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Hypoxic and temporal variation in the endocrine disrupting toxicity of perfluorobutanesulfonate in marine medaka(Oryzias melastigma)

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Journal of Environmental sciences 2024年第2期136卷 279-291页

作者： Baili sun Jing Li Yachen Bai Xiangzhen Zhou Paul K.s.lam Lianguo Chen state Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of sciences Beijing 100049China Office of the President Hong Kong Metropolitan University30 Good Shepherd StreetKowloonHong Kong SARChina

Perfluorobutanesulfonate(PFBs)is an emerging pollutant capable of potently disrupting the sex and thyroid endocrine s.s.ems of ***,the hypoxic and temporal variation in PFBs endocrine disrupting toxicity remain largely *** the present study,adult marine medaka were exposed to environmentally realistic concentrations of PFBs(0 and 10μg/L)under normoxia or hypoxia conditions for 7 days,aiming to explore the interactive behavior between PFBs and *** addition,PFBs.s.ngular exposure was extended till 21days under normoxia to elucidate the time-course progression in PFBs *** results.s.owed that hypoxia inhibited the growth and caused the s.s.ension of egg spawn regardless of PFBs *** regard to the sex endocrine s.s.em,7-day PFBs exposure led to an acute stimulation of transcriptional profiles in females,which,subsequently,recovered after the 21-day *** potency of hypoxia to disturb the sex hormones was much stronger than PFBs.A remarkable increase in estradiol concentration was noted in medaka blood after hypoxia *** in sex endocrinology of coexposed fish were largely determined by hypoxia,which drove the formation of an estrogenic *** further enhanced the endocrine disrupting effects of ***,the hepatic synthes.s.of vitellogenin and choriogenin,two commonly used sensitive biomarkers of estrogenic activity,failed to initiate in response to the estrogen *** to sex endocrine s.s.em,disturbances in thyroidal axis by PFBs or hypoxia were relatively ***,the present findings will advance our toxicological understanding about PFBs pollutant under the interference of hypoxia.

关键词： Perfluorobutanesulfonate(PFBs) Aquatic hypoxia Temporal toxicity Combined exposure Endocrine disruption Marine medaka

Analys.s.of the inflection points of height-diameter models

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Forest Ecos.s.ems 2024年第4期11卷 414-422页

作者： Tzeng Yih lam Mark J.Ducey Department of Forest Resources Management Faculty of ForestryThe University of British Columbia2045-2424 Main MallVancouverBCV6T 1Z4 Canada Department of Natural Resources and the Environment University of New Hampshire114 James HallDurhamNH 03824USA

The inflection point is an important feature of sigmoidal height-diameter(H-D)*** is often cited as one of the properties favoring sigmoidal model ***,there are very few studies analyzing the inflection points of H-D *** goals of this.s.udy were to theoretically and empirically examine the behaviors of inflection points of six common H-D models with a regional *** six models were the Wykoff(WYK),schumacher(sCH),Curtis(CUR),HossfeldⅣ(HOs),von Bertalanffy-Richards(VBR),and Gompertz(GPZ)*** models were first fitted in their base forms with tree species as random effects and were then expanded to include functional traits and spatial *** distributions of the estimated inflection points were similar between the two-parameter models WYK,sCH,and CUR,but were different between the threeparameter models HOs,VBR,and *** produced some of the largest inflection *** and VBR produced concave H-D curves without inflection points for 12.7%and 39.7%of the tree *** species or decreasing shade tolerance resulted in larger inflection *** trends in the estimated inflection points of HOs and VBR were entirely opposite across the ***,HOs could produce concave H-D curves for portions of the *** on the studied behaviors,the choice between two-parameter models may not *** recommend comparing seve ral three-parameter model forms for cons.s.ency in estimated inflection points before deciding on *** sigmoidal models to have inflection points does not necessarily mean that they will produce fitted curves with *** study highlights the need to integrate analys.s.of inflection points into modeling H-D relationships.

