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Antioxidant,cytotoxic,and anti-venom activity of Alstonia parvifolia ***

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Asian Pacific Journal of Tropical Biomedicine 2021年第10期11卷 460-468页

作者： Maria carmen S.Tan Mary Stephanie S.carranza Virgilio c.Linis Raymond S.Malabed Yves Ira A.Reyes Francisco c.Franco,jr. Glenn G.Oyong chemistry Department De La Salle University2401 Taft AvenueManila 1004Philippines Biology Department De La Salle University2401 Taft AvenueManila 1004Philippines Department of chemistry Graduate School of ScienceOsaka UniversityOsaka 563-0034Japan Molecular Science Unit Laboratory Center for Natural Sciences and Environmental ResearchDe la Salle University2401 Taft AvenueManila 1004Philippines

Objective:To evaluate antioxidant,cytotoxic,and anti-venom capacity of crude bark extracts of Alstonia parvifolia ***:Gas chromatography-mass spectrometry(Gc-MS)and energy dispersive X-ray analyses were accomplished to characterize the chemical constituents of Alstonia *** characterization was evaluated using an inhibitory phospholipase A_(2)(PLA_(2))assay,DPPH,and cytotoxicity *** the constituents listed in the Gc-MS analyses,molecular docking was conducted to inspect the binding energies between the chosen compounds and selected PLA_(2) ***:Gc-MS analyses showed that the Alstonia parvifolia crude extract consisted predominantly of acetylmarinobufogenin(14.89%),γ-sitosterol(10.44%),3-O-methyl-D-glucose(5.88%),3,5-dimethoxy-4-hydroxyphenylacetic acid(5.30%),(2α,5α)-17-methoxyaspidofractinin-3-one(AFM)(4.08%),and 2,3,5,6,7,8,9-heptahydro-1-phenyl-5-(p-chlorophenylimino)-1H-benzo[e][1,4]thiazepine(HPT)(1.37%).The principal elemental components of Alstonia parvifolia were ca(4.012%)and K(1.496%),as exhibited by energy dispersive X-ray *** parvifolia showed significant free radical scavenging ability(Ic_(50):0.287 mg/mL)and was non-cytotoxic to normal HDFn cells(Ic_(50)>100μg/mL).Moreover,Alstonia parvifolia was favorably cytotoxic to McF-7(Ic_(50):4.42µg/mL),followed by H69PR,HT-29,and THP-1,with Ic_(50) values of 4.94,5.07,and 6.27µg/mL,*** parvifolia also displayed notable inhibition against PLA_(2) activity of Naja philippinensis Taylor venom with Ic_(50) of(15.2±1.8)μg/*** and cluster analyses projected negative binding energies from AFM(−6.36 to−9.68 kcal/mol),HPT(−7.38 to−9.77 kcal/mol),and acetylmarinobufogenin(−7.22 to−9.59 kcal/mol).These calculations were for the particular interactions of Alstonia parvifolia constituents to PLA_(2) homologues where the utmost affinity was detected in HPT owing to the dipole interactions with amino acid ***:The bark e

关键词： Alstonia parvifolia Merr. Naja philippinensis Taylor Gas chromatography-electron ionization-mass spectrometry Secretory phospholipase A_(2) cytotoxicity assay Anti-venom

Role of Lactic Acid Bacteria-Myeloperoxidase Synergy in Establishing and Maintaining the Normal Flora in Man

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Food and Nutrition Sciences 2013年第11期4卷 67-72页

作者： Robert c. Allen Jackson T. Stephens jr. Department of Pathology School of Medicine Creighton University Omaha USA ExOxEmis Inc. Little Rock USA

