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Exosomal miR-155 from gastric cancer induces cancerassociated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ

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Cancer Biology & Medicine 2022年第9期19卷 1301-1314页

作者： Ying Liu Meng Wang Ting Deng Rui Liu Tao Ning ming bai Guoguang Ying Haiyang Zhang Yi ba Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Objective:The aim of this research was to identify whether exosomes were involved in impairing adipogenesis in cancer-associated cachexia(CAC)by detecting the adipodifferentiation capacity and the expressions of adipogenic proteins in gastric cancer(GC)-associated ***:Western blotting and RT-PCR were used to investigate the expressions of C/EPBβ,C/EPBα,PPARγ,and UCP1 in adipose mesenchymal stem cells(A-MSCs)to evaluate the function of exosomal ***/c nude mice were intravenously injected in vivo with GC exosomes with different levels of miR-155 to determine changes in adipodifferentiation of ***:Exosomes derived from GC cells suppressed adipogenesis in A-MSCs as characterized by decreased lipid ***,A-MSCs co-cultured with GC exosomes exhibited increased ATP production through brown adipose differentiation characterized by highly dense mitochondria and enhanced UCP1 expression(PmiR-155 secreted from GC cells suppressed adipogenesis and promoted brown adipose differentiation by targeting C/EPBβ,accompanied by downregulated C/EPBαand PPARγand upregulated UCP1(PmiR-155 in GC exosomes improved CAC in vivo,which was characterized by fat loss,suppressed expressions of C/EPBβ,C/EPBα,and PPARγin A-MSCs,and high expression of UCP1(PmiR-155 in injected GC exosomes abrogated the improved CAC ***:GC exosomal miR-155 suppressed adipogenesis and enhanced brown adipose differentiation in A-MSCs by targeting C/EPBβof A-MSCs,which played a crucial role in CAC.

关键词： Exosomes adipose mesenchymal stem cells miR-155 cachexia gastric cancer

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Fourth China-US Relations Conference Held in Beijing

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Voice of Friendship 2010年第1期 19-20页

作者： ba Cuicui

As 2009 marked the 30th anniversary of the establishment of diplomatic ties between the PRC and the United States,it was an appropriate moment for experts on both sides to consider where the two countries were heading in their partnership. Hence"US-China:Looking ahead after 30 years"was the theme for more than 300 participants to take part in in-depth discussion at the Fourth Chi-

关键词： ahead partnership heading diplomatic discussion mi

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Characterization of a broad-energy germanium detector for its use in CJPL

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Nuclear Science and Techniques 2017年第1期28卷 42-48页

作者： Zhi Zeng Yu-Hao mi ming Zeng Hao Ma Qian Yue Jian-Ping Cheng Jun-Li Li Rui Qiu Hui Zhang Key Laboratory of Particle and Radiation Imaging (ministry of Education) and Department of Engineering Physics Tsinghua University Beijing 100084 China

The broad-energy germanium(BEGe)detector,with the ability of background discrimination using pulse shape discrimination,is a competitive candidate for neutrinoless double beta decay(ovββ)*** this paper,we report our measurements of key parameters for detector modeling in a commercial p-type BEGe ***-like sources are used to investigate energy resolution and linearity of the detector.A cylindrical volume source is used for efficiency *** an assembled device for source positioning and a collimated ^(133)ba source,the detector is scanned to check its active *** an^(241)Am point-like source,the dead layer thicknesses is measured at about 0.17 mm on the front and 1.18 mm on the *** detector characterization is of importance for BEGe detectors to be used in the ovββ experiments at China JinPing underground Laboratory(CJPL).

关键词： BEGe Characterization Dead layer 0mbb CJPL

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Periportal thickening on magnetic resonance imaging for hepatic fibrosis in infantile cholestasis

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World Journal of Gastroenterology 2020年第21期26卷 2821-2830页

作者： Myung Hwan Lee Hyun Joo Shin Haesung Yoon Seok Joo Han Hong Koh mi-Jung Lee Department of Radiology Severance HospitalSeverance Pediatric Liver Disease Research GroupResearch Institute of Radiological ScienceYonsei University College of MedicineSeoul 03722South Korea Department of Surgery Severance HospitalSeverance Pediatric Liver Disease Research GroupYonsei University College of MedicineSeoul 03722South Korea Division of Gastroenterology Hepatology and NutritionDepartment of PediatricsSeverance Children’s HospitalSeverance Pediatric Liver Disease Research GroupYonsei University College of MedicineSeoul 03722South Korea

baCKGROUND Untreated neonatal cholestasis can progress to liver cirrhosis and end stage liver disease in infancy due to prolonged hepatocyte and biliary tree injury and may require liver ***,non-invasive evaluation of hepatic fibrosis is important in infants with *** To investigate the usefulness of periportal thickening(PT)measured on liver magnetic resonance imaging(MRI)for the assessment of hepatic fibrosis in infants with cholestasis including biliary atresia(ba).METHODS This retrospective study included infants less than 6 mo who underwent liver MRI and biopsy for the evaluation of infantile *** and spleen size were measured on *** assessment was based on aspartate transaminase to platelet ratio index(APRI).The grade of histopathologic fibrosis was assessed by the METAVIR grading *** and diagnostic performance of PT,normalized spleen size ratio(SR,using the upper normal size limit),and APRI for diagnosing hepatic fibrosis were obtained by receiveroperating characteristic(ROC)curve *** A total of 155 patients were included,110 of which were diagnosed with *** age at the time of MRI was 57.6±34.4 *** were positive correlations between fibrosis grade and PT and SR,even after adjusting age(all,Pba.