关键词： Concavity Forest inventory and analysis Generalized height-diameter models Growth functions Height-diameter functions Mixed-effects modeling Points of inflection species.s.ecific models

Epitranscriptomic Regulation of NMDA Receptors Rears its Ugly Head in Chemotherapy-Induced Neuropathic Pain

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Neuroscience Bulletin 2024年第8期40卷 1209-1211页

作者： Wing lam Yu Gerald W.Zamponi Department of Clinical Neurosciences Hotchkiss Brain InstituteAlberta Children's Hospital Research InstituteUniversity of CalgaryCalgaryAB T2N 4N1Canada

A number of different cancer chemotherapy agents.s.ch as cisplatin,oxaliplatin,and paclitaxel can lead to nerve damage,thereby giving rise to neuropathic pain states that present with mechanical and cold allodynia[1].Although these pain conditions often resolve after completion of the chemotherapy,a significant portion of patients exhibit longlasting pain that can pers.s. longer than 12 months with a negative impact on the quality of life of affected individuals[1].

关键词： chemotherapy pain damage

Interfacial friction induced capillary flow within nanofiber-supported ionic liquid droplets

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Green Energy & Environment 2024年第5期9卷 789-791页

作者： Yuanyuan Zhao Gang Xia Yintung lam John Haozhong Xin school of Fashion and Textiles The Hong Kong Polytechnic UniversityHong KongChina shenzhen Research Institute The Hong Kong Polytechnic UniversityShenzhenChina

As global economic growth increas.s.the demand for energy sources *** fossil fuels have traditionally satisﬁed this demand,their environmental inﬂuence and limited reserves require *** fuel combustion contributes.s.bstantially to greenhouse gas emissions,with a pressing need to halve these emissions by 2030 and target net-zero by *** energy sources,contributing currently to 29%of global electricity,are viewed as promising *** wind energy's potential,Zheng's team developed a novel method to harness even low wind speeds using well-aligned nanoﬁbers and an innovative“drop wind generator”.This.s.stem,combining moisture-saturated ionic liquid 3-Methyl-1-octylimidazolium chloride with speciﬁc nanoﬁber arrays,exploits wind-inducedﬂows for energy *** study highlights the vast untapped potential of low-speed wind as a s.s.ainable energy source potentially for electronics.

关键词： Wind energy Low-speed wind Ionic liquid Electronic devices

Genomics-driven derivatization of the bioactive fungal s.s.erterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill lam Lau Ying Lo Law Chi seng Leung Chun Yin Tong Kai Kap Wong Wing lam Yim Nikolay s.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.s.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal s.s.erterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the s.s.erterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analys.s.of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tes.s.of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products s.s.erterpenoids synthetic biology Terpene synthases Variecolin

Unknown DDos Attack Detection with Fuzzy C-Means Clustering and spatial Location Constraint Prototype Loss

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Computers, Materials & Continua 2024年第2期78卷 2181-2205页

作者： Thanh-lam Nguyen HaoKao Thanh-Tuan Nguyen Mong-Fong Horng Chin-shiuh shieh Department of Electronic Engineering National Kaohsiung University of Science and TechnologyKaohsiung807618Taiwan Department of Electronic and Automation Engineering Nha Trang UniversityNha Trang650000Vietnam

since its inception,the Internet has been rapidly *** the advancement of science and technology and the explosive growth of the population,the demand for the Internet has been on the *** applications in education,healthcare,entertainment,science,and more are being increasingly deployed based on the ***,malicious threats on the internet are on the rise as *** Denial of service(DDos)attacks are among the most common and dangerous threats on the internet *** scale and complexity of DDos attacks are constantly *** Detection s.s.ems(IDs)have been deployed and have demonstrated their effectiveness in defense against those *** addition,the research of Machine Learning(ML)and Deep Learning(DL)in IDs has gained effective results and significant ***,one of the challenges when applying ML and DL techniques in intrusion detection is the identification of unknown *** attacks,which are not encountered during the s.s.em’s training,can lead to misclassification with significant *** this research,we focused on addressing the issue of Unknown Attack Detection,combining two methods.s.atial Location Constraint Prototype Loss.s.CPL)and Fuzzy C-Means(FCM).With the proposed method,we achieved promising results compared to traditional *** proposed method demonstrates a very high accuracy of up to 99.8%with a low false positive rate for known attacks on the Intrusion Detection Evaluation Dataset(CICIDs2017)***,the accuracy is also very high,reaching 99.7%,and the precision goes up to 99.9%for unknown DDos attacks on the DDos Evaluation Dataset(CICDDos2019)*** success of the proposed method is due to the combination of sLCPL,an advanced Open-set Recognition(OsR)technique,and FCM,a traditional yet highly applicable clustering *** has yielded a novel method in the field of unknown attack *** further expands the trend of applying DL and M

