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Electromagnetic Treatment of Genetic Diseases

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Journal of Biomaterials and Nanobiotechnology 2012年第2期3卷 292-300页

作者： edgar E. Escultura Professor V. Lakshmikantham – GVP Institute for Advanced Studies GVP College of Engineering JNT University AP India

The paper offers an overview of quantum and macro gravity, two of the three pillars of the Grand Unified Theory (GUT), the other thermodynamics, developed in a series of papers since the solution of the gravitational n-body problem in 1997 (J. Nonlinear Analysis, A-Series: Theory, Methods and Applications, Vol. 30, No. 8, 1997, pp. 5021 - 5032) and consolidated in the paper, The Grand Unified Theory (J. Nonlinear Analysis, A-Series: Theory: Method and Applications, Vol. 69, No. 3, 2008, pp. 823 - 831). GUT is further advanced by the paper, The Mathematics of GUT (J. Nonlinear Analysis, A-Series: Theory: Method and Applications, Vol. 71, 2009, pp. e420 - e431) and the discovery of more natural laws in the course of analyzing and explaining the disastrous final flight of the Columbia Space Shuttle in 2004 (J. Nonlinear Studies, Vol. 14, No. 3, 2007, pp. 241 - 260). Qualitative modeling was the key to the development of GUT and its theoretical and practical applications. The relevant natural laws of GUT that provide the foundations of the Unified Theory of Evolution are stated. GUT provides the basis for the development of the electromagnetic engine and the Unified Theory of Evolution, its theoretical application, for the development of appropriate technology for electromagnetic treatment of genetic diseases such as cancer, systemic lupos erythematosus, diabetes, muscular dystrophy and mental disorder, the central focus of this paper.

关键词： Fractal Gene Chaos Primum Superstring Turbulence Brain Wave Composite Gene Dark Matter Electromagnetic Wave Qualitative Modeling Brain Wave Superposition Genetic Alteration Encoding Modification Sterilization

Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms

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Stroke & Vascular Neurology 2019年第1期4卷 36-42页

作者： edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa Pascal Jabbour David M Hasan Department of Neurology Neurosurgery and RadiologyUniversity of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery Thomas Jefferson UniversityPhiladelphiaPennsylvaniaUSA

Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow *** IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications *** sought to determine the safety of tirofiban and DAPT in these *** We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow *** tirofiban-DAPT protocol used is *** regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and *** One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 *** and major haemorrhagic events were recognised in 20%(30/148)*** 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 *** average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were *** haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was *** administration of heparin did not increase haemorrhagic *** The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was *** and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications.

关键词： aneurysm intracranial infusion

Is Human Activity Linked to Climate Change?

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Atmospheric and Climate Sciences 2014年第2期4卷 305-316页

作者： edgar E. Escultura GVP-Professor V. Lakshmikantham Institute for Advanced Studies GVP College of EngineeringVishakhapatnam India

This paper establishes the link between human activity and climate change, e.g., more frequent and devastating typhoons, tornadoes, bushfires, droughts, floods and snowstorms and melting of the norther polar ice cap and recent occurrences of super typhoons and tornadoes. Qualitative mathematics and modeling(QMAM) explains this link and its remarkable verification based on the grand unified theory(GUT).

关键词： Chaos Coriolis Effect Earthly Turbulence Coefficient of Elasticity Electromagnetic Wave GUT Technology Nested Generalized Fractal Northern Pacific Wind Cycle Primum Superstring

A Characterization of Semilinear Surjective Operators and Applications to Control Problems

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Applied Mathematics 2010年第4期1卷 265-273页

作者： edgar Iturriaga Hugo Leiva 不详

In this paper we characterize a broad class of semilinear surjective operators given by the following formula where Z are Hilbert spaces, and is a suitable nonlinear function. First, we give a necessary and sufficient condition for the linear operator to be surjective. Second, we prove the following statement: If and is a Lipschitz function with a Lipschitz constant small enough, then and for all the equation admits the following solution .We use these results to prove the exact controllability of the following semilinear evolution equation , , where , are Hilbert spaces, is the infinitesimal generator of strongly continuous semigroup in the control function belong to and is a suitable function. As a particular case we consider the semilinear damped wave equation, the model of vibrating plate equation, the integrodifferential wave equation with Delay, etc.

关键词： Semilinear Surjective Operators Evolution Equations Controllability Damped Wave Equation

Extending Electromagnetic Treatment to Infectious Diseases including the Ebola Virus

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Journal of Biomaterials and Nanobiotechnology 2015年第2期6卷 100-115页

作者： edgar E. Escultura Research Professor (Honorary) GVP-Professor V. Lakshmikantham Institute for Advanced Studies GVP College of Engineering JNT University Kakinada Vishakhapatnam India

A blueprint for research and development for design and development of suitable electromagnetic treatment of genetic diseases (Escultura, Journal of Biomaterials and Nanobiotechnology, 3(2), 2012) known as genetic sterilization is applied to infectious diseases including viruses. It is based on the Grand Unified Theory (Escultura, Nonlinear Analysis, A-Series, 69(3), 2008) and the Unified Theory of Evolution (Escultura, The Journal of the Science of Healing Outcomes, 2015). Since every physical characteristic of living thing is determined by a gene, so is the undesirable symptom of a disease. For virus, its undesirable symptom is determined principally by the wavelength of the natural vibration of its gene as sequence of base materials which is equal to its measure as a segment of a double helix. Radiation with wavelength equal to this measure will resonate with it. Raising its intensity suitably will sterilize the gene, stop its spread and render it harmless to the host;then the disease is treated without harm to normal cells. Another treatment is establishing resonance with radiation of wavelength equal to the measure of the virus (protein strand with the gene) across;raising its intensity suitably will burn the virus without side effect (since it is much smaller than normal cells).