关键词： Infants Cholestasis Biliary atresia Liver Fibrosis Magnetic resonance imaging

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辽西半干旱区玉米产量预报方法对比研究

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气象与环境科学 2024年第5期47卷 39-46页

作者：王阳米娜陈鹏狮李荣平张淑杰焦敏中国气象局沈阳大气环境研究所沈阳110166 辽宁省生态气象和卫星遥感中心沈阳110166

基于辽西半干旱区阜蒙县1986-2016年气象要素与玉米产量、发育期数据,使用产量丰歉相似年法、关键气象因子法、作物模型法开展了玉米产量预报研究,分析比较了3种产量预报方法的趋势预报正确率和定量预报准确率,结果表明,产量丰歉相似年... 详细信息

基于辽西半干旱区阜蒙县1986-2016年气象要素与玉米产量、发育期数据,使用产量丰歉相似年法、关键气象因子法、作物模型法开展了玉米产量预报研究,分析比较了3种产量预报方法的趋势预报正确率和定量预报准确率,结果表明,产量丰歉相似年法虽然可以实现玉米产量动态预报,但大概率法和加权分析法对玉米产量趋势的预报正确率均较低(33.3%~66.7%),其中加权平均法准确率高于大概率法的,但二者总体预报准确率都不高,且表现不稳定,不能满足业务服务需求。关键气象因子法提高了2014和2015年(生长季降水偏少年)的产量预报准确率,2年的产量预报趋势正确率为100%,产量预报准确率平均为89.5%。作物模型法随着发布预报日期的推迟,产量预报值更接近实际产量,降水正常年份预报效果好于降水偏少年份的预报效果。综上,将关键气象因子法与作物模型法相结合是准确预报半干旱区玉米产量的有效办法。两种方法相结合,对2011-2016年的产量预报准确率平均值达91.6%,能够满足业务服务需求。

关键词：半干旱区关键气象因子产量丰歉相似年作物模型预报准确率

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Callus culture of Cyclocarya paliurus (ba.a..) Iljinskaja leaves

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Forestry Studies in China 2010年第3期12卷 147-150页

作者： HU Dong-nan SHEN Yong-gen mi Li-xue SHANGGUAN Xin-chen Jiangxi Provincial Key Laboratory for bamboo Germplasm Resources and Utilization Jiangxi Agricultural University Nanchang 330045 P. R. China Plant Resources Exploitation and Utilization Laboratory Jiangxi Agricultural University Nanchang 330045 P. R. China

The hormone combinations and dark culture of the callus induction for Cyclocarya paliurus （ba.a..） Iljinskaja leaves were optimized by an orthogonal experiment. The effects of hormones on callus proliferation were also studied. The results show that the optimum medium for callus induction of C. paliurus leaves was MS ＋ 1.0 mg.L-1 6-ba ＋ 0.5 mg.L-1 NAA ＋ 1.0 mg·L-1 2,4-D. The combination of 6-ba.a.d NAA significantly affected the induction of callus, while the effect of 2,4-D was less. The maximum rate of callus induction was 95.4%. A 10-day darkness period was beneficial for callus induction. The best proliferation medium was 1/4 DKW ＋ 0.5 mg·L-1 6-ba ＋ 1.0 mg·L-1 2,4-D.

关键词： Cyclocarya paliurus (ba.a..) Iljinskaja leaf callus dark culture proliferation

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Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial

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World Journal of Gastroenterology 2008年第28期14卷 4492-4498页

作者： Richard Jaszewski Sabeena misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar John D Dingell Veterans Affairs Medical Center Karmanos Cancer InstituteDepartment of Internal MedicineWayne State University School of MedicineDetroitMI 48201United States

AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia.

关键词： Folic acid Adenoma, Colorectal cancer

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Pre-and intra-operative risk factors associated with delayed weaning from ventilator during early postoperative period in patients undergoing liver transplantation

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中华麻醉学杂志 2010年第B2期30卷 23-26页

作者： ZHANG Huan YANG ba-xian WANG Tian-long ZHU Feng-xue LI Guang-ming ZHU Ji-ye Department of Anesthesiology Peking University People's HospitalBeijing 100044 China Hepatobilary Surgery Center Peking University People's HospitalBeijing 100044 China