关键词： Cybersecurity DDos unknown attack detection machine learning deep learning incremental learning convolutional neural networks(CNN) open-set recognition(OsR) spatial location constraint prototype loss fuzzy c-means CICIDs2017 CICDDos2019

superior antibody and membrane protein‑specific T‑cell respons.s.to CoronaVac by intradermal vers.s.intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime s.Rosa Duque samuel M.s.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.lam sau Man Chan Wilfred H.s.Wong Issan Y.s.Tam Mas.s.i Mori sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina school of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell respons.s.of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two dos.s.of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC vers.s.ID-CC)and post-dose 3(IMCCC vers.s.ID-CCC).Dos.s.2 and 3 were administered to 173 and 104 adolescents,*** spike protein(s)immunoglobulin G(IgG),s-receptor-binding domain(RBD)IgG,s IgG Fcγreceptor IIIa(FcγRIIIa)-binding,sNM[sum of individual(s),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),sNM-specific IL-2^(+)CD8^(+),s.s.ecific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)respons.s.fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,s-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,s IgG avidity,s IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)respons.s.were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell respons.s.by ID inactivated sARsCoV-2 vaccination and serves as the bas.s.for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

编写诗乐大音乐史的理想与实际困难:我的个人体会

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黄钟（武汉音乐学院学报） 2024年第2期 6-13,167页

作者： [美]林萃青美国密歇根大学音乐学院安娜堡MI48109 中国音乐学院

该文是作者基于在《牛津手册:中国与海外华人音乐》中发表的“中国人为什么、又如何唱《诗经》歌曲?”(Why and How Do Chinese sing shijing songs?),以及正在写作的《孔子之歌:中国诗乐的大历史描述》(Confucius.s.songs:A Global His... 详细信息

该文是作者基于在《牛津手册:中国与海外华人音乐》中发表的“中国人为什么、又如何唱《诗经》歌曲?”(Why and How Do Chinese sing shijing songs?),以及正在写作的《孔子之歌:中国诗乐的大历史描述》(Confucius.s.songs:A Global History of Chinese shiyue)一书有关编写诗乐大音乐史的理论建构和相关思考。作者突破了对传统诗乐历史认知的框架,以“大历史”的理念观照诗乐和格里高利圣咏历史发展的异同,为当今理解诗乐提供了新路径。

关键词：诗经诗乐大历史大音乐史格里高利圣咏

Using Five Music Instructional Methods to Illustrate the social Constructive Music Teaching Framework in Hong Kong Primary Level Music Education

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sino-Us English Teaching 2024年第6期21卷 247-269页

作者： lam Wing Yin The Hong Kong University of science and Technology Hong Kong SAR

Music education under the frame name of arts education has been integrated into the primary and secondary education curriculums in Hong Kong for more than 20 years.s.arting from 2001,the year of launching the Learning to Learn curriculum for the reconstruction of the education s.s.em for the younger *** education,embedded into the arts education,was therefore regarded as one of the key subjects to cultivate and uplift student holistic development,focusing on aesthetic skill training and moral growth *** research was an exploration study of music teaching practices from two private international and two general public school music teachers at the primary school *** value of this.s.udy rested on borrowing the idea of shulman’s pedagogical content knowledge(PCK)principle to create a social constructivist music teaching framework from five commonly-used instructional methods,namely,Orff,Kodaly,Dalcrozes.s.zuki,and Gordon’s *** on the evaluations of these four case studies,hypothes.s.on the differences in the PCK were tested with the types of schools and found to be no *** preliminary results.s.ggested that music teachers in private international schools had similar pedagogical approaches to music instruction to teachers in aided-public ***,the modeling,guiding,and training approach was identified as a grounded teaching method for music education at the primary school level regardless of different types of *** implications like the further development of the framework were discussed.

关键词： pedagogy social constructivism music education primary school Hong Kong