinoma in sub- Saharan Africa: Implications for elimination of viral hepatitis by 2030?

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World Journal of Gastroenterology 2021年第36期27卷 6025-6038页

作者： edina Amponsah-Dacosta Vaccines for Africa Initiative School of Public Health and Family MedicineUniversity of Cape TownCape Town 7925Western CapeSouth Africa

Elimination of viral hepatitis in sub-Saharan Africa by 2030 is an ambitious ***,as stated by the World Health Organization,there are unprecedented opportunities to act and make significant contributions to the elimination *** 60 million people chronically infected with hepatitis B virus(HBV)of whom 38800 are at risk of developing highly fatal hepatocellular carcinoma(HCC)every year,sub-Saharan Africa faces one of the greatest battles towards elimination of viral *** is a need to examine progress in controlling the disproportionate burden of HBV-associated HCC in sub-Saharan Africa within the context of this elimination *** scaling-up coverage of hepatitis B birth dose and early childhood vaccination,we can significantly reduce new cases of HCC by as much as 50%within the next three to five *** the substantial reservoir of chronic HBV carriers however,projections show that HCC incidence and mortality rates in sub-Saharan Africa will double by *** warrants urgent public health *** trends in the burden of HCC over the next two decades,will be determined to a large extent by progress in achieving early diagnosis and appropriate linkage to care for high-risk chronic HBV infected persons.

关键词： Hepatitis B virus Viral hepatitis,Hepatocellular Carcinoma Elimination Human Immunodeficiency Virus Sub-Saharan Africa

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Solubilization of 2-Acetoxy-Benzencarboxylic Acid Using Beta Cyclodextrins

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Open Journal of Applied Sciences 2023年第11期13卷 1982-1995页

作者： Melita Huremovic edina Huseinovic Majda Srabovic Benjamin Catovic Emir Horozic Faculty of Natural Sciences and Mathematics University of Tuzla Tuzla Bosnia and Herzegovina Faculty of Technology University of Tuzla Tuzla Bosnia and Herzegovina

2-acetoxy-benzencarboxylic acid is one of the most famous salicylate drugs today, a pharmaceutically active compound known as aspirin. It is poorly soluble in water which results in decreased bioavailability of the drug in the organism. The increase in water solubility of insoluble or poorly soluble drugs is therefore of great importance, which is the aim of this study. Inclusion of the drug in the molecule with a higher water solubility significantly increases its solubility and biological availability. Natural and hydrophilic derivatives of natural cyclodextrins are in the spotlight for their role as solubilizing excipients. Studies indicate that the use of β-cyclodextrin inclusion complexes with acetylsalicylic acid formed, increases the solubility of the drug in water. Many advantages of drug-complexation with cyclodextrins have been reported in scientific literature which includes increased solubility, enhanced bioavailability, improved stability, masking of bad test or odour, reduced side effect. Orally administered aspirin requires high and frequent dosing because it undergoes extensive pre systematic metabolism. Also chronic oral aspirin use is associated with serious gastrointestinal side-effects. Complexation with CD alleviates the side effects to some extent. The bioavailability and solubility of aspirin has to be increased to overcome the side-effects of aspirin related to stomach and gastro intestinal tract. The phase solubility study was performed according to the method of Higuchi and Connors by adding the 2-acetoxi-benzencarboxylic acid in excess to different concentrations of different beta cyclodextrins solutions. Phase solubility study records shown that the stability constant and complex stoichiometry of 2-acetoxi-benzencarboxylic acid-CD complexes gives linearly improve with the concentration of CD. Complexes were analyzed by UV-VIS spectroscopy and were characterized by infrared spectroscopy.

关键词： 2-Acetoxi-Benzencarboxylic Acid Water Solubility Cyclodextrin Inclusion Complexes

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Factors Facilitating Adherence to Recommended Lifestyle-Modification amongst Hypertensive Clients at Malamulo Hospital, Thyolo, Malawi

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Journal of Biosciences and Medicines 2022年第5期10卷 191-205页

作者： Ndaona Chitani Mandayachepa Nyando Mary Miston Mbeba edina Taziona N. Kholowa School of Nursing Adult Health Department Kamuzu University of Health Sciences Lilongwe Malawi Nursing and Midwifery Department Malamulo College of Health Sciences Malawi Adventist University Thyolo Malawi

