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Glycosylation on proteins of the intestine and perimicrovillar membrane of Triatoma (Meccus) pallidipennis, under different feeding conditions

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Insect Science 2019年第5期26卷 796-808页

作者： Ana E.Gutierrez-Cabrera Wesley f.Zandberg edgar Zenteno Mario H.Rodriguez Bertha Espinoza Carl lowenberger CONACyT-Centro de Investigacion Sobre Enfermedades Infecciosas Instituto Nacional de Salud PublicaCuernavacaMorelosMexico Department of Chemistry Simon Fraser UniversityBurnabyBCCanada Department of Chemistry The University of British Columbia OkanaganKelownaBCCanada facultad de Medicina Departamento de BioquimicaUniversidad Nacional Autdmoma de Mexico Mexico CityDFMexico Centro de Investigacion Sobre Enfermedades Infecciosas Instituto Nacional de Salud PublicaCuernavaca MorelosMexico Departamento de Inmunologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de Mexico Ciudad UniversitariaMexico CityDFMexico Department of Biological Sciences Simon Fraser UniversityBurnabyBCCanada

Trypanosoma cruzi,the causative agent of Chagas disease, interacts with molecules in the midgut of its insect vector to multiply and reach the infective stage. Many studies suggest that the parasite binds to midgut-specific glycans. We identified several glycoproteins expressed in the intestine and perimicrovillar membrane (PMM) of Triatoma (Meccus) pallidipennis under different feeding conditions. In order to assess changes in protein-linked glycans, we performed lectin and immunoblot analyses on glycoprotein extracts from these intestinal tissues using well-characterized lectins, and an antibody, which collectively recognize a wide range of different glycans epitopes. We observed that the amount and composition of proteins and glycoproteins associated with different glycans structures changed over time in the intestines and PMM under different physiological conditions. PMM extracts contained a wide variety of glycoproteins with different sugar residues, including abundant high-mannose and complex sialylated glycans. We propose that these molecules could be involved in the process of parasite-vector interactions.

关键词： feeding conditions glycoproteins lectins perimicrovillar membrane triatomine vector-parasite interactions

Visual grading criteria for Japanese larch ( Larix kaempferi ) structural timber from Spain

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Journal of forestry Research 2020年第6期31卷 2605-2614页

作者： Mari-Jose Barriola José-Ramón Aira edgar Lafuente Tknika LHri Aplikatutako Ikerketa eta Berrikuntzako EAEko zentroaZamalbide Auzoa z/g20100 ErrenteriaGipuzkoaSpain Escuela de Ingeniería de la Industria forestal Agronómica y de la BioenergíaUniversidad de ValladolidUVa-Campus Duques de Sorias/n42005 SoriaSpain Cesefor Centro de Servicios y Promoción Forestal y de su Industria de Castilla y LeónCalle C42005 SoriaSpain

Larch wood is structurally classifi ed in many countries as one of conifers with the highest load-bearing capacity(strength class of C30).The Spanish visual classifi cation regulation only assigns a strength class to 4 pine woods:Laricio pine(Pinus nigra ***),Silvestre pine(Pinus sylvestris L.),Radiata pine(Pinus radiata ***),and Pinaster pine(Pinus pinaster Ait.).This work adds to the number of structurally characterised species by creating a visual classifi cation table for Japanese larch wood(Larix kaempferi(Lamb.)Carr.)which diff erentiates between 2 visual classes,MEG-1 and *** strength values were calculated for each class(fk,MEG-1=31.80 MPa,f k,MEG-2=24.55 MPa),mean module of elasticity(E 0,mean,MEG-1=13,082 MPA,E 0,mean,MEG-2=12,320 MPA)and density(ρk,MEG-1=456.6 kg m−3,ρk,MEG-2=469.1 kg m−3),before fi nally assigning a strength class of C30 to visual class MEG-1,and a strength class of C24 to visual class MEG-2.

