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Association of TNFA(-308G/A),IFNG(+874 A/T)and IL-10(-819 C/T)polymorphisms with protection and susceptibility to dengue in Brazilian population

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1065-1071页

作者： Ana Caroline Melo dos Santos edilson leite de moura Jean Moises Ferreira Alexandre Wendell Araujo de moura Ailson Darlan Sales Ferreira Rubens Pereira Bezerra Diego de Siqueira Figueiredo Karol Fireman de Farias Tiago Gomes de Andrade Elaine Virginia Martins de Souza Figueiredo Molecular Biology and Gene Expression Laboratory Federal University of AlagoasCampus ArapiracaAv Manoel Severino BarbosaBom SucessoArapiracaAL57309-005Brazil Faculty of Medicine Federal University of AlagoasCampus AC SimoesTabuleiro dos MartinsMaceioAlagoasBrazil

Objective: To evaluate gene polymorphisms and their association with susceptibility to ***: A retrospective case-control study was performed with 262 subjects,comprising 78 dengue fever(DF) patients, 49 dengue hemorrhagic fever(DHF) patients and 135 healthy controls. Genotypic and allelic profiles were identified using polymerase chain reaction based in real time and amplification-refractory mutation ***: We observed a protective association of IL-10(-819 C/T) C allele(P = 0.028,OR = 0.56, CI = 0.34–0.91) against DHF, while the C/T(P = 0.047, OR = 2.10,CI = 1.01–4.38) and T/T(P = 0.008, OR = 3.82, CI = 1.38–10.59) genotypes were associated with DHF and DF, respectively. The dominant model TNFA-308 GA + AA(P = 0.043, OR = 0.45, CI = 0.20–1.00) genotypes were found to have protective effect against dengue infection. A protective association among the IFNG(+874 A/T) A/T genotype against DF(P = 0.02, OR = 0.46, CI = 0.24–0.89) and DHF(P = 0.034,OR = 0.43, CI = 0.19–0.95) was observed. When the studied single-nucleotide polymorphism was analyzed in combination, the combination GTA(P = 0.022, OR = 2.95,CI = 1.18–7.41) was statistically significantly associated with susceptibility to DF and the combination GCT(P = 0.035, OR = 0.28, CI = 0.08–0.90) with protection against the development of ***: This research identifies the association of the IFNG(+874 A/T), TNFA(-308 G/A), IL-10(-819 C/T) genotypes as a factor for protection, susceptibility and severity to dengue.

关键词： Immune system IFNG TNFA IL-10 dengue Polymorphism

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T10 Test as an Alternative Method to Assess Critical Speed and its Potential Application to Runners

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Journal of Science in Sport and Exercise 2023年第4期5卷 369-377页

作者： edilson Fernando de Borba Lucio Follador Sara Crosatti Barbosa Marcus Peikriszwili Tartaruga Sergio Gregorio da Silva Postgraduate Program in Physical Education Federal University of ParanáCuritibaBrazi

Exercise intensity is usually prescribed based on a metabolic marker,such as maximum oxygen uptake or maximal lactate steady *** markers,however,face some difficulties regarding their practical applicability to the general *** critical speed emerges as an alternative parameter to determine aerobic exercise intensities through maximal tests using ergometers or field tests,demanding few *** evaluated the fidelity of test to predict critical speed and if this parameter could be used to prescribe intensity in aerobic *** hundred recreational runners performed the T10 test and a conventional critical speed test to define running *** of them,44 runners proceed continuous and interval *** critical speed assessed from T10 test was then compared to critical speed measured by three maximal runs in the track field(1200 m,2400 m,and 3600 m).We found a strong correlation(r=0.91)and did not find statistical differences(t=1.8,P=0.90)between critical speed assessed by T10(3.89±0.49 m/s)and field-test(3.85±0.51 m/s).T10 is also better associated with running and interval running speeds than metabolic markers.T10 test can be used as a valid alternative method to assess critical speed and to prescribe runs.