Objective To evaluate the pre- and intra-operative risk factors associated with delayed weaning from ventilator during the early postoperative period in patients undergoing liver *** Two hundred and twelve patients (152 male, 60 female) aged 22-69 yr undergoing liver transplantation from Sept 2004to Aug 2006 were enrolled in this study and were divided into 2 groups according to the time when the patients were weaned from ventilator: normal weaning group (Group A, the patients weaned from ventilator within 24 h after operation) and delayed weaning group (Group B, the patients weaned from ventilator more than 24 h after operation). Routine anesthesia wes performed. Blood and blood products were transfused according to the guidelines for blood transfusion to maintain the mean arterial pressure (MAP)≥60 mm Hg during operation. Sixteen preoperative variables (age＞64 yr, gender, Bmi ≥ 30kg/m2, PaO2＜75 mm Hg,pleural effusion, a history of asthma, smoking, drinking alcohol, coronary artery disease, diabetes mellitus, encephalopathy＞grade 3, spontaneous bacterial peritonitis, preoperative MELD score, serum albumin, ascites≥20 ml/kg and moderate hepatopulmonary hypertension) and 7 intraoperative variables (duration of operation, duration of anhepatic stage, transfusions of RBC,fresh frozen plasma (FFP), crystalloid and colloid, and urine output＜ 1 ml·kg-1·h-1) were recorded and compared between the two *** There were significant differences in 9 preoperative variables (age ＞ 64 yr, PaO2＜75 mm Hg, pleural effusion,encephalopathy＞grade 3, spontaneous bacterial peritonitis, preoperative MELD score, serum albumin, ascites≥20 ml/kg and moderate hepato-pulmonary hypertension) and 5 intraoperative variables (transfusions of RBC, FFP, crystalloid and colloid, and urine output＜1 mi·kg-1·h-1) between the two groups (P＜0.05 or 0.01). And logistic regression analysis showed that 5preoperative variables (age＞64 yr, PaO2＜75 mm Hg, encephalopathy ＞ grade 3, p

关键词：延迟相关呼吸器肝移植肝脏患者早期危险因素 Logistic回归分析

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心血管病的发育起源及早期干预窗口期

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中华预防医学杂志 2016年第1期50卷 1-3页

作者：米杰首都儿科研究所流行病学研究室北京100020

心血管疾病是人类健康的主要威胁，我国因心血管病死亡人数几乎占到总死亡人数的50％。更令人担忧的是肥胖和心血管代谢性危险因素已经在一些富裕地区的儿童人群中流行。越来越多来自健康与疾病发育起源领域的研究揭示了生命早期的营养... 详细信息

心血管疾病是人类健康的主要威胁，我国因心血管病死亡人数几乎占到总死亡人数的50％。更令人担忧的是肥胖和心血管代谢性危险因素已经在一些富裕地区的儿童人群中流行。越来越多来自健康与疾病发育起源领域的研究揭示了生命早期的营养不良或过剩及发育过程中暴露环境危险因素会增加心血管病发生风险。因此，建立和实施有效的早期预防策略势在必行，包括生命早期1000d的营养优化和减少整个儿童发育成长期暴露于致肥胖的环境风险因素，唯有此才能从根本上遏制心血管病的上升趋势，否则，未来用于诊断和治疗的费用是难以承受的。

关键词：心血管疾病早期干预(教育) 发育起源

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Kinetic Parameters of Methane Generated from Source Rocks in the Kuqa Depression of Tarim basin and Their Application

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Acta Geologica Sinica(English edition) 2008年第1期82卷 154-163页

作者： LI Xianqing XIAO Xianming mi Jingkui TANG Yongchun XIAO Zhongyao LIU Dehan SHEN Jiagui YANG Yunfeng WANG Yan DONG Peng State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China State Key Laboratory of Coal Resources and Safe mining China University of Mining and Technology Beijing 100083 China Research Center of Petroleum Energy and Environment California Institute of Technology 21910 Currier Rd Walnut CA 61769 USA Research Institute of Exploration and Development Tarim Oil Field Company PetroChina Korla Xinjiang 841000 China

In a thermal simulation experiment of gold tubes of closed-system, calculating with the KINETICS and GOR-ISOTOPE KINETICS software, kinetic parameters of gas generation and methane carbon isotopic fractionation from Triassic-Jurassic hydrocarbon source rocks in the Kuqa depression of Tarim basin are obtained. The activation energies of methane generated from Jurassic coal, Jurassic mudstone and Triassic mudstone in the Kuqa Depression are 197-268 kJ/mol, 180-260 kJ/mol and 214-289 kJ/mol, respectively, and their frequency factors are 5.265×10^13 s^-1, 9.761×10^11 s^-1 and 2.270×10^14 s^-1. This reflects their differences of hydrocarbon generation behaviors. The kinetic parameters of methane carbon isotopic fractionation are also different in Jurassic coal, Jurassic mudstone and Triassic mudstone, whose average activation energies are 228 kJ/mol, 205 kJ/mol and 231 kJ/mol, respectively. Combined with the geological background, the origin of natural gas in the Yinan-2 gas pool is discussed, and an accumulation model of natural gas is thus established. The Yinan- 2 gas is primarily derived from Jurassic coal-bearing source rocks in the Yangxia Sag. Main gas accumulation time is 5-0 Ma and the corresponding Ro is in the range from 1.25 %-1.95 %. The loss rate of natural gas is 25 %-30 %.

关键词： hydrocarbon source rock methane generation carbon isotopic fractionation kinetics Kuqa Depression Tarim basin

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