关键词： Japanese larch wood Visual grading Strength class Mechanical properties Density

Identification and characterization of GLOBE, a major gene controlling fruit shape and impacting fruit size and marketability in tomato

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Horticulture Research 2021年第1期8卷 1783-1797页

作者： edgar Sierra-Orozco Reza Shekasteband Eudald Illa-Berenguer Ashley Snouffer Esther van der Knaap Tong Geon Lee Samuel f.Hutton University of florida Gulf Coast Research and Education Center14625 County Road 672WimaumaFL 33598USA North Carolina State University Department of Horticultural ScienceMountain Horticultural Crops Research and Extension Center455 Research DriveMills RiverNC 28759USA University of Georgia Center for Applied Genetic Technologies111 Riverbend RoadAthensGA 30602USA University of Georgia Department of Horticulture1111 Plant Sciences BldgAthensGA 30602USA

Within large-fruited germplasm,fruit size is influenced by flat and globe *** flat fruits are smaller and retain better marketability,globe fruits are larger and more prone to cuticle *** hybrids are often developed from crosses between flat and globe shaped parents because flat shape is thought to be dominant and fruit size *** objectives of this study were to determine the genetic basis of flat/globe fruit shape in large-fruited fresh-market tomato germplasm and to characterize its effects on several fruit ***-three advanced single plant selections from the fla.8000×fla.8111B cross were selectively genotyped using a genome-wide SNP array,and inclusive composite interval mapping identified a single locus on the upper arm of chromosome 12 associated with shape,which we termed globe.A 238-plant f 2 population and 69 recombinant inbred lines for this region from the same parents delimited globe to approximately 392-kilobases.A germplasm survey representing materials from multiple breeding programs demonstrated that the locus explains the flat/globe shape broadly.A single base insertion in an exon of Solyc12g006860,a gene annotated as a brassinosteroid hydroxylase,segregated completely with shape in all populations ***/Cas9 knock out plants confirmed this gene as underlying the globe *** silico analysis of the mutant allele of GLOBE among 595 wild and domesticated accessions suggested that the allele arose very late in the domestication *** measurements in three genetic backgrounds evidenced that globe impacts fruit size and several fruit shape attributes,pedicel length/width,and susceptibility of fruit to weather *** mutant allele of GLOBE appears mostly recessive for all traits except fruit size where it acts additively.

关键词： breeding size shape

Effect of Nd3+doping on structure,microstructure,lattice distortion and electronic properties of TiO_2 nanoparticles

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Journal of Rare Earths 2017年第3期35卷 259-270页

作者： Balter Trujillo-Navarrete María del Pilar Haro-Vázquez Rosa María félix-Navarro francisco Paraguay-Delgado Henry Alvarez-Huerta Sergio Pérez-Sicairos edgar Alonso Reynoso-Soto institute technology of tijuana(itt) blvd.alberto limón padillaP.O.B 1166.Tijuana B.C.Mexico university autonomous of baja california(uabc) roadway university14418P.O.B 22390Tijuana B.C.Mexico investigations center of advanced materials(cimav).miguel de cervantes 120.P.O.B31109ChihuahuaMexico

Doped and undoped TiCh nanoparticles were prepared by Stober method and thermally treated at 600 ℃.The effect of Nd^（3＋） ion on the structure and micro structure of anatase-phase TiCh nanocrystals was studied by Rietveld refinement method using X-ray powder diffraction *** lengths,bond angles,and edges distances were *** phase formation was confirmed by high-resolution transmission electron *** adjustment of Ti-0 bond length induced by the addition of Nd^（3＋） ions,reduced the octahedral distortion and altered the octahedral array in the anatase-phase TiCh *** changes of structure and microstructure were mainly observed for TiCh nanoparticles doped with 0.1 at.%of Nd^（3＋） ions and attributed to the cationic substitution of Ti^（4＋） ions which promoted changes in the density of states and gap band of *** dopant insertion resulted in a better structural stability of the nanocrystals that enhanced their charge transference and photocatalytic efficiency.