关键词： Critical velocity Exercise intensity domains Race Running Interval aerobic training

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Preprocessing of 2-Dimensional Gel Electrophoresis Images Applied to Proteomic Analysis： A Review

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Genomics, Proteomics & Bioinformatics 2018年第1期16卷 63-72页

作者： Manuel Mauricio Goez Maria Constanza Torres-Madronero Sarah Rothlisberger edilson delgado-Trejos Automatics Electronics and Computer Science Research Group Faculty of Engineering Instituto Tecnologico Metropolitano Medellin 050012 Colombia Biomedical Innovation and Research Group Faculty of Applied and Exact Sciences lnstituto Tecnologico Metropolitano Medellin 050012 Colombia Quality Metrology and Production Research Group Faculty of Economic and Management Sciences Instituto Tecnologico Metropolitano Medellin 050012 Colombia

Various methods and specialized software programs are available for processing two- dimensional gel electrophoresis （2-DGE） images. However, due to the anomalies present in these images, a reliable, automated, and highly reproducible system for 2-DGE image analysis has still not been achieved. The most common anomalies found in 2-DGE images include vertical and hor- izontal streaking, fuzzy spots, and background noise, which greatly complicate computational anal- ysis. In this paper, we review the preprocessing techniques applied to 2-DGE images for noise reduction, intensity normalization, and background correction. We also present a quantitative comparison of non-linear filtering techniques applied to synthetic gel images, through analyzing the performance of the filters under specific conditions. Synthetic proteins were modeled into a two-dimensional Gaussian distribution with adjustable parameters for changing the size, intensity, and degradation. Three types of noise were added to the images： Gaussian, Rayleigh, and exponen- tial, with signal-to-noise ratios （SNRs） ranging 8-20 decibels （dB）. We compared the performanceof wavelet, contourlet, total variation （TV）, and wavelet-total variation （WTTV） techniques using parameters SNR and spot efficiency. In terms of spot efficiency, contourlet and TV were more sen- sitive to noise than wavelet and WTTV. Wavelet worked the best for images with SNR ranging 10- 20 dB, whereas WTTV performed better with high noise levels. Wavelet also presented the best per- formance with any level of Gaussian noise and low levels （20-14 dB） of Rayleigh and exponential noise in terms of SNR. Finally, the performance of the non-linear filtering techniques was evaluated using a real 2-DGE image with previously identified proteins marked. Wavelet achieved the best detection rate for the real image.

关键词： Background correction Filtering Noise reduction Preprocessing 2D gel electrophoresis

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Polyphenolic composition, antibacterial, modulator and neuroprotective activity of Tarenaya spinosa(Jacq.) Raf.(Cleomaceae)

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Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 12-17页

作者： Francisca Samara Muniz dos Santos Jose Weverton Almeida Bezerra Jean Paul Kamdem Aline Augusti Boligon Marli Matiko Anraku Ana Raquel Pereira da Silva Kleber Ribeiro Fidelis Nadghia Figueiredo leite Antonio Ivanildo Pinho Henrique Douglas Melo Coutinho Jose edilson Goncalves dos Santos Microscopy Laboratory Regional University of Cariri (URCA) Program Post graduate in Plant Biology (UFPE) Phytochemical Laboratory Department of Industrial Pharmacy Federal University of Santa Maria (UFSM) Microbiology and Molecular Biology Laboratory Regional University of Cariri (URCA)

Objective: To evaluate the antibacterial activity and neuroprotective capacity of the ethanolic and aqueous extracts of Tarenaya spinosa(T. spinosa) as well as to determine and quantify some of its polyphenols by high performance liquid chromatography with diode-array detection(HPLC-DAD). Methods: The bacterial Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa strains, grown in Heart Agar Infusion, were tested. The drugs gentamicin, norfloxacin and imipenem were used to evaluate the modulating or antagonistic capacity of the T. spinosa extracts. The extract was analysed by HPLC-DAD to determine the main phenolic compounds. For the cell viability tests, individual heads of the Nauphoeta cinerea arthropod model were removed, homogenized in Trifluoromethyl ketone and centrifuged afterwards. Subsequently, 20 μL of NaN O2 were added to the biological material, except in the control group, to evaluate the protection capacity of the extracts. The homogenate of the insect heads was incubated for 2 h in tubes containing tetrazolium bromide. Results: HPLC-DAD demonstrated that the ethanolic extract of T. spinosa presented caffeic acid as the major compound. The ethanolic extract also showed neuroprotective effects at concentrations ≥ 10 μg/mL, while aqueous extract was shown to have a protective effect only at the concentration of 100 μg/mL. The aqueous extract demonstrated a clinically relevant antibacterial activity against the Staphylococcus aureus multidrug resistant strain-MDR, with MIC 512 μg/m L. However, when the extracts were associated with gentamicin and imipenem, a synergism was detected against Staphylococcus aureus and Escherichia coli MDR strains. Conclusions: Although it does not present an antibacterial action, the extracts of T. spinosa can be used in the pharmaceutical industries since its extracts show modulating action of drugs. Besides, these natural products have neuroprotective capacity.