Lactic acid bacteria (LAB) are incapable of cytochrome synthesis and lack the heme electron transport mechanisms required for efficient oxygen-based metabolism. consequently, LAB redox activity is flavoenzyme-based and metabolism is fermentative, producing lactic acid, and in many cases, hydrogen peroxide (H2O2). Despite this seeming metabolic limitation, LAB dominate in the normal flora of the mouth, vagina and lower gastrointestinal tract in man. Myeloperoxidase (MPO) is produced by the neutrophil leukocytes and monocytes that provide the innate phagocyte defense against infecting pathogens. MPO is unique in its ability to catalyze the H2O2-dependent oxidation of chloride (cl-) to hypochlorite (Ocl-). In turn, this Ocl- directly reacts with a second H2O2 to produce singlet molecular oxygen (), a metastable electronic excitation state of oxygen with a microsecond lifetime that restricts its combustive reactivity within a submicron radius of its point of generation. Each day a healthy human adult produces about a hundred billion neutrophils containing about 4 femtograms MPO per neutrophil. Inflammatory states and G-cSF treatment increase both neutrophil production and the quantity of MPO per neutrophil. After a short circulating lifetime, neutrophils leave the blood and migrate into body spaces including the mouth, vagina, urinary tract, and gastrointestinal tract. Greater than a hundred thousand neutrophils are lavaged from the mouths of healthy humans;the quantity lavaged is proportional to the blood neutrophil count. MPO selectively and avidly binds to most Gram-positive and all Gram-negative bacteria tested, but LAB do not show significant MPO binding. Neutrophils migrating to normal flora sites release MPO into the LAB-conditioned milieu containing adequate acidity and H2O2 to support extra-phagocyte MPO microbicidal action. In combination, LAB plus MPO exert a potent synergistic microbicidal action against high MPO-binding microbes. This LAB-MPO synergy provid

关键词： Myeloperoxidase Lactic Acid Bacteria Hydrogen Peroxide Hypochlorite Singlet Oxygen Selective Binding Selective Microbicidal Action Normal Flora

A MESFET variable-capacitance analytical model

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chinese Science Bulletin 1997年第5期42卷 374-377页

作者： Sun, XW Luo, JS Zhou, ZM cao, jr Lin, JT Department of Electronic Engineering Xi’an Jiaotong University Xi’an China Nanjing Electronic Devices Institute Nanjing China

A GaAs MESFET three-terminal varactor diode fabricated on a semi-insulating substrate can be used for the MMIc active voltage-controlled filter because it is compatible with the standard GaAs MMIc process. The high capacitance ratio needed for wideband tuning filter requires the three-terminal varactor diode (TTVD) to be biased up pinch-off voltage or positive bias. Therefore a variable-capacitance model is applied to analyzing c-V characteristics of this TTVD. The earlier capacitance model for GaAs MESFET did not consider the free carrier move in active region which can cause varying the c-V characteristic, but only depletion layer model approximation. The new model described here takes into account the free carrier move for contributing to gate capacitance. The model analytical results agree well with experiment.

关键词： MMIc GaAs MESFET variable-capacitance model free carrier move.

Small Mammal Habitat Use within Restored Riparian Habitats Adjacent to channelized Streams in Mississippi

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Journal of Environmental Protection 2013年第11期4卷 1280-1291页

作者： Peter c. Smiley jr. charles M. cooper USDA-ARS National Sedimentation Laboratory Oxford Mis- sissippi USA USDA-ARS Soil Drainage Research Unit Columbus Ohio USA

Riparian zones of channelized agricultural streams in northwestern Mississippi typically consist of narrow vegetative corridors low in habitat diversity and lacking riparian wetlands. Land clearing practices and stream channelization have led to the development of gully erosion and further fragmentation of these degraded riparian zones. currently, installation of a gully erosion control structure (drop pipe) at the riparian zone-agricultural field interface leads to the incidental establishment of four riparian habitat types that differ in habitat area, vegetative structure, and pool size. Small mammals were sampled within four sites of each habitat type from June 1994 to July 1995. Small mammal diversity, abundance, and hispid cotton rat (Sigmodon hispidus) weight were the least within smallest Type I habitats with the least vegetative structural diversity and were the greatest within the larger Type II, III, or IV habitats having greater vegetative structural diversity and pool size. Small mammal diversity and abundance were the least in the summer 1994, increased in the fall 1994, and then declined later in our study. Hispid cotton rat abundance was the least in summer 1994, winter 1994, and spring 1995 and was the greatest in fall 1994 and summer 1995. Our results suggest that modifying the drop pipe installation design to facilitate the development of larger riparian habitats with greater vegetative structural diversity will provide the greatest benefits for small mammals.

