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As.es.ment of vas.ular invas.on in gas.ric cancer: A comparative s.udy

World Journal of Gas.roenterology 2013年第24期19卷 3761-3769页

作者： Letícia Trivellato Gres.a Is.ael Alves.Rodrigues.Júnior Lúcia Porto Fons.ca de Cas.ro Geovanni Dantas.Cas.ali Mnica Maria Demas.lva-res.Cabral Department of Anatomic Pathology and Medicine University Federal of Minas GeraisBelo Horizonte 30130-100 Brazil Ins.itute of Biological s.iences University Federal of Minas GeraisBelo Horizonte 31270-901 Brazil

AIM: To evaluate and compare detection of lymphatic and blood ves.el invas.on (LVI and BVI) by hematox-ylin-eos.n (HE) and immunohis.ochemis.ry (IHC) in gas.ric cancer s.ecimens. and to correlate with lymph node s.atus. METHODs. IHC us.ng D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was.performed to s.udy LVI and BVI in s.rgical s.ecimens.froma cons.cutive s.ries.of 95 primary gas.ric cancer cas.s. The res.lts.of the IHC s.udy were compared with the detection by HE us.ng McNemar tes. and kappa index. The morphologic features.of the tumors.and the pres.nce of LVI and BVI were related to the pres.nce of lymph node metas.as.s. A χ2 tes. was.performed to obtain as.ociations.between LVI and BVI and other prognos.ic factors.for gas.ric cancer. REs.LTs. The detection rate of LVI was.cons.derably higher than that of BVI. The IHC s.udy identified eight fals.-pos.tive cas.s.and 13 fals.-negative cas.s.for LVI, and 24 fals.-pos.tive cas.s.and 10 fals.-negative cas.s.for BVI. The average Kappa value determined was.moderate for LVI (k=0.50) and low for BVI (k=0.20). Both LVI and BVI were s.atis.ically as.ociated with the pres.nce of lymph node metas.as.s.(HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phologic features.as.ociated with LVI were location of the tumor in the dis.al third of the s.omach (P=0.039), Borrmann's.macros.opic type (P=0.001), organ inva-s.on (P=0.03) and the depth of tumor invas.on (P=0.001). The pres.nce of BVI was.related only to the depth of tumor invas.on (P=0.003). CONCLUs.ON: The immunohis.ochemical identification of lymphatic and blood ves.els.is.us.ful for increas.ng the accuracy of the diagnos.s.of ves.el invas.on and for predicting lymph node metas.as.s.

关键词： Gas.ric cancer Tumour-node-metas.es.s s.aging Lymph node metas.as.s Predictive factor Lymphatic ves.el invas.on Blood ves.el invas.on Immunohis.ochemis.ry CD34 D2-40

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Terahertz s.ructured light:nonparaxial Airy imaging us.ng s.licon diffractive optics

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Light(s.ience & Applications. 2022年第12期11卷 2909-2921页

作者： Rus.e Ivas.eviciute-Povilaus.iene Paulius.Kizevicius.Ernes.as.Nacius.Domas.Jokubaus.is.Kes.utis.Ikamas.Alvydas.Lis.us.as.Natalia Alexeeva Ieva Matulaitiene Vytautas.Jukna s.rgej Orlov Linas.Minkevicius.Gintaras.Valus.s Department of Optoelectronics Center for Physical Sciences and TechnologySauletekio av.3Vilnius 10257Lithuania Department of Fundamental Res.arch Center for Physical Sciences and TechnologySaulėtekio av.3Vilnius 10257Lithuania Ins.itute of Applied Electrodynamics.Telecommunications Vilnius UniversitySaulėtekio av.3Vilnius 10257Lithuania CENTERA Labs. Institute of High Pressure Physics PASul.Sokolowska 29/37Warsaw 01-142Poland Department of Organic Chemis.ry Center for Physical Sciences and TechnologySaulėtekio av.3Vilnius 10257Lithuania Ins.itute of Photonics.and Nanotechnology Department of PhysicsVilnius UniversitySaulėtekio av.3Vilnius 10257Lithuania

s.ructured light–electromagnetic waves.with a s.rong s.atial inhomogeneity of amplitude,phas.,and polarization–has.occupied far-reaching pos.tions.in both optical res.arch and ***(THz)waves.due to recent innovations.in photonics.and nanotechnology,became s. robus. that it was.not only implemented in a wide variety of applications.s.ch as.communications.s.ectros.opic analys.s.and non-des.ructive imaging,but als. s.rved as.a low-cos. and eas.ly implementable experimental platform for novel concept *** this.work,we s.ow that s.ructured nonparaxial THz light in the form of Airy,Bes.el,and Gaus.ian beams.can be generated in a compact way us.ng exclus.vely s.licon diffractive optics.prepared by femtos.cond las.r ablation *** accelerating nature of the generated s.ructured light is.demons.rated via THz imaging of objects.partially obs.ured by an opaque beam *** conventional paraxial approaches.when a combination of a lens.and a cubic phas.(or amplitude)mas. creates.a nondiffracting Airy beam,we demons.rate s.multaneous.lens.es. nonparaxial THz Airy beam generation and its.application in imaging *** of s.ngle objects.imaging with a controllable placed obs.acle,and imaging of s.acked graphene layers.are pres.nted,revealing hence potential of the approach to ins.ect quality of 2D *** nonparaxial THz illumination is.inves.igated both theoretically and experimentally with appropriate extens.ve *** s.ructured THz illumination cons.s.ently outperforms.the conventional one in res.lution and contras.,thus.opening new frontiers.of s.ructured light applications.in imaging and invers. s.attering problems.as.it enables.s.phis.icated es.imates.of optical properties.of the inves.igated s.ructures.

关键词： polarization axial optics

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利咽雾化液抗炎抑菌作用的实验观察

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中国中西医结合耳鼻咽喉科杂志 2005年第1期13卷 13-16页

作者：张虎张建基张子和程璐郑洪玲山东省章丘市人民医院 250200 山东省济南市儿童医院

目的观察利咽雾化液抗炎抑菌作用效果,验证其安全性。方法给健康小鼠灌胃相当于临床人用量的102倍的药量,验证其安全性;采用二甲苯引起小鼠耳廓肿胀、角叉菜胶引起大鼠足趾肿胀的炎症模型,观察其抗炎作用;采用杯碟法测定利咽雾化液对... 详细信息

目的观察利咽雾化液抗炎抑菌作用效果,验证其安全性。方法给健康小鼠灌胃相当于临床人用量的102倍的药量,验证其安全性;采用二甲苯引起小鼠耳廓肿胀、角叉菜胶引起大鼠足趾肿胀的炎症模型,观察其抗炎作用;采用杯碟法测定利咽雾化液对临床分离的46株临床常见的革兰氏阴性菌和革兰氏阳性菌的体外抗菌作用。结果利咽雾化液对动物无明显毒性,LD50大于144g/kg;对二甲苯引起的小鼠耳廓肿胀及角叉菜胶引起的大鼠足趾肿胀有较好的抗炎作用,体外抑菌实验可见利咽雾化液对临床常见的革兰氏阴性菌和革兰氏阳性菌均具有一定的抑制作用。结论利咽雾化液具有较好的抗炎、抑菌作用,且安全性高。

关键词：利咽雾化液抗炎小鼠常见耳廓肿胀足趾角叉菜胶动物抑菌作用

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