关键词： Tarenaya spinosa Cleome spinose Nauphoeta cinerea Synergism Antibiotic resistance

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The Tesistan, Mexico earthquake (M_w 4.9) of 11 May 2016: seismic-tectonic environment and resonance vulnerability on buildings

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Earthquake Engineering and Engineering Vibration 2019年第3期18卷 579-595页

作者： Alejandro Ramírez-Gaytán Adolfo Preciado William L. Bandy edilson F. Salazar-Monroy Miguel A. Jaimes Leonardo Alcantara departamento de Ciencias Computacionales Centro Universitario de Ciencias Exactas e Ingeniería Universidad de Guadalajara Boulevard Marcelino García Barragán # 1421 44430 Guadalajara Jalisco México departamento del Hábitat y desarrollo Urbano Instituto Tecnológico y de Estudios Superiores de Occidente (ITESO). Periférico Sur Manuel Gómez Morin 8585 45604 Tlaquepaque Jalisco México Instituto de Geofísica Universidad Nacional Autónoma de México Circuito Interior Ciudad Universitaria Del. Coyoacán 04510 México Programa de Posgrado en Ciencias de la Tierra Universidad Nacional Autó noma de Mé xico Circuito Interior Ciudad Universitaria Del. Coyoacá n 04510 Mé xico Instituto de Ingenieria Universidad Nacional Autónoma de México Circuito Interior Ciudad Universitaria Del. Coyoacán 04510 México

To highlight the importance of small earthquakes in seismic hazard, a study of the 11 May 2016, Mw 4.9, Tesistan, Mexico earthquake is presented. Due to the close proximity of the event to the city, accelerations were considerably higher than those caused by historical severe earthquakes (6.0 der to place the event in the context of the tectonic environment of this area. The second is focused on a vulnerability evaluation of buildings that suff ered resonance. Several building′s typologies with variations in construction system and height are assessed in terms of resonance with the structural and soil periods. The results show that around the Zapopan station, strong damage is expected in intermediate to high-rise buildings (12-30 m) with moment resistant frame systems and in reinforced concrete shear walls. Masonry structures around this station may not present resonance. In contrast, in the surroundings of the Guadalajara station, all intermediate height buildings from 9 to 21 m may present resonance.

关键词： Tesistan earthquake seismicity of Guadalajara site eff ects structural vulnerability

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Evaluation of Propargyl Alcohol as a Corrosion Inhibitor for Duplex Stainless Steel in Hydrochloric Acid

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Journal of Civil Engineering and Architecture 2020年第7期14卷 378-384页

作者： Fernando Benedicto Mainier Virgílio P.dos Reis edilson Ferreira de Barros Brígida B.de Almeida Escola de Engenharia Universidade Federal FluminenseNiteróiRio de Janeiro24020-140Brazil

ASTM A182 F51 duplex stainless steel with a 50:50 ratio of austenite to ferrite microstructure is a material used in mechanical *** uses include the manufacturing of equipment and components subject to acidification or acid stimulation for oil and gas *** acid stimulation or acidification,hydrochloric acid(HCl)solution with concentrations ranging from 5%to 28%(by volume)is injected into the limestone(CaCO3)and dolomite(CaCO3·MgCO3)reservoir rock to restore permeability and consequently increase oil well ***,it is important to use a corrosion inhibitor,such as propargyl alcohol,to prevent or inhibit the aggressive attack of HCl on duplex stainless *** present study evaluates the corrosion resistance of ASTM A182 F51 stainless steel using gravimetric(mass loss)and electrochemical(polarization)*** were completed with and without the addition of 500 and 1,000 mg/L propargyl alcohol in HCl solutions with concentrations of 10%and 15%(by volume)at temperatures of 25,40 and 55°*** good protection by propargyl alcohol of duplex steel immersed in HCl is observed.

关键词： Duplex stainless steel corrosion inhibitor propargyl alcohol hydrochloric acid acid stimulation

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Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host

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World Journal of Biological Chemistry 2017年第1期8卷 57-80页

作者： Vitor Sueth-Santiago debora decote-Ricardo Alexandre Morrot Celio Geraldo Freire-de-Lima Marco edilson Freire Lima Instituto Federal de Educacao Ciência e Tecnologia do Rio de JaneiroCampus Sao Goncalo Universidade Federal Rural do Rio de Janeiro Instituto de Ciências ExatasDepartamento de Química Universidade Federal Rural do Rio de Janeiro Instituto de VeterináriaDepartamento de Microbiologia e Imunologia Veterinária Universidade Federal do Rio de Janeiro

Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host.