Background: Adherence to recommended lifestyle modification regarding hypertension control remains a serious problem in Malawi, leading to poor blood pressure control. Objective: This study examined factors that facilitate adherence to recommended lifestyle modification among hypertensive clients’ at Malamulo hospital in Thyolo Malawi. Methods: A descriptive cross-sectional quantitative study was conducted with 108 clients who were recruited through a systematic sampling method. Data were collected through face-to-face interviews using a pre-tested structured questionnaire. Using statistical Packages for Social Sciences (SPSS) version 22, Chi-Square (x2) test was applied to test each predictor variable for statistical significance. The significant predictors were entered into the logistic regression model to determine the independent predictors of recommended lifestyle modifications amongst clients. Odds ratio (OR) at 95% Confidence Interval (CI) was used to declare the independent effect of each variable on the outcome variable. Results: 108 respondents were enrolled in the study, the majority of who were women (60.2%). Findings demonstrated that clients had adequate knowledge of lifestyle modification with an overall knowledge rate of 92% though the overall adherence rate was poor at 53.8%. Having family support (OR = 4.587, 95% CI: 1.625, 12.947, p = 0.004) and support groups (OR = 4.043, 95% CI: 1.496, 10.926, p = 0.006) are more likely to facilitate adherence to recommended lifestyle modification unlike situations of non-involvement of family and lack of support groups. Conclusion: Clients demonstrated adequate knowledge of recommended lifestyle modifications with poor adherence to them. The presence of support groups and a strong family support system are important factors for fostering adherence to the recommended lifestyle modifications regarding hypertension control.

关键词： Adherence Lifestyle Modification Hypertension Non-Communicable Diseases

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One in four patients with gastrointestinal bleeding develops shock or hemodynamic instability:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第28期29卷 4466-4480页

作者： Mahmoud Obeidat Brigitta Teutsch Anett Rancz edina Tari Katalin Márta Dániel Sándor Veres Nóra Hosszúfalusi Emese Mihály Péter Hegyi Bálint Erőss Centre for Translational Medicine Semmelweis UniversityBudapest 1085Hungary Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7623Hungary Department of Internal Medicine and Hematology Semmelweis UniversityFaculty of MedicineBudapest 1085Hungary Institute of Pancreatic Diseases Semmelweis UniversityBudapest 1083Hungary Department of Biophysics and Radiation Biology Semmelweis UniversityBudapest 1085Hungary

BACKGROUND Hemodynamic instability and shock are associated with untoward outcomes in gastrointestinal ***,there are no studies in the existing literature on the proportion of patients who developed these outcomes after gastrointestinal *** To determine the pooled event rates in the available literature and specify them based on the bleeding *** The protocol was registered on PROSPERO in advance(CRD42021283258).A systematic search was performed in three databases(PubMed,EMBASE,and CENTRAL)on 14^(th) October *** proportions with 95%CI were calculated with a random-effects model.A subgroup analysis was carried out based on the time of assessment(on admission or during hospital stay).Heterogeneity was assessed by Higgins and Thompson’s I^(2) *** Joanna Briggs Institute Prevalence Critical Appraisal Tool was used for the risk of bias *** Reference Citation Analysis(https://***/)tool was applied to obtain the latest highlight *** We identified 11589 records,of which 220 studies were eligible for data *** overall proportion of shock and hemodynamic instability in general gastrointestinal bleeding patients was 0.25(95%CI:0.17-0.36,I^(2)=100%).In non-variceal bleeding,the proportion was 0.22(95%CI:0.14-0.31,I^(2)=100%),whereas it was 0.25(95%CI:0.19-0.32,I^(2)=100%)in variceal *** proportion of patients with colonic diverticular bleeding who developed shock or hemodynamic instability was 0.12(95%CI:0.06-0.22,I^(2)=90%).The risk of bias was low,and heterogeneity was high in all *** One in five,one in four,and one in eight patients develops shock or hemodynamic instability on admission or during hospitalization in the case of non-variceal,variceal,and colonic diverticular bleeding,respectively.