关键词： Basic Primum Genetic Activation and Sterilization Resonance and Superposition Law Superstring

Chaos, Turbulence and Fractal: Theory and Applications

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International Journal of Modern Nonlinear Theory and Application 2013年第3期2卷 176-185页

作者： edgar E. Escultura V. Laksshmikantham Institute for Advanced Studies GVP College of Engineering J. Nehru Technical University Kakinada India

The paper identifies chaos, turbulence and fractal of quantum and macro gravity and studies their behavior, properties and applications based on the grand unified theory (GUT) and qualitative mathematics and modeling. Applications include devising electromagnetic engines, tornado aborter and terminator and technologies for electromagnetic treatment of genetic diseases such as cancer, systemic lupos erythematosus, diabetes and mental disorder without harm to normal cell and side effect. Typhoon in the Western Pacific which is turbulence is impossible to terminate and impractical to deflect but prediction can be improved because it follows the Northern Pacific Wind Cycle (Southern Pacific Wind Cycle in the Southern Hemisphere) and is affected by the temperature variation over the Philippine Deep and around Mayon Volcano. The electromagnetic engine uses the clean, inexhaustible, free dark matter, specifically, the energy of magnetic flux, in place of conventional fuel, e.g., fossil, nuclear and geothermal. The tornado aborter and terminator utilize the gravitational flux of the Earth, its vortex flux of superstrings as a cosmological vortex which is turbulence. The technologies for electromagnetic treatment of genetic diseases utilize electromagnetic waves based on resonance. All of them are GUT technologies because they are applications of GUT. Except for the magnetic train which is in operation the rest is still at the conceptual and research and development (R&D) phase but the theory is complete and the strategy for R&D are laid down in detail in the cited original papers.

关键词： Chaos Cosmological Vortex Dark Matter Electromagnetic Engine Electromagnetic Treatment of Genetic Diseases Fractal Gravitational Flux Magnetic Flux Prima Quantum and Macro Gravity Superstring Toroidal Flux Turbulence

Bioinformatic Analysis of Insertion, Deletion, and Substitution Mutations in the Human <i>β</i>-Globin Gene

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Computational Molecular Bioscience 2021年第1期11卷 1-17页

作者： edgar Miguel Bustamante Cárdenas Faculty of Pharmaceutical Biochemical and Biotechnological Sciences Catholic University of Santa María Arequipa Peru

Beta-thalassemia is delineated as a bunch of heritable blood disorders characterized by abnormalities within the synthesis of beta chains of hemoglobin. Most defects in hemoglobin arise directly from mutations in the structure of the β-globin sequence (HBB). Recent advances in computational tools have made it possible to study the relationship between genotype and phenotype in many diseases, including β-thalassemia. Due to the high prevalence of β-thalassemia, these analyses have helped to know the molecular basis in a better way. In this direction, a related database, called HbVar, was developed in 2001 by a collective academic effort to provide quality and up-to-date information on genomic variations that lead to hemoglobinopathies and thalassemia. Within present study, the aim was to investigate insertion, substitution, and deletion mutations in HBB collected from HbVar and their effects using the in-silico approach. In this comparative analysis, three sequences, one wild-type and two mutated HBB sequences were studied in the South American region. It was determined that the Brazilian nd-HPFH mutated sequence presents the formation of a beta chain in the protein structure, not being able to align or overlap in the wild-type, which results in the alteration of the function of the protein, and therefore the development of Thalassemia disease.

关键词： Hemoglobin Mutation Thalassemia

Cement Bonded Particle Boards with Different Types of Natural Fibres—Using Carbon Dioxide Injection for Increased Initial Bonding

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Open Journal of Composite Materials 2018年第1期8卷 28-42页

作者： Bjorn Marteinsson edgar Gudmundsson Faculty of Civil and Environmental Engineering University of IcelandReykjavikIceland Innovation Center Iceland ReykjavikIceland Speca ReykjavikIceland

The effect of CO2 injection on initial strength increase and hardening of cement-fibre mix in a cement bonded particle board (CBPB) production was evaluated. Different cement contents, formation pressure and types of fibres were considered. The initial strength increase with CO2 injection is so much faster than this caused by conventional hydration that the produced samples do not need additional curing before they can be stored. Similar strength and stiffness values as in conventional products on the market are gained with lower cement content for similar types of fibres. Visual inspection of board surfaces aged for 13 years in a harsh exterior environment as well as comparison of strength and stiffness values for these boards when new and after ageing, gives a very satisfying result. The combined effect of the above discussed gains results in markedly increased productivity at lower cost and lower environmental impacts than is possible in traditional CBPB production.

关键词： Fibre Cements Carbon Dioxide Initial Hardening Natural Fibres Strength Durability

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The Tell-Tale Heart

英语学习 1994年第12期 7-10页

作者： edgar A. Poe

IT’S TRUE! Yes, I have been ill, very ill. But why do you saythat I have lost control of my mind, why do you say that I ammad? Can you not see that I have full control of my mind? Is itnot clear that I am not mad? In... 详细信息

关键词： The Tell-Tale Heart