关键词： Gully Erosion channelization channel Incision Erosion control Small Mammals

中国多省市急性冠状动脉综合征住院患者高胆固醇血症患病现况

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中华心血管病杂志 2009年第5期37卷 449-453页

作者：刘军赵冬刘群刘静孙佳艺 Sidney c Smith jr 首都医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病研究室北京100029 美国北卡大学医学院

目的了解中国多省市急性冠状动脉综合征（AcS）住院患者高胆固醇血症的患病、知晓及治疗现状。方法以2751例住院诊断的AcS患者为研究对象。2006年在中国31个省市自治区选择32家三级医院和32家二级医院，每家医院以研究启动时点起连续选... 详细信息

目的了解中国多省市急性冠状动脉综合征（AcS）住院患者高胆固醇血症的患病、知晓及治疗现状。方法以2751例住院诊断的AcS患者为研究对象。2006年在中国31个省市自治区选择32家三级医院和32家二级医院，每家医院以研究启动时点起连续选择50例经住院诊断的AcS患者。为避免研究可能带来的干预影响，采用回顾形式收集已出院患者的病历，填写统一表格，分析患者高胆固醇血症的患病、院前知晓及治疗情况。结果（1）在调查的2751例AcS住院患者中，男性占68.8％（1893例），女性占31.2％（858例），平均年龄（65±11）岁；其中心电图ST段抬高心肌梗死占39.4％，非ST段抬高心肌梗死8.8％，不稳定性心绞痛占51.8％；既往有AcS病史者27.3％。（2）2751例AcS住院患者中19.6％伴有高胆固醇血症，女性（25.5％）高于男性（16.9％，P〈0.01）；按地理区域分为7个地区（华北、华东、华南、华中、东北、西北和西南），其中华东地区患者高胆固醇血症患病率最高（24.7％），华中地区最低（10.0％），各地区间的差异具有统计学意义（P〈0.01）。（3）在540例高胆固醇血症患者中，入院前知晓率为12.2％，各地区间知晓率的差异具有统计学意义（P〈0.05）；入院前高胆固醇血症的治疗率为8.2％，知晓者的治疗率为66.7％；治疗率最高的是华南地区（83.3％），最低是西南地区（0％）。（4）既往有AcS史的患者中高胆固醇血症的患病率为22.1％，知晓率为18.1％，治疗率为76.7％，上述三率均高于既往无AcS病史者（18.7％、9.7％、58.3％）；其中仅有21.2％的患者胆固醇控制达标。结论AcS住院患者中近20％伴有高胆固醇血症；入院前高胆固醇血症知晓率为12.2％；治疗率为66.7％。既往有AcS史的高胆固醇血症患者仅有1／5控制达标，这在冠心病二级预防中应当引起重视。

关键词：冠状动脉疾病高胆固醇血症患病率

Laparoscopic resection of primary retroperitoneal schwannoma:A case report

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World Journal of clinical cases 2020年第18期8卷 4114-4121页

作者： Marcelo AF Ribeiro jr Yasmin GB Elias Samara de S Augusto Paola R Néder cássia TK costa Andressa D Maurício Adriano P Sampaio Alexandre Z Fonseca General Surgery and Trauma Department Catholic University of São Paulo–PUC-Sorocaba and Moriah HospitalSão Paulo 04083-002São Paulo CEPBrazil Department of Surgery Medical SchoolSanto Amaro UniversitySão Paulo 04743-030São Paulo StateBrazil General Surgery and Trauma Department Moriah HospitalSão Paulo 04083-002São Paulo StateBrazil

BAcKGROUND Schwannomas are rare,often benign,tumors deriving from Schwann cells that have low incidence in the retroperitoneal region(0.5%to 5%).Their diagnosis is hardly confirmed at early stage due to lack of specific features in signs,symptoms and imaging ***,it is necessary performing guided punch biopsy in order to identify *** removal is the treatment of choice due to its low sensitivity to radiation and *** SUMMARY Forty-seven years old female patient who was hospitalized for elective orthopedic procedure,without complications,evolved with severe pain in the lower limbs,thigh and gluteal region associated with neurogenic *** pain required magnetic resonance imaging(MRI)of the lumbar spine,which showed epidural collection with dural compression and massive heterogeneous perihepatic nodular *** surgical team opted for draining the collection,as well as requested an MRI of the abdomen and pelvis,whose analysis showed expansive lesion in the retroperitoneum,in close contact with the inferior vena cava and with the right renal vein.A guided puncture was performed for diagnostic clarification,which showed immunohistochemical profile compatible with *** selected treatment comprised retroperitoneum tumor resection in association with laparoscopic *** patient was discharged and remained stable after 4-mo follow-up;she remains under followup to check the need of cancer *** Schwannoma features requires surgical treatment based on laparoscopic resection,which often presents low relapse rates and optimistic prognosis.