关键词： Gastrointestinal bleeding Hemodynamic instability Shock Meta-analysis Statistics Review

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Mechanisms of vascularization in murine models of primary and metastatic tumor growth

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Chinese Journal of Cancer 2016年第2期35卷 80-87页

作者： edina Bugyik Ferenc Renyi-Vamos Vanessza Szabo Katalin Dezso Nora Ecker Andras Rokusz Peter Nagy Balazs Dome Sandor Paku 1 st Department of Pathology and Experimental Cancer Research Semmelweis University Department of Thoracic Surgery Semmelweis University-National Institute of Oncology Hungarian Academy of Sciences Postdoctoral Research Programme Department of Thoracic Surgery Medical University of Vienna Department of Biomedical Imaging and Image-guided Therapy Medical University of Vienna Tumor Progression Research Group Joint Research Organization of the Hungarian Academy of Sciences and Semmelweis University

Directed capillary ingrowth has long been considered synonymous with tumor ***,the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting;instead,malignant tumors can acquire blood vessels via alternative vascularization mechanisms,such as intussusceptive microvascular growth,vessel co-option,and glomeruloid ***,in response to anti-angiogenic therapies,malignant tumors can switch from one vascularization mechanism to *** this article,we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.

关键词： Vascularization, Primary tumor, Metastasis, Angiogenesis

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Short-term effects of cleaning-respacing in a silver fir-dominated stand in Romania

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Journal of Forestry Research 2018年第6期29卷 1591-1599页

作者： Valeriu-Norocel Nicolescu Cornelia Hernea Diana-Cristina Simon3 Matei-Nicolae Ciolan Monica-Elena Barti Hendrik Schubert edina Borbely Faculty of Silviculture and Forest Engineering Transylvania University of Brasov.irul Beethoven 1500123 BrasovRomania Faculty of Horticulture and Forestry Banat’s University of Agricultural Sciences and Veterinary Medicine“King Michael I of Romania”from Timi.oaraCalea Aradului 119300645 Timi.oaraRomania Barzava Forest District 317030 BarzavaAradRomania LIGNUM Forest District 605300 DarmanestiBacauRomania

This paper discusses the early silviculture of silver fir(Abies alba Mill.), a major softwood in Romania covering more than 294,000 ha. Three research plots(DRP1, DRP2 and DRP3) were established in a 25-year-old silver fir-dominated stand in May 2012. In DRP1 and DRP2, heavy cleaning-respacing were carried out while DRP3 was kept as a control. After the treatments in 2012,the plots had stocking between 1470 trees ha-1(DRP2) and10,030 trees ha-1(DRP3), basal areas between11.8 m2ha-1(DRP2) and 31.6 m2ha-1(DRP3). The average diameters were between 5.7 cm(DRP3) and 9.6 cm(DRP2). Measurements in September 2016 confirmed the rapid response of silver fir to *** best results in average diameter increments and basal area between 2012 and 2016 were in DRP2: 3.7 cm(36.4%) and 7.7 m2ha-1(85.0%) respectively. The largest diameter trees in 2012 were the best growers, and a strong linear correlation between the initial diameter of the remaining trees and their increment was established. Natural dieback of trees occurred only in DRP3(8.6%). The selection of crop trees based on the vigour, quality, and spacing criteria during cleaning-respacing was possible as individuals stood out in terms of vigour and early diameter growth. An issue encountered in DRP1 and DRP2 was the occurrence of epicormic shoots, especially on less vigorous individuals with small crowns. However, four years after cleaning-respacing, these branches are small and do not significantly affect the wood quality.

关键词： Abies alba Tending operations Stocking Basal area Increment

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Salt Stress Triggers Phosphorylation of the Arabidopsis Vacuolar K＋ Channel TPK1 by Calcium-Dependent Protein Kinases （CDPKs）

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Molecular Plant 2013年第4期6卷 1274-1289页

作者： Andreas Latz Norbert Mehlmer Simone Zapf Thomas D. Mueller Bernhard Wurzinger Barbara Pfister edina Csaszar Rainer Hedrich Markus Teige Dirk Becker Department of Molecular Plant Physiology and Biophysics Julius-von-Sachs-lnstitute University of Wurzburg Julius-von-Sachs-Platz 2 D-97082 Wurzburg Germany Department of Biochemistry and Cell Biology Max F. Perutz Laboratories University of Vienna Dr. Bohrgasse 9 A-1030 Vienna Austria Present address: Department of Biology I Botany Munich Center for Integrated Protein Science CiPSM Ludwig-Maximilians-Universitat Munchen D-82152 Planegg-Martinsried Germany College of Science King Saud University Riyadh 11451 Saudi Arabia