关键词： neodymium TiO_2 nanoparticles microstructure lattice distortion photocatalytic activity optical properties Rietveld refinement rare earths

Kinetic analysis via mathematical modeling for ferrous iron oxidation in a class of SBR-type system

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2472-2480页

作者： edgar NTec-Caamal Refugio Rodríguez-Vázquez Luis GTorres-Bustillos Ricardo Aguilar-López Center for Research and Advanced Studies of the National Polytechnic Institute Av.Instituto Politécnico Nacional No.2508Colonia San Pedro ZacatencoC.P.07360 Ciudad de México D.F.Mexico Interdisciplinary Professional Unit of Biotechnology-National Polytechnic Institute(UPIBI-IPN) Acueducto s/nLa Laguna TicománGustavo A.Madero07340Ciudad de MéxicoMexico

This paper analyses the oxidation of ferrous iron via chemical and biological means in a class of Sequential Batch Reactors(SBR-type).for this,a kinetic model for the study of iron oxidation system is proposed,followed by a parametric sensitivity analysis and a bifurcation analysis,which allow selecting the most influential kinetic parameters in order to ensure a suitable prediction capacity of the mathematical *** system consists of two SBR bioreactors,the first being used to produce hydrogen peroxide(H2O2)that is fed to a second reactor where the iron oxidation is carried out by chemical–biological *** predictions were compared with experimental data for the production of H2O2 and for ferrous iron oxidation,finding suitable correlation coefficients(r2 N 0.98)for each state *** bifurcation analysis showed the trajectories of the main variables,such as,biomass,H2O2 and ferrous iron,under the change of the most influential kinetic *** analysis demonstrates the usefulness of the constructed model to predict the kinetic behaviour of the SBR-type process.

关键词： Bifurcation analysis Hydrogen peroxide Iron oxidation Modeling Simulation

Huu S. TIEU Request for fDA to Establish Regenerating Human Cells as Law on December 13, 2016 President Barack H. Obama Signed the 21st Century CURES Act into fDA Regulation and Law

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Open Journal of Regenerative Medicine 2022年第3期11卷 55-62页

作者： Huu S. Tieu Martin f. Loeffler edgar A. Ayala Golden Sunrise Nutraceutical Inc. Porterville USA

Background and Aims: On November 24, 2009, Huu S. TIEU and Golden Sunrise Pharmaceutical, Inc. (Golden Sunrise) applied for the Technology and Innovation to be reviewed and evaluated by the U.S. food and Drug Administration (fDA). In the review and evaluation, it was requested by Golden Sunrise designated the new indications for this application under Serious or Life-threatening conditions or diseases. Discussions followed with the fDA, Huu S. TIEU, and Golden Sunrise for fDA approval on new products and new indications on existing new Medical Technology and Innovation. It was agreed in Year-2015 that the fDA would take the request for new indications to the United States Congress to establish into fDA regulation and law. At that time the following was the fDA Guidance—“Emergency Use of a Test Article” is exempt from prior Institutional Review Board or Advisory Committee evaluation and approval, provided that such emergency use is reported to the Institutional Review Board within five working days after use. Expedited Institutional Review Board or Advisory Committee approval is not permitted in emergency use. There has been no funding to the authors for the writing or publication of this article. Methods: It was requested by Huu S. TIEU and Golden Sunrise in documents given to the fDA to have Serious or Life-threatening conditions or diseases indication be recognized by law. On August 08, 2015, the fDA responding to this request took the documentation produced by Golden Sunrise to the United States Congress on behalf of Golden Sunrise and Huu S. TIEU. This article encompasses the fDA regulatory method as well as the discussion and results of the establishment of the fDA and the 21st Century Cures Act. Results: On December 13, 2016, H.R.34—114th United States Congress (2015-2016) 21st Century CURES Act was signed into law by President Barack H. Obama which included the Serious or Life-threatening indication to be written into the CURE

关键词： Huu S. TIEU Request for fDA to Establish Regenerating Human Cells as Law on December 13 2016 President Barack H. Obama Signed the 21st Century CURES Act into fDA Regulation and Law

Design and Construction of a Solar Hybrid Car （Electric Motor and Human Propulsion）

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Journal of Energy and Power Engineering 2017年第1期11卷 44-47页

作者： edgar A. Salazar Juan f. Arroyave felipe Gomez Technology faculty Department of Mechanical Technology. Technological University of Pereira C.P 660003 Colombia Mechatronic Engineering Technological Faculty Technological University of Pereira C.P 660003 Colombia

This work presents the design and the construction of a solar hybrid vehicle whose principal driving force is a photovoltaic system, assisted by human propulsion. The solar race of Atacama Desert （Chile） was the In＇st challenge that the solar vehicle faced, with a maximum catchment area of 4 m^2 storage 1,500 Wh and a maximum cost of 7,000 USD. Built vehicle was tested, reaching speeds on fiat terrain of 40 km/h with engine and 50 km/h with human-powered contribution. Proposed design could be projected as a vehicle for transporting person average Latin American roads.