关键词： Neurilemmoma Neoplasms Retroperitoneal space Laparoscopy case report

Botryosphaeria, Neofusicoccum, Neoscytalidium and Pseudofusicoccum species associated with mango in Brazil

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Fungal Diversity 2013年第4期61卷 195-208页

作者： Marília W.Marques Nelson B.Lima Marcos A.de Morais jr Sami J.Michereff Alan J.L.Phillips Marcos P.S.câmara Departamento de Agronomia Universidade Federal Rural de Pernambuco52171-900 RecifeBrazil Departamento de Genética Universidade Federal de Pernambuco50732-970 RecifeBrazil centro de Recursos Microbiológicos Departamento de Ciências da VidaFaculdade de Ciências e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal

Members of the Botryosphaeriaceae are well known fungi associated with dieback,canker and fruit rot on various hosts worldwide,including *** aim of this study was identify a large collection of Botryosphaeriaceae species associated with dieback and stem-end rot of mango in the semi-arid region of Northeastern Brazil,and compare the species in relation to mycelial growth,pathogenicity and virulence.A total of 115 isolates were sampled and based on morphology and DNA sequence data(ITS and EF1-α)seven taxa were identified,namely,Botryosphaeria dothidea,***,Fusicoccum fabicercianum,Neofusicoccum parvum,*** ***,Neoscytalidium dimidiatum and Pseudofusicoccum *** and *** were the most commonly isolated species,which represented 37%and 33%of all isolates *** is reported for the first time in association with mango diseases *** were significant differences among the species obtained in this study in relation to optimum temperature for mycelial growth and mycelial growth *** species were pathogenic on mango *** were significant differences in virulence among the species,with *** and *** being the most virulent species,while *** was the least virulent.

关键词： Botryosphaeriaceae Dieback Stem-end rot Mangifera indica Pathogenicity Virulence Phylogeny

Lightning changes in Response to Global Warming in Rio de Janeiro, Brazil

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American Journal of climate change 2020年第3期9卷 266-273页

作者： Osmar Pinto jr. Iara R. c. A. Pinto Brazilian Institute of Space Research (INPE) S. J. dos Campos Brazil

Physical concepts based on the clausius-clapeyron relation and on the thermodynamics and aerosol characteristics associated with updrafts, global climate models assuming different parametrizations and lightning-relat... 详细信息

Physical concepts based on the Clausius-Clapeyron relation and on the thermodynamics and aerosol characteristics associated with updrafts, global climate models assuming different parametrizations and lightning-related output variables, and lightning-related data (thunderstorm days) are being used to infer the lightning incidence in a warmer planet, motivated by the global warming observed. In all cases, there are many gaps to be overcome making the lightning response to the global temperature increase still unpredicted. Values from almost 0% (no increase) to 100% have been estimated, being 10% the most common value. While the physical concepts address only part of the problem and the global climate models need to make many simple assumptions, lightning-relate data have strong time and space limitations. In this context, any new evidence should be considered as an important contribution to better understand how will be the lightning incidence in the future. In this article, we described new results about the occurrence of thunderstorms from 1850 to 2010 (a period of 160 years) in the city of Rio de Janeiro, in the Southeast of Brazil. During this period thunderstorm days were recorded in the same location, making this time series one of the longest series of this type available worldwide. The data support an increase of 21% in the mean annual thunderstorm days during the period, while surface temperature increased by 0.6ckground-color:#ffffff;font-style:normal;text-indent:0px;display:inline !important;font-family:Verdana;white-space:normal;orphans:2;flo

关键词： Lightning Global change Rio de Janeiro Brazil

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