14-3-3 proteins play an important role in the regulation of many cellular processes. The Arabidopsis vacuolar two-pore K＋ channel 1 （TPK1） interacts with the 14-3-3 protein GRF6 （GF14-λ）. Upon phosphorylation of the putative binding motif in the N-terminus of TPK1, GRF6 binds to TPK1 and activates the potassium channel. In order to gain a deeper understanding of this 14-3-3-mediated signal transduction, we set out to identify the respective kinases, which regulate the phosphorylation status of the 14-3-3 binding motif in TPK1. Here, we report that the calcium-dependent protein kinases （CDPKs） can phosphorylate and thereby activate the 14-3-3 binding motif in TPK1. Focusing on the stress-activated kinase CPK3, we visualized direct and specific interaction of TPK1 with the kinase at the tonoplast in vivo. In line with its proposed role in K＋ homeostasis, TPK1 phosphorylation was found to be induced by salt stress in planta, and both cpk3 and tpkl mutants displayed salt-sensitive phenotypes. Molecular modeling of the TPK1-CPK3 interaction domain provided mechanistic insights into TPK1 stress-regulated phosphorylation responses and pinpointed two arginine residues in the N-terminal 14-3-3 binding motif in TPK1 critical for kinase interaction. Taken together, our studies provide evidence for an essential role of the vacuolar potassium channel TPK1 in salt-stress adaptation as a target of calcium-regulated stress signaling pathways involving Ca2＋, Ca2＋-dependent kinases, and 14-3-3 proteins.

关键词： potassium channel vacuole calcium calcium-dependent kinase 14-3-3 protein salt stress.

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Modeling Chemical Reactions in Enzymes and Solution with Proper Sampling:Using the Constrained DFT Approach in Generating Diabatic Surfaces

Modeling Chemical Reactions in Enzymes and Solution with Pro...

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中国化学会第九届全国量子化学学术会议

作者： edina Rosta Arieh Warshel Department of Chemistry University of Southern California CA 90007USA Department of Chemistry University of Southern California CA 90007USA

＜正＞Modeling reactions in enzymes and solution have remained a major challenge for theoretical chemistry. One of the main problems has been associated with the difficulties of obtaining an appropriate sampling, which is essential for proper free energy calculations. The Empirical valence bond （EVB） method has been shown to provide significant advantages over other methods in

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Chronic hepatitis B-associated liver disease in the context of human immunodeficiency virus co-infection and underlying metabolic syndrome

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World Journal of Virology 2020年第5期9卷 54-66页

作者： edina Amponsah-Dacosta Cynthia Tamandjou Tchuem Motswedi Anderson Vaccines for Africa Initiative School of Public Health and Family MedicineUniversity of Cape TownCape Town 7925Western CapeSouth Africa Health Economics Unit School of Public Health and Family MedicineUniversity of Cape TownCape Town 7925Western CapeSouth Africa Botswana Harvard AIDS Institute Partnership GaboroneBotswana

Globally,a shift in the epidemiology of chronic liver disease has been *** has been mainly driven by a marked decline in the prevalence of chronic hepatitis B virus infection(CHB),with the greatest burden restricted to the Western Pacific and sub-Saharan African *** this is a growing burden of metabolic syndrome(MetS)worldwide.A disproportionate co-burden of human immunodeficiency virus(HIV)infection is also reported in sub-Saharan Africa,which poses a further risk of liver-related morbidity and mortality in the *** reviewed the existing evidence base to improve current understanding of the effect of underlying MetS on the development and progression of chronic liver disease during CHB and HIV *** the mechanistic association between CHB and MetS remains poorly resolved,the evidence suggests that MetS may have an additive effect on the liver damage caused by *** HIV infected individuals,MetS-associated liver disease is emerging as an important cause of non-AIDS related morbidity and mortality despite antiretroviral therapy(ART).It is plausible that underlying MetS may lead to adverse outcomes among those with concomitant CHB and HIV ***,this remains to be explored through rigorous longitudinal studies,especially in sub-Saharan ***,there is a need for a comprehensive package of care that integrates ART programs with routine screening for MetS and promotion of lifestyle modification to ensure an improved quality of life among CHB and HIV coinfected individuals.

关键词： Hepatitis B virus Human immunodeficiency virus Metabolic syndrome Fatty liver disease Chronic liver disease Sub-Sharan Africa

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