关键词： Trypanosoma cruzi Trans-sialidase Trypanothione reductase CYP51 Cruzipain Tubulin

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Adaptive Strategies for Accelerating the Convergence of Average Cost Markov decision Processes Using a Moving Average Digital Filter

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American Journal of Operations Research 2013年第6期3卷 514-520页

作者： edilson F. Arruda Fabrício Ourique Federal University of Rio de Janeiro Alberto Luiz Coimbra Institute—Graduate School and Research in Engineering Rio de Janeiro Brazil Federal University of Santa Catarina (Campus Araranguá) Araranguá Brazil

This paper proposes a technique to accelerate the convergence of the value iteration algorithm applied to discrete average cost Markov decision processes. An adaptive partial information value iteration algorithm is proposed that updates an increasingly accurate approximate version of the original problem with a view to saving computations at the early iterations, when one is typically far from the optimal solution. The proposed algorithm is compared to classical value iteration for a broad set of adaptive parameters and the results suggest that significant computational savings can be obtained, while also ensuring a robust performance with respect to the parameters.

关键词： Average Cost Markov decision Processes Value Iteration Computational Effort Gradient

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Fruit Mass of <i>Carica papaya</i>L. from Cultivars Aliança and THB from the Width and Length of the Fruit

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Agricultural Sciences 2021年第1期12卷 9-17页

作者： Karina Tiemi Hassuda dos Santos Vinicius de Souza Oliveira Gleyce Pereira Santos Jéssica Sayuri Hassuda Santos Omar Schmildt edilson Romais Schmildt Federal University of Espírito Santo Center Noth of Espírito Santo S&#227 o Mateus Espírito Santo Brazil Federal University of Espírito Santo Center for Agricultural Sciences and Engineering Alegre Espírito Santo Brazil

Papaya (Carica papaya L.) is a typical plant with a tropical climate, but also grown in subtropical regions. Using mathematical models well-adjusted allows with good precision to estimate characteristics of interest. The objective was to adjust an equation that estimates the fruit mass for each cultivar of papaya, Aliança and THB, using only one measure, length or width. The experiment was conducted in the municipality of Linhares in the state of Espírito Santo, Brazil. Seedlings were planted on the same day, spaced 3.6 × 1.5 m and in rows side by side. Initially, the equations were modeled, they were linearized and then the covariance analysis was performed in order to verify the possibility of an equation that would serve both cultivars. As the covariance was significant, it was necessary to develop equations for each cultivar. To obtain the growth equations, 350 fruits of cultivar Aliança and 550 of THB were used. The validation was performed with 50 fruits of each. The characteristics evaluated were the largest width (W in mm), the longest fruit length (L, in mm) and the observed mass (OM in g). The equations that best fit were those of the power model that use width (W) as an independent variable.

关键词： Non-destructive Method Regression Validation Mathematical Equations Growth Modeling

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Artificial defoliation to Simulate Losses on Production of Bean (<i>Phaseolus vulgaris</i>L. cv. Goytacazes)

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Agricultural Sciences 2019年第8期10卷 1023-1031页

作者： Omar Schmildt Vinicius de Souza Oliveira Dirceu Pratissoli José Augusto Teixeira do Amaral Marcio Paulo Czepak Adriel Lima Nascimento edilson Romais Schmildt Postgraduate Program in Tropical Agriculture Federal University of Espírito Santo S&#227 o Mateus ES Brazil department of Agronomy Federal University of Espírito Santo Alegre ES Brazil departament of Agrarian and Biological Sciences Federal University of Espírito Santo S&#227 o Mateus ES Brazil

The reduction of foliar area can cause yield reduction in common bean crops. The objective of this work was to verify which is the effect of different defoliation levels realized in several development stages of common bean (Phaseolus vulgaris L. cv. Goytacazes) over yield, weight of 100 seeds and number of pods per plant. The experimental design was randomized blocks, in a split-plot arrangement with five replications. The plot corresponded to the five defoliation epochs (first trifoliate leaf, flowering, pods formation, pods filling, and dry pods). In each plot, the split plot was represented by the four defoliation levels (0%, 33%, 67% and 100%). It was observed a decrease of yield for all levels defoliation considering all development stages, except for dried pods. The highest decrease was detected for flowering and pods formation. Through the regression analysis got a greater reduction in yield with 100% defoliation made at 42 days after emergence. The evaluation parameter that showed better relation with yield was a number of pods per plant.

关键词： Common Bean defoliation Grain Productivity Mass of Seeds Pods

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