检索结果-南通市图书馆

Potential therapeutic targets identified by integrated miRNA and mRNA expression profiling in Chagas disease:miRNA-associated pathology Development and Immune Response pathways

Potential therapeutic targets identified by integrated miRNA...

引用

第十届全国免疫学学术大会

作者： Ludmila Rodrigues Pinto Ferreira Frederico Moraes Ferreira Monique Andrade Baron Darlan da Silva Candido Laurie Laugier Sandrine Cabantous Amanda Farage Frade Ronaldo Honorato Barros Santos Christophe Chevillard Jorge Kalil edecio cunha-neto Laboratory of Immunology Heart Institute (InCor) University of Sao PauloSchool of Medicine Division of Clinical Immunology and Allergy University of Sao Paulo School of Medicine Universidade Santo Amaro (UNISA) INSERM U906 Aix-Marseille University AMU Faculte de Medecine Division of Transplantation Heart Institute (InCor) University of Sao PauloSchool of Medicine

Chronic Chagas Cardiomyopathy (CCC) is the severe manifestation of Chagasdisease, caused by infection with the protozoan parasite Trypanosoma *** is characterized by myocardial inflammation, arrhythmias, heart

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Interferon-γ and other inflammatory mediators in cardiomyocyte signaling during Chagas disease cardiomyopathy

引用

World Journal of Cardiology 2014年第8期6卷 782-790页

作者： Ludmila Rodrigues Pinto Ferreira Amanda Farage Frade Monique Andrade Baron Isabela cunha Navarro Jorge Kalil Christophe Chevillard edecio cunha-neto Laboratory of Immunology Heart Institute (InCor)School of MedicineUniversity of S o Paulo05403-001 S o PauloBrazil Division of Clinical Immunology and Allergy School of MedicineUniversity of S o Paulo05403-001 S?o PauloBrazil Institute for Investigation in Immunology (iii) INCT05403-001 S o PauloBrazil Aix-Marseille Université INSERMGIMP UMR_S90613385 MarseilleFrance

Chagas disease cardiomyopathy(CCC), the main consequence of Trypanosoma cruzi(***) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected individuals. The heart inflammation in CCC patients is characterized by a Th1 T cell-rich myocarditis with increased production of interferon(IFN)-γ, produced by the CCC myocardial infiltrate and detected at high levels in the periphery. IFN-γ has a central role in the cardiomyocyte signaling during both acute and chronic phases of *** infection. In this review, we have chosen to focus in its pleiotropic mode of action during CCC, which may ultimately be the strongest driver towards pathological remodeling and heart failure. We describe here the antiparasitic protective and pathogenic dual role of IFN-γ in Chagas disease.

关键词： Chagas disease Trypanosoma cruzi Interferon-gamma Gene expression Cardiomyopathy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathogenesis of Chagas disease cardiomyopathy

引用

World Journal of Clinical Infectious Diseases 2012年第3期2卷 39-53页

作者： Priscila Camillo Teixeira Amanda Farrage Frade Luciana Gabriel Nogueira Jorge Kalil Christophe Chevillard edecio cunha-neto Labora-tory of Immunology Heart Institute (Incor) School of Medicine University of Sao Paulo Institute for Investigation in Immunology (III) INCT Division of Clinical Immunol-ogy and Allergy School of Medicine University of Sao Paulo INSERM Aix-Marseille University

Chagas disease, or American trypanosomiasis, is a parasitic infection caused by the flagellate protozoanTrypanosoma cruzi. Chagas disease is mainly affecting rural populations in Mexico and Central and South America. The World Health Organization estimates that 300 000 new cases of Chagas disease occur every year and approximately 20 000 deaths are attributable to Chagas. However, this organisation classified Chagas disease as a neglected tropical disease. The economic burden of this disease is significant. In many Latin American countries, the direct and indirect costs, including the cost of health care in dollars and loss of productivity, attributable to Chagas disease ranges from $40 million to in excess of $800 million per nation per annum. So, it remains a contemporary public health concern. In chronic phase, mortality is primarily due to the rhythm disturbances and congestive heart failure that result from the chronic inflammatory cardiomyopathy(CCC) due to the persistence presence of parasites in the heart tissue. Mechanisms underlying differential progression to CCC are still incompletely understood. In the last decades immunological proteomic genetic approaches lead to significant results which help to disperse the veil covering the knowledge of the pathogenic process. Here, we reported these significant progresses.

关键词： Chagas Pathogenesis Cardiomyopathy Susceptibility Parasitic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：