关键词： Renewable energy sustainable transportation solar vehicle embedded electrical motor.

Enduring association between irritable bowel syndrome and war trauma during the Nicaragua civil war period:A population-based study

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World Journal of Gastroenterology 2023年第45期29卷 5953-5961页

作者： edgar M Peña-Galo Daniel Wurzelmann Javier Alcedo Rodolfo Peña Loreto Cortes Douglas Morgan Department of Digestive Diseases Miguel Servet University HospitalZaragoza 50009AragonSpain Javier Alcedo Aragon Health Research InstituteIIS AragonZaragoza 50009AragonSpain Department of Mental Health Carolina PartnersDurhamNC 27707United States Department of Data Analysis CIDE(ResearchDevelopment and Epidemiology Center)Tegucigalpa 11101Francisco MorazánHonduras School of Medicine National Autonomous University of NicaraguaLeon 21000LeonNicaragua Department of Gastroenterology and Hepatology UAB University of Alabama BirminghamBirminghamAL 35233United States School of Medcine The University of North CarolinaChapel HillNC 9500United States

BACKGROUND Psychosocial and physical trauma are known risk factors for irritable bowel syndrome(IBS),including in war veterans,whereas war exposure in civilians is *** experienced two wars,1970-1990:The Sandinistas Revolution(1970s)and The Contra War(1980s).Our aim was to investigate the role of exposure to war trauma in the subsequent development of IBS in the context of an established health surveillance system(11000 households).AIM To investigate in a civilian population the relationship between exposure to war trauma and events and the subsequent development of IBS in the context of an established public health and demographic surveillance system in western *** We conducted a nested population-based,cross-sectional study focused on functional gastrointestinal disorders based on Rome II criteria.1617 adults were randomly *** Spanish Rome II Modular Questionnaire and Harvard Trauma Questionnaire were validated in *** exposure was assessed with 10 measures of direct and indirect war trauma and post-war *** exposures were defined by≥3 *** The prevalence of IBS was 15.2%[female(f)17.1%,Male(M)12.0%],war exposure 19.3%(f 9.3%,M 36.7%),and post-traumatic stress disorder(PTSD)5.6%(f 6.4%,M 4.3%).Significant associations with IBS in the civilian population were observed(adjusted by gender,age,socioeconomic status,education):physical and psychological abuse[adjusted odds ratio(aOR):2.25;95%confidence interval:1.1-4.5],witnessed execution(aOR:2.4;1.1-5.2),family member death(aOR:2.2;1.2-4.2),and multiple exposures(aOR:2.7;1.4-5.1).PTSD was independently associated with IBS(aOR:2.6;1.2-5.7).CONCLUSION An enduring association was observed in the Nicaragua civilian population between specific civil war-related events and subsequent *** populations in regions with extended armed conflict may warrant provider education and targeted interventions for patients.

关键词： Irritable bowel syndrome functional gastrointestinal disorders War trauma Civil war Post-traumatic stress disorder Central America

Prader-Willi Syndrome:16-Year Experience in Hong Kong

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Journal of Genetics and Genomics 2012年第4期39卷 191-194页

作者： Ivan f.M. Lo Ho Ming Luk luksite@*** Tony M.f. Tong Kent K.S. Lai Daniel H.C. Chan Albert C.f. Lam David K.H. Chan edgar W.L. Hau Connie O.Y. fung Stephen T.S. Lam Clin Genet Serv Dept Hlth Kowloon Hong Kong Peoples R China

Prader-Willi syndrome （PWS） is an important, well-recognized syndromic form of neurodevelopmental disorder. The incidence is about 1 in 15,000-25,000 live births, and it affects both males and females （Vogels et al... 详细信息

关键词： PWS Prader-Willi Syndrome